MyMedR

A novel caryophyllene type sesquiterpene lactone from Asparagus falcatus (Linn.); structure elucidation and anti-angiogenic activity on HUVECs

Ghalib RM, Hashim R, Sulaiman O, Mehdi SH, Valkonen A, Rissanen K, et al.

Eur J Med Chem, 2012 Jan;47(1):601-7.

PMID: 22074984 DOI: 10.1016/j.ejmech.2011.10.037

In this study the novel caryophyllene type sesquiterpene lactone (aspfalcolide) has been isolated from the leaves of Asparagus falcatus (Linn.) and characterized by IR, 1D NMR, 2D NMR, EI-MS, HR-ESI-MS and X-ray single crystal diffraction analysis. The aspfalcolide crystallizes in the orthorhombic space group P2(1)2(1)2(1) with a = 6.37360(10), b = 7.6890(2), c = 27.3281(6) Å, α = β = γ = 90(°) and Z = 4. One intermolecular O-H⋯O hydrogen bond enforces these natural molecules to form infinite chains through the crystal. Aspfalcolide was screened for its anti-angiogenic activity in human umbilical vein endothelial cells (HUVECs) and the result showed the remarkable inhibitory effect of aspfalcolide on the proliferation (IC(50) 1.82 μM), migration and tube formation of HUVECs.

Fulltext Crystal structure of 2-(1,3-dioxoindan-2-yl)iso-quinoline-1,3,4-trione

Ghalib RM, Chidan Kumar CS, Hashim R, Sulaiman O, Fun HK

Acta Crystallogr E Crystallogr Commun, 2015 Jan 1;71(Pt 1):o6-7.

PMID: 25705509 DOI: 10.1107/S2056989014025997

In the title iso-quinoline-1,3,4-trione derivative, C18H9NO5, the five-membered ring of the indane fragment adopts an envelope conformation with the nitro-gen-substituted C atom being the flap. The planes of the indane benzene ring and the iso-quinoline-1,3,4-trione ring make a dihedral angle of 82.06 (6)°. In the crystal, mol-ecules are linked into chains extending along the bc plane via C-H⋯O hydrogen-bonding inter-actions, enclosing R 2 (2)(8) and R 2 (2)(10) loops. The chains are further connected by π-π stacking inter-ations, with centroid-to-centroid distances of 3.9050 (7) Å, forming layers parallel to the b axis.

An assay for selection of sera with circulating Toxoplasma gondii antigens

Emelia O, Zeehaida M, Sulaiman O, Rohela M, Saadatnia G, Yeng C, et al.

J Immunoassay Immunochem, 2010;31(1):79-91.

PMID: 20391020 DOI: 10.1080/15321810903405134

We have developed an ELISA that employs monoclonal anti-Toxoplasma SAG1 (p30) as the capture antibody to detect T. gondii circulating antigens in patients' serum samples. Using serum spiked with Toxoplasma soluble and with SAG1 recombinant proteins, the detection limits were 31.25 ng/mL and 62.50 ng/mL, respectively. We obtained positive results in 28% (21/75) and 11% (23/206) of probable active and chronic toxoplasmosis serum samples, respectively. Western blot analysis on pooled antigen-positive serum samples showed antigenic bands of molecular weights 25 and 75 kDa from sera of probable active infection and five antigenic bands ranging in size from 26 to 33 kDa from chronic infection sera. This assay would be useful as an initial serum selection step in developing a Toxoplasma antigen detection test and for characterization studies.

Fulltext Bioprospecting medicinal plants for antioxidant components

Coulibaly AY, Hashim R, Sulaiman SF, Sulaiman O, Ang LZ, Ooi KL

Asian Pac J Trop Med, 2014 Sep;7S1:S553-9.

PMID: 25312183 DOI: 10.1016/S1995-7645(14)60289-3

OBJECTIVE: To evaluate antioxidant activities of seven medicinal plant species and their fractions, and to identify their phenolic compounds.

METHODS: Two extractions were processed and further fractionated by column chromatography to evaluate the concentration that inhibit 50% of 2,2'-azinobis (3-ethylbenzothiazoline-6-suslfonic acid, 1,1-diphenyl-2-picryl-hydrazyl radicals, and their ferric reducing antioxidant power. The identification of the fractions of phenolic compounds was done by ultra performance liquid chromatography.

RESULTS: The aqueous-acetone extracts of Feretia apodanthera and Ozoroa insignis exhibited the highest antioxidant potentials comparable to those of the standard quercetin. Their subsequently silica gel column fractionation showed three most active fractions from which the major constituents quercetin, myricetin, kampferol, rutin and isoquercetin were identified.

CONCLUSIONS: These plant species have potent antioxidant profiles and polyphenol compounds that may help to manage with radical related disease and aging.

Seroprevalence of toxoplasmosis among migrant workers from different Asian countries working in Malaysia

Chan BT, Amal RN, Hayati MI, Kino H, Anisah N, Norhayati M, et al.

Southeast Asian J. Trop. Med. Public Health, 2008 Jan;39(1):9-13.

PMID: 18567437

A serologic study of Toxoplasma antibodies among 501 foreign migrant workers in Malaysia was conducted in a plantation and detention camp. The highest prevalence rate of 46.2% was among Nepalese workers. Statistical analysis indicated the IgG positivity rate among local residents was significantly higher than the migrants studied (p < 0.05). The IgM positivity rate showed no significant difference between the two groups (p > 0.05). No significant difference in the prevalence rate was noted between the migrants and the local workers when grouped by agricultural and non-agricultural occupations (p > 0.05). The continuous introduction of these infections may influence the epidemiology and further compromise efforts in control and prevention. It is therefore important to monitor of non-notifiable diseases.

Oil palm biomass-based adsorbents for the removal of water pollutants--a review

Ahmad T, Rafatullah M, Ghazali A, Sulaiman O, Hashim R

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2011 Jul;29(3):177-222.

PMID: 21929380 DOI: 10.1080/10590501.2011.601847

This article presents a review on the role of oil palm biomass (trunks, fronds, leaves, empty fruit bunches, shells, etc.) as adsorbents in the removal of water pollutants such as acid and basic dyes, heavy metals, phenolic compounds, various gaseous pollutants, and so on. Numerous studies on adsorption properties of various low-cost adsorbents, such as agricultural wastes and its based activated carbons, have been reported in recent years. Studies have shown that oil palm-based adsorbent, among the low-cost adsorbents mentioned, is the most promising adsorbent for removing water pollutants. Further, these bioadsorbents can be chemically modified for better efficiency and can undergo multiple reuses to enhance their applicability at an industrial scale. It is evident from a literature survey of more than 100 recent papers that low-cost adsorbents have demonstrated outstanding removal capabilities for various pollutants. The conclusion is been drawn from the reviewed literature, and suggestions for future research are proposed.

Removal of pesticides from water and wastewater by different adsorbents: a review

Ahmad T, Rafatullah M, Ghazali A, Sulaiman O, Hashim R, Ahmad A

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2010 Oct;28(4):231-71.

PMID: 21069614 DOI: 10.1080/10590501.2010.525782

In this review article, the use of various low-cost adsorbents for the removal of pesticides from water and wastewater has been reviewed. Pesticides may appear as pollutants in water sources, having undesirable impacts to human health because of their toxicity, carcinogenicity, and mutagenicity or causing aesthetic problems such as taste and odors. These pesticides pollute the water stream and it can be removed very effectively using different low-cost adsorbents. It is evident from a literature survey of about 191 recently published papers that low-cost adsorbents have demonstrated outstanding removal capabilities for pesticides.

The use of date palm as a potential adsorbent for wastewater treatment: a review

Ahmad T, Danish M, Rafatullah M, Ghazali A, Sulaiman O, Hashim R, et al.

Environ Sci Pollut Res Int, 2012 Jun;19(5):1464-84.

PMID: 22207239 DOI: 10.1007/s11356-011-0709-8

BACKGROUND: In tropical countries, the palm tree is one of the most abundant and important trees. Date palm is a principal fruit grown in many regions of the world. It is abundant, locally available and effective material that could be used as an adsorbent for the removal of different pollutants from aqueous solution.

REVIEW: This article presents a review on the role of date palm as adsorbents in the removal of unwanted materials such as acid and basic dyes, heavy metals, and phenolic compounds. Many studies on adsorption properties of various low cost adsorbent, such as agricultural waste and activated carbons based on agricultural waste have been reported in recent years.

CONCLUSION: Studies have shown that date palm-based adsorbents are the most promising adsorbents for removing unwanted materials. No previous review is available where researchers can get an overview of the adsorption capacities of date palm-based adsorbent used for the adsorption of different pollutants. This review provides the recent literature demonstrating the usefulness of date palm biomass-based adsorbents in the adsorption of various pollutants.

Scavenging behaviour of meranti sawdust in the removal of methylene blue from aqueous solution

Ahmad A, Rafatullah M, Sulaiman O, Ibrahim MH, Hashim R

J Hazard Mater, 2009 Oct 15;170(1):357-65.

PMID: 19464117 DOI: 10.1016/j.jhazmat.2009.04.087

Meranti (Philippine mahogany) sawdust, an inexpensive material, showed strong scavenging behaviour through adsorption for the removal of methylene blue (MB) from aqueous solution. Batch studies were performed to evaluate and optimize the effects of various parameters such as contact time, pH, initial dye concentrations and adsorbent dosage. Langmuir, Freundlich and Temkin isotherms were used to analyze the equilibrium data at different temperatures. The experimental data fitted well with the Langmuir adsorption isotherm, indicating thereby the mono layer adsorption of the dye. The monolayer sorption capacity of meranti sawdust for MB was found to be 120.48, 117.64, 149.25 and 158.73 mg/g at 30, 40, 50 and 60 degrees C, respectively. Thermodynamic calculations showed that the MB adsorption process is endothermic and spontaneous in nature. Kinetic studies showed that the adsorption followed a pseudo-second-order kinetic model. The results indicated that the meranti sawdust could be an alternative material in place of more costly adsorbents used for dye removal.

Fulltext Comparing the effectiveness of ropivacaine 0.5% versus ropivacaine 0.2% for transabdominis plane block in providing postoperative analgesia after appendectomy

Abdul Jalil RM, Yahya N, Sulaiman O, Wan Mat WR, Teo R, Izaham A, et al.

Acta Anaesthesiol Taiwan, 2014 Jun;52(2):49-53.

PMID: 25016507 DOI: 10.1016/j.aat.2014.05.007

The basis for the transversus abdominis plane (TAP) block involves infiltration of a local anesthetic into the neurofascial plane between the internal oblique and the transversus abdominis muscles, causing a regional block that spreads between the L1 and T10 dermatomes. Thus, the TAP block is said to be suitable for lower abdominal surgery. This study was designed to compare the analgesic efficacy of two different concentrations of ropivacaine for TAP block in patients undergoing appendectomy.

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