Affiliations 

  • 1 De La Salle University Medical Center, Dasmariñas, Cavite Philippines
  • 2 Apollo Children Hospital, Chennai, India
  • 3 D. Y. Patil Medical College & Hospital, Navi Mumbai, India
  • 4 Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
  • 5 D. Y. Patil Medical College, Pune, India
  • 6 KPJ Sabah Specialist Hospital, Kota Kinabalu, Sabah Malaysia
  • 7 Vietnam Pediatric Association, Hanoi, Vietnam
  • 8 Hanoi Medical University, Hanoi, Vietnam
  • 9 Pai's Clinic, Chembur, Mumbai, India
  • 10 University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Vietnam
  • 11 National University Hospital, Singapore, Singapore
  • 12 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • 13 Institute of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, The Medical City, Pasig City, Philippines
PMID: 33110611 DOI: 10.1186/s40794-020-00120-4

Abstract

This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Evidence-based recommendations and randomized controlled trials in the region are included. Cultural aspects, health management issues and economic factors were also considered. Final recommendations were approved by utilizing a modified Delphi process and applying the Likert scale in an electronic voting process. Bacillus clausii was recommended as an adjunct treatment with oral rehydration solution for acute viral diarrhea. B. clausii may also be considered for prevention of antibiotic-associated diarrhea, Clostridium difficile-induced diarrhea, and as adjunct treatment of Helicobacter pylori. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological, socioeconomical and health system conditions, similar recommendations currently apply to most Asia-Pacific countries. Ideally, these need to be validated with local randomized-controlled trials.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.