Effect of photobiomodulation therapy on inflammatory cytokines in healing dynamics of diabetic wounds: a systematic review of preclinical studies

Karkada G 1 , Maiya GA 1 , Houreld NN 2 , Arany P 3 , Rao Kg M 4 , Adiga S 5 Show all authors , Kamath SU 6 , Shetty S 7

Affiliations 

  • 1 Department of Physiotherapy, Centre for Diabetic Foot Care and Research, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India
  • 2 Department of Health Sciences, Laser Research Centre, University of Johannesburg, Johannesburg, South Africa
  • 3 Department of Oral Biology, School of Dental Medicine, Engineering & Applied Sciences, University at Buffalo, Buffalo, NY, USA
  • 4 Department of Anatomy, Melaka Manipal Medical College-Manipal Campus, Manipal Academy of Higher Education, Manipal, India
  • 5 Department of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India
  • 6 Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India
  • 7 Department of Biochemistry, Melaka Manipal Medical College-Manipal Campus, Manipal Academy of Higher Education, Manipal, India
Arch Physiol Biochem, 2020 Dec 28.
PMID: 33370535 DOI: 10.1080/13813455.2020.1861025

Abstract

CONTEXT: Delayed wound healing in diabetes mellitus (DM) is due to the overlapping phases of the healing process. The prolonged inflammation and altered levels of inflammatory cytokines lead to deformed cell proliferation. Photobiomodulation alleviates the expression of inflammatory cytokines and promotes tissue repair, thereby restoring the wound healing process.

OBJECTIVE: To find out the effect of photobiomodulation therapy (PBMT) in the healing dynamics of diabetic wounds with particular emphasis on interleukin-6, interleukin-1β, and tumour necrosis factor-α.

METHODS: Scientific databases searched using keywords of the population: DM, intervention: PBMT, and outcomes: inflammatory cytokines.

RESULTS: We have included five preclinical studies in the present systematic review for qualitative analysis. These studies evaluated the effect of PBMT at different wavelengths, dosage, and time on wound healing in DM.

CONCLUSIONS: The systematic review concludes that PBMT regulates inflammatory cytokines levels, enhances cell proliferation, and migration, thereby improving the wound healing properties.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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