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Methanol extract of Muntingia calabura leaves attenuates CCl4-induced liver injury: possible synergistic action of flavonoids and volatile bioactive compounds on endogenous defence system

Zakaria ZA 1 , Mahmood ND 2 , Omar MH 3 , Taher M 4 , Basir R 5

Affiliations 

  • 1 a Laboratory of Halal Science Research, Halal Products Research Institute , Universiti Putra Malaysia , Serdang , Malaysia
  • 2 c Department of Biomedical Science, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
  • 3 d Phytochemistry Unit Herbal Medicine Research Centre, Institute for Medical Research , Kuala Lumpur , Malaysia
  • 4 e Department of Pharmaceutical Technology , Kulliyah of Pharmacy International Islamic University Malaysia , Kuantan , Malaysia
  • 5 f Department of Human Anatomy, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Malaysia
Pharm Biol, 2019 Dec;57(1):335-344.
PMID: 31068038 DOI: 10.1080/13880209.2019.1606836

Abstract

CONTEXT: Muntingia calabura L. (Muntingiaceae) exerts antioxidant and anti-inflammatory activities, thus, it might be a good hepatoprotective agent.

OBJECTIVE: This study investigates the effect of methanol extract of M. calabura leaves (MMCL) on hepatic antioxidant and anti-inflammatory activities in CCl4-induced hepatotoxic rat.

MATERIALS AND METHODS: Sprague Dawley rats (n = 6) were treated (p.o.) with 10% DMSO (Groups 1 and 2), 50 mg/kg N-acetylcysteine (Group 3) or, 50, 250, or 500 mg/kg MMCL (Groups 4-6) for 7 consecutive days followed by pretreatment (i.p.) with vehicle (Group 1) or 50% CCl4 in olive oil (v/v) (Groups 2-6) on day 7th. Plasma liver enzymes and hepatic antioxidant enzymes and pro-inflammatory cytokines concentrations were measured while liver histopathology was examined.

RESULTS: MMCL, at 500 mg/kg, significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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