Affiliations 

  • 1 Centre of Advanced Manufacturing and Material Processing, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: mmmhaniffa@um.edu.my
  • 2 Centre of Advanced Manufacturing and Material Processing, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: khadija_munawar@um.edu.my
  • 3 Centre of Advanced Manufacturing and Material Processing, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: chingyc@um.edu.my
  • 4 Functional and Biomaterials Engineering Lab, Department of Mechanical Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram, 603203, Chennai, Tamil Nadu, India. Electronic address: sumitprs@srmist.edu.in
  • 5 Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 6 Centre of Advanced Manufacturing and Material Processing, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Electrical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: h.illias@um.edu.my
  • 7 Department of Chemistry, The University of Lahore, Lahore, Pakistan
  • 8 Department of Chemistry, Faculty of Natural Sciences, The Open University of Sri Lanka, 10250 Nawala, Nugegoda, Sri Lanka
  • 9 Department of Chemistry, Faculty of Science, University of Colombo, 0070 Colombo-3, Sri Lanka
  • 10 Center for MicroElectroMechanics Systems (CMEMS), University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
  • 11 Physics Division, Centre for foundation studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
Carbohydr Polym, 2021 Sep 01;267:118136.
PMID: 34119125 DOI: 10.1016/j.carbpol.2021.118136

Abstract

Cellulose and its forms are widely used in biomedical applications due to their biocompatibility, biodegradability and lack of cytotoxicity. It provides ample opportunities for the functionalization of supported magnetic nanohybrids (CSMNs). Because of the abundance of surface hydroxyl groups, they are surface tunable in either homogeneous or heterogeneous solvents and thus act as a substrate or template for the CSMNs' development. The present review emphasizes on the synthesis of various CSMNs, their physicomagnetic properties, and potential applications such as stimuli-responsive drug delivery systems, MRI, enzyme encapsulation, nucleic acid extraction, wound healing and tissue engineering. The impact of CSMNs on cytotoxicity, magnetic hyperthermia, and folate-conjugates is highlighted in particular, based on their structures, cell viability, and stability. Finally, the review also discussed the challenges and prospects of CSMNs' development. This review is expected to provide CSMNs' development roadmap in the context of 21st-century demands for biomedical therapeutics.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.