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The viral capsid as novel nanomaterials for drug delivery

Aljabali AA 1 , Hassan SS 2 , Pabari RM 3 , Shahcheraghi SH 4 , Mishra V 5 , Charbe NB 6 Show all authors , Chellappan DK 7 , Dureja H 8 , Gupta G 9 , Almutary AG 10 , Alnuqaydan AM 10 , Verma SK 11 , Panda PK 11 , Mishra YK 12 , Serrano-Aroca Á 13 , Dua K 14 , Uversky VN 15 , Redwan EM 16 , Bahar B 17 , Bhatia A 18 , Negi P 19 , Goyal R 19 , McCarron P 20 , Bakshi HA 20 , Tambuwala MM 20

Affiliations 

  • 1 Faculty of Pharmacy, Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid, 21163, Jordan
  • 2 Department of Mathematics, Pingla Thana Mahavidyalaya, Paschim Medinipur, India
  • 3 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland
  • 4 Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • 5 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India
  • 6 Department of Pharmaceutical Sciences, Rangel College of Pharmacy, Texas A&M University, Kingsville, TX 78363, USA
  • 7 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia
  • 8 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India
  • 9 School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, 302017, India
  • 10 Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia
  • 11 Condensed Matter Theory Group, Materials Theory Division, Department of Physics & Astronomy, Uppsala University, Uppsala, 75120, Sweden
  • 12 University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, Sønderborg 6400, Denmark
  • 13 Biomaterials & Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, Valencia, 46001, Spain
  • 14 Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Australia
  • 15 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
  • 16 King Abdulazizi University, Faculty of Science, Department of Biological Science, Saudi Arabia
  • 17 International Institute of Nutritional Sciences & Food Safety Studies, School of Sport & Health Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK
  • 18 Maharaja Ranjit Singh Punjab Technical University Dabwali Road, Bathinda, Punjab, 151001, India
  • 19 School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan, 173229, India
  • 20 School of Pharmacy & Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, Northern Ireland, BT52 1SA, UK
Future Sci OA, 2021 Oct;7(9):FSO744.
PMID: 34737885 DOI: 10.2144/fsoa-2021-0031

Abstract

The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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