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Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids

Zakaria ZA 1 , Sahmat A 2 , Hizami Azmi A 2 , Zainol ASN 2 , Omar MH 3 , Balan T 4 Show all authors , Abdul Kadir A 5 , Abdullah S 6 , Azizah R 7 , Sulistyorini L 7

Affiliations 

  • 1 Borneo Research on Algesia, Inflammation and Neurodegeneration (BRAIN) Group, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Jalan UMS, Sabah, Malaysia
  • 2 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
  • 3 Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Shah Alam, Malaysia
  • 4 Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia
  • 5 Department of Veterinary Pre-clinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia
  • 6 Institute of Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, Sabah, Malaysia
  • 7 Department of Environmental Health, Faculty of Public Health, Campus C Universitas Airlangga, Jalan Mulyorejo Surabaya, East Java, Indonesia
Pharm Biol, 2023 Dec;61(1):1152-1161.
PMID: 37559390 DOI: 10.1080/13880209.2023.2241510

Abstract

CONTEXT: Bauhinia purpurea L. (Fabaceae) is used in the Ayurvedic system to treat various oxidative-related ailments (e.g., wounds, ulcers etc.). Therefore, it is believed that the plant also has the potential to alleviate oxidative-related liver damage.

OBJECTIVE: This study elucidates the hepatoprotective activity of chloroform extract of B. purpurea leaves (CEBP) in paracetamol (PCM)-induced liver injury (PILI) rats.

MATERIALS AND METHODS: Male Sprague-Dawley rats (n = 6) were pre-treated once daily (p.o.) with CEBP (50-500 mg/kg) for seven consecutive days before being administered (p.o.) a hepatotoxic agent, 3 g/kg PCM. Liver enzyme levels were determined from the collected blood, while the collected liver was used to determine the activity of endogenous antioxidant enzymes and for histopathological examination. CEBP was also subjected to radical scavenging assays and phytochemical analysis.

RESULTS: CEBP significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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