Displaying publications 1 - 20 of 23 in total

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  1. Kanaheswari Y, Lai C, Raja Lope RJ, Azizi AB, Zulfiqar MA
    J Paediatr Child Health, 2015 Feb;51(2):223-5.
    PMID: 25099316 DOI: 10.1111/jpc.12707
    Congenital dermal sinus (CDS) and occult spinal dysraphism are suspected when a cutaneous marker overlies the spine of a newborn. CDS can have the appearance of a simple dimple and occur within the gluteal cleft without any skin markers. CDS are the commonest cause of intramedullary spinal cord abscess.
    Matched MeSH terms: Spinal Cord Diseases/etiology; Spinal Cord Diseases/pathology*
  2. Carol L, Tai MS, Yusoff SM, Rose N, Rafia MH, Viswanathan S
    Neurol India, 2018 7 25;66(4):1181-1183.
    PMID: 30038119 DOI: 10.4103/0028-3886.237012
    Matched MeSH terms: Spinal Cord Diseases/complications*; Spinal Cord Diseases/diagnosis*; Spinal Cord Diseases/surgery
  3. Tan CT
    Aust N Z J Med, 1989 Aug;19(4):297-302.
    PMID: 2783084
    Fifty-four per cent of 52 patients presenting to the University of Malaya Medical Centre with a myelopathy for which appropriate investigations uncovered no definite etiology, subsequently developed clinically definite or probable multiple sclerosis. In the subgroup of patients with a presentation indicative of acute/subacute transverse myelopathy, 14 or 52% also went on to develop clinically definite or probable multiple sclerosis, a far higher proportion than previously recorded in the literature. This finding is probably a further manifestation of racial difference in the behaviour of multiple sclerosis. For the group as a whole, the only factor which appeared to be associated with an increased risk of developing multiple sclerosis was female sex; 67% of 33 female patients went on to develop multiple sclerosis after a mean follow-up period of 5.5 years. Other factors such as age of onset, racial composition, level of spinal cord involvement, presence of fever and CSF finding were found not to be important.
    Matched MeSH terms: Spinal Cord Diseases/complications; Spinal Cord Diseases/diagnosis*; Spinal Cord Diseases/ethnology
  4. Harreld JH, Mohammed N, Goldsberry G, Li X, Li Y, Boop F, et al.
    AJNR Am J Neuroradiol, 2015 May;36(5):993-9.
    PMID: 25614472 DOI: 10.3174/ajnr.A4221
    Postoperative intraspinal subdural collections in children after posterior fossa tumor resection may temporarily hinder metastasis detection by MR imaging or CSF analysis, potentially impacting therapy. We investigated the incidence, imaging and clinical features, predisposing factors, and time course of these collections after posterior fossa tumor resection.
    Matched MeSH terms: Spinal Cord Diseases/etiology*; Spinal Cord Diseases/epidemiology*; Spinal Cord Diseases/pathology
  5. Chee CP, Tan CT, Nuruddin R
    Br J Neurosurg, 1990;4(6):529-33.
    PMID: 2076215
    An unusual case of syringomyelia secondary to a cauda equina meningioma involving the conus medullaris is described. The tumour was totally removed with decompression of an adjacent cyst and syrinx resulting in resolution of the symptoms and radiological appearance.
    Matched MeSH terms: Spinal Cord Diseases/etiology; Spinal Cord Diseases/surgery
  6. Julia PE, Nazirah H
    Spinal Cord, 2007 Dec;45(12):804-5.
    PMID: 17710102
    Case report.
    Matched MeSH terms: Spinal Cord Diseases/cerebrospinal fluid; Spinal Cord Diseases/diagnosis*; Spinal Cord Diseases/pathology
  7. Yakub F, Md Khudzari AZ, Mori Y
    Int J Rehabil Res, 2014 Mar;37(1):9-21.
    PMID: 24126254 DOI: 10.1097/MRR.0000000000000035
    This paper presents and studies various selected literature primarily from conference proceedings, journals and clinical tests of the robotic, mechatronics, neurology and biomedical engineering of rehabilitation robotic systems. The present paper focuses of three main categories: types of rehabilitation robots, key technologies with current issues and future challenges. Literature on fundamental research with some examples from commercialized robots and new robot development projects related to rehabilitation are introduced. Most of the commercialized robots presented in this paper are well known especially to robotics engineers and scholars in the robotic field, but are less known to humanities scholars. The field of rehabilitation robot research is expanding; in light of this, some of the current issues and future challenges in rehabilitation robot engineering are recalled, examined and clarified with future directions. This paper is concluded with some recommendations with respect to rehabilitation robots.
    Matched MeSH terms: Spinal Cord Diseases/rehabilitation
  8. Qi Y, Montague P, Loney C, Campbell C, Shafie INF, Anderson TJ, et al.
    Eur J Neurosci, 2019 12;50(12):3896-3905.
    PMID: 31336405 DOI: 10.1111/ejn.14526
    Canine degenerative myelopathy (DM) is a progressive neurological disorder that may be considered to be a large animal model for specific forms of the fatal human disease, familial amyotrophic lateral sclerosis (fALS). DM is associated with a c118G>A mutation of the superoxide dismutase 1 (Sod1) gene, and a significant proportion of cases are inherited in an autosomal recessive manner in contrast to the largely, but not exclusively, dominant mode of inheritance in fALS. The consensus view is that these Sod1/SOD1 mutations result in a toxic gain of function but the mechanisms remain unclear. Here we used an in vitro neuroblastoma cell line transfection system to monitor wild-type and mutant forms of SOD1 fusion proteins containing either a Cherry or an enhanced green fluorescent protein (EGFP) tag. These fusion proteins retained SOD1 enzymatic activity on a native gel assay system. We demonstrate that SOD1 aggregate density is significantly higher in DM transfectants compared to wild-type. In addition, we show by co-immunoprecipitation and confocal microscopy, evidence for a potential interaction between wild-type and mutant forms of SOD1 in co-transfected cells. While in vitro studies have shown SOD1 heterodimer formation in fALS models, this is the first report for DM SOD1. Therefore, despite for the majority of cases there is a difference in the mode of inheritance between fALS and DM, a similar interaction between wild-type and mutant SOD1 forms can occur. Clarifying the role of SOD1 in DM may also be of benefit to understanding the role of SOD1 in fALS.
    Matched MeSH terms: Spinal Cord Diseases/genetics
  9. Cheung JPY, Cheung PWH, Chiu CK, Chan CYW, Kwan MK
    Asian Spine J, 2019 Feb;13(1):45-55.
    PMID: 30326696 DOI: 10.31616/asj.2018.0135
    STUDY DESIGN: Surgeon survey.

    PURPOSE: To study the various surgical practices of different surgeons in the Asia-Pacific region.

    OVERVIEW OF LITERATURE: Given the diversity among Asia-Pacific surgeons, there is no clear consensus on the preferred management strategies for cervical myelopathy. In particular, the role of prophylactic decompression for silent cervical spinal stenosis is under constant debate and should be addressed.

    METHODS: Surgeons from the Asia-Pacific Spine Society participated in an online questionnaire comprising 50 questions. Data on clinical diagnosis, investigations and outcome measures, approach to asymptomatic and silent cervical spinal stenosis, guidelines for surgical approach, and postoperative immobilization were recorded. All parameters were analyzed by the Mantel-Haenszel test.

    RESULTS: A total of 79 surgeons from 16 countries participated. Most surgeons used gait disturbance (60.5%) and dyskinetic hand movement (46.1%) for diagnosis. Up to 5.2% of surgeons would operate on asymptomatic spinal stenosis, and 18.2% would operate on silent spinal stenosis. Among those who would not operate, most (57.1%) advised patients on avoidance behavior and up to 9.5% prescribed neck collars. For ossification of the posterior longitudinal ligament (OPLL), anterior removal was most commonly performed for one-level disease (p<0.001), whereas laminoplasty was most commonly performed for two- to four-level disease (p=0.036). More surgeons considered laminectomy and fusion for multilevel OPLL. Most surgeons generally preferred to use a rigid neck collar for 6 weeks postoperatively (p<0.001).

    CONCLUSIONS: The pooled recommendations include prophylactic or early decompression surgery for patients with silent cervical spinal stenosis, particularly OPLL. Anterior decompression is primarily suggested for one- or two-level disease, whereas laminoplasty is preferred for multilevel disease.

    Matched MeSH terms: Spinal Cord Diseases
  10. Nizlan MN, Selvakumar K, Looi LM, Kunasegaran R
    Juxtafacet cyst of the spine is a rare occurrence. Reports have described them as synovial cysts; ganglion cysts; extradural cysts as well as degenerative cysts of the spine. Patients may present with radicular pain, motor deficits, sensory disturbances, cauda equina syndrome and even myelopathy. Lumbar juxtafacet cysts may be confused clinically with prolapsed intervertebral discs or other conditions involving nerve root compression such as arachnoid cysts, ependymal cysts, dermoid cysts or teratomatous cysts. In the case of the juxtafacet cyst, surgical excision is usually curative. We report a case of spinal synovial juxtafacet cyst found intraoperatively in a case that was preoperatively diagnosed as prolapsed intervertebral disc. Synovial juxtafacet cyst of the spine should be considered as one of the differential diagnoses in patients, especially in older patients, presenting with nerve root compression.
    Matched MeSH terms: Spinal Cord Diseases
  11. Wazir NN, Kareem BA
    Singapore Med J, 2011 Jan;52(1):47-9.
    PMID: 21298241
    Cervical spondylotic myelopathy (CSM) represents a spectrum of pathologies with progressive compression of the spinal cord. The clinical signs and symptoms play a key role in diagnosis. The characteristic hand myelopathy signs are of significant clinical importance. The aim of this descriptive study was to report a relatively easy to elicit new hand myelopathy sign. The basis for this is finger and wrist flexor disinhibition, which is used for the spinal specificity of cord compression at or above the C5/6 level.
    Matched MeSH terms: Spinal Cord Diseases/diagnosis*; Spinal Cord Diseases/physiopathology*
  12. Vinodh VP, Rajapathy SK, Sellamuthu P, Kandasamy R
    Surg Neurol Int, 2018;9:136.
    PMID: 30090668 DOI: 10.4103/sni.sni_96_18
    Background: Reperfusion injury of the spinal cord or "white cord syndrome" refers to the sudden onset of neurological deterioration after spinal decompressive surgery. Associated magnetic resonance (MR) findings only include focal hyperintensity on T2-weighted images without any other pathological changes.

    Case Description: A patient with cervical stenosis secondary to metastatic tumor in the intradural and extradural compartments presented with lower limb paraparesis. She underwent an uneventful tumor excision accompanied by posterior cervical decompression and fusion. Postoperatively, she was quadriplegic and required ventilator support. The emergent postoperative MR scan revealed focal hyperintensity on the T2-weighted image consistent with spinal cord edema extending into the lower brain stem.

    Conclusion: Very few cases of reperfusion injury of the cervical spinal cord or "white cord syndrome" are described in the literature. Here we present a patient who, following cervical laminectomy and fusion for excision of metastatic tumor, developed quadriplegia. Notably, postoperative MR showed only findings of upper cervical cord and lower brain stem edema consistent with a "white cord syndrome" without other compressive pathology.

    Matched MeSH terms: Spinal Cord Diseases
  13. Tay CH, Jek WT
    Med J Malaya, 1972 Jun;26(4):272-7.
    PMID: 5069417
    Matched MeSH terms: Spinal Cord Diseases*
  14. Lin LC, Jason R
    Asian J Neurosurg, 2018 4 24;13(2):468-470.
    PMID: 29682063 DOI: 10.4103/ajns.AJNS_310_16
    Spinal extradural arachnoid cysts are rare lesions which typically involve the thoracic spine and are an asymptomatic condition of unknown origin. They may also produce symptoms by compressing the spinal cord or nerve roots. Surgery is the treatment of choice in such lesions, but asymptomatic patients can be managed conservatively. We present a case of symptomatic, probable traumatic origin, spinal arachnoid cyst at our center in Hospital Kuala Lumpur, Malaysia. Magnetic resonance imaging spine showed well-defined, nonenhancing extradural cystic lesion from T5 to T6 vertebrae level compressing spinal cord anteriorly. The patient underwent T5, T6 laminoplasty, T4 partial laminectomy and excision of the cyst. Histologically, the cyst wall comprised of collagen and meningothelial cells. This surgical intervention achieved neurological improvement in terms of motor power in our follow-up of this patient.
    Matched MeSH terms: Spinal Cord Diseases
  15. Hoad W
    Matched MeSH terms: Spinal Cord Diseases
  16. Fischer H
    Zentralbl Veterinarmed A, 1966 Jun;13(4):352-5.
    PMID: 4961318
    Matched MeSH terms: Spinal Cord Diseases/genetics
  17. Fadzil F
    Med J Malaysia, 2011 Oct;66(4):365-6.
    PMID: 22299561 MyJurnal
    A Median Occipital Condyle is a rare occurrence. We have not found any clinical studies in the literature and myelopathy due to a median condyle has been reported once before. Myelopathy due to anomalies of the craniovertebral junction is rare in neurosurgical practice. We describe a case of a 72-year-old man presenting with progressive myelopathy related to a median occipital condyle located at the anterior foramen magnum region.
    Matched MeSH terms: Spinal Cord Diseases/etiology*
  18. Cheng, Yin Tan, Lingam, Ganeshwara, Suhailah Abdullah, Ai, Huey Tan, Tai, Sharon Mei-Ling, Norlisah Ramli, et al.
    Neurology Asia, 2015;20(1):79-84.
    MyJurnal
    Primary angiitis of the central nervous system (PACNS) is a rare vasculitis restricted to the central nervous system without systemic involvement. Delay in diagnosis and treatment is common due to its non-specific symptoms and lack of non-invasive diagnostic tests. Myelopathy can occur in PACNS, during the clinical course of the illness, with or without cerebral symptoms. We describe here a 51 year-old ethnic Chinese woman who presented initially with paraparesis without cerebral symptoms. The diagnosis of PACNS was eventually made from brain biopsy when she subsequently developed cerebral involvement. Despite aggressive treatment, the patient developed progressive neurological deterioration and died. This patient demonstrates the rare occurrence of myelopathy as the sole initial presentation of PACNS.
    Matched MeSH terms: Spinal Cord Diseases
  19. Chooi YS, Siow YS, Chong CS
    J Bone Joint Surg Br, 2005 Feb;87(2):257-9.
    PMID: 15736753
    We report a case of vertebral osteochondroma of C1 causing cord compression and myelopathy in a patient with hereditary multiple exostosis. We highlight the importance of early diagnosis and the appropriate surgery in order to obtain a satisfactory outcome.
    Matched MeSH terms: Spinal Cord Diseases/etiology*; Spinal Cord Diseases/surgery
  20. Chong YH, Cheong I
    Med J Malaysia, 1985 Dec;40(4):333-4.
    PMID: 3870350
    We report a case of systemic lupus erythematosus complicated by transverse myelopathy and hyperphagia. To our knowledge the latter has not been reported before.
    Matched MeSH terms: Spinal Cord Diseases/etiology*
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