MyMedR

Transcanal endoscopic excision of glomus tympanicum: A case report

Teh CS, Azrina A, Fadzilah I, Prepageran N

Med J Malaysia, 2020 03;75(2):189-190.

Glomus tympanicum is a highly vascular tumour traditionally treated surgically via a post-auricular approach. We present here the first published case in Malaysia where total excision was achieved transcanal endoscopically. The procedure was safe, quick and effective due to the better visualisation of the surgical field with the endoscope. Haemostasis was achieved with a modified suction catheter that performed as a functioning suction diathermy.

Fulltext Gastric strongyloidiasis in a Malaysian patient

Shekhar KC, Krishnan R, Pathmanathan R, Fook CS

Southeast Asian J Trop Med Public Health, 1997 Mar;28(1):158-60.

PMID: 9322300

Strongyloides stercoralis infection is of low prevalence in Malaysia. We report an unusual case presenting primarily with gastric symptoms. The patient was a 72 years old Chinese male admitted for progressive weight loss and abdominal bloating. Gastroscopic examination revealed mucosal prepyloric elevations in the gastric mucosa. Gastric strongyloidiasis was confirmed by the presence of adult forms, as well as ova and larval rhabditiform stages of the worm in the gastric mucosal crypts. We believe that this is the first histologically documented case of gastric strongyloidiasis in Malaysia.

Evaluating the quality of images produced by soft X-ray units

Bradley DA, Wong CS, Ng KH

Appl Radiat Isot, 2000 9 26;53(4-5):691-7.

PMID: 11003508

For broad-beam soft X-ray sources, assessment of the quality of image produced by such units is made complex by the low penetration capabilities of the radiation. In the present study we have tested the utility of several types of test tool, some of which have been fabricated by us, as part of an effort to evaluate several key image defining parameters. These include the film characteristic, focal-spot size, image resolution and detail detectability. The two sources of X-rays used in present studies were the University of Malaya flash X-ray device (UMFX1) and a more conventional soft X-ray tube (Softex, Tokyo), the latter operating at peak accelerating potentials of 20 kVp. We have established, for thin objects, that both systems produce images of comparable quality and, in particular, objects can be resolved down to better than 45 microm.

Fulltext The value of routine chest radiographs in acute asthma admissions

Ismail Y, Loo CS, Zahary MK

Singapore Med J, 1994 Apr;35(2):171-2.

PMID: 7939814

We reviewed 116 chest radiographs done in 70 adult asthmatic patients who were admitted to the Hospital Universiti Sains Malaysia from January to December 1989. The chest radiographs were abnormal in 23% of cases. Twelve percent showed hyperinflation and 7% had pneumonia. Eight patients diagnosed clinically to have pneumonia had normal chest radiographs. Seven patients had radiographic findings of conditions which were unsuspected clinically. These included two cases of pneumonia, one case each of fibrosing alveolitis, pneumothorax, pneumomediastinum, mitral stenosis with left ventricular failure and right pleural effusion. In conclusion, we found that significant chest radiograph abnormalities in adult patients admitted for asthma were uncommon although chest radiographs were helpful in detecting complications or coincidental conditions. Chest radiograph is therefore an important investigation in adult asthmatic patients who are admitted. However, considering the cost and the risk of radiation, it should be done only in selective cases rather than as a routine procedure.
Study site: Hospital Universiti Sains Malaysia, Kelantan, Malaysia

Fulltext Hepatitis delta virus in intravenous drug users in Kuala Lumpur

Duraisamy G, Zuridah H, Ariffin Y, Kek CS

Med J Malaysia, 1994 Sep;49(3):212-6.

PMID: 7845268

The hepatitis delta virus (HDV) is an RNA containing virus that requires hepatitis B virus (HBV) to supply the envelope proteins. HDV only infect man in the presence of HBV, either as a coinfection or as superinfection in HBV carriers. In the presence of hepatitis B infection, the HDV may cause more severe liver damage than that caused by the hepatitis B virus alone. HDV infection was studied in 44 HBsAg positive serum samples collected from male intravenous drug users sent for screening to the Blood Services Centre (BSC), Hospital Kuala Lumpur (HKL) between 1990 and 1992. The majority (39) were in the 20 to 39 age group. The youngest was 19 years old and the oldest was 61 years old. There were 25 Malays, 13 Chinese, five Indians and one Albanian. Anti hepatitis delta antibody (Anti-HDV) was detected in 15 out of 44 (34%) of the drug addicts. These results shows an increased in delta infection in HBsAg positive intravenous drug addicts compared to the surveillance results in 1985 when no delta antibodies were detected, and the 1986 and 1989 surveillance which showed 17.8% and 20% delta antibody positivity respectively.

Fulltext Addisonian-like crisis in congenital hypopituitarism and cholestatic jaundice

Lee WS, Lum LCS, Harun F

Med J Malaysia, 2003 Jun;58(2):279-81.

PMID: 14569750

A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuclide hepatobiliary scintigraphy was non-excretory. After an operative cholangiogram, the infant developed Addisonian-like crisis with bradycardia, hypotension, respiratory distress, metabolic acidosis, hypoglycaemia, hyponatraemia, and hyperkalaemia. Blood investigations confirmed congenital hypopituitarism. Hormone replacement therapy with L-thyroxine and cortisone acetate resulted in dissolution of jaundice and the reduction of the liver size.

238U and 232Th in cassiterites samples and amang by-products

Hu SJ, Chong CS, Subas S

Health Phys, 1981 Feb;40(2):248-50.

PMID: 7216807

The lethal and biochemical properties of Bungarus candidus (Malayan krait) venom and venom fractions

Tan NH, Poh CH, Tan CS

Toxicon, 1989;27(9):1065-70.

PMID: 2799837

Bungarus candidus venom exhibited high hyaluronidase, acetylcholinesterase and phospholipase A activities; low proteinase, 5'-nucleotidase, alkaline phosphomonoesterase and phosphodiesterase activities and moderately high L-amino acid oxidase activity. SP-Sephadex C-50 ion exchange chromatographic fractionation of the venom and Sephadex G-50 chromatography of the major lethal venom fractions indicate that the venom contains at least two highly lethal, basic phospholipases A with LD50 (i.v.) values of 0.02 micrograms/g (F6A) and 0.18 micrograms/g (F4A), respectively; as well as two polypeptide toxins with LD50 (i.v.) values of 0.17 micrograms/g and 0.83 micrograms/g, respectively. The major lethal toxin is the basic lethal phospholipase A, F6A, which accounts for approximately 13% of the venom protein and has a mol. wt of 21,000.

A comparative study of the enzymatic and toxic properties of venoms of the Asian lance-headed pit viper (Genus Trimeresurus)

Tan NH, Armugam A, Tan CS

Comp. Biochem. Physiol., B, 1989;93(4):757-62.

PMID: 2553329

1. The lethalities, anticoagulant effects, hermorrhagic, thrombin-like enzyme, hyaluronidase, protease, arginine ester hydrolase, 5'-nucleotidase, L-amino acid oxidase, alkaline phosphomonoesterase, phosphodiesterase and phospholipase A activities of twenty-three samples of venoms from twelve species of Asian lance-headed pit vipers (genus Trimeresurus) were examined. 2. The results indicate that notwithstanding individual variations in venom properties, the differences in biological properties of the Trimeresurus venoms can be used for the differentiation of venoms from different species of Trimeresurus. 3. The results also suggest that differences in the biological properties of snake venoms are useful parameters in the classification of snake species. 4. Our results indicate that venoms from the species T. okinavensis exhibited biological properties markedly different from other Trimeresurus venoms examined. This observation supports the recently proposed reclassification of T. okinavensis as a member of the genus Ovophis, rather than the genus Trimeresurus.

Fulltext Fibreoptic bronchoscopy in the diagnosis of pulmonary tuberculosis--a Malaysian experience

Jalleh RD, Kuppusamy I, Parameswary V, Yeow CS

Singapore Med J, 1993 Feb;34(1):55-7.

PMID: 8266131

We report our experience on the use of fibreoptic bronchoscopy in the diagnosis of pulmonary tuberculosis. The case records of 1,274 patients who underwent fibreoptic bronchoscopy at the National Tuberculosis Centre, Kuala Lumpur, Malaysia during a three-year period were reviewed. In 120 of them the final diagnosis was tuberculosis. Bronchoscopy confirmed the diagnosis in 37 patients (30.8%). This was achieved by bronchial aspiration for culture in 26 patients (70.3%) and bronchial biopsy for histopathology in 11 patients (29.7%). It was the exclusive method of confirmation in 16 patients (13.3%). Sputum culture was positive in 62 patients (51.7%) including 41 patients (34.2%) in whom bronchoscopy was unhelpful. Six patients had diagnosis confirmed by other means while in 36 others (30%) it was based on clinical features and supportive basic investigations. There were no complications noted. We conclude that while sputum examination remains the mainstay for diagnosing pulmonary tuberculosis, fibreoptic bronchoscopy serves as a safe and useful adjunct.

Efficacy of ivermectin against Parastrongylus malaysiensis infection in rats

Ambu S, Mak JW, Ng CS

J Helminthol, 1992 Dec;66(4):293-6.

PMID: 1293196

The efficacy of ivermectin on experimental infections of P. malaysiensis in rats was determined. Ivermectin was 99.4% and 97.9% effective at a dosage of 400 meg and 800 meg respectively at seven days post-infection. The same two dosages of ivermectin when given at 14 days post infection had an efficacy of 100%. However, as an adulticide it had only 40.7% efficacy. Ivermectin may therefore be useful for the treatment of parastrongyliasis due to the larval stages of the worm which can cause significant pathology in man and animals.

Fulltext Leucostasis: an uncommon cause of respiratory distress

Goh KL, Bosco J, Wong CS

Med J Malaysia, 1983 Sep;38(3):194-6.

PMID: 6584709

Fulltext 5-Fluorocytosine resistance in clinical isolates of Cryptococcus neoformans

Chin CS, Cheong YM, Wong YH

Med J Malaysia, 1989 Sep;44(3):194-8.

PMID: 2696871

Thirty six clinical isolates of Cryptococcus neoformans were tested for their susceptibility to 5-fluorocytosine and amphotericin B by the determination of minimum inhibitory concentrations and minimum fungicidal concentrations. 22.2% of the isolates were resistant to 5-fluorocytosine and 36.1% indicated 5-fluorocytosine tolerance. All strains were sensitive to amphotericin B.

Fulltext Phialophora richardsiae isolated from a cutaneous lesion

Suppiah M, Chin CS, Keah KC

Med J Malaysia, 1987 Dec;42(4):306-8.

PMID: 3454404

Human infections due to Phialophora richardsiae, first described in 1968, is usually associated with subcutaneous cysts, although there have been reported cases of ulcerative lesions with discharging sinuses as well as infection of bones and tendon sheaths.1,2,3 Because infections by P.richardsiae are rare and the fungus relatively unknown in Malaysia, it was thought worthwhile to report the isolation of this fungus from a cutaneous lesion.

Fulltext Variants of Monteggia Type Injury: Case Reports

Kamudin N, Firdouse M, Han CS, M Yusof A

Malays Orthop J, 2015 Mar;9(1):23-27.

PMID: 28435591 MyJurnal DOI: 10.5704/MOJ.1503.001

BACKGROUND: Monteggia fracture-dislocation is rare in children. Various reports attest to its rarity, while recording the many variant of this injury. It is, therefore, easy to miss the diagnosis in the absence of proper clinical examination and radiographs.

CASE REPORT: This report highlights two rare variants of Monteggia fracture-dislocation seen in children. The first case was a 12-year old girl alleged to have fallen from a 15- feet tall tree and sustaining a combined type III Monteggia injury with ipsilateral Type II Salter-Harris injury of distal end radius with a metaphyseal fracture of the distal third of the ulna. The second case was a 13-year old who had sustained a closed fracture of atypical Type I Monteggia hybrid lesion, in a road traffic accident.

CONCLUSION: This report highlights the rare variants of Monteggia fracture dislocation which could have been missed without proper clinical examinations and radiographs.

A survey on the prevalence of toxoplasmic antibodies in animal sera

Singh M, Zaman V, Goh TK, Kheng CS

Med J Malaya, 1967 Dec;22(2):115-7.

PMID: 4231976

Pattern of toxoplasma antibodies in Malaysian pregnant women

Cheah WC, Fah CS, Fook CW

Med J Malaysia, 1975 Jun;29(4):275-9.

PMID: 1196176

Fulltext Cancer in Sabah (Borneo) a prelimanry survey

Muir CS, Evans MD, Roche PJ

Br. J. Cancer, 1968 Dec;22(4):637-45.

PMID: 5705133 DOI: 10.1038/bjc.1968.75

PRELIMINARY OBSERVATIONS ON LEPTOTROMBIDIUM (LEPTOTROMBIDIUM) AKAMUSHI AND LEPTOTROMBIDIUM (LEPTOTROMBIDIUM) DELIENSIS IN THEIR NATURAL HABITAT IN MALAYA: (ACARINA: TROMBICULIDAE)

GENTRY JW, YUEH CS, WAH PO

Am J Hyg, 1963 Sep;78:181-90.

PMID: 14063722

Fulltext Ulnar Osteotomy with 2-Pin Unilateral Gradual Distraction for Treatment of Chronic Monteggia Fracture: A Case Report

Gooi SG, Wang CS, Saw A, Zulkiflee O

Malays Orthop J, 2017 Mar;11(1):79-81.

PMID: 28435583 MyJurnal DOI: 10.5704/MOJ.1703.015

Missed Monteggia fracture leading to chronic radial head dislocation is a known complication. The surgical treatment options remain challenging. The aim of treatment is to reduce the radial head and to maintain the stability of the elbow in all ranges of motion. A few surgical techniques have been described with complications. We report the case of a 13 years old boy with chronic radial head dislocation as a result of an unrecognised Monteggia fracture-dislocation for eight years. We successfully reduced the radial head and corrected the cubital valgus from 45 degrees to 10 degrees with a proximal ulna osteotomy and gradual distraction with 2-pin Monotube external fixator. The correction was uneventful with good functional outcome.

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