Displaying publications 41 - 60 of 275 in total

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  1. Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition
    Hossan MS, Chan ZY, Collins HM, Shipton FN, Butler MS, Rahmatullah M, et al.
    Cancer Lett, 2019 07 01;453:57-73.
    PMID: 30930233 DOI: 10.1016/j.canlet.2019.03.034
    Natural products possess a significant role in anticancer therapy and many currently-used anticancer drugs are of natural origin. Cerberin (CR), a cardenolide isolated from the fruit kernel of Cerbera odollam, was found to potently inhibit cancer cell growth (GI50 values 60% bioavailability and rapid absorption; doses of 1-10 mg/kg CR were predicted to maintain efficacious unbound plasma concentrations (>GI50 value). CR's potent and selective anti-tumour activity, and its targeting of key signalling mechanisms pertinent to tumourigenesis support further preclinical evaluation of this cardiac glycoside.
    Matched MeSH terms: Family Characteristics
  2. Catastrophic payments for health care in Asia
    van Doorslaer E, O'Donnell O, Rannan-Eliya RP, Somanathan A, Adhikari SR, Garg CC, et al.
    Health Econ, 2007 Nov;16(11):1159-84.
    PMID: 17311356
    Out-of-pocket (OOP) payments are the principal means of financing health care throughout much of Asia. We estimate the magnitude and distribution of OOP payments for health care in fourteen countries and territories accounting for 81% of the Asian population. We focus on payments that are catastrophic, in the sense of severely disrupting household living standards, and approximate such payments by those absorbing a large fraction of household resources. Bangladesh, China, India, Nepal and Vietnam rely most heavily on OOP financing and have the highest incidence of catastrophic payments. Sri Lanka, Thailand and Malaysia stand out as low to middle income countries that have constrained both the OOP share of health financing and the catastrophic impact of direct payments. In most low/middle-income countries, the better-off are more likely to spend a large fraction of total household resources on health care. This may reflect the inability of the poorest of the poor to divert resources from other basic needs and possibly the protection of the poor from user charges offered in some countries. But in China, Kyrgyz and Vietnam, where there are no exemptions of the poor from charges, they are as, or even more, likely to incur catastrophic payments.
    Matched MeSH terms: Family Characteristics
  3. Changing patterns of marriage and household formation in Peninsular Malaysia
    Tan PC, Jones GW
    Sojourn, 1990;5(2):163-93.
    PMID: 12283691
    "Based on surveys conducted among different ethnic groups in rural and urban settings in Peninsular Malaysia in 1981-82, this paper analyses changes in patterns of marriage and household formation among Malays, Chinese, and Indians. Aspects covered include social mixing before marriage, choice of spouse, comparison of spouses' characteristics, and place of residence after marriage. There are important cultural differences between the main Malaysian ethnic groups in matters related to marriage, but in many important respects, attitudes and practice are tending to converge...."
    Matched MeSH terms: Family Characteristics*
  4. Child sexual abuse: psychosocial aspects of 101 cases seen in an urban Malaysian setting
    Kassim K, Kasim MS
    Child Abuse Negl, 1995 Jul;19(7):793-9.
    PMID: 7583735
    This paper describes a case note and interview study of a cross sectional sample comprised of all children seen and confirmed as being sexually abused between June 1985 and December 1990 by the Suspected Child Abuse and Neglect (SCAN) Team of Kuala Lumpur General Hospital. A total of 101 cases, which represented 18.2% of all child abuse cases, were seen together with their accompanying adults. Information about ethnicity, socioeconomic status, family constellation relationship of perpetrator to the child, and reported psychosocial factors that could have contributed towards the abuse were recorded. The Indian ethnicity group was found to be overrepresented. The mean age of children was 6-8 years, SD 4.1, with age ranging 1.5-16 years. Forty-one and one-half percent were in the age range 5-9 years. Among the important associated psychosocial factors found were the absence of another adult at home, unemployment, and history of drug abuse among the perpetrators.
    Matched MeSH terms: Family Characteristics
  5. Fulltext Childhood Cryptosporidium infection among aboriginal communities in Peninsular Malaysia
    Al-Mekhlafi HM, Mahdy MA, 'Azlin MY, Fatmah MS, Norhayati M
    Ann Trop Med Parasitol, 2011 Mar;105(2):135-43.
    PMID: 21396250 DOI: 10.1179/136485911X12899838683368
    Cryptosporidium is a coccidian parasite that is prevalent worldwide, some species of which cause morbidity in both immunocompromised and immunocompetent individuals. The prevalence and predictors of Cryptosporidium infection, and its effect on nutritional status, have recently been explored among 276 children (141 boys and 135 girls, aged 2-15 years) in aboriginal (Orang Asli) villages in the Malaysian state of Selangor. Faecal smears were examined by the modified Ziehl-Neelsen staining technique while socio-economic data were collected using a standardized questionnaire. Nutritional status was assessed by anthropometric measurements. Cryptosporidium infection, which was detected in 7.2% of the aboriginal children, was found to be significantly associated with low birthweight (≤2.5 kg), being part of a large household (with more than seven members) and prolonged breast feeding (>2 years). The output of a binary logistic regression confirmed that large household size was a significant predictor of Cryptosporidium infection (giving an odds ratio of 2.15, with a 95% confidence interval of 1.25-5.02). Cryptosporidium infection is clearly a public-health problem among the aboriginal children of Selangor, with person-to-person the most likely mode of transmission.
    Matched MeSH terms: Family Characteristics
  6. Childhood deaths from physical abuse
    Kasim MS, Cheah I, Shafie HM
    Child Abuse Negl, 1995 Jul;19(7):847-54.
    PMID: 7583742
    This paper gives a detailed account of 30 cases of childhood deaths caused by physical abuse, detected by the Suspected Child Abuse and Neglect (SCAN) team, General Hospital, Kuala Lumpur. They consisted of 12 Malays, 6 Chinese, 9 Indian, and 1 Indonesian child. Three cases could not be ascertained as to their ethnic origin. There were 13 male and 17 female children. The average age of the abused children was 2 years 5 months. The most frequent causes of death were intracranial hemorrhage and intraabdominal trauma. Of the 17 cases of intracranial hemorrhage, only four had X-ray evidence of skull fracture. This suggests the possibility of whiplash injuries with/without the abuser suspecting that he/she had injured the child. Of the 22 abusers who could be identified, there was no sex differentiation. Fathers formed the largest group of perpetrators, followed by mothers and childminders. Fifteen of the natural parents of the abused children were married, four were divorced and four were never married. Five of the abusers had aggressive personalities and three were drug addicts. Only one abuser was found to be an alcoholic even though a few were also under suspicion. For most cases, trigger factors could not be identified.
    Matched MeSH terms: Family Characteristics
  7. Fulltext Coastal proximity of populations in 22 Pacific Island Countries and Territories
    Andrew NL, Bright P, de la Rua L, Teoh SJ, Vickers M
    PLoS One, 2019;14(9):e0223249.
    PMID: 31568527 DOI: 10.1371/journal.pone.0223249
    The coastal zones of Small Island States are hotspots of human habitation and economic endeavour. In the Pacific region, as elsewhere, there are large gaps in understandings of the exposure and vulnerability of people in coastal zones. The 22 Pacific Countries and Territories (PICTs) are poorly represented in global analyses of vulnerability to seaward risks. We combine several data sources to estimate populations to zones 1, 5 and 10 km from the coastline in each of the PICTs. Regional patterns in the proximity of Pacific people to the coast are dominated by Papua New Guinea. Overall, ca. half the population of the Pacific resides within 10 km of the coast but this jumps to 97% when Papua New Guinea is excluded. A quarter of Pacific people live within 1 km of the coast, but without PNG this increases to slightly more than half. Excluding PNG, 90% of Pacific Islanders live within 5 km of the coast. All of the population in the coral atoll nations of Tokelau and Tuvalu live within a km of the ocean. Results using two global datasets, the SEDAC-CIESIN Gridded Population of the World v4 (GPWv4) and the Oak Ridge National Laboratory Landscan differed: Landscan under-dispersed population, overestimating numbers in urban centres and underestimating population in rural areas and GPWv4 over-dispersed the population. In addition to errors introduced by the allocation models of the two methods, errors were introduced as artefacts of allocating households to 1 km x 1 km grid cell data (30 arc-seconds) to polygons. The limited utility of LandScan and GPWv4 in advancing this analysis may be overcome with more spatially resolved census data and the inclusion of elevation above sea level as an important dimension of vulnerability.
    Matched MeSH terms: Family Characteristics
  8. Fulltext Collecting Forest Resources as Livelihood Strategies in Kampung Tambirat, Sarawak
    NURUL NADZATUL FARAH MOHD KHAIRI
    Trends in Undergraduate Research, 2018;1(1):0-0.
    MyJurnal
    A livelihood is a means of making a living, securing necessities of life such as water, shelter medicine and clothing. For communities dependent on forest resources for livelihoods, sustainability of forests are important. In Kampung Tambirat this study aims to find the income generated from forest resources particularly Nypah palm forests, the measures of conservation, challenges and type of assistance required so that the villagers engagement in the activities will flourish in the future and benefit the younger generations. It is found that there are no conservation measures for Nypah forests and seasonal floods further increases the difficulty for the villagers to sustain their livelihood activities.
    Matched MeSH terms: Family Characteristics
  9. Fulltext Community empowerment for malaria control and prevention in Kampung Tong Nibong, Sarawak: an intervention study
    Hasnor Hadi Asim, Normawati Ahmad, Abu Bakar Rahman, Nik Mansor Ibrahim, Mohd Nasir Abdullah, Md Sabtuah Royali, et al.
    Int J Public Health Res, 2017;7(2):807-813.
    MyJurnal
    Introduction Tong Nibong is a Bidayuh village located at Sarawak Kalimantan border.
    Since the year 2004 to 2009, a total of 537 cases of malaria were recorded in
    Serian District of which 14 cases were reported from Kampung Tong
    Nibong. Community empowerment programme for malaria infection
    prevention showed tremendous improvement in implementation. This
    intervention study aims to gauge the effectiveness of community
    empowerment approach in malaria elimination programme in Kampung Tong
    Nibong Serian.
    Methods An intervention study was conducted with pre and post data collection. Data
    was collected using validated questionnaire by face to face interview.
    Universal sampling method was used to select respondents from head of
    household and post data was collected after intervention activities were
    carried out within a year of study period.
    Results The study showed significant difference on level of knowledge of
    respondents on vector of malaria between pre and post data with a P < 0.05.
    There was significant difference between pre and post data on practices on
    control and prevention of malaria with a P < 0.05. The same goes to level of
    positive attitude of respondents towards malaria control.
    Conclusions In conclusion, the study can be considered successful because there is
    significant difference in knowledge, attitude and practice among the
    respondents between pre and post data. This indicates that community
    empowerment (voluntary participation) measures can be implemented in high
    risk or endemic areas where malaria is a persistent problem to the community
    and health institutions faces many limiting factors.
    Matched MeSH terms: Family Characteristics
  10. Fulltext Community knowledge, health beliefs, practices and experiences related to dengue fever and its association with IgG seropositivity
    Wong LP, AbuBakar S, Chinna K
    PLoS Negl Trop Dis, 2014 May;8(5):e2789.
    PMID: 24853259 DOI: 10.1371/journal.pntd.0002789
    Demographic, economic and behavioural factors are central features underpinning the successful management and biological control of dengue. This study aimed to examine these factors and their association with the seroprevalence of this disease.
    Matched MeSH terms: Family Characteristics
  11. Fulltext Contact screening and risk factors for TB among the household contact of children with active TB: a way to find source case and new TB cases
    Laghari M, Sulaiman SAS, Khan AH, Talpur BA, Bhatti Z, Memon N
    BMC Public Health, 2019 Sep 18;19(1):1274.
    PMID: 31533689 DOI: 10.1186/s12889-019-7597-0
    BACKGROUND: Source case investigation, for children with tuberculosis (TB), is conducted to establish the source of infection and to minimize the extent of on-going transmission from infectious persons in the community. The aim of the study was to evaluate the secondary TB cases and to investigate the risk factors in developing TB among the household contacts (HHC) of children with active TB.

    METHODS: A prospective cross-sectional study was conducted where 443 caregivers, of 508 children with active TB receiving treatment, were interviewed using a structured questionnaire. Logistic regression analysis was used to examine the risk factors for TB.

    RESULTS: A total of 2397 family members at the median of 5 persons were recorded. Of these, 223 (9.3%) were screened on symptoms basis and 35 (15.7%) of these contacts were diagnosed with TB. Multivariate analysis revealed HHC with TB (OR = 15.288, 95% CI: 5.378-43.457), HHC with smoking (OR = 7.094, 95% CI: 2.128-23.648), and contact of > 18 h with TB individual (OR = 4.681, 95% CI: 1.198-18.294) as statistically significant risk factors of TB among the HHC.

    CONCLUSION: With the current system of contact screening for TB, only 9.3% of all HHC were screened. The low rates of contacts screened are possibly a repercussion of the passive nature of the program, which mainly depend on distinctive clinical symptoms being experienced by the contacts. Strategies are required to certify adherence with contact screening among children with active TB and to critically consider the factors responsible for TB transmission.

    Matched MeSH terms: Family Characteristics*
  12. Contraceptive method switching in Peninsular Malaysia: ethnic differences, 1940s-1970s
    Davanzo J, Starbird E, Reboussin D, Tan Boon Ann, Abdullah SH
    Malays J Reprod Health, 1988 Jun;6(1):1-21.
    PMID: 12281591
    Matched MeSH terms: Family Characteristics
  13. Contraceptive use in Cambodia: does household decision-making power matter?
    Lai SL, Tey NP
    Cult Health Sex, 2020 07;22(7):778-793.
    PMID: 32037969 DOI: 10.1080/13691058.2019.1685683
    In Cambodia, the growth of family planning services and socio-economic development have resulted in a spectacular rise in contraceptive prevalence rate and an equally remarkable reduction in contraceptive use differentials. With rising educational levels and increased participation in the modern labour market, Cambodian women are playing an increasingly pivotal role in household decision-making. This study used data from three rounds of Cambodia Demographic and Health Surveys to elucidate trends and patterns of contraceptive use. It then examined the determinants of contraceptive use through the use of logistic regression. The central hypothesis to be tested was whether or not women's involvement in household decision-making affected contraceptive use. Multivariate analysis showed that apart from the number of living children, women's work status and education of both men and women had a more significant impact on contraceptive use, as compared to women's power in household decision-making. More effort is needed to empower women in all aspects in order to reduce the socio-economic differentials in contraceptive use and improve their reproductive health, in line with the goal of the global agenda of the sustainable development goals (SDGs) to leave no one behind.
    Matched MeSH terms: Family Characteristics
  14. Fulltext Contrasting Computational Models of Mate Preference Integration Across 45 Countries
    Conroy-Beam D, Buss DM, Asao K, Sorokowska A, Sorokowski P, Aavik T, et al.
    Sci Rep, 2019 11 15;9(1):16885.
    PMID: 31729413 DOI: 10.1038/s41598-019-52748-8
    Humans express a wide array of ideal mate preferences. Around the world, people desire romantic partners who are intelligent, healthy, kind, physically attractive, wealthy, and more. In order for these ideal preferences to guide the choice of actual romantic partners, human mating psychology must possess a means to integrate information across these many preference dimensions into summaries of the overall mate value of their potential mates. Here we explore the computational design of this mate preference integration process using a large sample of n = 14,487 people from 45 countries around the world. We combine this large cross-cultural sample with agent-based models to compare eight hypothesized models of human mating markets. Across cultures, people higher in mate value appear to experience greater power of choice on the mating market in that they set higher ideal standards, better fulfill their preferences in choice, and pair with higher mate value partners. Furthermore, we find that this cross-culturally universal pattern of mate choice is most consistent with a Euclidean model of mate preference integration.
    Matched MeSH terms: Family Characteristics
  15. Controlled Synthesis of Well-Aligned and Highly Ordered TiO₂ Nanotubes Without Bundling for Enhanced Solar-Powered Photoelectrochemical Responses
    Lai CW, Lau KS, Chou PM
    J Nanosci Nanotechnol, 2019 Dec 01;19(12):7934-7942.
    PMID: 31196312 DOI: 10.1166/jnn.2019.16777
    Using solar-powered water electrolysis systems for hydrogen generation is a key decision for the development of a sustainable hydrogen economy. A facile approach is presented in the present investigation to improve the solar-powered photoelectrochemical performance of water electrolysis systems by synthesising well-aligned and highly ordered TiO₂ nanotube films without bundling through the electrochemical anodisation technique. Herein, geometrical calculations were conducted for all synthesised TiO₂ nanotubes, and determination of the aspect ratio (AR) and geometric surface area factor (G) was achieved. On the basis of the collected data, well-aligned TiO₂ nanotubes with an AR of approximately 60 and G of approximately 400 m² ·g-1 were successfully formed in an electrolyte mixture of ethylene glycol with 0.3 wt% NH4F and 5 wt% H₂O₂ at 40 V for 60 min. The nanotubes were subsequently annealed at 400 °C to form anatase-phase TiO₂ nanotube films. The resultant well-aligned and highly ordered TiO₂ nanotube films exhibited a photocurrent density of 1.5 mA · cm-2 due to a large number of photo-induced electrons moving along the tube axis and perpendicular to the Ti substrate, which greatly reduces interfacial recombination losses.
    Matched MeSH terms: Family Characteristics
  16. Cross-cultural differences in the sleep of preschool children
    Mindell JA, Sadeh A, Kwon R, Goh DY
    Sleep Med, 2013 Dec;14(12):1283-9.
    PMID: 24269649 DOI: 10.1016/j.sleep.2013.09.002
    The aim of our study was to characterize cross-cultural sleep patterns and sleep problems in a large sample of preschool children ages 3-6years in multiple predominantly Asian (P-A) and predominantly Caucasian (P-C) countries/regions.
    Matched MeSH terms: Family Characteristics/ethnology
  17. Fulltext DISCOVERING FACTORS THAT AFFECT IGEN ACADEMIC PERFORMANCE IN THE UNIVERSITY
    NURUL NADHILAH FEIZAL, SHAHNAZ ISMAIL, WAN ZURIATI WAN ZAKARI, NADIA MOHD NAWI
    UMT Journal of Undergraduate Research, 2021;3(1):75-86.
    MyJurnal
    The advancement of technology in digital revolution such as Internet of Things has gained attention in all over the world. This myriad of technology innovations affects all aspects of the human lives today. The generation who has grown up during this era, knownastheiGens,mostlyreliesonthetechnologyineveryaspectoftheirlives,including education. Thus, technology also gives profound impact in educational transformation nowadays to convey innovative education. However, lack of innovation in education becomes a challenge to meet this demand. Therefore, this study was carried out with the aim to discover factors which may affect academic performance of the iGen students in the university. A total of 250 self-administered questionnaires were distributed to the accountingstudentsatUMTwitharesponserateof93.6%(234).Usingmultipleregression analysis, the findings showed that parental involvement and student’s attitude contribute more towards academic performance of iGen students rather than the technology itself. This finding showed that human factor such as support fromtheir parents and individual factor are vital towards their academic performance regardless of from technology savvy generation or not.
    Matched MeSH terms: Family Characteristics
  18. Demographic and fertility characteristics of 4 squatter settlements
    Yusof K, Zulkifli SN
    Malays J Reprod Health, 1985;3(1):31-45.
    PMID: 12268887
    Matched MeSH terms: Family Characteristics*
  19. Fulltext Dengue patients exhibit higher levels of PrM and E antibodies than their asymptomatic counterparts
    Yeo AS, Rathakrishnan A, Wang SM, Ponnampalavanar S, Manikam R, Sathar J, et al.
    Biomed Res Int, 2015;2015:420867.
    PMID: 25815314 DOI: 10.1155/2015/420867
    Dengue virus infection is a common tropical disease which often occurs without being detected. These asymptomatic cases provide information in relation to the manifestation of immunological aspects. In this study, we developed an ELISA method to compare neutralizing effects of dengue prM and E antibodies between dengue patients and their asymptomatic household members. Recombinant D2 premembrane (prM) was constructed, cloned, and tested for antigenicity. The recombinant protein was purified and tested with controls by using an indirect ELISA method. Positive dengue serum samples with their asymptomatic pair were then carried out onto the developed ELISA. In addition, commercially available recombinant envelope (E) protein was used to develop an ELISA which was tested with the same set of serum samples in the prM ELISA. Asymptomatic individuals showed preexisting heterotypic neutralizing antibodies. The recombinant prM was antigenically reactive in the developed ELISA. Dengue patients had higher prM and E antibodies compared to their household members. Our study highlights the neutralizing antibodies levels with respect to dengue prM and E between dengue patients and asymptomatic individuals.
    Matched MeSH terms: Family Characteristics
  20. Fulltext Depression and its associated factors among secondary school students in Malaysia
    Abdul Latiff L, Tajik E, Ibrahim N, Abubakar AS, Ali SS
    Southeast Asian J. Trop. Med. Public Health, 2016 Jan;47(1):131-41.
    PMID: 27086434
    Research in the field of factors associated with depression among adolescents is lacking in Malaysia. The aims of the present study were to assess the current prevalence of depression and its related factors among secondary school students in Pasir Gudang, South Malaysia. In this cross sectional study, 2,927 secondary school students (13-17 years old) from urban areas were screened for symptoms of mental disorder as well as demographic and risk behaviors using a validated Depression, Anxiety and Stress Scale (DASS) 12 questionnaire. The majority of the respondents (53.8%) were Malay, of which 53.1% were female. Symptoms of mild depression were found in 33.2% of the respondents, while the prevalence of the symptoms of moderate, severe, and extremely severe depression was 21.5%, 18.1%, and 3.0%, respectively. Logistic regression suggested that participants who were Chinese or had a lower average grade were three times more likely to have depression, while those who came from a single-parent family were twice as likely to have this condition. This study indicated that academic performance and risk behaviors along with the demographic characteristics are important contributors to adolescent depression.
    Matched MeSH terms: Family Characteristics*
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