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Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat

Zakaria ZA 1 , Sahmat A 2 , Azmi AH 2 , Nur Zainol AS 2 , Omar MH 3 , Balan T 4 Show all authors , Sulistyorini L 5 , Azizah R 5 , Abdullah MNH 2

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia. zaz@upm.edu.my
  • 2 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia
  • 3 Phytochemistry Unit, Herbal Medicine Research Level 5, Block C7, National Institutes of Health (NIH), Setia Alam, 40170, Shah Alam, Selangor, Malaysia
  • 4 Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, 30450, Ipoh, Perak, Malaysia
  • 5 Department of Environmental Health, Faculty of Public Health, Campus C Universitas Airlangga, Jalan Mulyosari, Surabaya, Indonesia
BMC Complement Med Ther, 2021 Jan 14;21(1):35.
PMID: 33446155 DOI: 10.1186/s12906-020-03200-2

Abstract

INTRODUCTION: Water-soluble, but not lipid-soluble, extract of Dicranopteris linearis leaves has been proven to possess hepatoprotective activity. The present study aimed to validate the hepatoprotective and antioxidant activities, and phytoconstituents of lipid-soluble (chloroform) extract of D. linearis leaves.

METHODS: The extract of D. linearis leaves (CEDL; 50, 250 and 500 mg/kg) was orally administered to rats for 7 consecutive days followed by the oral administration of 3 g/kg PCM to induce liver injury. Blood was collected for liver function analysis while the liver was obtained for histopathological examination and endogenous antioxidant activity determination. The extract was also subjected to antioxidant evaluation and phytochemicals determination via phytochemical screening, HPLC and UPLC-HRMS analyses.

RESULTS: CEDL exerted significant (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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