MyMedR

Displaying publications 4161 - 4180 of 6728 in total

Abstract:

Sort:

Fulltext Ferrocene-Based Terpolyamides and Their PDMS-Containing Block Copolymers: Synthesis and Physical Properties

Mushtaq I, Jabeen E, Akhter Z, Javed F, Hassan A, Khan MSU, et al.

Polymers (Basel), 2022 Nov 23;14(23).
PMID: 36501482 DOI: 10.3390/polym14235087

Aromatic polyamides are well-known as high-performance materials due to their outstanding properties making them useful in a wide range of applications. However, their limited solubility in common organic solvents restricts their processability and becomes a hurdle in their applicability. This study is focused on the synthesis of processable ferrocene-based terpolyamides and their polydimethylsiloxane (PDMS)-containing block copolymers, using low-temperature solution polycondensation methodology. All the synthesized materials were structurally characterized using FTIR and 1H NMR spectroscopic techniques. The ferrocene-based terpolymers and block copolymers were soluble in common organic solvents, while the organic analogs were found only soluble in sulfuric acid. WXRD analysis showed the amorphous nature of the materials, while the SEM analysis exposed the modified surface of the ferrocene-based block copolymers. The structure-property relationship of the materials was further elucidated by their water absorption and thermal behavior. These materials showed low to no water absorption along with their high limiting oxygen index (LOI) values depicting their good flame-retardant behavior. DFT studies also supported the role of various monomers in the polycondensation reaction where the electron pair donation from HOMO of diamine monomer to the LUMO of acyl chloride was predicted, along with the calculation of various other parameters of the representative terpolymers and block copolymers.
Fulltext A green and efficient synthetic methodology towards the synthesis of 1-allyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives

Gill MSA, Azzman N, Hassan SS, Shah SAA, Ahemad N

BMC Chem, 2022 Dec 08;16(1):111.
PMID: 36482476 DOI: 10.1186/s13065-022-00902-1

Quinolone is a privileged scaffold in medicinal chemistry and 4-Quinolone-3-Carboxamides have been reported to harbor vast therapeutic potential. However, conversion of N-1 substituted 4-Quinolone 3-Carboxylate to its corresponding carbamates is highly restrictive. This motivated us to adopt a much simpler, scalable and efficient methodology for the synthesis of highly pure N-1 substituted 4- Quinolone-3-Carboxamides with excellent yields. Our adopted methodology not only provides a robust pathway for the convenient synthesis of N-1 substituted 4- Quinolone-3-Carboxamides which can then be explored for their therapeutic potential, this may also be adaptable for the derivatization of other such less reactive carboxylate species.
Energy, exergy and economic (3E) analysis of flat-plate solar collector using novel environmental friendly nanofluid

Amar M, Akram N, Chaudhary GQ, Kazi SN, Soudagar MEM, Mubarak NM, et al.

Sci Rep, 2023 Jan 09;13(1):411.
PMID: 36624198 DOI: 10.1038/s41598-023-27491-w

The use of solar energy is one of the most prominent strategies for addressing the present energy management challenges. Solar energy is used in numerous residential sectors through flat plate solar collectors. The thermal efficiency of flat plate solar collectors is improved when conventional heat transfer fluids are replaced with nanofluids because they offer superior thermo-physical properties to conventional heat transfer fluids. Concentrated chemicals are utilized in nanofluids' conventional synthesis techniques, which produce hazardous toxic bi-products. The present research investigates the effects of novel green covalently functionalized gallic acid-treated multiwall carbon nanotubes-water nanofluid on the performance of flat plate solar collectors. GAMWCNTs are highly stable in the base fluid, according to stability analysis techniques, including ultraviolet-visible spectroscopy and zeta potential. Experimental evaluation shows that the thermo-physical properties of nanofluid are better than those of base fluid deionized water. The energy, exergy and economic analysis are performed using 0.025%, 0.065% and 0.1% weight concentrations of GAMWCNT-water at varying mass flow rates 0.010, 0.0144, 0.0188 kg/s. The introduction of GAMWCNT nanofluid enhanced the thermal performance of flat plate solar collectors in terms of energy and exergy efficiency. There is an enhancement in efficiency with the rise in heat flux, mass flow rate and weight concentration, but a decline is seen as inlet temperature increases. As per experimental findings, the highest improvement in energy efficiency is 30.88% for a 0.1% weight concentration of GAMWCNT nanofluid at 0.0188 kg/s compared to the base fluid. The collector's exergy efficiency increases with the rise in weight concentration while it decreases with an increase in flow rate. The highest exergy efficiency is achieved at 0.1% GAMWCNT concentration and 0.010 kg/s mass flow rate. GAMWCNT nanofluids have higher values for friction factor compared to the base fluid. There is a small increment in relative pumping power with increasing weight concentration of nanofluid. Performance index values of more than 1 are achieved for all GAMWCNT concentrations. When the solar thermal collector is operated at 0.0188 kg/s and 0.1% weight concentration of GAMWCNT nanofluid, the highest size reduction, 27.59%, is achieved as compared to a flat plate solar collector with water as a heat transfer fluid.
Fulltext In Vitro Assessment on Designing Novel Antibiofilms of Pseudomonas aeruginosa Using a Computational Approach

Rachmawati D, Fahmi MZ, Abdjan MI, Wasito EB, Siswanto I, Mazlan N, et al.

Molecules, 2022 Dec 15;27(24).
PMID: 36558064 DOI: 10.3390/molecules27248935

An anti-biofilm that can inhibit the matrix of biofilm formation is necessary to prevent recurrent and chronic Pseudomonas aeruginosa infection. This study aimed to design compounds with a new mechanism through competitive inhibitory activity against phosphomannomutase/phosphoglucomutase (PMM/PGM), using in vitro assessment and a computational (in silico) approach. The active site of PMM/PGM was assessed through molecular redocking using L-tartaric acid as the native ligand and other small molecules, such as glucaric acid, D-sorbitol, and ascorbic acid. The docking program set the small molecules to the active site, showing a stable complex formation. Analysis of structural similarity, bioavailability, absorption, distribution, metabolism, excretion, and toxicity properties proved the potential application of ligands as an anti-biofilm. In vitro assessment with crystal violet showed that the ligands could reach up to 95.87% inhibition at different concentrations. The nitrocellulose membrane and scanning electron microscopic visualization showed that the untreated P. aeruginosa biofilm was denser than the ligand-treated biofilm.
Fulltext Gelatin-based hemostatic agents for medical and dental application at a glance: A narrative literature review

Irfan NI, Mohd Zubir AZ, Suwandi A, Haris MS, Jaswir I, Lestari W

Saudi Dent J, 2022 Dec;34(8):699-707.
PMID: 36570577 DOI: 10.1016/j.sdentj.2022.11.007

Uncontrolled bleeding is linked to higher treatment costs, risk of post-surgical infection and increased disease and death. Hemostatic agents are used to treat excessive bleeding. A good hemostatic agent controls bleeding effectively, reduces the need for blood transfusion, removes the need for systemic drugs to control bleeding, results in shorter surgery time, and reduces the cost and length of hospital stay of the patient. Gelatin-based hemostatic agents have been widely used in medical and dental procedures, owing to their biodegradability and biocompatibility, as well as availability and low cost of raw materials. In this narrative literature review, we discuss the background and different types of gelatin-based hemostatic agents in medical and dental procedures, the comparison of gelatin-based and non-gelatin-based hemostatic agents, and the usage and development of enhanced or novel gelatin-based hemostatic agents. Gelatin-based hemostatic agents are effective and important part of bleeding control, as evidenced by its wide application in medicine and dentistry. The development of novel combination gelatin-based hemostatic agents has much potential for effective control of excessive bleeding.
Fulltext Sequence, Secondary Structure, and Phylogenetic Conservation of MicroRNAs in Arabidopsis thaliana

Mazhar MW, Yusof NY, Shaheen T, Saif S, Raza A, Mazhar F

Bioinform Biol Insights, 2022;16:11779322221142116.
PMID: 36570328 DOI: 10.1177/11779322221142116

MicroRNAs are small non-coding RNA molecules that are produced in a cell endogenously. They are made up of 18 to 26 nucleotides in strength. Due to their evolutionary conserved nature, most of the miRNAs provide a logical basis for the prediction of novel miRNAs and their clusters in plants such as sunflowers related to the Asteraceae family. In addition, they participate in different biological processes of plants, including cell signaling and metabolism, development, growth, and tolerance to (biotic and abiotic) stresses. In this study profiling, conservation and characterization of novel miRNA possessing conserved nature in various plants and their targets annotation in sunflower (Asteraceae) were obtained by using various computational tools and software. As a result, we looked at 152 microRNAs in Arabidopsis thaliana that had already been predicted. Drought tolerance stress is mediated by these 152 non-coding RNAs. Following that, we used local alignment to predict novel microRNAs that were specific to Helianthus annuus. We used BLAST to do a local alignment, and we chose sequences with an identity of 80% to 100%. MIR156a, MIR164a, MIR165a, MIR170, MIR172a, MIR172b, MIR319a, MIR393a, MIR394a, MIR399a, MIR156h, and MIR414 are the new anticipated miRNAs. We used MFold to predict the secondary structure of new microRNAs. We used conservation analysis and phylogenetic analysis against a variety of organisms, including Gossypium hirsutum, H. annuus, A. thaliana, Triticum aestivum, Saccharum officinarum, Zea mays, Brassica napus, Solanum tuberosum, Solanum lycopersicum, and Oryza sativa, to determine the evolutionary history of these novel non-coding RNAs. Clustal W was used to analyze the evolutionary history of discovered miRNAs.
Anammox process for aquaculture wastewater treatment: operational condition, mechanism, and future prospective

Ismail IN, Taufik M, Umor NA, Norulhuda MR, Zulkarnaini Z, Ismail S

Water Sci Technol, 2022 Dec;86(12):3093-3112.
PMID: 36579872 DOI: 10.2166/wst.2022.403

Treatment of ammonia- and nitrate-rich wastewater, such as that generated in the aquaculture industry, is important to prevent environmental pollution. The anaerobic ammonium oxidation (anammox) process has been reported as a great alternative in reducing ammoniacal nitrogen concentration in aquaculture wastewater treatment compared to conventional treatment systems. This paper will highlight the impact of the anammox process on aquaculture wastewater, particularly in the regulation of ammonia and nitrogen compounds. The state of the art for anammox treatment systems is discussed in comparison to other available treatment methods. While the anammox process is viable for the treatment of aquaculture wastewater, the efficiency of nitrogen removal could be further improved through the proper use of anammox bacteria, operating conditions, and microbial diversity. In conclusion, a new model of the anammox process is proposed in this review.
Fulltext Integrating sustainable Islamic social finance: An Analytical Network Process using the Benefit Opportunity Cost Risk (ANP BOCR) framework: The case of Indonesia

Widiastuti T, Robani A, Sukmaningrum PS, Mawardi I, Ningsih S, Herianingrum S, et al.

PLoS One, 2022;17(5):e0269039.
PMID: 35617300 DOI: 10.1371/journal.pone.0269039

The utilization of Islamic social finance instruments is far behind what is expected. To realize its full potential, Islamic social finance instruments must be integrated. This study examined solutions and priority strategies for integrating sustainable Islamic social finance that could be implemented in the short and long term using the Benefit, Opportunity, Cost, and Risk (BOCR) framework, which includes six aspects: Governance, sustainable financing, institutional aspect, human resources, regulations, and supporting technology. This qualitative research employed the Analytic Network Process (ANP) method using the benefit, opportunity, cost, and risk analysis. The data were obtained mainly through focus group discussions and in-depth interviews with respondents among academics, practitioners, associations, regulators, and community leaders. The respondents were selected for their expertise and experience in the selected topic. The data were processed using the Microsoft Excel and Super Decision software. There are several findings worth considering from the analysis. First, the highest priority in integrating Islamic social finance aspects are human resources (0.97), regulation (0.86), and technology (0.76). Second, based on the short- and long-term analysis, financial integration through sustainable financing (0.01 and 1.44, respectively) and improving human resource quality through certification and training (0.01 and 1.56, respectively) is a priority solution and strategy to integrate sustainable Islamic social finance. Meanwhile, according to expert judgments, integrating national data (0.24) and optimizing technology use (0.18) are priority solutions and strategies. The findings emphasize the critical role of improving human resource quality to utilize technology, with experts identifying a national data integration as the most critical solution. As a result, relevant stakeholders are concerned about technology management training for Islamic philanthropic managers, with the goal of maximizing the potential of technology's growing role and adoption.
Fulltext ReSTiNet: An Efficient Deep Learning Approach to Improve Human Detection Accuracy

Sumit SS, Rambli DRA, Mirjalili S, Miah MSU, Ejaz MM

MethodsX, 2023;10:101936.
PMID: 36578294 DOI: 10.1016/j.mex.2022.101936

Human detection is an important task in computer vision. It is one of the most important tasks in global security and safety monitoring. In recent days, Deep Learning has improved human detection technology. Despite modern techniques, there are very few optimal techniques to construct networks with a small size, deep architecture, and fast training time while maintaining accuracy. ReSTiNet is a novel small convolutional neural network that overcomes the problems of network size, detection speed, and accuracy. The developed ReSTiNet contains fire modules by evaluating their number and position in the network to minimize the model parameters and network size. To improve the detection speed and accuracy of ReSTiNet, the residual block within the fire modules is carefully designed to increase the feature propagation and maximize the information flow in the network. The developed approach compresses the well-known Tiny-YOLO architecture while improving the following features: (i) small model size, (ii) faster detection speed, (iii) resolution of overfitting, and (iv) better performance than other compact networks such as SqueezeNet and MobileNet in terms of mAP on the Pascal VOC and MS COCO datasets. ReSTiNet is 10.7 MB, five times smaller than Tiny-YOLO. On Tesla k80, mAP is 27.3% for MS COCO and 63.74% for PASCAL VOC. The validation of the proposed ReSTiNet model has been done on INRIA person dataset using the Tesla K80.•All the necessary steps, algorithms, and mathematical formulas for building the net- work are provided.•The network is small in size but has a faster detection speed with high accuracy.
Oestrogen-induced epithelial-mesenchymal transition (EMT) in endometriosis: Aetiology of vaginal agenesis in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome

Lih Yuan T, Sulaiman N, Nur Azurah AG, Maarof M, Rabiatul Adawiyah Razali, Yazid MD

Front Physiol, 2022;13:937988.
PMID: 36582359 DOI: 10.3389/fphys.2022.937988

Endometriosis occurs when endometrial-like tissue forms and grows outside the uterus due to oestrogen-induced epithelial-mesenchymal transition in the female reproductive tract. Factors that suppress this event could become potential therapeutic agents against disease occurrence and progression. However, an overview of these studies is still lacking. This review assessed the impact of a number factors on oestrogen-mediated epithelial-mesenchymal transition in the emergence of several diseases in the female reproductive tract, primarily endometriosis. The association between epithelial-mesenchymal transition and Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome was also investigated. Oestrogen, Wnt4 and epithelial-mesenchymal transition were chosen as keywords in Scopus, PubMed, and Web of Science searches performed on 28th June 2021. Study selection was refined to cancer-irrelevant, English, original articles published between years 2011-2021. The full-text assessment was carried out for topic-related articles after title and abstract screening. Included studies were summarised and assessed for their risk of bias using the Office of Health Assessment and Translation tool. In this review, 10 articles investigating oestrogen and epithelial-mesenchymal transition in the female reproductive tract were summarised and classified into two groups: seven studies under 'factor'-modulated epithelial-mesenchymal transition and three studies under 'factor'-manipulated oestrogen-induced epithelial-mesenchymal transition. The current evidence proposes that epithelial-mesenchymal transition is one of the prime causes of reproductive-related disease. This event could be mediated by distinct stimuli, specifically oestrogen and Wnt4 aberration. The results of this review suggest that oestrogen and Wnt4 participate in epithelial-mesenchymal transition in vaginal epithelial cells in MRKH syndrome, adopting from the theories of endometriosis development, which could therefore serve as a foundation for novel target treatment, specifically related to vaginal epithelialisation, to ensure better surgical outcomes.
Impact of age and breast thickness on mean glandular dose of standard digital mammography and digital breast tomosynthesis

Norsuddin NM, Mei Sin JG, Ravintaran R, Arasaratnam S, Abdul Karim MK

Appl Radiat Isot, 2023 Feb;192:110525.
PMID: 36436228 DOI: 10.1016/j.apradiso.2022.110525

This study compares the mean glandular dose (MGD) across 2D, 3D projection and Contrast-Enhanced Digital Mammography (CEDM) mammographic techniques. The important metadata were extracted from the digital mammography console. 650 subjects were clustered based on projections, age and CBT. The MGD of 2D, 3D, and CEDM was positively correlated with CBT but inversely correlated with the age factor. This study indicate MGD of CEDM was 16% and 22% lower compared to 2D and 3D techniques, respectively.
Fulltext Prevalence of glycemic variability and factors associated with the glycemic arrays among end-stage kidney disease patients on chronic hemodialysis

Yusof Khan AHK, Zakaria NF, Zainal Abidin MA, Kamaruddin NA

Medicine (Baltimore), 2021 Jul 30;100(30):e26729.
PMID: 34397709 DOI: 10.1097/MD.0000000000026729

Glycemic variability (GV) confers a significantly higher risk of diabetic-related complications, especially cardiovascular. Despite extensive research in this area, data on end-stage kidney disease (ESKD) patients on chronic hemodialysis are scarce. This study aims to determine the magnitude of GV among ESKD (diabetic vs nondiabetic) patients and its associated factors on hemodialysis days (HDD) and non-hemodialysis days (NHDD) where postulation of a higher GV observed among diabetic on HDD.We recruited 150 patients on hemodialysis, 93 patients with type 2 diabetic (DM-ESKD), and 57 with nondiabetic (NDM-ESKD). The GV indices (standard deviation [SD] and percentage coefficient variant [%CV]) were obtained from 11-point and 7-point self-monitoring blood glucose (fasting to post-meal) (SMBG) profiles on HDD and NHDD. The GV indices and its associated factors of both DM-ESKD and NDM-ESKD were analyzed to compare HDD vs NHDD.Mean blood glucose on HDD was 9.33 [SD 2.7, %CV 30.6%] mmol/L in DM-ESKD compared with 6.07 [SD 0.85, %CV 21.3%] mmol/L in NDM-ESKD (P =
Prevalence and risk factors contributing to recidivism among patients admitted to Forensic Unit Hospital Permai Johor Bahru Malaysia

Jacob MFF, Razali S, Ali NF, Khamis J, Ahmad Y

Asian J Psychiatr, 2023 Jan;79:103325.
PMID: 36395701 DOI: 10.1016/j.ajp.2022.103325
Antagonistic activity of wild growing mushrooms against various fungal rice pathogen

Mohd-Baseri N, Kheirel Anuar MS, Shamsuhazli NAS, Zulkifli MAF, Wasoh H, Yusof MT

Int Microbiol, 2023 Jan;26(1):91-98.
PMID: 36089618 DOI: 10.1007/s10123-022-00275-4

Paddy is an important crop in Malaysia. There are various pathogens able to infect paddy causing a loss in yield's production. In this study, dual culture method, volatile organic compound (VOC) analysis, and non-volatile compound analysis were used to assess the ability of mushroom to control fungal rice pathogens including Curvularia lunata, Bipolaris panici-miliacei, and Nigrospora sp. Four mushroom isolates were further analysed for their antagonistic activity against rice pathogen. The highest percentage inhibition of radial growth (PIRG) was recorded between 45.55 and 73.68% observed in isolate 42b. The 4 isolates with the highest PIRG based on the dual culture analysis were then tested for their production of VOCs and non-volatile compound. Internal transcribed spacer (ITS) region analysis of the 4 mushroom isolates revealed their identity as Coprinellus disseminates (isolate 12b), Marasmiellus palmivorus (isolate 42b), Trametes maxima (isolate 56e), and Lentinus sajor-caju (isolate 60a). This study showed that mushroom isolates have the potential of antagonistic effect on various fungal rice pathogens tested by the production of secondary metabolites and mycoparasitic interaction.
Identification of Newcastle Disease Virus sub-genotype VII 1.1 isolated from chickens in Sabah, Malaysia

Syamsiah Aini S, Leow BL, Faizul Fikri MY, Muhammad Redzwan S, Faizah Hanim MS

Trop Biomed, 2022 Dec 01;39(4):579-586.
PMID: 36602219 DOI: 10.47665/tb.39.4.015

Newcastle disease (ND) is an extremely contagious and fatal viral disease causing huge economic losses to the poultry industry. Following recent ND outbreaks in Sabah in commercial poultry and backyard farms, it was speculated that this could be due to a new introduction of Newcastle Disease Virus (NDV) genotype/sub-genotype. Here we report the genetic characterization of NDVs isolated from Sabah during early 2021. All isolates were amplified and sequenced with primers specific to the viral fusion (F) gene using reverse transcription-polymerase chain reaction (RT-PCR). Nucleotide sequence analysis of the F gene showed that all isolates shared similar homology of 99.4% with NDV strain from Iran isolated in 2018. Amino acid sequences of the F protein cleavage site revealed the motif of 112RRQKRF117 indicating all isolates were of virulent strain. Phylogenetic analysis demonstrated that all isolates were clustered under sub-genotype VII 1.1 and clustered together with isolates from Iran (previously known as subgenotype VIIl). The present findings suggested that there is an emerging of a new sub-genotype into the poultry population in Sabah and this sub-genotype has never been reported before in Malaysia. Therefore, transboundary monitoring and continuous surveillance should be implemented for proper control and prevention of the disease. A further molecular epidemiological analysis of NDV is needed to well understand the circulatory patterns of virulent strains of NDV in the country to prevent future outbreaks.
Prevalence of smartphone addiction and its associated factors among pre-clinical medical and dental students in a public university in Malaysia

Said AH, Mohd FN, Yusof MZ, Mohd Win NAN, Mazlan AN, Shaharudin AS

Malays Fam Physician, 2022 Nov 30;17(3):64-73.
PMID: 36606166 DOI: 10.51866/oa.75

INTRODUCTION: Smartphone addiction is becoming a global concern affecting every part of society, including healthcare professionals. This study aimed to identify the prevalence of risk of smartphone addiction and its associated factors among medical and dental students in a public university in Malaysia.
METHOD: This cross-sectional study was conducted among pre-clinical medical and dental students using convenience sampling. Questions regarding sociodemographic profile and responses to the Smartphone Addiction Scale Short Version (SAS-SV) and Depression, Anxiety and Stress Score questionnaire (DASS-21) were collected. Multiple logistic regression testing was used to analyse the factors associated with smartphone addiction.
RESULTS: We invited 409 pre-clinical medical and dental students to participate voluntarily, resulting in a response rate of 80.2%. The prevalence of high-risk smartphone addiction among the participants was 47.9%. Male participants, participants who used smartphones mainly for social media, and participants with depressive symptoms were more likely to have a high risk of smartphone addiction. Medical students, participants who spent less than 3 hours per day on a smartphone, and participants who used smartphones for education-related activities were less likely to have a high risk of smartphone addiction.
CONCLUSION: Smartphone addiction prevalence among pre-clinical medical and dental students was high. Therefore, the authorities should overcome this problem by implementing early measures.
Fulltext Why Did I Consult My Pharmacist about Herbal and Dietary Supplements? An Online Survey Amid the COVID-19 Pandemic in Malaysia

Wahab MSA, Jalani MM, Goh KW, Ming LC, Faller EM

Int J Environ Res Public Health, 2022 Sep 02;19(17).
PMID: 36078707 DOI: 10.3390/ijerph191710994

Herbal and dietary supplements (HDSs) are frequently obtained from community pharmacies, but community pharmacists (CPs) have been underutilized for information regarding them. This study aimed to determine the prevalence of, factors behind, and reasons for consultation with CPs among HDS consumers in Malaysia. A cross-sectional study using an online survey was conducted among conveniently sampled individuals in Malaysia. Reasons for consultation or non-consultation with CPs about HDSs were sought from the respondents. A logistic regression analysis was conducted to determine the predictors of consultation with CPs. Overall, 40.3% (239/593) of participants consulted CPs about the HDSs that they purchased. The participants were predominantly unmarried (362/588, 61.6%) and belonged to the 18-29 age group (332/593, 56%). The multivariate analysis showed that a suburban residential setting was the only significant predictor for consultation with CPs (adjusted odds ratio = 0.390, 95% CI = 0.260-0.583). Respondents who consulted CPs generally agreed that the CPs were the right people to consult on HDSs (mean = 4.37, SD = 0.73). However, their discussion with CPs regarding HDSs mostly revolved around the benefits and directions for use, but little on the potential risks. Meanwhile, most respondents who did not consult CPs agreed that they had never thought of consulting CPs about their HDS use (mean = 3.45, SD = 1.02). The majority of them referred to the Internet (61.3%, 217/354) and social media (59.9%, 212/354) for information about HDSs. The findings from this study show that more efforts are warranted in encouraging consumers to consult CPs about their HDS use and to enhance their awareness of the roles of CPs in ensuring the safe use of HDSs.
Fulltext Readiness of Bystander Cardiopulmonary Resuscitation (BCPR) during the COVID-19 Pandemic: A Review

Fazel MF, Mohamad MHN, Sahar MA, Juliana N, Abu IF, Das S

Int J Environ Res Public Health, 2022 Sep 02;19(17).
PMID: 36078684 DOI: 10.3390/ijerph191710968

Early cardiopulmonary resuscitation (CPR) is a strong link in the of survival for sudden cardiac arrest. Hence, bystander CPR (BPCR) plays an important role in curbing mortality and morbidity from out-of-hospital sudden cardiac arrest. However, the recent global Coronavirus disease 2019 (COVID-19) pandemic has impacted both public training and confidence in performing out-of-hospital CPR. This paper reviews detailed information from databases including Google Scholar, Scopus, PubMed and Web of Science on the readiness of BCPR during the pandemic. We also discussed the challenges bystanders encountered during the COVID-19 pandemic and the precautions to follow. Finally, we also highlighted the limitations which would benefit future endeavours in establishing well-planned and sustainable CPR training programs for the public. Therefore, regardless of the existing COVID-19 pandemic, BCPR must be emphasised to curb out-of-hospital cardiac arrest (OHCA) mortality.
Fulltext Effects of blanching and pickling process on the alcohol acyltransferase (AAT) activity, myristicin content and quality parameters of pickled nutmeg (Myristica fragrans)

Rahman N, Mahmood K, Kamilah H, Sulaiman S, Ibrahim M, Ariffin F

J Food Sci Technol, 2022 Feb;59(2):542-551.
PMID: 35153307 DOI: 10.1007/s13197-021-05038-z

Myristicin, a potential toxicant, is a major ester present in the pericarp of nutmeg (Myristica fragrans) and alcohol acyltransferase (AAT) is responsible for its generation. The objective of the study was firstly to estimate the effect of blanching and pickling process on the inactivation of AAT and production of myristicin in nutmeg pericarp. Secondly, the effect of pickling process on the physical, microbial, antioxidant and sensory properties of nutmeg was evaluated. The nutmeg fruit pericarp was water-blanched for 0, 3, 5, 7 and 9 min. The increased blanching time significantly (p
Fulltext Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Ahmed S, Ahmed MZ, Rafique S, Almasoudi SE, Shah M, Jalil NAC, et al.

Biomed Res Int, 2023;2023:5250040.
PMID: 36726844 DOI: 10.1155/2023/5250040

Antimicrobial resistance (AMR) is a ubiquitous public health menace. AMR emergence causes complications in treating infections contributing to an upsurge in the mortality rate. The epidemic of AMR in sync with a high utilization rate of antimicrobial drugs signifies an alarming situation for the fleet recovery of both animals and humans. The emergence of resistant species calls for new treatments and therapeutics. Current records propose that health drug dependency, veterinary medicine, agricultural application, and vaccination reluctance are the primary etymology of AMR gene emergence and spread. Recently, several encouraging avenues have been presented to contest resistance, such as antivirulent therapy, passive immunization, antimicrobial peptides, vaccines, phage therapy, and botanical and liposomal nanoparticles. Most of these therapies are used as cutting-edge methodologies to downplay antibacterial drugs to subdue the resistance pressure, which is a featured motive of discussion in this review article. AMR can fade away through the potential use of current cutting-edge therapeutics, advancement in antimicrobial susceptibility testing, new diagnostic testing, prompt clinical response, and probing of new pharmacodynamic properties of antimicrobials. It also needs to promote future research on contemporary methods to maintain host homeostasis after infections caused by AMR. Referable to the microbial ability to break resistance, there is a great ultimatum for using not only appropriate and advanced antimicrobial drugs but also other neoteric diverse cutting-edge therapeutics.

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links