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  1. Fulltext Bromocriptine for visual field defects in prolactinomas
    Embong M, Satgunasingam N, Rejab SM, Singh H
    Med J Malaysia, 1981 Mar;36(1):29-36.
    PMID: 7321934
  2. Fulltext Dialysis encephalopathy in Kuala Lumpur
    Suleiman AB, Rejab SM, Khoo HE
    Med J Malaysia, 1986 Mar;41(1):12-8.
    PMID: 3796341
    The clinical syndrome of dialysis encephalopathy which has been observed all over the world has also been seen here. The clinical syndrome and clinical course are reported; it has been associated with high levels of aluminium in untreated water used for haemodialysis. Since the introduction of water treatment, this disease has not been observed.
  3. Efficacy of spray administration of formalin-killed Streptococcus agalactiae in hybrid Red Tilapia
    Noraini O, Sabri MY, Siti-Zahrah A
    J Aquat Anim Health, 2013 Jun;25(2):142-8.
    PMID: 23724958 DOI: 10.1080/08997659.2013.781553
    An initial evaluation of spray vaccination was carried out with 60 hybrid Red Tilapia Oreochromis spp., divided into three groups that consisted of 10 fish per group with duplicates. The formalin-killed cells (FKCs) of Streptococcus agalactiae were administered once to group 1 by spray and once daily for five consecutive days to group 2. Group 3 remained as the untreated control group and was sprayed with normal saline. A booster was given twice to all the groups, once at the second week and again at the fourth week after the first vaccination. After this initial evaluation, a challenge study was conducted with 40 tilapia divided into two groups that consisted of 10 fish per group with duplicates. Group 1 was vaccinated with FKCs of S. agalactiae by a single spray administration while group 2 remained as the untreated control group. A booster was given twice using the same protocol as in the initial evaluation. After 6 weeks, fish from one of the duplicate tanks from each of groups 1 and 2 were challenged with pathogenic S. agalactiae by intraperitoneal (IP) injection, while fish in another tank were challenged through immersion. Based on the observations, serum immunoglobulin M (IgM) levels were significantly higher (P < 0.05) in the challenged fish than in the either the preexposed fish or the control group 1 week after the initial exposure. However, no significant differences (P > 0.05) were noted between challenged groups 1 and 2. In addition, no significant differences (P > 0.05) were observed between the frequencies of exposure. The mucus IgM level, however, remained high after each booster until the end of the 8-week study period. Meanwhile, serum IgM levels decreased after the challenge. A higher percentage of survival was noted for fish challenged through immersion (80%) compared with IP injection (70%). These results suggested that single spray exposure was able to induce IgM, which gave moderate to high protection during the challenge study.
  4. Fulltext Effects of timed artificial insemination following estrus synchronization in postpartum beef cattle
    Malik A, Wahid H, Rosnina Y, Kasim A, Sabri M
    Open Vet J, 2012;2(1):1-5.
    PMID: 26623282
    The objectives of this study were to evaluate estrus response and pregnancy rates resulting from timed artificial insemination (AI) following estrus synchronization using CIDR in postpartum beef cattle. A total of 100 cows were randomly divided into three groups. Groups 1, 2 and 3 were artificially inseminated at 48-50 h (n=30), 53-55 h (n=30) and 58-60 h (n=40) after CIDR removal, respectively. Estrus synchronization was carried out using a CIDR containing 1.38 mg progesterone. All cows were given 2 mg estradiol benzoate, intramuscularly on the day of CIDR insertion (D 0). The CIDR was removed after 8 days and 125 μg of prostaglandin F2α (PGF2α) was injected intramuscularly. One day after CIDR removal all cows were given 1 mg of estradiol benzoate intramuscularly (D 9). Cows were observed visually for estrus after removal of CIDR. Between 30 and 32 days after timed AI, pregnancy was determined using transrectal ultrasonography. The first estrus observation which is approximately 32 h after CIDR removal showed no significant difference (P>0.05) among the three groups. The onset response of estrus after 32 h removal of CIDR was less than 10% in all three groups 6.6% (G1), 6.8% (G2) and 7.3% (G3). Furthermore, percentages of estrus response (D 10) following CIDR removal were 76.6%, 75.0% and 77.5%. The difference between on D 9 and D 10 estrus response were statistically significant (P<0.05). The pregnancy rates were 23.3% (G1), 26.6% (G2) and 37.5% (G3), which were not significant (P>0.05).
  5. Development and efficacy of feed-based recombinant vaccine encoding the cell wall surface anchor family protein of Streptococcus agalactiae against streptococcosis in Oreochromis sp
    Nur-Nazifah M, Sabri MY, Siti-Zahrah A
    Fish Shellfish Immunol, 2014 Mar;37(1):193-200.
    PMID: 24486904 DOI: 10.1016/j.fsi.2014.01.011
    This study was carried out to determine the antibody responses and protective capacity of an inactivated recombinant vaccine expressing the cell wall surface anchor family protein of Streptococcus agalactiae following oral vaccination against streptococcosis in tilapia. Tilapia were vaccinated orally with 10(6) CFU/mL of the recombinant vaccine incorporated in feed (feed-based recombinant vaccine) (vaccinated group or Group 1), 10(6) CFU/mL of pET-32 Ek/LIC vector without cell wall surface anchor family protein (control group or Group 2), 10(6) CFU/mL of formalin-killed cells of S. agalactiae vaccine incorporated in feed was also prepared (feed-based vaccine) (vaccinated group or Group 3), and unvaccinated control group or Group 4 (fed with commercial pellets). During the course of study, serum, mucus and gut lavage fluid were collected to evaluate the antibody levels via enzyme-linked immunosorbent assay (ELISA). The results showed that tilapia immunized with the feed-based recombinant vaccine developed a strong and significantly (P 
  6. Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2
    Zamri-Saad M, Ernie ZA, Sabri MY
    Trop Anim Health Prod, 2006 Oct-Nov;38(7-8):541-6.
    PMID: 17265769
    This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-week interval, to 7 x 10(6) cfu/ml of live P. multocida B:2. Goats of group 2 were not exposed to P. multocida B:2 but were kept together with the exposed group 1. Goats of group 3 remained as unexposed controls and were kept separated from the other two groups. Serum samples were collected at weekly intervals to determine the antibody levels. At week 5 post exposure, all goats were challenged subcutaneously with 3.7 x 10(10) cfu/ml of live P. multocida B:2. Following challenge exposure, 8 (67%) goats (4 goats from each of groups 1 and 2) were killed owing to haemorrhagic septicaemia. Four goats were killed peracutely within 48 h post challenge, while the other four goats were killed acutely between 2 and 4 days post challenge. None of the goats of group 3 were killed for haemorrhagic septicaemia. Goats of groups 1 and 2 showed significantly (p < 0.05) higher antibody levels following the first intranasal exposure to P. multocida B:2. However, only group 1 retained the significantly (p < 0.05) high antibody levels following a second intranasal exposure, and remained significantly (p < 0.05) higher than groups 2 and 3 at the time of challenge. P. multocida B:2 was successfully isolated from various organs of goats that were killed between 1 and 4 days post challenge.
  7. Fulltext Efficient models for enhancing the link adaptation performance of LTE/LTE-A networks
    Bin-Salem AA, Wan TC, Naeem H, Anbar M, Hanshi SM, Redjaimia A
    EURASIP J Wirel Commun Netw, 2022;2022(1):10.
    PMID: 35132311 DOI: 10.1186/s13638-022-02091-w
    Link adaptation (LA) is the ability to adapt the modulation scheme (MS) and the coding rate of the error correction in accordance with the quality of the radio link. The MS plays an important role in enhancing the performance of LTE/LTE-A, which is typically dependent on the received signal to noise ratio (SNR). However, using the SNR to select the proper MSs is not enough given that adaptive MSs are sensitive to error. Meanwhile, non-optimal MS selection may seriously impair the system performance and hence degrades LA. In LTE/ LTE-A, the LA system must be designed and optimized in accordance with the characteristics of the physical (e.g., MSs) and MAC layers (e.g., Packet loss) to enhance the channel efficiency and throughput. Accordingly, this study proposes using two LA models to overcome the problem. The first model, named the cross-layer link adaptation (CLLA) model, is based on the downward cross-layer approach. This model is designed to overcome the accuracy issue of adaptive modulation in existing systems and improve the channel efficiency and throughput. The second model, named the Markov decision process over the CLLA (MDP-CLLA) model, is designed to improve on the selection of modulation levels. Besides that, our previous contribution, namely the modified alpha-Shannon capacity formula, is adopted as part of the MDP-CLLA model to enhance the link adaptation of LTE/LTE-A. The effectiveness of the proposed models is evaluated in terms of throughput and packet loss for different packet sizes using the MATLAB and Simulink environments for the single input single output (SISO) mode for transmissions over Rayleigh fading channels. In addition, phase productivity, which is defined as the multiplication of the total throughput for a specific modulation with the difference between adjacent modulation SNR threshold values, is used to determine the best model for specific packet sizes in addition to determine the optimal packet size for specific packet sizes among models. Results generally showed that the throughput improved from 87.5 to 89.6% for (QPSK → 16-QAM) and from 0 to 43.3% for (16-QAM → 64-QAM) modulation transitions, respectively, using the CLLA model when compared with the existing system. Moreover, the throughput using the MDP-CLLA model was improved by 87.5-88.6% and by 0-43.2% for the (QPSK → 16-QAM)and (16-QAM → 64-QAM) modulation transitions, respectively, when compared with the CLLA model and the existing system. Results were also validated for each model via the summation of the phase productivity for every modulation at specific packet sizes, followed by the application one-way analysis of variance (ANOVA) statistical analysis with a post hoc test, to prove that the MDP-CLLA model improves with best high efficiency than the CLLA model and the existing system.
  8. Efficacy of an outer membrane protein of Pasteurella haemolytica A2, A7 or A9-enriched vaccine against intratracheal challenge exposure in sheep
    Sabri MY, Zamri-Saad M, Mutalib AR, Israf DA, Muniandy N
    Vet Microbiol, 2000 Apr 04;73(1):13-23.
    PMID: 10731614
    The outer membrane proteins (OMP) were extracted from the P. haemolytica A2, A7 and A9 to determine their potential as immunogens and their capability for cross-protection. Sixty lambs of approximately 9 months old were divided into four main groups. Animals in Group 1 were vaccinated with 2ml vaccine containing 100microg/ml of the outer membrane proteins of P. haemolytica A2. Animals in Group 2 were similarly vaccinated with the OMPs of P. haemolytica A7 while Group 3 with OMPs of P. haemolytica A9. Animals in Group 4 were unvaccinated control. During the course of the study, serum was collected to evaluate the antibody levels toward each OMP. There appeared to be good immune responses. However, high antibody levels did not necessarily result in good protection of the animals, particularly against cross-infection with P. haemolytica A9 in animals vaccinated with the OMPs of P. haemolytica A2. It seemed that the antibody responses were more specific toward the homologous challenge but generally did not cross-protect against heterologous serotype challenge. However, the OMPs of P. haemolytica A7 produced good in vivo cross-protection and excellent correlations when good antibody responses against all serotypes led to successful reductions of the extent of lung lesions following homologous and heterologous challenge exposures. Thus, the OMPs of P. haemolytica A7 was effective in protecting animals against homologous and heterologous infection by live P. haemolytica A2, A7 and A9.
  9. Fulltext A Midgut Digestive Phospholipase A2 in Larval Mosquitoes, Aedes albopictus and Culex quinquefasciatus
    Abdul Rahim NA, Othman M, Sabri M, Stanley DW
    Enzyme Res, 2018;2018:9703413.
    PMID: 29862070 DOI: 10.1155/2018/9703413
    Phospholipase A2 (PLA2) is a secretory digestive enzyme that hydrolyzes ester bond at sn-2 position of dietary phospholipids, creating free fatty acid and lysophospholipid. The free fatty acids (arachidonic acid) are absorbed into midgut cells. Aedes albopictus and Culex quinquefasciatus digestive PLA2 was characterized using a microplate PLA2 assay. The enzyme showed substantial activities at 6 and 8 μg/μl of protein concentration with optimal activity at 20 and 25 μg/μl of substrate concentration in Aedes albopictus and Culex quinquefasciatus, respectively. PLA2 activity from both mosquitoes increased in a linear function up to 1 hour of the reaction time. Both enzymes were sensitive to pH and temperature. PLA2 showed higher enzyme activities in pH 8.0 and pH 9.0 from Aedes albopictus and Culex quinquefasciatus, respectively, at 40°C of incubation. The PLA2 activity decreased in the presence of 5 mM (Aedes albopictus) and 0.5 mM (Culex quinquefasciatus) site specific PLA2 inhibitor, oleyloxyethylphosphorylcholine. Based on the migration pattern of the partially purified PLA2 on SDS-PAGE, the protein mass of PLA2 is approximately 20-25 kDa for both mosquitoes. The information on PLA2 properties derived from this study may facilitate in devising mosquitoes control strategies especially in the development of inhibitors targeting the enzyme active site.
  10. Biofilm is associated with chronic streptococcal meningoencephalitis in fish
    Isiaku AI, Sabri MY, Ina-Salwany MY, Hassan MD, Tanko PN, Bello MB
    Microb Pathog, 2017 Jan;102:59-68.
    PMID: 27890651 DOI: 10.1016/j.micpath.2016.10.029
    Biofilms are aggregates of attached microbial organisms whose existence on tissues is often recognised as a mechanism for the establishment of most chronic diseases. Herein we investigated the ability of piscine Streptococcus agalactiae, an important aquatic pathogen, for adaptation to this sessile lifestyle in vitro and in the brain of a tilapia fish model. Piscine S. agalactiae exhibited a weak attachment to polystyrene plates and expressed a low biofilm phenotype under the study conditions. Furthermore, fluorescent in situ hybridization and confocal laser scanning microscopy revealed discrete aggregates of attached S. agalactiae within brain tissues and around meningeal surfaces. They were embedded in an exopolysaccharide containing matrix, intractable to inflammatory response and showed some level of resistance to penicillin despite proven susceptibility on sensitivity test. Intracellular bacterial aggregates were also observed, moreover, antibody mediated response was not demonstrated during infection. Nucleated erythrocytes appear to facilitate brain invasion possibly via the Trojan horse mechanism leading to a granulomatous inflammation. We have demonstrated that biofilm is associated with persistence of S. agalactiae and the development of chronic meningoencephalitis in fish.
  11. Isolation and Pathogenicity of Streptococcus iniae in Cultured Red Hybrid Tilapia in Malaysia
    Rahmatullah M, Ariff M, Kahieshesfandiari M, Daud HM, Zamri-Saad M, Sabri MY, et al.
    J Aquat Anim Health, 2017 Dec;29(4):208-213.
    PMID: 28787246 DOI: 10.1080/08997659.2017.1360411
    This study describes the isolation and pathogenicity of Streptococcus iniae in cultured red hybrid tilapia (Nile Tilapia Oreochromis niloticus × Mozambique Tilapia O. mossambicus) in Malaysia. The isolated gram-positive S. iniae appeared punctiform, transparently white, catalase and oxidase negative and produced complete β-hemolysis on blood agar, while a PCR assay resulted in the amplification of the 16 S rRNA gene and lactate oxidase encoded genes. The isolate was sensitive to tetracycline, vancomycin, and bacitracin but was resistant to streptomycin, ampicillin, penicillin, and erythromycin. Pathogenicity trials conducted in local red hybrid tilapia (mean ± SE = 20.00 ± 0.45 g) showed 90.0, 96.7, and 100.0% mortality within 14 d postinfection following intraperitoneal exposure to 104, 106, and 108 CFU/mL of the pathogen, respectively. The clinical signs included erratic swimming, lethargy, and inappetance at 6 h postinfection, while mortality was recorded at less than 24 h postinfection in all infected groups. The LD50-336 h of S. iniae against the red hybrid tilapia was 102 CFU/mL. The post mortem examinations revealed congested livers, kidneys, and spleens of the infected fish. This is the first report of S. iniae experimental infection in cultured red hybrid tilapia in Malaysia. Received January 20, 2017; accepted July 16, 2017.
  12. Fulltext Intelligent ground vibration prediction in surface mines using an efficient soft computing method based on field data
    Keshtegar B, Piri J, Asnida Abdullah R, Hasanipanah M, Muayad Sabri Sabri M, Nguyen Le B
    Front Public Health, 2022;10:1094771.
    PMID: 36817184 DOI: 10.3389/fpubh.2022.1094771
    Ground vibration induced by blasting operations is considered one of the most common environmental effects of mining projects. A strong ground vibration can destroy buildings and structures, hence its prediction and minimization are of high importance. The aim of this study is to estimate the ground vibration through a hybrid soft computing (SC) method, called RSM-SVR, which comprises two main regression techniques: the response surface model (RSM) and support vector regression (SVR). The RSM-SVR model applies an RSM in the first calibrating process and an SVR in the second calibrating process to improve the accuracy of the ground vibration predictions. The predicted results of an RSM, which are obtained using the input data of problems, are used as the input dataset for the regression process of an SVR. The effectiveness and agreement of the RSM-SVR model were compared to those of an SVR optimized with the particle swarm optimization (PSO) and genetic algorithm (GA), RSM, and multivariate linear regression (MLR) based on several statistical factors. The findings confirmed that the RSM-SVR model was considerably superior to other models in terms of accuracy. The amounts of coefficient of determination (R 2) were 0.896, 0.807, 0.782, 0.752, 0.711, and 0.664 obtained from the RSM-SVR, PSO-SVR, GA-SVR, MLR, SVR, and RSM models, respectively.
  13. Neph-ex: A 3D Printed Interventional Radiology (IR) Training Tool for Nephrostomy Exchange
    Ch'ng LS, Mahfudz AS, Azman H, Zainal Alam MM, Saib E, Rosaland NSA, et al.
    Br J Radiol, 2024 Sep 10.
    PMID: 39254598 DOI: 10.1093/bjr/tqae184
    INTRODUCTION: Fluoroscopic guided procedures are a mainstay for Interventional Radiology (IR) procedures. Practice is needed for the novice to interpret fluoroscopic images and simultaneously perform the procedure hands-on as well as control the foot pedal to screen. We describe the development of a training simulation model which simulates the human kidney, ureter and bladder.

    METHOD: Stereolithography (SLA) 3D Print technology using SLA resin and Anycubic SLA printer were employed. A plastic tubing was used to connect the 3D printed kidney and bladder as the ureter. This simulation model permits fluoroscopic guided filling of "pelvicalyceal system" with contrast as well as ureteric stenting, guidewire and drainage catheter manipulation. Effectiveness of the model to attain skills for nephrostomy exchange and ureteric stenting was obtained via questionnaire from trainees prior to and after utilising the model.

    RESULT: The 3D printing simulation model of the kidney, ureter and bladder system enable trainees to perform nephrostomy exchange, nephrostogram and antegrade stenting. Participants felt more confident to perform the procedures as they were more familiar with the procedure. Besides that, participants felt their wire and catheter manipulation skills have improved after using the simulation model.

    CONCLUSION: Neph-ex simulation model is safe and effective for hands-on training in improving proficiency of fluoroscopy-guided nephrostomy exchange and antegrade ureteric stenting.

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