• 1 Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK
  • 2 Stroke Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK
  • 3 School of Medicine, University of Western Australia, Perth, Australia
  • 4 Radiological Sciences, University of Nottingham, Nottingham, UK
  • 5 Department of Neurology, Medical Faculty, Selcuk University, Konya, Turkey
  • 6 The First University Clinic of Tbilisi State Medical University, Tbilisi, Georgia
  • 7 Stroke Service, Adelaide and Meath Hospital, Tallaght, Ireland
European stroke journal, 2020 Jun;5(2):123-129.
PMID: 32637645 DOI: 10.1177/2396987320901391


Introduction: Seizures are common after intracerebral haemorrhage. Tranexamic acid increases the risk of seizures in non-intracerebral haemorrhage population but its effect on post-intracerebral haemorrhage seizures is unknown. We explored the risk factors and outcomes of seizures after intracerebral haemorrhage and if tranexamic acid increased the risk of seizures in the Tranexamic acid for IntraCerebral Haemorrhage-2 trial.

Patients and methods: Seizures were reported prospectively up to day 90. Cox regression analyses were used to determine the predictors of seizures within 90 days and early seizures (≤7 days). We explored the effect of early seizures on day 90 outcomes.

Results: Of 2325 patients recruited, 193 (8.3%) had seizures including 163 (84.5%) early seizures and 30 (15.5%) late seizures (>7 days). Younger age (adjusted hazard ratio (aHR) 0.98 per year increase, 95% confidence interval (CI) 0.97-0.99; p = 0.008), lobar haematoma (aHR 5.84, 95%CI 3.58-9.52; p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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