Affiliations 

  • 1 Department of Oral Biology, Kulliyyah of Dentistry, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • 2 Kulliyyah of Dentistry, IIUM, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • 3 Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, IIUM, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • 4 International Institute for Halal Research and Training, Level 3, KICT Building, IIUM, 53100 Jalan Gombak, Selangor, Malaysia
  • 5 Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jl. Salemba Raya IV, 10430 Jakarta, Indonesia
Jpn Dent Sci Rev, 2020 Nov;56(1):147-154.
PMID: 33204370 DOI: 10.1016/j.jdsr.2020.09.001

Abstract

Managing a bleeding patient can be a challenge during dental surgery. Profuse hemorrhage due to platelet defects, coagulation disorders, vascular anomalies, medication-induced patients, as well as inherited bleeding ailments result in soft tissue hematoma, septic shock, compromised airway, and in some severe cases, death could occur. A vast array of surgical hemostatic agents are available to stop bleeding, including chitosan-based hemostatic agents. Chitosan has an advantage over other topical hemostatic materials for its ability to promote shorter bleeding times and assist in healing. Massive behind-the-scene research and development efforts are ongoing to increase the performance of chitosan as a hemostatic agent. Numerous studies on chitosan use in dental hemostasis have registered it as being safe, biodegradable, biocompatible, promoting healing, antimicrobial and bioactive. This article reviews the application of chitosan in managing hemostasis in dental patients.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.