MyMedR

Non-surgical options in the management of hepatocellular carcinoma

Harjit S

Med J Malaysia, 2005 Jul;60 Suppl B:108-11.

PMID: 16108189

Matched MeSH terms: Carcinoma, Hepatocellular/drug therapy; Carcinoma, Hepatocellular/therapy*

Mucoepidermoid carcinoma of the trachea (a case report)

Said H, Phang KS, Gibb AG

J Laryngol Otol, 1988 Jan;102(1):83-6.

PMID: 3343572

A case of mucoepidermoid carcinoma of the trachea in a 26-year-old female is presented. Diagnosis was confirmed by histopathology. On the basis of the clinical and histological picture, the tumour is classified as a low grade mucoepidermoid carcinoma. Conservative surgical treatment was the primary mode of treatment. The patient showed no clinical evidence of recurrence twelve months after local resection of the tumour.

Matched MeSH terms: Carcinoma/pathology*; Carcinoma/surgery

Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma

Memon MA, Awaiz A, Yunus RM, Memon B, Khan S

Am J Surg, 2018 11;216(5):1004-1015.

PMID: 29958656 DOI: 10.1016/j.amjsurg.2018.06.012

BACKGROUND: We conducted a meta-analysis of the randomized evidence to determine the relative merits of histopathological outcomes of laparoscopic assisted (LARR) versus open rectal resection (ORR) for rectal cancer.

DATA SOURCES: A search of PubMed and other electronic databases comparing LARR and ORR between Jan 2000 and June 2016 was performed. Histopathological variables analyzed included; location of rectal tumors; complete and incomplete TME; positive and negative circumferential resection margins (+/-CRM); positive distal resected margins (+DRM); distance of tumor from DRM; number of lymph nodes harvested; resected specimen length; tumor size and perforated rectum.

RESULTS: Fourteen RCTs totaling 3843 patients (LARR = 2096, ORR = 1747) were analyzed. Comparable effects were noted for all these histopathological variables except for the variable perforated rectum which favored ORR.

CONCLUSIONS: LARR compares favorably to ORR for rectal cancer treatment. However, there is significantly higher risk of rectal perforation during LARR compared to ORR.

Matched MeSH terms: Carcinoma/pathology; Carcinoma/surgery*

Approach to the treatment of primary liver cancer

Primrose JN

Med J Malaysia, 2005 Jul;60 Suppl B:104-7.

PMID: 16108188

Matched MeSH terms: Carcinoma, Hepatocellular/drug therapy; Carcinoma, Hepatocellular/surgery; Carcinoma, Hepatocellular/therapy*

Fine needle aspiration cytology of secretory carcinoma of breast: a case report

Jayaram G, Looi LM, Yip CH

Malays J Pathol, 1997 Jun;19(1):69-73.

PMID: 10879245

A 39-year-old female presented with a mobile 1.5 cm nodule in the right breast. Fine needle aspiration cytology smears stained with May Grunwald Giemsa were highly cellular with a monotonous population of dissociated and clustered tumour cells that showed a bland cytological appearance with cytoplasmic vacuolation and occasional signet ring forms. Intracellular and extracellular mucus was present. Histological study of the excised breast mass showed a secretory carcinoma. This is a rare breast neoplasm in which cytological features are characteristic enough to permit a specific diagnosis on needle aspirates.

Matched MeSH terms: Carcinoma/pathology*; Carcinoma/secretion; Carcinoma/therapy

Cervical dysplasia - A follow-up study of 118 cases by cytologic smears

Pillay B, Gregory ARA, Subbiah M, Yap SK

Family Physician, 1993;5:34-36.

118 cases of cervical dysplasia were followed up by cytological smears for over 9 years to determine their biologic outcome. All grades of dysplasia showed evidence of regression and progression to more severe lesions, including carcinoma. Severe dysplasia however did not regress to normalcy and had the maximum conversion rates to malignancy. The period taken for transition to malignancy was found to be shorter than that generally described. Since even mild dysplasia carries with it a malignant potential, all patients with cervical dysplasia, irrespective of the grade, have to be followed up by repeated clinical and cytological examinations.

Matched MeSH terms: Carcinoma

Primary squamous cell carcinoma of the endometrium: A rare case report

Purbadi S, Saspriyana KY, Hellyanti T

Med J Malaysia, 2020 09;75(5):603-605.

PMID: 32918438

Primary endometrial squamous cell carcinomas (PESCC) occur sporadically. It is defined as a primary carcinoma of the endometrium composed of squamous cells of varying degrees of differentiation. A 57-year-old female patient was referred to the gynaecological clinic of Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo National Referral Hospital because of abdominal enlargement with pain. Total hysterectomy and bilateral salpingectomy were performed. Histopathological examination confirmed a moderately differentiated squamous cell carcinoma, with lymph-vascular invasion. Two weeks after the operation, the patient complained of a mass on her left supraclavicular area. Fine needle aspiration biopsy revealed squamous cell carcinoma metastatic in nature. The recommended treatment was paclitaxel (175mg/m2) and carboplatin (AUC- 6), combined with pelvic radiotherapy.

Matched MeSH terms: Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/physiopathology*; Carcinoma, Squamous Cell/surgery

Difficulty of Achieving Clear Margins in Nonpalpable Ductal Carcinoma of the Breast

Yip CH

JAMA Surg, 2017 04 01;152(4):385.

PMID: 28002571 DOI: 10.1001/jamasurg.2016.4752

Matched MeSH terms: Carcinoma, Intraductal, Noninfiltrating/surgery; Carcinoma, Ductal, Breast/surgery*

Racial incidence of carcinoma of the bronchus in Malaya

Snelling MR, Chooi MUN KAM

Thorax, 1966 Sep;21(5):434-6.

PMID: 5969242

Matched MeSH terms: Adenocarcinoma/epidemiology*; Carcinoma/epidemiology; Carcinoma, Squamous Cell/epidemiology*

Fulltext Nasopharyngeal carcinoma: Epidemiological review in relation to its etiology

Prasad U

JUMMEC, 1996;1(2):23-27.

Matched MeSH terms: Carcinoma

Fulltext Post-operative immunohistochemical diagnosis of two synchronous primary non-small cell lung cancers in a single lobe

Sachithanandan A, Nor Y

Med J Malaysia, 2013 Apr;68(2):175-6.

PMID: 23629571 MyJurnal

Synchronous primary non-small cell lung cancers (NSCLC) are rare and may be discovered unexpectedly following lung resection. Discrimination from intrapulmonary metastases is important to guide treatment and prognosis but is difficult solely on clinical or radiological findings. Histopathological evaluation with immunohistochemistry (IHC) markers can prove decisive and should feature in the diagnostic algorithm of such patients. We report a rare case of two synchronous primary NSCLCs diagnosed post operatively following pathological examination of the resected lobe, highlighting the value of IHC and discuss the management of such patients.

Matched MeSH terms: Carcinoma, Non-Small-Cell Lung*

Fulltext Papillary thyroid carcinoma presenting with intraluminal tracheal mass symptoms

Mohamad I, Haron A

Med J Malaysia, 2013 Apr;68(2):164-5.

PMID: 23629566 MyJurnal

Papillary thyroid carcinoma is a common thyroid malignancy reported world wide. It affects females more commonly in the 4th to 6th decades of life. The patients usually present with a painless anterior neck mass and occasionally with lymph node involvement. We report a case of an elderly male who presented with hoarseness and hemoptysis, which warranted bronchoscopy. Biopsy of the intraluminal tracheal mass revealed the diagnosis of papillary thyroid carcinoma. Computed tomography scan of the neck confirmed the presence of the primary lesion in the right thyroid lobe with invasion into the adjacent trachea and esophagus.

Matched MeSH terms: Carcinoma, Papillary*

Roles of ethnicity in survival of hepatocellular carcinoma patients in malaysia

Azmawati M, Krisnan R

Asian Pac J Cancer Prev, 2012;13(12):6023-6.

PMID: 23464397

The incidence of hepatocellular carcinoma (HCC) in Malaysia for the year 2001 was 2.8 per 100,000 people. The mortality rate is increasing. A retrospective cohort study measuring the survival of HCC patients who received treatment in Selayang Hospital was conducted from 1 January 2003 to 31 December 2006. The main objectives of the study were to measure the survival of the patients and to understand the influencing factors, especially ethnicity. The subjects were newly diagnosed cases of HCC by CT scan and histopathological assessment who underwent futher investigations and treatments in Hospital Selayang (inception cohort). The survival time was measured from the date of diagnosis until the subjects died, or failed to follow-up at the end of the study period (31 December 2007). A total of 299 patients were selected with 95 patients dying, the majority among Chinese (39.1%). Subgroup analysis according to ethnicity proved significantly that Chinese patients who had smaller tumor, less number of nodules, low AFP level, Child Pugh Class A and received surgical treatment had a better median survival rate compared to other ethnic groups. Malay (cHR: 1.3, 95%CI; 0.89-1.85) and Indian (cHR: 1.3, 95%CI; 0.74-2.26) patients had a poor survival compared to Chinese patients, but not in the final model. Therefore ethnicity may play a role in survival of HCC patients, but not as a main hazard prognostic factor.

Matched MeSH terms: Carcinoma, Hepatocellular*

Fulltext Carcinoma of the larynx in Malaysia

Sani A, Said H, Lokman S

Med J Malaysia, 1992 Dec;47(4):297-302.

PMID: 1303483

A retrospective study of cases with carcinoma of the larynx seen in the Universiti Kebangsaan Malaysia (UKM) and General Hospital Kuala Lumpur (GHKL) between 1981 to 1988 was performed. The aim was to document the distribution and the pattern of behaviour of this tumour amongst our patients. There were 137 cases, the majority of whom were Chinese (54%). The peak incidence was in the seventh decade and the male to female ratio was 7.6:1. The most common symptom at presentation was hoarseness (90%). The most common histological type was squamous cell carcinoma (87%) whilst by site, transglottic involvement was commonest (55%). The overall 3 year survival rate was 68%. Supraglottic carcinoma behaved differently in that a significantly large number presented with dysphagia (33.3%) and neck nodes (42%). Compared to tumours of other sites of the larynx, they had the poorest 3 year survival rate of 50%. Amongst the T2 and T3 tumours, the results of surgery appeared better than primary radiotherapy. Considering that 26% of patients presented with stridor, 20% with neck nodes and 55% with multiple site involvement, it can be concluded that our patients present themselves late.

Matched MeSH terms: Carcinoma/ethnology; Carcinoma/mortality; Carcinoma/epidemiology*; Carcinoma, Squamous Cell/ethnology; Carcinoma, Squamous Cell/mortality; Carcinoma, Squamous Cell/epidemiology*

Fulltext Carcinoma of thyroid--clinical presentation and outcome

Sothy K, Mafauzy M, Mohamad WB, Mustaffa BE

Med J Malaysia, 1991 Sep;46(3):212-7.

PMID: 1839914

The clinical, biochemical and pathological features of 31 patients with thyroid carcinoma managed at Hospital Universiti Sains Málaysia, Kubang Kerian from 1985 to 1989 were analyzed. There were 25 females and 6 males. The types of carcinoma were: papillary-17 cases; follicular-10 cases; medullary-2 cases and anaplastic-2 cases. For papillary carcinoma the mean age of the patients was 52.9 years. For follicular carcinoma the mean age was 48.3 years, for medullary carcinoma, 48.5 years and for anaplastic, 74.5 years. All patients had pre-existing goitre except for 2 and most presented with advanced disease. The mean duration of symptoms for papillary carcinoma was 3.7 years, follicular carcinoma 1.6 years, medullary carcinoma 13.5 years and anaplastic carcinoma 6 months. 12 patients presented with goitre of increasing size; 9 had compression symptoms; 4 presented with cervical lymph node enlargement and 6 presented with bony pains of whom 2 had paraplegia. None of the patients were ever thyrotoxic or hypothyroid. Treatment in general was unsatisfactory because of patients' non-acceptance of surgery and/or radioactive iodine.

Matched MeSH terms: Adenocarcinoma/radiotherapy; Adenocarcinoma/surgery; Adenocarcinoma/therapy*; Carcinoma/radiotherapy; Carcinoma/surgery; Carcinoma/therapy*; Carcinoma, Papillary/radiotherapy; Carcinoma, Papillary/surgery; Carcinoma, Papillary/therapy*

Fulltext Choroid plexus carcinoma in an infant

Muhaizan WMW, Zurin AAR, Siti Aishah MA

Med J Malaysia, 2003 Dec;58(5):763-5.

PMID: 15190665

Choroid plexus carcinoma is a rare intracranial neoplasm, affecting mainly very young children. The commonest site is within the lateral ventricles and the prognosis is very poor. We report a seven month old baby boy who presented with raised intracranial pressure and seizures. Brain CT scan showed large intraventricular mass with calcification and hydrocephalus. Total macroscopic resection of the tumour was performed and diagnosis of choroid plexus carcinoma was made. However, the patient died 11 days after the tumour excision. The histopathology of this rare childhood neoplasm is discussed.

Matched MeSH terms: Carcinoma/surgery*

Changes in the tissues adjacent to oral squamous cell carcinomas

Yeow CS

Dent J Malaysia Singapore, 1973 May;13(1):51-62.

PMID: 4521126

Matched MeSH terms: Carcinoma, Squamous Cell/pathology

Fulltext Metastatic carcinoma of the lung presenting as jugular venous thrombosis: a valuable clinical lesson

Thong HK, Sugumaran V, Mohamad Mahbob HB, Tengku Kamalden TMIB

J Med Life, 2021 8 12;14(3):419-423.

PMID: 34377211 DOI: 10.25122/jml-2020-0061

Thromboses of the upper extremity and neck are rare and not as commonly seen as lower extremity deep vein thrombosis (DVT). Internal jugular vein thrombosis (IJVT) is a serious condition with a potentially fatal outcome. Jugular vein thrombosis refers to the formation of intraluminal thrombi anywhere from the intracranial part of the jugular vein to the junction between the internal jugular vein (IJV) and subclavian vein. The relationship between malignancy and thromboembolic disorders has been well established, as Trousseau first described it in 1865. Tumor cells are known to promote hypercoagulability by expressing tissue factors that activate clotting cascades and procoagulants while promoting interactions between the tumor cells, platelets, and endothelial cells via different cytokines, tumor antigens, and their immune complexes. We are reporting our encounter with a patient who presented with extensive left internal jugular vein thrombosis as the first presenting sign of primary lung malignancy.

Matched MeSH terms: Carcinoma*

Fulltext An Unusual Presentation of a Thyroid Malignancy: A Case Report

Irfan, M., Baharuddin, A., Ananda Dorai, A.

International Medical Journal Malaysia, 2010;9(1):55-57.

MyJurnal

Patient with thyroid mass rarely presents in emergency situation. It is because the nature of the mass is that it usually increases slowly in size. Thus, any surgical intervention can be planned electively. The most common condition that necessitates urgent intervention, is upper airway compromise due to sudden rapid increase in size of the swelling. This can be due to intralesional bleeding or superimposed infection on the enlarged gland. We report a case of urgent completion thyroidectomy performed to a patient with fungating recurrent papillary carcinoma who present with bleeding from the mass externally.

Matched MeSH terms: Carcinoma; Carcinoma, Papillary

Fulltext Invasive Lobular Carcinoma of Breast Presenting with Left Sterno-chondral Junction Swelling. A Case Report

Amran, A.R., Azlin Saat, Cheung, H.S.

International Medical Journal Malaysia, 2007;6(2):1-8.

MyJurnal

Invasive Lobular Carcinoma of the breast is less common than Invasive Ductal Carcinoma and the presentation can be different from other types of breast carcinomas. It can present as diffuse swelling or thickening of breast rather than a mass. Sometimes, it can present as metastatic deposits from a very small primary breast lesion. These make the diagnosis of this type of breast carcinoma difficult and challenging for the radiologist and surgeon. We describe a case of Invasive Lobular Carcinoma of the breast, which presented with a left sterno-chondral metastasis and discuss the imaging findings and treatment of this condition.

Matched MeSH terms: Carcinoma, Lobular; Carcinoma, Ductal

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