A cobalt oxide nanocubes interleaved reduced graphene oxide nanocomposite modified glassy carbon electrode for amperometric detection of serotonin

Shahid MM 1 , Rameshkumar P 2 , Numan A 3 , Shahabuddin S 4 , Alizadeh M 5 , Khiew PS 6 Show all authors , Chiu WS 7

Affiliations 

  • 1 Higher Institution Centre of Excellence (HICoE), UM Power Energy Dedicated Advanced Centre (UMPEDAC), Level 4, Wisma R&D University of Malaya, Jalan Pantai Baharu, 59990 Kuala Lumpur, Malaysia. Electronic address: shahid@um.edu.my
  • 2 Department of Chemistry, Kalasalingam University (Kalasalingam Academy of Research and Education), Krishnankoil 626 126, Tamil Nadu, India
  • 3 School of Science and Technology, Sunway University, No. 5, Jalan University, Bandar Sunway, 47500 Subang Jaya, Selangor
  • 4 Research Centre for Nano-Materials and Energy Technology (RCNMET), School of Science and Technology, Sunway University, Malaysia
  • 5 Higher Institution Centre of Excellence (HICoE), UM Power Energy Dedicated Advanced Centre (UMPEDAC), Level 4, Wisma R&D University of Malaya, Jalan Pantai Baharu, 59990 Kuala Lumpur, Malaysia; Laser-Plasma Research Institute, Shahid Beheshti University, G.C, Evin, Tehran 19839, Iran
  • 6 Center of Nanotechnology and Advanced Materials, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
  • 7 Low Dimensional Materials Research Centre, Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Mater Sci Eng C Mater Biol Appl, 2019 Jul;100:388-395.
PMID: 30948075 DOI: 10.1016/j.msec.2019.02.107

Abstract

Cobalt oxide nanocubes incorporated with reduced graphene oxide (rGO-Co3O4) was prepared by using simple one-step hydrothermal route. Crystallinity and structural characteristics of the nanocomposite were analyzed and confirmed using X-ray diffraction (XRD) and Raman analysis, respectively. The cubical shape of the Co3O4 nanostructures and the distribution of Co3O4 nanocubes on the surface of rGO sheets were identified through field emission scanning electron microscopy (FESEM) and energy dispersive X-ray (EDX) mapping analysis, respectively. Raman spectra depicted the presence of D and G bands for GO and rGO with different ID/IG values and thus confirmed the reduction of GO into rGO. The electrochemical study reflects that the rGO-Co3O4 nanocomposite shows good electrocatalytic activity in oxidation of depression biomarker serotonin (5-HT) in phosphate buffer (pH 7.2). The detection of 5-HT was carried out by using rGO-Co3O4 nanocomposite modified glassy carbon electrode under dynamic condition using amperometry technique with a linear range of 1-10 μM. The limit of detection and limit of quantification were calculated and found to be 1.128 and 3.760 μM, respectively with a sensitivity value of 0.133 μΑ·μM-1. The sensor showed selectivity in the presence of different interferent species such as ascorbic acid, dopamine and uric acid.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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