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Genistein-induced fluid accumulation in ovariectomised rats' uteri is associated with increased cystic fibrosis transmembrane regulator expression

Chinigarzadeh A 1 , Kassim NM 2 , Muniandy S 3 , Salleh N 1

Affiliations 

  • 1 University of Malaya, Faculty of Medicine, Department of Physiology, Kuala Lumpur, Malaysia, University of Malaya, Faculty of Medicine, Department of Physiology, Kuala Lumpur/Malaysia
  • 2 University of Malaya, Faculty of Medicine, Department of Anatomy, Kuala Lumpur, Malaysia, University of Malaya, Faculty of Medicine, Department of Anatomy, Kuala Lumpur/Malaysia
  • 3 University of Malaya, Faculty of Medicine, Department of Molecular Medicine, Kuala Lumpur, Malaysia, University of Malaya, Faculty of Medicine, Department of Molecular Medicine, Kuala Lumpur/Malaysia
Clinics (Sao Paulo), 2014 Feb;69(2):111-9.
PMID: 24519202 DOI: 10.6061/clinics/2014(02)07

Abstract

High genistein doses have been reported to induce fluid accumulation in the uteri of ovariectomised rats, although the mechanism underlying this effect remains unknown. Because genistein binds to the oestrogen receptor and the cystic fibrosis transmembrane regulator mediates uterine fluid secretion, we hypothesised that this genistein effect involves both the oestrogen receptor and cystic fibrosis transmembrane regulator.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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