A novel nano-anti-malarial induces redox damage and elicits cytokine response to the parasite

Das S 1 , Tripathy S 2 , Pramanik P 3 , Saha B 4 , Roy S 5

Affiliations 

  • 1 Faculty of Medicine, Manipal University College Malaysia, Jalan Padang Jambu, Bukit Baru, 75150 Melaka, Malaysia; Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721102, West Bengal, India. Electronic address: sabyasachi.das@manipal.edu.my
  • 2 University of the Free State, Bloemfontein 9300, South Africa
  • 3 Nanomaterials Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302 West Bengal, India
  • 4 National Centre for Cell Science, Ganeshkhind, Pune 411007, India
  • 5 Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721102, West Bengal, India. Electronic address: roysomenath1954@yahoo.in
Cytokine, 2021 08;144:155555.
PMID: 33992538 DOI: 10.1016/j.cyto.2021.155555

Abstract

Emergence and spread of resistant parasites to the newest chemotherapeutic anti-malarial agents are the biggest challenges against malaria control programs. Therefore, developing a novel effective treatment to reduce the overgrowing burden of multidrug resistant malaria is a pressing need. Herein, we have developed a biocompatible and biodegradable, non-toxic chitosan-tripolyphosphate-chloroquine (CS-TPP CQ) nanoparticle. CS-TPP CQ nanoparticles effectively kill the parasite through redox generation and induction of the pro- and anti-inflammatory cytokines in both sensitive and resistant parasite in vitro. The in vitro observations showed a strong inhibitory effect (p 

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