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Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors

Sivasothy Y 1 , Krishnan T 2 , Chan KG 3 , Abdul Wahab SM 4 , Othman MA 5 , Litaudon M 6 Show all authors , Awang K 7

Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. yasodhasivasothy@gmail.com
  • 2 Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. thibavengdes@yahoo.com
  • 3 Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. kokgan@um.edu.my
  • 4 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. maryamabdwahab@gmail.com
  • 5 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. qmalxez44@gmail.com
  • 6 Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, Cedex, France. marc.LITAUDON@cnrs.fr
  • 7 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. khalijah@um.edu.my
Molecules, 2016 Mar 21;21(3):391.
PMID: 27102164 DOI: 10.3390/molecules21030391

Abstract

Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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