Affiliations 

  • 1 Department of Cardiovascular Medicine, Danyang Peoples Hospital of Jiangsu Province, Danyang, Jiangsu, China
  • 2 Innoscience Research Sdn Bhd, Selangor, Malaysia
  • 3 Department of Endocrinology, Peace Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
  • 4 Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, Thailand
Arch Physiol Biochem, 2023 Feb;129(1):261-267.
PMID: 33522287 DOI: 10.1080/13813455.2021.1876733

Abstract

The present study investigated the effect of polyphenol-rich extract of Parkia speciosa (PPS) against pancreatic and hepatorenal dysfunction in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Diabetic rats were treated with PPS (100 and 400 mg/kg) and glibenclamide. The results revealed that diabetic rats displayed marked hyperglycaemia, hyperlipidaemia, hypoinsulinemia as well as alterations in serum renal and kidney function markers. Furthermore, diabetic rats showed significant increase in hepatorenal level of malonaldehyde as well as suppression of antioxidant enzyme activities. Whereas, diabetic rats that received PPS displayed marked attenuation in most of the aforementioned parameters compared to the untreated diabetic rats. Additionally, histological examination revealed restoration of histopathological alterations of the pancreas, liver, and kidney of PPS treated diabetic rats. In conclusion, the results demonstrated that PPS could decrease serum lipids and blood glucose level, enhance insulin level and hepatorenal antioxidant capacity, as well as ameliorate hepatorenal dysfunction in rats.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.