Testosterone decreases fluid and chloride secretions in the uterus of adult female rats via down-regulating cystic fibrosis transmembrane regulator (CFTR) expression and functional activity

Mohd Mokhtar H 1 , Giribabu N 1 , Kassim N 2 , Muniandy S 3 , Salleh N 4

Affiliations 

  • 1 Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
  • 2 Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
  • 3 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
  • 4 Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address: naguib.salleh@yahoo.com.my
J Steroid Biochem Mol Biol, 2014 Oct;144 Pt B:361-72.
PMID: 25125390 DOI: 10.1016/j.jsbmb.2014.08.007

Abstract

Estrogen is known to stimulate uterine fluid and Cl(-) secretion via CFTR. This study investigated testosterone effect on these changes in a rat model.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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