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  1. Fulltext Laboratory aspects of asymptomatic bacteriuria in pregnancy
    Mohammad M, Mahdy ZA, Omar J, Maan N, Jamil MA
    Southeast Asian J Trop Med Public Health, 2002 Sep;33(3):575-80.
    PMID: 12693594
    A total of 1,661 pregnant women aged between 13 and 45 years were screened for bacteriuria by urine culture. Of the 1,661 culture results, 615 (37%) yielded no growth; 728 (43.8%) yielded no significant growth (presence of <10(5) organisms/ml urine of one or more types of bacteria); 286 (17.2%) yielded mixed growth (presence of >10(5) organisms/ml urine of more than one type of bacteria) and only 32 (1.9%) showed significant growth (presence of >10(5) organisms/ml urine of a single bacterium). Urine microscopy was also conducted. Two hundred and twenty-four (13.5%) specimens had >10 white blood cells/ml urine, of which 66 had >100 white blood cells; 13 were from the significant growth group. Three hundred and seventy-four (22.5%) specimens showed the presence of bacteria, 42 (2.5%) had red blood cells, 370 (22.3%) had epithelial cells, 58 (3.5%) had crystals, and 14 (0.8%) had yeasts. The most common bacterium isolated was Escherichia coli (12; 40%); the others included group B Streptococcus (5; 15%), Klebsiella spp (5; 15%), Diphtheroids (2), and Candida albicans (2). Fifty-two percent of tested strains were sensitive to ampicillin; 24 of 28 strains (85.7%) were sensitive to ciprofloxacin; all 7 strains tested were sensitive to nitrofurantoin and all 20 strains tested were sensitive to cotrimoxazole; 14/20 (70%) and 16/17 (94.1%) were sensitive to cephalexin and cefuroxime respectively. This study shows that asymptomatic bacteriuria does occur in pregnant women, albeit at a very low rate in an urban setting like Cheras. Urine microscopy is not specific and only serves as a guide to bacteriuria. The commonest causative organisms are those from the gastrointestinal tract and vagina. The antibiogram showed that cefuroxime and cephalexin are likely to be effective in treating bacteriuria: ampicillin must be reserved for Gram-negative organisms. For Gram-positive organisms, of which Group B Streptococcus is important, ampicillin is still effective in vitro. Nitrofurantion and cotrimoxazole have excellent activity in vitro and should be considered for therapy. 17.2% of the urine culture yielded mixed growth: likely to indicate that contamination of urine specimens still happens despite the strict instructions given to patients about the collection of a midstream urine specimen. Proper collection, appropriate transport, and the early processing of urine specimens remain essential.
    Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/diagnosis*; Pregnancy Complications, Infectious/drug therapy; Pregnancy Complications, Infectious/microbiology; Pregnancy Complications, Infectious/epidemiology
  2. Fulltext Impact of carpal tunnel syndrome on the expectant woman's life
    Rozali ZI, Noorman FM, De Cruz PK, Feng YK, Razab HW, Sapuan J, et al.
    Asia Pac Fam Med, 2012 Jan 30;11(1):1.
    PMID: 22283968 DOI: 10.1186/1447-056X-11-1
    INTRODUCTION: Carpal Tunnel Syndrome is known to be a common complication during pregnancy especially during the third trimester.

    AIM: This article focuses on its impact to the third trimester pregnant mothers with CTS.

    METHODS: Third trimester pregnant mothers with no other known risk factors for CTS, were interviewed and examined for a clinical diagnosis of CTS. The severity of CTS was assessed by means of symptoms severity and functionality using the Boston Carpal Tunnel Questionnaire.

    RESULTS: Out of 333 third trimester pregnant mothers, 82 (24.6%) were clinically diagnosed with CTS. Malay race was found to have significant correlation with the diagnosis of CTS (p = 0.024) and are two times more likely to get CTS during pregnancy (OR = 2.26) compare to the non-Malays. Bilateral CTS was two times higher (n = 58, 63.4%) than unilateral cases (n = 30, 36.6%), however no significant correlation between the two was found with severity (p = 0.284) or functional (p = 0.906). The commonest complaint was numbness/tingling during day time (n = 63, 76.8%). Majority of the CTS cases were mild (n = 66, 80.5%) and approximately one third (n = 28, 34.1%) had affected hand functions. All symptoms related to pain was found to have significant correlation with severity (p = 0.00, OR = 12.23) and function (p = 0.005, OR = 5.01), whereas numbness and tingling does not (Severity, p = 0.843, function, p = 0.632).

    CONCLUSION: This study shows that even though CTS in third trimester pregnancy is prevalent, generally it would be mild. However, function can still be affected especially if patients complain of pain.
    Matched MeSH terms: Pregnancy; Pregnancy Trimester, Third
  3. Fulltext Placenta accreta: clinical risk factors, accuracy of antenatal diagnosis and effect on pregnancy outcome
    Sofiah S, Fung YC
    Med J Malaysia, 2009 Dec;64(4):298-302.
    PMID: 20954554 MyJurnal
    The aim of this study is to evaluate the clinical risk factors, accuracy of antenatal ultrasound for diagnosis, and the effect of these on pregnancy outcome. It is a retrospective study looking at cases which had hysterectomy following vaginal or caesarean section deliveries from 1993 to 2005. Data regarding the maternal demographic characteristics, number of previous CS, number of previous termination/curettage, antenatal scan findings (state features) and the gestation at which accreta was first suspected/diagnosed, MRI scan findings, pregnancy outcome (need for hysterectomy, amount of blood loss, amount of transfusion, length of ICU and hospital stay, other maternal complications, and neonatal outcome) were collected and evaluated. There were a total of 40 cases diagnosed to have abnormal placental attachment and majority of these were actually diagnosed antenatally by sonography. Visualisation of an absence or thinning of hypoechoic myometrial zone had the highest sensitivity to detect placenta accreta followed by intraplacental lacunae, focal mass tissue elevation and disruption of uterine serosal bladder wall.
    Matched MeSH terms: Pregnancy; Pregnancy Outcome
  4. Fulltext A preliminary finding: immunohistochemical localisation and distribution of placental angiotensin II receptor subtypes in normal and preeclamptic pregnancies
    Judson JP, Nadarajah VD, Bong YC, Subramaniam K, Sivalingam N
    Med J Malaysia, 2006 Jun;61(2):173-80.
    PMID: 16898308
    Pre-eclampsia or pregnancy induced hypertension (PIH) affects 6-8% of all pregnancies. Although the underlying mechanism of PIH is still unknown, it is widely believed that the placenta plays an important role. It was thought that an ischemic placenta due to poor perfusion can precipitate the signs and symptoms of PIH. This study aims to investigate the possible role of Type 1(AT1) and Type 2 (AT2) angiotensin II receptor subtypes in the mechanism of PIH. AT1 receptor stimulation causes vasoconstriction and AT2 receptor stimulation causes vasodilatation. Investigating the interactions of these two receptors in the placenta provides an insight as to the balance that may exist between AT1 and AT2 receptors in normal pregnancy. Any disruption to the balance might cause a disruption of the blood flow in the placenta, leading to PIH. Placentas were collected from 11 PIH patients and 11 normal patients. Immunohistochemistry techniques were performed on the placental tissue to determine the distribution of AT1 and AT2 receptors in the placental tissue qualitatively and quantitatively. It was observed that in normal patients, the balance between AT1 and AT2 receptors is that the level of AT2 receptors is higher than the level of AT1 receptors. However in the PIH patient, it was observed that the normal balance was disrupted. In PIH patients the level of AT1 receptors was observed to be higher than the level of AT2 receptors. This study suggests that disruption of the balance between AT1 and AT2 receptors observed in PIH placentas might cause a decrease in blood flow to the placenta, causing it to be poorly perfused. This may cause placental ischemia which may lead to PIH.
    Matched MeSH terms: Pregnancy/metabolism*
  5. Molecular factors in human implantation: adhesion molecules, proteases and cytokines
    Lim KJ
    Malays J Pathol, 2003 Jun;25(1):1-13.
    PMID: 16196373
    Successful human reproduction remains an enigma, but this is slowly changing in the current era of expanding scientific knowledge. The discovery of various molecular factors such as adhesion molecules, proteases and cytokines have in recent years been at the forefront of medical research. The growing importance of immunology in particular has led to novel new immuno-modulatory therapies and increasing research into this new aspect of reproductive immunology may well prove to be the most important breakthrough in understanding the fundamentals of human reproduction. Implantation represents the first step in the complex interactions and processes involved in foetal-maternal interaction, which continues throughout pregnancy gestation and culminates in the birth of an infant. It is therefore vital that we understand the myriad processes controlling implantation in order to build a firm foundation for exploring reproductive immunology research in the new millennium. This review brings together and presents an overview of the potential roles of currently known molecular factors such as adhesion molecules, proteases, cytokines and its interaction with the maternal immune response, incorporating the findings of previous published research performed by the author on cytokines and reproductive immunology.
    Matched MeSH terms: Pregnancy*
  6. Anastrozole is a dose-specific superovulator and favors implantation in rats: a prospective study
    Mwakikunga A, Hosie MJ
    Cell Tissue Res, 2016 Apr;364(1):209-17.
    PMID: 25971929 DOI: 10.1007/s00441-015-2180-1
    An alternative superovulator to replace clomiphene citrate (CC) is needed as it is unsuitable for women with polycystic ovarian syndrome and is associated with low pregnancy rates. Anastrozole is an effective superovulator, but has not been well researched. The aim of this study was to determine the optimal dose of anastrozole as a superovulator and ascertain its effects on implantation and uterine ultrastructure during early pregnancy in Wistar rats using scanning electron microscopy. The uterine morphological characteristics which were studied in day 1 and 6 pregnant rats include microvilli density, length, surface "beads", surface glycocalyx, cell borders and apices, uterine surface fording and large surface protrusions. A significant increase in implantation sites is seen in the 15 mg/kg anastrozole group, compared to control. Day 1 and 6 anastrozole groups have similar morphology to the control and different to the CC group. At day 6, large surface protrusions are mostly noted but not limited to anastrozole-treated rats; anastrozole also appears to retain glycocalyx to some extent. The increased number of implantation sites in the 15 mg/kg anastrozole group suggests that this dose superovulates and favors implantation. Anastrozole is probably dose-/species-specific and additionally the surface uterine morphology suggests that anastrozole is implantation friendly.
    Matched MeSH terms: Pregnancy; Pregnancy Rate
  7. Intravaginal misoprostol for termination of midtrimester pregnancy
    Lim JM, Soh EB, Raman S
    Aust N Z J Obstet Gynaecol, 1995 Feb;35(1):54-5.
    PMID: 7772001
    Misoprostol seems to be a drug with many potential uses apart from the treatment of gastric and duodenal ulcers. The oral tablet appears to be effective for termination of midtrimester pregnancy when administered intravaginally. Further research should be carried out to determine its full range of action in order that the drug can be utilized to its maximum potential.
    Matched MeSH terms: Pregnancy; Pregnancy Trimester, Second
  8. Fulltext A halfway house for pregnant women
    Ahmad Z, Jaafar R, Hassan MH, Awang CW
    World Health Forum, 1998;19(2):133-5.
    PMID: 9652210
    Matched MeSH terms: Pregnancy; Pregnancy, High-Risk
  9. Fulltext First trimester prenatal diagnosis of beta-thalassaemia following chorionic villus sampling
    Chandran R, Ainoon O, Anson I, Anne J, Cheong SK
    Med J Malaysia, 1993 Sep;48(3):341-4.
    PMID: 8183149
    DNA analysis for the diagnosis of beta-thalassaemia is a relatively new technique in Malaysia. This, combined with chorionic villus sampling, has enabled us to offer prenatal diagnosis in the first trimester for this common condition. To the best of our knowledge, this has not hitherto been reported in Malaysia.
    Matched MeSH terms: Pregnancy; Pregnancy Trimester, First
  10. The use of the semen analysis in predicting fertility outcome
    Arumugam K, Omar SZ
    Aust N Z J Obstet Gynaecol, 1992 May;32(2):154-7.
    PMID: 1520202
    The study investigates the use of the various parameters of the semen analysis in predicting the fertility outcome in 82 infertile couples. The sperm density, % progressive motility, % normal morphology were divided into 'normal' and 'abnormal' based on the criteria proposed by WHO. The subsequent cumulative pregnancy rates were then calculated according to this criteria. A life-table method of analysis was used. All female related fertility factors were excluded. With the exception of a sperm density of less than 20 x 10(6) per ml the other parameters showed no significant correlation with the cumulative pregnancy rates at 12 months or 24 months respectively. We concluded that the semen analysis does not predict the probable outcome of the subsequent rates even when female fertility related factors were excluded apart from a sperm density less than 20 x 10(6) per ml.
    Matched MeSH terms: Pregnancy*
  11. Grandmultiparity in Malaysian women
    Tai C, Urquhart R
    Asia Oceania J Obstet Gynaecol, 1991 Dec;17(4):327-34.
    PMID: 1801678
    Grandmultiparity is an ill defined term, but it is generally believed that increasing parity after the fifth delivery increases the risks of child bearing for both the mother and fetus. Four hundred seventy-seven women aged less than 35 years of parity 5 and above who delivered during one year period at the University Hospital, Kuala Lumpur were studied. There were 406 women of parity 5 and 6 and 71 women of parity 7 and above. The 2 groups as a whole comprised 7.5% of the obstetric population for that year. Obstetric performance in the 2 groups of grandmultipara was compared with 1,135 women, aged 25 to 34 years, having their second baby during the same period. Women of parity 7 and above were significantly more likely to be from lower socioeconomic groups, and suffer from anaemia, hypertension and pre-eclampsia. They were also significantly at risk of preterm delivery and delivering infants weighing less than 2.5 kg. In addition, the perinatal mortality rate was significantly greater in the highly parous group (Para greater than 7) than in women of parity 5 and 6 or the control group. Apart from a significant increase in the incidence of anaemia, women of parity 5 and 6 had a similar obstetric performance and perinatal outcome to that of the control group. We conclude that grandmultiparity per se is not an obstetric risk factor until after the seventh delivery. These findings have implications for those who plan the provision of obstetric services for the community.
    Matched MeSH terms: Pregnancy; Pregnancy Outcome
  12. Fulltext Influence of maternal factors and sex of newborn on birthweight
    Yadav H
    Med J Malaysia, 1988 Sep;43(3):224-8.
    PMID: 3241580
    Matched MeSH terms: Pregnancy/physiology*
  13. Fulltext Eclampsia in Kelantan
    Nalliah S, Abdullah AR
    Med J Malaysia, 1990 Mar;45(1):49-56.
    PMID: 2152069
    A review of eclampsia in Kelantan was undertaken from 1983-1988. There were 146 documented cases in the state (66 per 100,000 deliveries). Eight maternal deaths occurred. Sixty seven (45.9%) were primigravida. Six of the 79 multiparous women developed eclampsia for the first time following remarriages to new partners. The multisystem dysfunction resulting from eclampsia resulted in varied maternal complications. Fatal cerebral haemorrhage (3 cases), acute pulmonary oedema (8 cases), acute renal failure (6 cases), HELLP Syndrome (8 cases) and acute abruptio placentae were the commoner complications. The average number of convulsions per patient was 1.3. The mean gestation of mothers who delivered prematurely (28.2%) was 34.6 weeks and that for those at term (71.8%) was 39.1 weeks. The caesarean section rate was 42.5%. The perinatal mortality rate was 185.9 per 1000. The implications of this high maternal and fetal mortality and morbidity are discussed in the light of the health delivery system and patient education. A team approach to medical management of eclampsia with the need for intensive care monitoring is suggested.
    Matched MeSH terms: Pregnancy; Pregnancy Outcome
  14. Fulltext HLA-A and HLA-B antibodies of pregnant mothers in Malaysia
    Sukumaran KD, Joo OK
    Med J Malaysia, 1990 Jun;45(2):144-7.
    PMID: 2152019
    The aim of this study was to determine the frequency and specificity of HLA-A and B antibodies in multiparous mothers in the Malaysian population. 1,100 maternal serum samples obtained during normal childbirth were screened against a panel of 100 lymphocytes with known HLA antigen types for HLA antibodies by the complement dependent lymphocyte microcytotoxicity dye exclusion test. From the total number of 1,100 samples of maternal serum that were screened for HLA antibodies only 205 specimens (18.6%) tested positive for antibodies. The percentage of maternal sera which contained HLA-B specificities (10.6%) were significantly higher than those which contained HLA-A specificities (3.0%). Sixty maternal serum samples (5.5%) had high enough titres to be utilised as tissue typing reagents. Thirty nine maternal serum samples (3.5%) contained monospecific HLA antibodies. In this study the most common monospecific HLA antibodies characterised included the following specificities: A2, B5, B17 and B40. Malaysian multiparous mothers of gravida 3, 4 and 5 had a higher frequency for producing HLA-antibodies.
    Matched MeSH terms: Pregnancy/immunology*
  15. Fulltext The disappearance of sleep-related changes of serum prolactin in pregnant women
    Rajikin MH, Abdullah R, Hamid Arshat
    Med J Malaysia, 1983 Dec;38(4):311-4.
    PMID: 6599989
    Serum prolactin (hPRL) levels in nonpregnant, pregnant and postpartum women during sleep were investigated. The study showed that in non-pregnant women, there is an immediate shift of hPRL release with reversal of sleeping period. Thus, the nocturnal surge for prolactin is sleep related. In pregnant women, however, while there is an increase in hPRL level during pregnancy, the nocturnal rise of this hormone is not detected and this is observed as early as the first trimester of pregnancy.
    Matched MeSH terms: Pregnancy/blood*
  16. Human placental lactogen physiological role in pregnancy
    Ong HC
    Med J Malaysia, 1976 Mar;30(3):165-7.
    PMID: 958050
    Matched MeSH terms: Pregnancy*
  17. Obstetric performance of the rural primigravidae 1965 to 1968, in Kuantan, Pahang
    Thambu JA
    Med J Malaya, 1972 Jun;26(4):278-84.
    PMID: 5069418
    Matched MeSH terms: Pregnancy*
  18. Knowledge on involvement during pregnancy among fathers in respective areas in Kuantan, Malaysia
    Hanapi NNM, Isa MLM, Yusof AM
    Enferm Clin, 2019 09;29 Suppl 2:572-578.
    PMID: 31302017 DOI: 10.1016/j.enfcli.2019.06.008
    OBJECTIVE: This study aims to identify the knowledge on the involvement of father during pregnancy among fathers in the respective area in Kuantan.

    METHOD: The study was conducted as a cross-sectional with a quantitative study. There were 103 participants recruited. The data of this study were analyzed by using Statistical Package for Social Science (SPSS) with one-way ANOVA and Pearson correlation test for significant analyses.

    RESULT: The result showed that half of the fathers have high knowledge of pregnancy and knowledge on involvement regarding pregnancy. There is a significant difference between age factors with mean knowledge of father regarding pregnancy. Meanwhile, there is also a significant difference between age and knowledge on the involvement of father during pregnancy. In addition, a number of children and knowledge on the involvement of father during pregnancy also showed a significant association. The knowledge level of father regarding pregnancy and the knowledge on involvement during pregnancy among fathers is directly, linearly and moderately correlated.

    CONCLUSION: This study can be concluded that fathers in Kuantan are possessed average knowledge on involvement regarding pregnancy. This shows that man lag behind in their responsibilities in pregnancy. In which, they do not clearly know what their role is during pregnancy.

    Matched MeSH terms: Pregnancy*
  19. Fulltext Pre-Pregnancy BMI Influences the Association of Dietary Quality and Gestational Weight Gain: The SECOST Study
    Yong HY, Mohd Shariff Z, Mohd Yusof BN, Rejali Z, Tee YYS, Bindels J, et al.
    Int J Environ Res Public Health, 2019 10 04;16(19).
    PMID: 31590213 DOI: 10.3390/ijerph16193735
    Poor diet quality in pregnancy could impact gestational weight gain (GWG) and consequently fetal growth and development. But today there is limited data available on gestational diet quality. This study investigated the association between diet quality in each pregnancy trimester and GWG in Malaysian women. Diet quality was assessed using the modified Healthy Eating Index for Malaysians (HEI). Total GWG was defined as the difference between measured weight at last prenatal visit and pre-pregnancy weight. About one-fourth of women (23.3%) had excessive total GWG. There were significant differences in the HEI component score across trimesters, except for fruits. Overall, overweight/obese women had lower total HEI score (51.49-55.40) during pregnancy compared to non-overweight/obese women (53.38-56.50). For non-overweight/obese women, higher total HEI scores in the second and third trimesters were significantly associated with lower risk of inadequate GWG (aOR = 0.97, 95% CI = 0.95-0.99, p = 0.01) and higher risk of excessive GWG (aOR = 1.04, 95% CI = 1.01-1.07, p = 0.03), respectively. Overweight/obese women with higher total HEI scores in the second (aOR = 1.04, 95% CI = 1.01-1.07, p = 0.02) and third trimester (aOR = 1.04, 95% CI = 1.01-1.08, p = 0.02) were significantly at higher risk for excessive GWG. Pregnant women had relatively low diet quality throughout pregnancy. Diet quality and GWG association differed according to pre-pregnancy BMI with excessive GWG more likely to be associated with higher total HEI scores in the third trimester.
    Matched MeSH terms: Pregnancy; Pregnancy Trimesters
  20. Fulltext Sociodemographic and foetal charateristics of mothers with premature deliveries in Hospital Tuanku Jaafar Seremban, Negeri Sembilan, Malaysia
    Zaini I, Ghani SN, Moy FM
    JUMMEC, 2008;11(2):59-65.
    MyJurnal
    This is a retrospective case control study conducted between 1 January 2005 and 30 June 2006 at the Hospital Tuanku Jaafar, Seremban, Malaysia. The objective was to study the maternal sociodemographics and foetal characteristics associated with premature delivery. There were 387 cases selected universally and 387 controls selected by using systematic random sampling involving every 13 cases. The patients were women who had delivered their babies before 37 completed weeks, while the control were women who had term deliveries during the same period. Data were collected using structured questionnaire through secondary data. Results showed that having multiple pregnancies (OR=8.33, 95% CI: 2.91, 23.84), congenital abnormality (OR=4.6, 95% CI: 0.98, 21.84) and intrauterine growth retardation (OR=15.59, 95% CI: 3.69, 65.82) were the risk factors of premature delivery. Being an ethnic Indian also raised the odds (OR=1.67, 95% CI: 1.14, 2.43) but this was not significant in the multivariate analysis. Other sociodemographic characteristics did not contribute significantly to the risk factors for premature delivery in this sample. In conclusion, foetal characteristics were found to be significantly associated with premature delivery after adjustment for other confounding factors.
    Study site: Hospital Tuanku Jaafar, Seremban, Negeri Sembilan, Malaysia
    Matched MeSH terms: Pregnancy; Pregnancy, Multiple
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