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Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence

Hagen RM , Adamo P , Karamat S , Oxley J , Aning JJ 1 , Gillatt D 1 Show all authors , Persad R 1 , Ladomery MR , Rhodes A 2

Affiliations 

  • 1 North Bristol NHS Trust, Bristol, UK; and
  • 2 From the Faculty of Health & Life Sciences, University of the West of England, Bristol, UK; Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. Anthony.Rhodes@ummc.edu.my
Am J Clin Pathol, 2014 Oct;142(4):533-40.
PMID: 25239421 DOI: 10.1309/AJCPH88QHXARISUP

Abstract

The proto-oncogene ETS-related gene (ERG) is consistently overexpressed in prostate cancer. Alternatively spliced isoforms of ERG have variable biological activities; inclusion of exon 11 (72 base pairs [bp]) is associated with aggressiveness and progression of disease. Exon 10 (81 bp) has also been shown to be alternatively spliced. Within this study, we assess whether ERG protein, messenger RNA (mRNA), and ERG splice isoform mRNA expression is altered as prostate cancer progresses.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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