Displaying publications 4421 - 4440 of 7301 in total

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  1. Hatta MNA, Mohamad Hanif EA, Chin SF, Low TY, Neoh HM
    Biosci Rep, 2023 Jun 28;43(6).
    PMID: 37218575 DOI: 10.1042/BSR20230609
    The gut microbiota Parvimonas micra has been found to be enriched in gut mucosal tissues and fecal samples of colorectal cancer (CRC) patients compared with non-CRC controls. In the present study, we investigated the tumorigenic potential of P. micra and its regulatory pathways in CRC using HT-29, a low-grade CRC intestinal epithelial cell. For every P. micra-HT-29 interaction assay, HT-29 was co-cultured anaerobically with P. micra at an MOI of 100:1 (bacteria: cells) for 2 h. We found that P. micra increased HT-29 cell proliferation by 38.45% (P=0.008), with the highest wound healing rate at 24 h post-infection (P=0.02). In addition, inflammatory marker expression (IL-5, IL-8, CCL20, and CSF2) was also significantly induced. Shotgun proteomics profiling analysis revealed that P. micra affects the protein expression of HT-29 (157 up-regulated and 214 down-regulated proteins). Up-regulation of PSMB4 protein and its neighbouring subunits revealed association of the ubiquitin-proteasome pathway (UPP) in CRC carcinogenesis; whereas down-regulation of CUL1, YWHAH, and MCM3 signified cell cycle dysregulation. Moreover, 22 clinically relevant epithelial-mesenchymal transition (EMT)-markers were expressed in HT-29 infected with P. micra. Overall, the present study elucidated exacerbated oncogenic properties of P. micra in HT-29 via aberrant cell proliferation, enhanced wound healing, inflammation, up-regulation of UPPs, and activation of EMT pathways.
  2. Amin M, Prajati G, Humairoh GP, Putri RM, Phairuang W, Hata M, et al.
    Heliyon, 2023 May;9(5):e15936.
    PMID: 37215863 DOI: 10.1016/j.heliyon.2023.e15936
    A cascade impactor type sampler equipped with an inertial filter was used to collect size-segregated particles down to ultrafine particles (UFPs or PM0.1) on Batam Island in Sumatra, Indonesia, bordered by Singapore and Malaysia during a wet and the COVID-19 pandemic season in 2021. Carbonaceous species, including organic carbon (OC) and elemental carbon (EC), were analyzed by a thermal/optical carbon analyzer to determine the carbon species and their indices. The average UFP was 3.1 ± 0.9 μg/m3, which was 2-4 times lower than in other cities in Sumatra during the same season in the normal condition. The PMs mass concentration was largely affected by local emissions but long-range transportation of particles from Singapore and Malaysia was also not negligible. The air mass arrived at the sampling site passed the ocean, which introduced out clean air with a low level of PMs. The backward trajectory of the air mass and the largest fraction of OC2 and OC3 in all sizes was identified as being transported from the 2 above countries. OC is the dominant fraction in TC and the ratio of carbonaceous components indicated that origin of all particle sizes was predominantly vehicle emissions. UFPs were dominantly emitted from vehicles exhaust emission, while coarser particles (>10 μm) were influenced by the non-exhaust emissions, such as tire wear. Other particles (0.5-1.0; 1.0-2.5; and 2.5-10 μm) were slightly affected by biomass burning. The effective carbon ratio (ECR) and inhalation dose (ID) related EC indicated that finer particles or UFPs and PM0.5-1 contributed more to human health and global warming.
  3. En ETS, Ismail N, Nasir NSM, Ismadi YKM, Zuraina NMNN, Hassan SA
    J Infect Public Health, 2023 Jul;16(7):1089-1092.
    PMID: 37224619 DOI: 10.1016/j.jiph.2023.05.015
    Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathotype in addition to classical Klebsiella pneumoniae, with its ability to cause life-threatening, community-acquired metastatic infections even in healthy individuals. We presented a case of cerebral abscess preceded by otitis media in a 10-year-old child caused by hvKp. The isolates from blood pus aspirate were later identified as K. pneumoniae capsular serotype K2 and closely related to sequence type (ST65), with multiple hypervirulent genes detected (rmpA, rmpA2, iucA and peg344). She succumbed to death despite surgical drainage and susceptible antibiotic therapy. Clinicians should be cognizant of the rising incidence of hvKp infections in pediatric populations.
  4. Mat Husin MA, Mohd Yasin NH, Takriff MS, Jamar NH
    Prep Biochem Biotechnol, 2024 Feb;54(2):159-174.
    PMID: 37220018 DOI: 10.1080/10826068.2023.2214923
    Microalgal lipids are promising and sustainable sources for the production of third-generation biofuels, foods, and medicines. A high lipid yield during the extraction process in microalgae could be influenced by the suitable pretreatment and lipid extraction methods. The extraction method itself could be attributed to the economic and environmental impacts on the industry. This review summarizes the pretreatment methods including mechanical and non-mechanical techniques for cell lysis strategy before lipid extraction in microalgae biomass. The multiple strategies to achieve high lipid yields via cell disruption techniques are discussed. These strategies include mechanical (shear forces, pulse electric forces, waves, and temperature shock) and non-mechanical (chemicals, osmotic pressure, and biological) methods. At present, two techniques of the pretreatment method can be combined to increase lipid extraction from microalgae. Therefore, the extraction strategy for a large-scale application could be further strengthened to optimize lipid recovery by microalgae.
  5. Zhang G, Basit A, Khan MI, Daraz A, Saqib N, Zubir F
    Micromachines (Basel), 2023 Apr 17;14(4).
    PMID: 37421099 DOI: 10.3390/mi14040866
    The key elements used for receiving and processing signals in communication systems are the bandpass filters. Initially, a common operating mechanism was applied for the design of broadband filters, i.e., by cascading low-pass filters or high-pass filters using multiple line resonators with length quarter-half- or full-wavelength with central frequency, but using these approaches, the design topology becomes expensive and complex. The above mechanisms can be possibly overcome using a planar microstrip transmission line structure due to its simple design fabrication procedure and low cost. So, pointing out the above problems in bandpass filters such as low-cost, low insertion loss, and good out-of-band performance, this article presents a broadband filter with multifrequency suppression capability at 4.9 GHz, 8.3 GHz, and 11.5 GHz using a T-shaped shorted stub-loaded resonator with a central square ring coupled to the basic broadband filter. Initially, the C-shaped resonator is utilized for the formation of a stopband at 8.3 GHz for a satellite communication system, and then a shorted square ring resonator is added to the existing C-shaped structure for the realization of two more stopbands at 4.9 GHz and 11.5 GHz for 5G (WLAN 802.11j) communication, respectively. The overall circuit area covered with the proposed filter is 0.52 λg × 0.32 λg (λg is the wavelength of the feed lines at frequency 4.9 GHz). All the loaded stubs are folded in order to save the circuit area, which is an important requirement of next-generation wireless communication systems. The proposed filter has been analyzed using a well-known transmission line theory, even-odd-mode, and simulated with the 3D software HFSS. After the parametric analysis, some attractive features were obtained, i.e., compact structure, simple planar topology, low insertion losses of 0.4 dB over the entire band, good return loss greater than 10 dB, and independently controlled mutli stopbands, which make the proposed design unique and can be used in various wireless communication system applications. Finally, a Rogers RO-4350 substrate is selected for the fabrication of the prototype using an LPKF S63 ProtoLaser machine and then measured using a ZNB20 vector network analyzer for matching the simulated and measured results. After testing the prototype, a good agreement was found between the results.
  6. Musa AS, Abdul Hadi MFR, Hashikin NAA, Ashour NI, Ying CK
    Appl Radiat Isot, 2023 Sep;199:110916.
    PMID: 37393764 DOI: 10.1016/j.apradiso.2023.110916
    A common therapeutic radionuclide used in hepatic radioembolization is yttrium-90 (90Y). However, the absence of gamma emissions makes it difficult to verify the post-treatment distribution of 90Y microspheres. Gadolinium-159 (159Gd) has physical properties that are suitable for therapy and post-treatment imaging in hepatic radioembolization procedures. The current study is innovative for conducting a dosimetric investigation of the use of 159Gd in hepatic radioembolization by simulating tomographic images using the Geant4 application for tomographic emission (GATE) Monte Carlo (MC) simulation. For registration and segmentation, tomographic images of five patients with hepatocellular carcinoma (HCC) who had undergone transarterial radioembolization (TARE) therapy were processed using a 3D slicer. The tomographic images with 159Gd and 90Y separately were simulated using the GATE MC Package. The output of simulation (dose image) was uploaded to 3D slicer to compute the absorbed dose for each organ of interests. 159Gd were able to provide a recommended dose of 120 Gy to the tumour, with normal liver and lungs absorbed doses close to that of 90Y and less than the respective maximum permitted doses of 70 Gy and 30 Gy, respectively. Compared to 90Y, 159Gd requires higher administered activity approximately 4.92 times to achieve a tumour dose of 120 Gy. Thus; this research gives new insights into the use of 159Gd as a theranostic radioisotope, with the potential to be used as a90Y alternative for liver radioembolization.
  7. Khan HW, Zailan AA, Bhaskar Reddy AV, Goto M, Moniruzzaman M
    Environ Technol, 2024 Aug;45(19):3828-3839.
    PMID: 37415504 DOI: 10.1080/09593330.2023.2234669
    In the present investigation, a total of 108 combinations of ionic liquids (ILs) were screened using the conductor-like screening model for real solvents (COSMO-RS) with the aid of six cations and eighteen anions for the extraction of succinic acid (SA) from aqueous streams through dispersive liquid-liquid microextraction (DLLME). Using the screened ILs, an ionic liquid-based DLLME (IL-DLLME) was developed to extract SA and the role of different reaction parameters in the effectiveness of IL-DLLME approach was investigated. COSMO-RS results suggested that, quaternary ammonium and choline cations form effective IL combinations with [OH¯], [F¯], and [SO42¯] anions due to hydrogen bonding. In view of these results, one of the screened ILs, tetramethylammonium hydroxide [TMAm][OH] was chosen as the extractant in IL-DLLME process and acetonitrile was adopted as the dispersive solvent. The highest SA removal efficiency of 97.8% was achieved using 25 μL of IL [TMAm][OH] as a carrier and 500 μL of acetonitrile as dispersive solvent. The highest amount of SA was extracted with a stir time of 20 min at 300 rpm, followed by centrifugation for 5 min at 4500 rpm. Overall, the findings showed that IL-DLLME is efficient in extracting succinic acid from aqueous environments while adhering to the first-order kinetics.
  8. Khan MUA, Stojanović GM, Abdullah MFB, Dolatshahi-Pirouz A, Marei HE, Ashammakhi N, et al.
    Int J Biol Macromol, 2024 Jan;254(Pt 3):127882.
    PMID: 37951446 DOI: 10.1016/j.ijbiomac.2023.127882
    Tissue engineering is an advanced and potential biomedical approach to treat patients suffering from lost or failed an organ or tissue to repair and regenerate damaged tissues that increase life expectancy. The biopolymers have been used to fabricate smart hydrogels to repair damaged tissue as they imitate the extracellular matrix (ECM) with intricate structural and functional characteristics. These hydrogels offer desired and controllable qualities, such as tunable mechanical stiffness and strength, inherent adaptability and biocompatibility, swellability, and biodegradability, all crucial for tissue engineering. Smart hydrogels provide a superior cellular environment for tissue engineering, enabling the generation of cutting-edge synthetic tissues due to their special qualities, such as stimuli sensitivity and reactivity. Numerous review articles have presented the exceptional potential of hydrogels for various biomedical applications, including drug delivery, regenerative medicine, and tissue engineering. Still, it is essential to write a comprehensive review article on smart hydrogels that successfully addresses the essential challenging issues in tissue engineering. Hence, the recent development on smart hydrogel for state-of-the-art tissue engineering conferred progress, highlighting significant challenges and future perspectives. This review discusses recent advances in smart hydrogels fabricated from biological macromolecules and their use for advanced tissue engineering. It also provides critical insight, emphasizing future research directions and progress in tissue engineering.
  9. Arbain D, Sinaga LMR, Taher M, Susanti D, Zakaria ZA, Khotib J
    Front Pharmacol, 2022;13:849704.
    PMID: 35685633 DOI: 10.3389/fphar.2022.849704
    The genus Alocasia (Schott) G. Don consists of 113 species distributed across Asia, Southeast Asia, and Australia. Alocasia plants grow in tropical and subtropical forests with humid lowlands. Featuring their large green heart-shaped or arrow-shaped ear leaves and occasionally red-orange fruit, they are very popular ornamental plants and are widely used as traditional medicines to treat various diseases such as jaundice, snake bite, boils, and diabetes. This manuscript critically analysed the distribution, traditional uses, and phytochemical contents of 96 species of Alocasia. The numerous biological activities of Alocasia species were also presented, which include anti-cancer, antidiabetic and antihyperglycaemic, antioxidant, antidiarrhoea, antimicrobial and antifungal, antiparasitic (antiprotozoal and anthelminthic), antinociceptive and anti-inflammatory, brine shrimp lethality, hepatoprotective, anti-hemagglutinin, anti-constipation and diuretic, and radioprotective activities as well as acute toxicity studies. Research articles were acquired by the accessing three scientific databases comprising PubMed, Scopus, and Google Scholar. For this review, specific information was obtained using the general search term "Alocasia", followed by the "plant species names" and "phytochemical" or "bioactivity" or "pharmacological activity". The accepted authority of the plant species was referred from theplantlist.org. Scientific studies have revealed that the genus is mainly scattered throughout Asia. It has broad traditional benefits, which have been associated with various biological properties such as cytotoxic, antihyperglycaemic, antimicrobial, and anti-inflammatory. Alocasia species exhibit diverse biological activities that are very useful for medical treatment. The genus Alocasia was reported to be able to produce a strong and high-quality anti-cancer compound, namely alocasgenoside B, although information on this compound is currently limited. Therefore, it is strongly recommended to further explore the relevant use of natural compounds present in the genus Alocasia, particularly as an anti-cancer agent. With only a few Alocasia species that have been scientifically studied so far, more attention and effort is required to establish the link between traditional uses, active compounds, and pharmacological activities of various species of this genus.
  10. Nasoha NZ, Luthfi AAI, Roslan MF, Hariz HB, Bukhari NA, Manaf SFA
    Sci Rep, 2023 Nov 07;13(1):19284.
    PMID: 37935748 DOI: 10.1038/s41598-023-46061-8
    This study explores utilizing pineapple peel (PP) hydrolysate as a promising carbon source for xylitol production, covering scopes from the pre-treatment to the fermentation process. The highest xylose concentration achieved was around 20 g/L via mild acid hydrolysis (5% nitric acid, 105 °C, 20-min residence time) with a solid loading of 10%. Two sets fermentability experiments were carried out of varying pH levels in synthetic media that includes acetic acid as the main inhibitors and hydrolysate supplemented with diverse nitrogen source. The results revealed that pH 7 exhibited the highest xylitol production, yielding 0.35 g/g. Furthermore, urea was found to be a highly promising and cost-effective substitute for yeast extract, as it yielded a comparable xylitol production of 0.31 g/g with marginal difference of only 0.01 g/g compared to yeast extract further highlights the viability of urea as the preferred option for reducing xylitol production cost. The absence of a significant difference between the synthetic media and hydrolysate, with only a marginal variance of 0.35 to 0.32 g/g, implies that acetic acid is indeed the primary constraint in xylitol production using PP hydrolysate. The study sheds light on PP biomass's potential for xylitol production, aligning economic benefits with environmental sustainability and waste management.
  11. Anuar MA, Zainal Abidin M', Tan SH, Yeap CF, Yahaya NA
    Pediatr Neurol, 2024 Jan;150:10-14.
    PMID: 37931500 DOI: 10.1016/j.pediatrneurol.2023.10.004
    BACKGROUND: Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. Although considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularly concerning the factors influencing outcomes. Therefore, our study aims to elucidate seizure control, developmental outcomes, and prognostic factors in infants with epilepsy during their first year of life, within a single-center study in Malaysia.

    METHODS: We retrieved data from patients who experienced seizures before age 12 months and were followed for over two years, using electronic patient records at Hospital Raja Perempuan Zainab II in Kelantan, a state in Malaysia's east coast. We retrospectively reviewed these records and assessed clinical outcomes based on the last follow-up.

    RESULTS: Of 75 patients, 61 (81.3%) achieved good seizure control or remission. At the last follow-up, 24 (32%) exhibited developmental delay, whereas 19 (25.3%) displayed abnormal neuroimaging. Patients with abnormal background electroencephalographic (EEG) activity, as well as abnormal radiological findings, were more likely to experience poor seizure control and unfavorable developmental outcomes (P 

  12. Haron MZ, Rohana AJ, Hamid NAA, Omar MA, Abdullah NH
    Malays J Med Sci, 2023 Oct;30(5):155-168.
    PMID: 37928780 DOI: 10.21315/mjms2023.30.5.13
    BACKGROUND: Child malnutrition problems still occur in Malaysia, particularly stunting. This study aimed to determine the proportion of stunting among children below 5 years old and investigate the factors associated with stunting on the East Coast of Peninsular Malaysia.

    METHODS: This study utilised data from the 2016 National Health and Morbidity Survey (NHMS). Multiple logistic regression was used to determine the factors associated with malnutrition among non-stunted and stunted children.

    RESULTS: The proportion of stunting among children below 5 years old in this East Coast region was 26.2%. When divided by state, Kelantan had the highest proportion of stunting, followed by Pahang and Terengganu, at 28.8%, 26.2% and 23.4%, respectively. In this study, the factors associated with stunting were children aged 24 months old-59 months old (adjusted odds ratio [aOR]: 1.52; 95% CI: 1.26, 1.83; P < 0.001), male children (aOR: 1.47; 95% CI: 1.23, 1.76; P < 0.001), Orang Asli children (aOR: 2.84; 95% CI: 1.86, 4.32; P < 0.001), children with low birth weight from 1,500 g to 2,499 g (aOR: 1.86; 95% CI: 1.36, 2.55; P < 0.001) and children from households that practice unsanitary waste disposal (aOR: 1.42; 95% CI: 1.16, 1.74; P = 0.001).

    CONCLUSION: Stunting among children under the age of 5 years old on the East Coast of Peninsular Malaysia remains a public health problem. To reduce the prevalence of stunting in this region, intervention programmes should be intensified. Emphasis should be placed on public health programmes that target the associated factors, such as dietary habits, Orang Asli children, low birth weight and unsanitary waste disposal.

  13. Fareed M, Ahmad A, Salleh SSMM, Noor WSWM, Isa MFM
    Front Psychol, 2022;13:774165.
    PMID: 35664196 DOI: 10.3389/fpsyg.2022.774165
    Extant research primarily focuses on the driving factors of human resource (HR) professionals' effectiveness in Telco firms of Pakistan. That is due to the need for HR professionals to be effective has risen in the 21st century for gaining sustainable competitive advantage. This research paper aims to examine the level of HR professionals' effectiveness in Telco firms of Pakistan and explores the strategic functions and their elements, owing to which HR professionals can be effective in fulfilling their tasks and duties. Ten HR executives from five Telco firms were interviewed. The study finds nine key strategic functions along with their forty elements, which indicate the effectiveness of HR professionals. Successful implementation of these strategic functions and their elements offers Telco firms to sustain competitive advantage. Hence, it extends the resource-based view (RBV) theory by accumulating the additional determinants in the context of Pakistan. The research provides the insights for policy makers and practitioners, which explain the key strategic functions and substantial variables through which HR professionals can augment their effectiveness in sustaining competitive advantage.
  14. Mahdzir ANK, Mat S, Seow SR, Abdul Rani R, Che Hasan MK, Mohamad Yahaya NH
    World J Clin Cases, 2023 Oct 16;11(29):7043-7052.
    PMID: 37946758 DOI: 10.12998/wjcc.v11.i29.7043
    BACKGROUND: The study sought to understand the self-management strategies used by patients during the postponement of their total knee arthroplasty (TKA) procedure, as well as the associations between the length of waiting time, pain, and physical frailty and function. The study focused on individuals aged 50 years and above, as they are known to be more vulnerable to the negative impacts of delayed elective surgery and rehabilitation. This study hypothesizes that delayed TKR due to coronavirus disease 2019 (COVID-19) will bear negative effect in self-management, pain, and physical frailty and function in older adults.

    AIM: To investigate the effects of COVID-19 pandemic on self-management, pain, and physical function in older adults awaiting TKA in Malaysia.

    METHODS: This cross-sectional study has the data of participants, who matched the criteria and scheduled for TKA for the first time, extracted from the TKA registry in the Department of Orthopaedics and Traumatology, Hospital Canselor Tuanku Mukhriz. Data on pain status, and self-management, physical frailty, and instrumental activities daily living were also collected. Multiple linear regression analysis with a significant level of 0.05 was used to identify the association between waiting time and pain on physical frailty and functional performance.

    RESULTS: Out of 180 had deferred TKA, 50% of them aged 50 years old and above, 80% were women with ethnic distribution Malay (66%), Chinese (22%), Indian (10%), and others (2%) respectively. Ninety-two percent of the participants took medication to manage their pain during the waiting time, while 10% used herbs and traditional supplements, and 68% did exercises as part of their osteoarthritis (OA) self-management. Thirty-six participants were found to have physical frailty (strength, assistance with walking, rising from a chair, climbing stairs, and falls questionnaire score > 4) which accounted for 72%. Increased pain was associated with physical frailty with odds ratio, odds ratio (95% confidence interval): 1.46 (1.04-2.05). This association remained significant even after the adjustment according to age and self-management.

    CONCLUSION: While deferring TKA during a pandemic is unavoidable, patient monitoring for OA treatment during the waiting period is important in reducing physical frailty, ensuring the older patients' independence.

  15. Abd Latif MH, Wan Ismail WS, Abdul Manaf MR, Abdul Taib NI
    J Autism Dev Disord, 2023 Nov 21.
    PMID: 37987948 DOI: 10.1007/s10803-023-06155-8
    PURPOSE: Accepting and adapting to the child's diagnosis of Autism Spectrum Disorder (ASD) can be challenging for parents. We aimed to assess domains of parental adjustment namely despair, self-blame, and acceptance among parents whose children were diagnosed with ASD.

    METHODS: A cross-sectional study was conducted among 111 parents of children with autism who attended Child and Adolescent Psychiatry Unit (CAPU), in a university teaching hospital in Kuala Lumpur, Malaysia. Sociodemographic profiles of both parents and children were gathered. Parental adjustment focusing on parental self-blame, despair and acceptance were assessed using self-reported questionnaires namely Adjustment to the Diagnosis of Autism (ADA).

    RESULTS: Higher level of despair was associated with parents who have medical illness (β = 0.214, p = 0.016) and children who received antipsychotic medications (β = 0.329, p 

  16. Sukatis FF, Looi LJ, Lim HN, Abdul Rahman MB, Mohd Zaki MR, Aris AZ
    Environ Pollut, 2024 Jan 15;341:122980.
    PMID: 37992953 DOI: 10.1016/j.envpol.2023.122980
    The presence of emerging water pollutants such as endocrine-disrupting compounds (EDCs), including 17-ethynylestradiol (EE2), bisphenol A (BPA), and perfluorooctanoic acid (PFOA), in contaminated water sources poses significant environmental and health challenges. This study aims to address this issue by investigating the efficiency of novel calcium-based metal-organic frameworks, known as mixed-linker calcium-based metal-organic frameworks (Ca-MIX), in adsorbing these endocrine-disrupting compounds. This study analyzed the influence of influent concentration, bed height, and flow rate on pollutant removal, with bed height emerging as a crucial factor. From the breakthrough curves, it was determined that the column maximum adsorption capacities followed the order of 17-ethynylestradiol (101.52 μg/g; 40%) > bisphenol A (99.07 μg/g; 39%) > perfluorooctanoic acid (81.28 μg/g; 32%). Three models were used to predict the adsorption process, with the Yan model outperforming the other models. This suggests the potential of mixed-linker calcium-based metal-organic frameworks for removing endocrine-disrupting compounds from water, using the Yan model as an effective predictor. Overall, this study provides valuable insights for the development of effective water treatment methods using mixed-linker calcium-based metal-organic frameworks to remove endocrine-disrupting compounds from contaminated water sources.
  17. Norfarhana AS, Ilyas RA, Ngadi N, Othman MHD, Misenan MSM, Norrrahim MNF
    Int J Biol Macromol, 2024 Jan;256(Pt 1):128256.
    PMID: 38000585 DOI: 10.1016/j.ijbiomac.2023.128256
    The potential for the transformation of lignocellulosic biomass into valuable commodities is rapidly growing through an environmentally sustainable approach to harness its abundance, cost-effectiveness, biodegradability, and environmentally friendly nature. Ionic liquids (ILs) have received considerable and widespread attention as a promising solution for efficiently dissolving lignocellulosic biomass. The fact that ILs can act as solvents and reagents contributes to their widespread recognition. In particular, ILs are desirable because they are inert, non-toxic, non-flammable, miscible in water, recyclable, thermally and chemically stable, and have low melting points and outstanding ionic conductivity. With these characteristics, ILs can serve as a reliable replacement for traditional biomass conversion methods in various applications. Thus, this comprehensive analysis explores the conversion of lignocellulosic biomass using ILs, focusing on main components such as cellulose, hemicellulose, and lignin. In addition, the effect of multiple parameters on the separation of lignocellulosic biomass using ILs is discussed to emphasize their potential to produce high-value products from this abundant and renewable resource. This work contributes to the advancement of green technologies, offering a promising avenue for the future of biomass conversion and sustainable resource management.
  18. Abasi F, Raja NI, Mashwani ZU, Ehsan M, Ali H, Shahbaz M
    Int J Biol Macromol, 2024 Jan;256(Pt 1):128379.
    PMID: 38000583 DOI: 10.1016/j.ijbiomac.2023.128379
    Extreme changes in weather including heat-wave and high-temperature fluctuations are predicted to increase in intensity and duration due to climate change. Wheat being a major staple crop is under severe threat of heat stress especially during the grain-filling stage. Widespread food insecurity underscores the critical need to comprehend crop responses to forthcoming climatic shifts, pivotal for devising adaptive strategies ensuring sustainable crop productivity. This review addresses insights concerning antioxidant, physiological, molecular impacts, tolerance mechanisms, and nanotechnology-based strategies and how wheat copes with heat stress at the reproductive stage. In this study stress resilience strategies were documented for sustainable grain production under heat stress at reproductive stage. Additionally, the mechanisms of heat resilience including gene expression, nanomaterials that trigger transcription factors, (HSPs) during stress, and physiological and antioxidant traits were explored. The most reliable method to improve plant resilience to heat stress must include nano-biotechnology-based strategies, such as the adoption of nano-fertilizers in climate-smart practices and the use of advanced molecular approaches. Notably, the novel resistance genes through advanced molecular approach and nanomaterials exhibit promise for incorporation into wheat cultivars, conferring resilience against imminent adverse environmental conditions. This review will help scientific communities in thermo-tolerance wheat cultivars and new emerging strategies to mitigate the deleterious impact of heat stress.
  19. Othman MK, Konok MZ, Engku Ismail EH, Yusof Z, W Isa WYH
    Cureus, 2023 Dec;15(12):e50221.
    PMID: 38084258 DOI: 10.7759/cureus.50221
    Atrioventricular (AV) block in pregnancy is rare, but it is a serious arrhythmia that needs to be carefully managed in pregnancy. However, as of now, there are no clear guidelines or consensus for intrapartum management. Most of the time, an intrapartum AV block is secondary to hypervagatonic sinus node dysfunction and is treated conservatively. Hypervagatonic sinus node dysfunction has a heterogeneous presentation of AV block, and pseudo-Mobitz type II in labor is rarely reported. We report a case of pseudo-Mobitz type II AV block during pregnancy due to labor pain, which is successfully managed conservatively.
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