MyMedR

Displaying all 5 publications

Abstract:

Sort:

Fulltext Antibodies in systemic lupus antineutrophil cytoplasmic erythematosus: prevalence, disease activity correlations and organ system associations

Fauzi AR, Kong NCT, Chua MK, Jeyabalan V, Idris MN, Azizah R

Med J Malaysia, 2004 Aug;59(3):372-7.
PMID: 15727383

Systemic Lupus Erythematosus (SLE) is a disease with multiorgan involvement and multiple autoantibody production including antineutrophil cytoplasmic antibodies (ANCA). Despite its reported prevalence in more than one third of SLE patients, the role of ANCA in the pathogenesis or otherwise in SLE remains unresolved. 131 SLE patients had been previously studied for various serologic parameters of disease activity. Their cumulative organ involvement in the course of their disease had also been determined and the Lupus Activity Index (LAI) calculated. Their stored sera were then screened for the presence of ANCA by two methods viz Indirect immunofluorescence (IIF) and also enzyme-linked immunosorbent assay (ELISA). ANCA was present in 24.8% of these SLE patients. The atypical ANCA pattern was predominant and accounted for an overall of 20.6%. Anti-MPO and anti-PR3 were detected in 1.5% of patients respectively. No association was found between ANCA positivity and disease activity. There was also no association of ANCA with specific organ involvement. Despite the high prevalence of ANCA especially the atypical variant in SLE, they probably represent only one of the wide repertoire of autoantibodies found in this disease. Routine testing for ANCA in lupus patients is therefore not recommended.
Fulltext Analysis of waste management effect on the climate related disease in Larangan Village, Sidoarjo

Azizah R, Mohamed AFH, Sulistyorini L, Mulia SA, Arfiani ND, Rahmawati A

Environ Anal Health Toxicol, 2024 Mar;39(1):e2024010-0.
PMID: 38631402 DOI: 10.5620/eaht.2024010

The repercussions of climate change have profound implications for human health, leading to the emergence of climate-related diseases. Recognizing this, the Ministry of Environment and Forestry in Indonesia has established the Climate Village Program to tackle and mitigate the impact of climate change. Despite the implementation of this program, Larangan Village in Candi Sub-district, Sidoarjo Regency, continues to struggle with cases of climate-related diseases. This research aims to assess the impact of waste management on the prevalence of climate-related diseases in Larangan Village. Using a quantitative, analytical, observational approach with a cross-sectional design, the study concentrates on two neighborhoods within Larangan Village. The population consists of 330 families in the 2nd neighborhood (Non-Climate Village Program) and 344 families in the 9th neighborhood (Climate Village Program), with a sample size of 109. The variables under investigation encompass waste management and climate-related diseases. Data collection involves conducting interviews and distributing questionnaires among community members in both neighborhoods. The collected data undergo analysis using Multigroup Analysis SEM PLS with a significance level of 0.05. The findings reveal a significant negative correlation between waste management and climate-related diseases, suggesting that enhanced waste management is linked to a reduced incidence of such diseases in the community.
Fulltext Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Zakaria ZA, Sahmat A, Azmi AH, Nur Zainol AS, Omar MH, Balan T, et al.

BMC Complement Med Ther, 2021 Jan 14;21(1):35.
PMID: 33446155 DOI: 10.1186/s12906-020-03200-2

INTRODUCTION: Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activities, and phytoconstituents of lipid-soluble (chloroform) extract of D. linearis leaves.
METHODS: The extract of D. linearis leaves (CEDL; 50, 250 and 500 mg/kg) was orally administered to rats for 7 consecutive days followed by the oral administration of 3 g/kg PCM to induce liver injury. Blood was collected for liver function analysis while the liver was obtained for histopathological examination and endogenous antioxidant activity determination. The extract was also subjected to antioxidant evaluation and phytochemicals determination via phytochemical screening, HPLC and UPLC-HRMS analyses.
RESULTS: CEDL exerted significant (p
Fulltext Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids

Zakaria ZA, Sahmat A, Hizami Azmi A, Zainol ASN, Omar MH, Balan T, et al.

Pharm Biol, 2023 Dec;61(1):1152-1161.
PMID: 37559390 DOI: 10.1080/13880209.2023.2241510

CONTEXT: Bauhinia purpurea L. (Fabaceae) is used in the Ayurvedic system to treat various oxidative-related ailments (e.g., wounds, ulcers etc.). Therefore, it is believed that the plant also has the potential to alleviate oxidative-related liver damage.
OBJECTIVE: This study elucidates the hepatoprotective activity of chloroform extract of B. purpurea leaves (CEBP) in paracetamol (PCM)-induced liver injury (PILI) rats.
MATERIALS AND METHODS: Male Sprague-Dawley rats (n = 6) were pre-treated once daily (p.o.) with CEBP (50-500 mg/kg) for seven consecutive days before being administered (p.o.) a hepatotoxic agent, 3 g/kg PCM. Liver enzyme levels were determined from the collected blood, while the collected liver was used to determine the activity of endogenous antioxidant enzymes and for histopathological examination. CEBP was also subjected to radical scavenging assays and phytochemical analysis.
RESULTS: CEBP significantly (p
Medicinal plants of Southeast Asia with anti-α-glucosidase activity as potential source for Type-2 diabetes mellitus treatment

Benjamin MAZ, Mohd Mokhtar RA, Iqbal M, Abdullah A, Azizah R, Sulistyorini L, et al.

J Ethnopharmacol, 2024 Apr 23;330:118239.
PMID: 38657877 DOI: 10.1016/j.jep.2024.118239

ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus, a widespread chronic illness, affects millions worldwide, and its incidence is increasing alarmingly, especially in developing nations. Current pharmacological treatments can be costly and have undesirable side effects. To address this, medicinal plants with antidiabetic effects, particularly targeting α-glucosidase for controlling hyperglycaemia in type-2 diabetes mellitus (T2DM), hold promise for drug development with reduced toxicity and adverse reactions.
AIM OF THIS REVIEW: This review aims to succinctly collect information about medicinal plant extracts that exhibit antidiabetic potential through α-glucosidase inhibition using acarbose as a standard reference in Southeast Asia. The characteristics of this inhibition are based on in vitro studies.
MATERIALS AND METHODS: Relevant information on medicinal plants in Southeast Asia, along with α-glucosidase inhibition studies using acarbose as a positive control, was gathered from various scientific databases, including Scopus, PubMed, Web of Science, and Google Scholar.
RESULTS: About 46 papers were found from specific counties in Southeast Asia demonstrated notable α-glucosidase inhibitory potential of their medicinal plants, with several plant extracts showcasing activity comparable to or surpassing that of acarbose. Notably, 19 active constituents were identified for their α-glucosidase inhibitory effects.
CONCLUSIONS: The findings underscore the antidiabetic potential of the tested medicinal plant extracts, indicating their promise as alternative treatments for T2DM. This review can aid in the development of potent therapeutic medicines with increased effectiveness and safety for the treatment of T2DM.