Synthesis of porous 2D layered nickel oxide-reduced graphene oxide (NiO-rGO) hybrid composite for the efficient electrochemical detection of epinephrine in biological fluid

Ramu AG 1 , Umar A 2 , Ibrahim AA 3 , Algadi H 4 , Ibrahim YSA 5 , Wang Y 6 Show all authors , Hanafiah MM 7 , Shanmugam P 8 , Choi D 9

Affiliations 

  • 1 Department of Materials Science and Engineering, Hongik University, 2639-Sejong- Ro, Jochiwon-eup, Sejong-city, 30016, South Korea
  • 2 Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, Najran, 11001, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science and Arts, Najran, 11001, Kingdom of Saudi Arabia. Electronic address: ahmadumar786@gmail.com
  • 3 Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, Najran, 11001, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science and Arts, Najran, 11001, Kingdom of Saudi Arabia
  • 4 Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, Najran, 11001, Kingdom of Saudi Arabia; Department of Electrical Engineering, College of Engineering, Najran University, Najran, 11001, Kingdom of Saudi Arabia
  • 5 Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, Najran, 11001, Kingdom of Saudi Arabia
  • 6 Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou, 510006, PR China; National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou, 510006, PR China
  • 7 Department of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi UKM, Selangor, Malaysia; Centre for Tropical Climate Change System, Institute of Climate Change, Universiti Kebangsaan Malaysia, 43600, Bangi UKM, Selangor, Malaysia
  • 8 Department of Chemistry, St. Joseph University, Dimapur, Nagaland, India
  • 9 Department of Materials Science and Engineering, Hongik University, 2639-Sejong- Ro, Jochiwon-eup, Sejong-city, 30016, South Korea. Electronic address: djchoi@hongik.ac.kr
Environ Res, 2021 09;200:111366.
PMID: 34029547 DOI: 10.1016/j.envres.2021.111366

Abstract

In the present research work, 2D-Porous NiO decorated graphene nanocomposite was synthesized by hydrothermal method to monitored the concentration of epinephrine (EPI). The morphology (SEM and TEM) results confirmed 2D-Porous NiO nanoparticles firmly attached over graphene nanosheets. FTIR and XPS analysis confirmed the formation of nickel oxide formation and complete reduction of GO to rGO. The electrochemical activity of the proposed NiO-rGO/GCE modified electrode on epinephrine was analyzed by simple cyclic voltammetry technique. The proposed low cost NiO-rGO/GCE modified electrode showed excellent catalytic activity over GCE and rGO/GCE electrodes. Due to its high conductivity and charge transfer ability of the NiO-rGO/GCE modified electrode exhibited high sensitivity of EPI at optimized conditions. The anodic peak current of the EPI linearly increases with increasing the concertation of EPI. A wide linear range (50 μM-1000 μM) was achieved with high correlation coefficient (R2 = 0.9986) and the limit of detection (LOD) of NiO-rGO/GCE modified electrode was calculated to be 10 μM. NiO-rGO/GCE electrode showed good stability and repeatability towards the EPI oxidation. Mainly, the proposed NiO-rGO/GCE modified electrode showed good sensitivity of EPI in the human biological fluid with high recovery percentage. The low cost, NiO-rGO/GCE electrode could be the promising sensor electrode for the detection of Epinephrine in the real samples.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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