MoS2-nanoflower enhanced programmable adsorption/desorption plasmonic detection for bipolar-molecules with high sensitivity

Chen Y 1 , Chen Y 1 , Shi W 1 , Hu S 1 , Huang Q 2 , Liu GS 3 Show all authors , Shi J 4 , Chen L 1 , Azeman NH 5 , Ashrif A Bakar A 5 , Luo Y 6 , Chen Z 1

Affiliations 

  • 1 Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication Technology, Department of Optoelectronic Engineering, College of Science and Engineering, Jinan University, Guangzhou, 510632, China
  • 2 School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China
  • 3 Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication Technology, Department of Optoelectronic Engineering, College of Science and Engineering, Jinan University, Guangzhou, 510632, China. Electronic address: guishiliu@163.com
  • 4 Siyuan Laboratory, Department of Physics, Jinan University, Guangzhou , 510632, China. Electronic address: Shijifu2017@126.com
  • 5 Photonics Technology Laboratory, Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia
  • 6 Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication Technology, Department of Optoelectronic Engineering, College of Science and Engineering, Jinan University, Guangzhou, 510632, China. Electronic address: yunhanluo@163.com
Biosens Bioelectron, 2022 Feb 15;198:113787.
PMID: 34864241 DOI: 10.1016/j.bios.2021.113787

Abstract

High sensitivity and capturing ratio are strongly demanded for surface plasmon resonance (SPR) sensors when applied in detection of small molecules. Herein, an SPR sensor is combined with a novel smart material, namely, MoS2 nanoflowers (MNFs), to demonstrate programmable adsorption/desorption of small bipolar molecules, i.e., amino acids. The MNFs overcoated on the plasmonic gold layer increase the sensitivity by 25% compared to an unmodified SPR sensor, because of the electric field enhancement at the gold surface. Furthermore, as the MNFs have rich edge sites and negatively charged surfaces, the MNF-SPR sensors exhibit not only much higher bipolar-molecule adsorption capability, but also efficient desorption of these molecules. It is demonstrated that the MNF-SPR sensors enable controllable detection of amino acids by adjusting solution pH according to their isoelectric points. In addition, the MNFs decorated on the plasmonic interface can be as nanostructure frameworks and modified with antibody, which allows for specific detection of proteins. This novel SPR sensor provides a new simple strategy for pre-screening of amino acid disorders in blood plasma and a universal high-sensitive platform for immunoassay.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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