METHODOLOGY: The review encompasses historical climate data comprising mean daily temperature, precipitation, mean sea level and occurrences of extreme weather events. Future climate projections have also been reviewed in addition to scholarly papers and news articles related to impacts, contributors, mitigation and adaptations in relation to climate change.

FINDINGS: The review shows that annual mean temperature, occurrences of extreme weather events and mean sea level are rising while rainfall shows variability. Future projections point to continuous rise of temperature and mean sea level till the end of the 21st century, highly variable rainfall and increased frequency of extreme weather events. Climate change impacts particularly on agriculture, forestry, biodiversity, water resources, coastal and marine resources, public health and energy. The energy and waste management sectors are the major contributors to climate change. Mitigation of and adaptations to climate change in Malaysia revolve around policy setting, enactment of laws, formulation and implementation of plans and programmes, as well as global and regional collaborations, particularly for energy, water resources, agriculture and biodiversity. There are apparent shortcomings in continuous improvement and monitoring of the programmes as well as enforcement of the relevant laws.

HYPOTHESIS: The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe.

STUDY DESIGN: Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of the health care systems in developing countries still remain. Current approaches to secure primary health care offer only fragmentary solutions at best. Conventional medicine from industrialized countries cannot be afforded by the impoverished population in the Third World. Confronted with exploding costs, even health systems in Western countries are endangered to burst. Complementary and alternative medicine (CAM) is popular among the general public in industrialized countries, although the efficacy is not sufficiently proven according to the standards of evidence-based medicine. CAM is often available without prescription as over-the-counter products with non-calculated risks concerning erroneous self-medication and safety/toxicity issues. The concept of integrative medicine attempts to combine holistic CAM approaches with evidence-based principles of conventional medicine.