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  1. Abbas Q, Hina S, Sajjad H, Zaidi KS, Akbar R
    PeerJ Comput Sci, 2023;9:e1552.
    PMID: 37705624 DOI: 10.7717/peerj-cs.1552
    Network intrusion is one of the main threats to organizational networks and systems. Its timely detection is a profound challenge for the security of networks and systems. The situation is even more challenging for small and medium enterprises (SMEs) of developing countries where limited resources and investment in deploying foreign security controls and development of indigenous security solutions are big hurdles. A robust, yet cost-effective network intrusion detection system is required to secure traditional and Internet of Things (IoT) networks to confront such escalating security challenges in SMEs. In the present research, a novel hybrid ensemble model using random forest-recursive feature elimination (RF-RFE) method is proposed to increase the predictive performance of intrusion detection system (IDS). Compared to the deep learning paradigm, the proposed machine learning ensemble method could yield the state-of-the-art results with lower computational cost and less training time. The evaluation of the proposed ensemble machine leaning model shows 99%, 98.53% and 99.9% overall accuracy for NSL-KDD, UNSW-NB15 and CSE-CIC-IDS2018 datasets, respectively. The results show that the proposed ensemble method successfully optimizes the performance of intrusion detection systems. The outcome of the research is significant and contributes to the performance efficiency of intrusion detection systems and developing secure systems and applications.
  2. Ahmad M, Zafar M, Sultana S, Ahmad M, Abbas Q, Ayoub M, et al.
    Microsc Res Tech, 2018 Sep;81(9):1004-1016.
    PMID: 30303585 DOI: 10.1002/jemt.23066
    Pollen micro-morphological features have proven to be helpful for the plant taxonomists in the identification and classification of plants. The utilization of this plantmayhelpfulin the areas of lignocellulosic conversion to biofuels and diversify application toward biomass. The current study was planned with the aim to evaluate the pollen features of complex Ranunculaceous flora of District Chitral, Northern Pakistan using both scanning electron microscopy (SEM) and Light Microscope (LM) for their taxonomic importance. Pollens of 18 Ranunculaceous species belonging to 6 genera were collected from different localities of the research area. SEM and LM were used to examine both qualitative and quantitative micro-morphological features. Sculptring of the sexine include; Scabrate, psilate, echinate, verrucate, perforate gemmate, and reticulate and so forth. Shape of the pollens was sub-spheroidal, spheroidal, prolate, subprolate and oblate and so forth. Type of pollen was ranged from mono to tricolpate and tricolporate. Quantitative characters include length/width of the pollen, colpus, exine thickness, and P/E ratio. Based on these micro-morphological features a taxonomic key was prepared for the fast and correct identification. RESEARCH HIGHLIGHT: Study of the pollen micro-morphological features of Ranunculaceous species by SEM and LM. Analysing both qualitative and quantitative characters of the pollens. Preparation of taxonomic key based on micro-morphological features for the correct and fast identification.
  3. Abbas Q, Nurunnabi M, Alfakhri Y, Khan W, Hussain A, Iqbal W
    Environ Sci Pollut Res Int, 2020 Dec;27(36):45476-45486.
    PMID: 32794094 DOI: 10.1007/s11356-020-10413-y
    Economic integration in the form of Belt and Road Initiative project opens many opportunities and hazards, especially of the participating nations' environment. The current study attempted to empirically test the economic and energy usage (renewable and non-renewable) impact on some selected countries of belt and road projects. For this purpose, the panel data set of twenty-four emerging economies of belt and road projects was selected from 1995 to 2014. The autoregressive distributed lags technique of econometric applied to determine the effect of renewable and non-renewable energy, GDP and GDP2 for EKC, and gross fixed capital formation on carbon emission in the selected countries of Belt and Road Initiative project. The outcomes of this study confirm the existence of EKC in these underlined countries. Here, fossil fuel-based energy consumption is a source of environmental degradation, while renewable and clean energy usage can help sustain environmental conditions without affecting economic growth progress. Capital fixed formation in these economies can enhance economic growth and help to sustainable environmental conditions in the belt and road countries. Thus, based on these empirical outcomes, this study suggests economic and financial assistance in green renewable energy sources and clean technological innovation to enhance economic benefits of Belt and Road Initiative project without compromising the environmental conditions of the region.
  4. Raza H, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Hassan M, Abbas Q, et al.
    Bioorg Chem, 2020 01;94:103445.
    PMID: 31826809 DOI: 10.1016/j.bioorg.2019.103445
    In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (2) in aqueous basic medium to give various electrophiles, 4-chloro-N-(substituted-phenyl)butanamides (3a-e). These electrophiles were then coupled with 1-[(E)-3-phenyl-2-propenyl]piperazine (4) in polar aprotic medium to attain the targeted N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides (5a-e). The structures of all derivatives were identified and characterized by proton-nuclear magnetic resonance (1H NMR), carbon-nuclear magnetic resonance (13C NMR) and Infra-Red (IR) spectral data along with CHN analysis. The in vitro inhibitory potential of these butanamides was evaluated against Mushroom tyrosinase, whereby all compounds were found to be biologically active. Among them, 5b exhibited highest inhibitory potential with IC50 value of 0.013 ± 0.001 µM. The same compound 5b was also assayed through in vivo approach, and it was explored that it significantly reduced the pigments in zebrafish. The in silico studies were also in agreement with aforesaid results. Moreover, these molecules were profiled for their cytotoxicity through hemolytic activity, and it was found that except 5e, all other compounds showed minimal toxicity. The compound 5a also exhibited comparable results. Hence, some of these compounds might be worthy candidates for the formulation and development of depigmentation drugs with minimum side effects.
  5. Poh PF, Sng QW, Latour JM, He L, Fong MF, Muralidharah J, et al.
    Pediatr Crit Care Med, 2022 Nov 01;23(11):e498-e506.
    PMID: 35834674 DOI: 10.1097/PCC.0000000000003023
    OBJECTIVES: To identify nursing research priorities in pediatric critical care in Asia.

    DESIGN: We conducted a modified three-round eDelphi survey with pediatric critical care nurses in Asia. The eDelphi technique has been extensively used within health research to achieve a common viewpoint from experts using questionnaires to gather research priorities. In round 1, participants were asked to list three to five research topics that they deemed important. These topics were thematically analyzed and categorized into a questionnaire. Participants rated the research topics in round 2 on a 6-point scale (1 = not important to 6 = extremely important). In round 3, the same questionnaire was used with addition of the calculated mean scores from round 2 for each topic. Research topics ranked among the top 10 were considered extremely important.

    SETTINGS: Twenty-two PICUs in eight Asian countries.

    SUBJECTS: Clinical nurses, managers, educators, and researchers.

    INTERVENTIONS: None.

    MEASUREMENTS AND MAIN RESULTS: In round 1, 146 PICU nurses across eight countries provided 520 research topics. Topics from round 1 were categorized into seven domains with 52 research topics. Prioritized research topics included early recognition of patient deterioration (mean 5.58 ± 0.61), prevention of healthcare-associated infections (mean 5.47 ± 0.70), and interventions to reduce compassion fatigue (mean 5.45 ± 0.80). The top three research domains were end-of-life care (mean 5.34 ± 0.68), professionalism (mean 5.34 ± 0.69), and management of pain, sedation, and delirium (5.32 ± 0.72).

    CONCLUSIONS: This first PICU nursing research prioritization exercise within Asia identified key nursing research themes that should be prioritized and provide a framework for future collaborative studies.

  6. Wong JJM, Abbas Q, Chuah SL, Malisie RF, Pon KM, Katsuta T, et al.
    Am J Trop Med Hyg, 2021 Jun 15;105(2):413-420.
    PMID: 34129517 DOI: 10.4269/ajtmh.21-0299
    There is a scarcity of data regarding coronavirus disease 2019 (COVID-19) infection in children from southeast and south Asia. This study aims to identify risk factors for severe COVID-19 disease among children in the region. This is an observational study of children with COVID-19 infection in hospitals contributing data to the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Laboratory-confirmed COVID-19 cases were included in this registry. The primary outcome was severity of COVID-19 infection as defined by the World Health Organization (WHO) (mild, moderate, severe, or critical). Epidemiology, clinical and laboratory features, and outcomes of children with COVID-19 are described. Univariate and multivariable logistic regression models were used to identify risk factors for severe/critical disease. A total of 260 COVID-19 cases from eight hospitals across seven countries (China, Japan, Singapore, Malaysia, Indonesia, India, and Pakistan) were included. The common clinical manifestations were similar across countries: fever (64%), cough (39%), and coryza (23%). Approximately 40% of children were asymptomatic, and overall mortality was 2.3%, with all deaths reported from India and Pakistan. Using the multivariable model, the infant age group, presence of comorbidities, and cough on presentation were associated with severe/critical COVID-19. This epidemiological study of pediatric COVID-19 infection demonstrated similar clinical presentations of COVID-19 in children across Asia. Risk factors for severe disease in children were age younger than 12 months, presence of comorbidities, and cough at presentation. Further studies are needed to determine whether differences in mortality are the result of genetic factors, cultural practices, or environmental exposures.
  7. Yock-Corrales A, Lee JH, Domínguez-Rojas JÁ, Caporal P, Roa JD, Fernandez-Sarmiento J, et al.
    J Pediatr Surg, 2024 Mar;59(3):494-499.
    PMID: 37867044 DOI: 10.1016/j.jpedsurg.2023.09.038
    INTRODUCTION: We aimed to identify clinical characteristics, risk factors for diagnosis, and describe outcomes among children with AHT.

    METHODS: We performed an observational cohort study in tertiary care hospitals from 14 countries across Asia and Ibero-America. We included patients <5 years old who were admitted to participating pediatric intensive care units (PICUs) with moderate to severe traumatic brain injury (TBI). We performed descriptive analysis and multivariable logistic regression for risk factors of AHT.

    RESULTS: 47 (12%) out of 392 patients were diagnosed with AHT. Compared to those with accidental injuries, children with AHT were more frequently < 2 years old (42, 89.4% vs 133, 38.6%, p 

  8. Wooldridge G, O'Brien N, Muttalib F, Abbas Q, Adabie Appiah J, Baker T, et al.
    Andes Pediatr, 2021 Dec;92(6):954-962.
    PMID: 35506809 DOI: 10.32641/andespediatr.v92i6.4030
    The Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children was released in 2020 and is intended for use in all global settings that care for children with sepsis. However, practitioners managing children with sep sis in resource-limited settings (RLS) face several challenges and disease patterns not experienced by those in resource-rich settings. Based upon our collective experience from RLS, we aimed to reflect on the difficulties of implementing the international guidelines. We believe there is an urgent need for more evidence from RLS on feasible, efficacious approaches to the management of sepsis and septic shock that could be included in future context-specific guidelines.
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