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Fulltext Doctors, do not forget to advise your diabetic patient to exercise

Hassan, B. M.

Asian Journal of Medicine and Biomedicine, 2018;1(1):17-18.
MyJurnal

As primary care doctors, treating patients with Type 2 DM is our bread and butter, as the majority of them seek treatment at health clinics. It is true that some of the patients have managed to achieve good glycaemic control, but more than half of them still have poorly controlled blood sugar as compared to the clinical practice guideline recommendation [1]. And usually, the first thing that comes to our mind when seeing these patients is to increase the dosage of anti-diabetic medication that they are currently on or to add another agent, including insulin. We also frequently tell them that the high blood sugar level is not surprising, as such is the nature of diabetes, where the worsening of blood sugar is expected due to progressive deterioration of pancreatic beta cell function.
The effects of honey compared to silver sulfadiazine for the treatment of burns: A systematic review of randomized controlled trials

Aziz Z, Abdul Rasool Hassan B

Burns, 2017 Feb;43(1):50-57.
PMID: 27576926 DOI: 10.1016/j.burns.2016.07.004

Evidence from animal studies and trials suggests that honey may accelerate wound healing. The objective of this review was to assess the effects of honey compared with silver dressings on the healing of burn wounds. Relevant databases for randomized controlled trials (RCTs) of honey compared with silver sulfadiazine (SSD) were searched. The quality of the selected trials was assessed using the Cochrane Risk of Bias Assessment Tool. The primary endpoints considered were wound healing time and the number of infected wounds rendered sterile. Nine RCTs met the inclusion criteria. Based on moderate quality evidence there was a statistically significant difference between the two groups, favoring honey in healing time (MD -5.76days, 95% CI -8.14 to -3.39) and the proportions of infected wounds rendered sterile (RR 2.59; 95% CI 1.58-2.88). The available evidence suggests that honey dressings promote better wound healing than silver sulfadiazine for burns.
Fulltext On Scalability of FDD-Based Cell-Free Massive MIMO Framework

Hassan B, Baig S, Aslam S

Sensors (Basel), 2023 Aug 07;23(15).
PMID: 37571774 DOI: 10.3390/s23156991

Cell-free massive multiple-input multiple-output (MIMO) systems have the potential of providing joint services, including joint initial access, efficient clustering of access points (APs), and pilot allocation to user equipment (UEs) over large coverage areas with reduced interference. In cell-free massive MIMO, a large coverage area corresponds to the provision and maintenance of the scalable quality of service requirements for an infinitely large number of UEs. The research in cell-free massive MIMO is mostly focused on time division duplex mode due to the availability of channel reciprocity which aids in avoiding feedback overhead. However, the frequency division duplex (FDD) protocol still dominates the current wireless standards, and the provision of angle reciprocity aids in reducing this overhead. The challenge of providing a scalable cell-free massive MIMO system in an FDD setting is also prevalent, since computational complexity regarding signal processing tasks, such as channel estimation, precoding/combining, and power allocation, becomes prohibitively high with an increase in the number of UEs. In this work, we consider an FDD-based scalable cell-free network with angular reciprocity and a dynamic cooperation clustering approach. We have proposed scalability for our FDD cell-free and performed a comparative analysis with reference to channel estimation, power allocation, and precoding/combining techniques. We present expressions for scalable spectral efficiency, angle-based precoding/combining schemes and provide a comparison of overhead between conventional and scalable angle-based estimation as well as combining schemes. Simulations confirm that the proposed scalable cell-free network based on an FDD scheme outperforms the conventional matched filtering scheme based on scalable precoding/combining schemes. The angle-based LP-MMSE in the FDD cell-free network provides 14.3% improvement in spectral efficiency and 11.11% improvement in energy efficiency compared to the scalable MF scheme.
Fulltext Prevalence of obesity in Malaysia: perspectives in Terengganu

Muhammad, I. N., Saifullah, K., Hassan, B., Yasrul, I., Norizan, A./G., Ahmed Zubaidi, A. L., et al.

Asian Journal of Medicine and Biomedicine, 2018;2(1):0-0.
MyJurnal

A normal health status is highly depends on body weight. Many health problems may occur or impose risk for
extremely obese individuals. Etiopathology of obesity includes interaction of several factors inclusive of
genetic and non-genetic factors such as lifestyle changes. This study aimed to launch Malaysian Obesity
DNA Bank and determine the prevalence of obesity along with anthropometric measurements of the subjects.
The cross-sectional study was conducted on total of 340 subjects (obese = 95, overweight = 122 and normal =
123), aged 19-60 years, in Terengganu. The BMI and well appropriate anthropometric measurements (waist
circumference, hip circumference, waist to hip ratio, fat percentage and ASindex) were determined through
standard protocols and formulae. The mean difference of anthropometrics was determined by independent ttest. Data was analysed using SPSS ver.16.0.0. The BMI was determined for all subjects and it was found that
out of 340 subjects, a total of 95 (27.9%) subjects were obese , followed by a total of 122 (35.8%) subjects
were overweight and normal individuals were 123 (36.1%). The mean of the BMI, WHR, Fat% and ASindex,
in Malay obese were 32.83, 0.88, 33.5 and 13.21 respectively, while in normal healthy individuals were 22.1,
0.78, 24.2 and 20.1 respectively. The difference of mean of BMI, WHR, Fat% and ASindex was calculated to
be 10.73, 0.1, 9.3 and 6.89 respectively. To the best of our knowledge, this is the first report in Malaysia,
reporting that this is very first Obesity DNA Bank in South East Asia region and prevalence of obesity in
Terengganu, Malaysia to be 27.9%. In addition, it indicates a significant mean difference for anthropometric
measurements among obese and normal individuals. For Asindex calculations suggest that the prevalence of
genocide obesity is greater 89.9% of android obesity in Malay obese attributes
.
Inflammation of the Gums

Intan Suhana MA, Farha A, Hassan BM

Malays Fam Physician, 2020;15(1):71-73.
PMID: 32284812
Prevalence, risk factors and secondary prevention of stroke recurrence in eight countries from south, east and southeast asia: a scoping review

Chin YY, Sakinah H, Aryati A, Hassan BM

Med J Malaysia, 2018 Apr;73(2):90-99.
PMID: 29703872

INTRODUCTION: In most Asian countries, stroke is one of the major causes of mortality. A stroke event is life-changing for stroke survivors, which results in either mortality or disability. Therefore, this study comprehensively focuses on prevalence, risk factors, and secondary prevention for stroke recurrence identified in South, East, and Southeast Asian countries.
METHODS: This scoping review uses the methodological framework of Arksey and O'Malley. A comprehensive search of academic journals (English) on this topic published from 2007 to 2017 was conducted. A total of 22 studies were selected from 585 studies screened from the electronic databases.
RESULTS: First-year stroke recurrence rates are in the range of 2.2% to 25.4%. Besides that, modifiable risk factors are significantly associated with pathophysiological factors (hypertension, ankle-brachial pressure index, atherogenic dyslipidaemia, diabetes mellitus, metabolic syndrome, and atrial fibrillation) and lifestyle factors (obesity, smoking, physical inactivity, and high salt intake). Furthermore, age, previous history of cerebrovascular events, and stroke subtype are also significant influence risk factors for recurrence. A strategic secondary prevention method for recurrent stroke is health education along with managing risk factors through a combination of appropriate lifestyle intervention and pharmacological therapy.
CONCLUSION: To prevent recurrent stroke, health intervention should be geared towards changing lifestyle to embody a healthier approach to life. This is of great importance to public health and stroke survivors' quality of life.
Association of neutropenia onset and severity with chemotherapy regimens and schedules

Abdul Rasool Hassan B, Yusoff ZB, Bin Othman S

Asian Pac J Cancer Prev, 2011;12(6):1425-8.
PMID: 22126475

INTRODUCTION: Neutropenia, defined as a decrease in the absolute neutrophil count lower than the normal that is < 1500 cell/ ?l, has a detrimental effect on cancer patients' quality of life, also possibly resulting in a reduction in the chemotherapy dose which could lead to an increment in the size of a cancer. There are so many causative factors for neutropenia like hematological disorders, autoimmune diseases and infection, drugs reactions and chemotherapy or radiotherapy. So the main aim of this study is to find the association between chemotherapy drug or regimens, schedule of administration used for treatment of solid cancer diseases with neutropenia onset and severity.
METHODS: This is an observational retrospective study carried out in a general hospital on 117 solid tumor patients who admitted between January 2003 to December 2006. The main statistical tests used were Chi- square test and Fisher' s Exact test. The significance of the result will be when the P<0.05, while the confidence interval for this study was 95%.
RESULTS: The highest chemotherapeutic regimen was (5-FU+epirubicin+cyclophosphamide) (47, 40.2%) followed by (gemcitabine+cisplatin) (6, 5.1%) and many others. Majority of the patients receive their chemotherapy schedule of administration was one day schedule (90, 76.9%) followed by more than one day schedule (27, 23.1%).
CONCLUSION: The doses of these drugs were not high enough to produce a sufficient pharmacological effect to cause bone marrow suppression and lead to neutropenia. Besides the schedule of administration for each drug was long enough to overcome neutropenia also the high uses of granulocyte colony stimulation factor (G-CSF) which will play a major role in reducing the time and severity of neutropenia. All these factors play an important role in giving non- significant association between neutropenia onset and severity with chemotherapeutics drugs and their schedule of administration.
Bluish swelling on the floor of the mouth

Hassan BM, Intan Suhana MA, Megat Mustaqim MI

Malays Fam Physician, 2020;15(1):64-67.
PMID: 32284810
Accuracy of trabecular bone microstructural measurement at planned dental implant sites using cone-beam CT datasets

Ibrahim N, Parsa A, Hassan B, van der Stelt P, Aartman IH, Wismeijer D

Clin Oral Implants Res, 2014 Aug;25(8):941-5.
PMID: 23581278 DOI: 10.1111/clr.12163

Cone-beam CT (CBCT) images are infrequently utilized for trabecular bone microstructural measurement due to the system's limited resolution. The aim of this study was to determine the accuracy of CBCT for measuring trabecular bone microstructure in comparison with micro CT (μCT).
Fulltext Comparison of anterior and posterior trabecular bone microstructure of human mandible using cone-beam CT and micro CT

Ibrahim N, Parsa A, Hassan B, van der Stelt P, Rahmat RA, Ismail SM, et al.

BMC Oral Health, 2021 05 08;21(1):249.
PMID: 33964918 DOI: 10.1186/s12903-021-01595-z

BACKGROUND: The aim of this study was to compare the trabecular bone microstructures of anterior and posterior edentulous regions of human mandible using cone-beam computed tomography (CBCT) and micro computed tomography (µCT).
METHODS: Twenty volumes of interests consisting of six anterior and fourteen posterior edentulous regions were obtained from human mandibular cadavers. A CBCT system with a resolution of 80 µm (3D Accuitomo 170, J. Morita, Kyoto, Japan) and a µCT system with a resolution of 35 µm (SkyScan 1173, Kontich, Belgium) were used to scan the mandibles. Three structural parameters namely, trabecular number (Tb.N), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp) were analysed using CTAn software (v 1.11, SkyScan, Kontich, Belgium). For each system, the measurements obtained from anterior and posterior regions were tested using independent sample t-test. Subsequently, all measurements between systems were tested using paired t-test.
RESULTS: In CBCT, all parameters of the anterior and posterior mandible showed no significant differences (p > 0.05). However, µCT showed a significant different of Tb.Th (p = 0.023) between anterior and posterior region. Regardless of regions, the measurements obtained using both imaging systems were significantly different (p ≤ 0.021) for Tb.Th and Tb.N.
CONCLUSIONS: The current study demonstrated that only the variation of Tb.Th between anterior and posterior edentulous region of mandible can be detected using µCT. In addition, CBCT is less feasible than µCT in assessing trabecular bone microstructures at both regions.
Advancements in Perovskite-Based Cathode Materials for Solid Oxide Fuel Cells: A Comprehensive Review

Samreen A, Ali MS, Huzaifa M, Ali N, Hassan B, Ullah F, et al.

Chem Rec, 2024 Jan;24(1):e202300247.
PMID: 37933973 DOI: 10.1002/tcr.202300247

The high-temperature solid oxide fuel cells (SOFCs) are the most efficient and green conversion technology for electricity generation from hydrogen-based fuel as compared to conventional thermal power plants. Many efforts have been made to reduce the high operating temperature (>800 °C) to intermediate/low operating temperature (400 °C
Fulltext Exploring the role of artificial intelligence in chemotherapy development, cancer diagnosis, and treatment: present achievements and future outlook

Abdul Rasool Hassan B, Mohammed AH, Hallit S, Malaeb D, Hosseini H

Front Oncol, 2025;15:1475893.
PMID: 39990683 DOI: 10.3389/fonc.2025.1475893

BACKGROUND: Artificial intelligence (AI) has emerged as a transformative tool in oncology, offering promising applications in chemotherapy development, cancer diagnosis, and predicting chemotherapy response. Despite its potential, debates persist regarding the predictive accuracy of AI technologies, particularly machine learning (ML) and deep learning (DL).
OBJECTIVE: This review aims to explore the role of AI in forecasting outcomes related to chemotherapy development, cancer diagnosis, and treatment response, synthesizing current advancements and identifying critical gaps in the field.
METHODS: A comprehensive literature search was conducted across PubMed, Embase, Web of Science, and Cochrane databases up to 2023. Keywords included "Artificial Intelligence (AI)," "Machine Learning (ML)," and "Deep Learning (DL)" combined with "chemotherapy development," "cancer diagnosis," and "cancer treatment." Articles published within the last four years and written in English were included. The Prediction Model Risk of Bias Assessment tool was utilized to assess the risk of bias in the selected studies.
CONCLUSION: This review underscores the substantial impact of AI, including ML and DL, on cancer diagnosis, chemotherapy innovation, and treatment response for both solid and hematological tumors. Evidence from recent studies highlights AI's potential to reduce cancer-related mortality by optimizing diagnostic accuracy, personalizing treatment plans, and improving therapeutic outcomes. Future research should focus on addressing challenges in clinical implementation, ethical considerations, and scalability to enhance AI's integration into oncology care.
Need for approval from others and face concerns as predictors of interpersonal conflict outcome in 29 cultural groups

Lun VM, Smith PB, Grigoryan L, Torres C, Papastylianou A, Lopukhova OG, et al.

Int J Psychol, 2023 Jan 27.
PMID: 36707726 DOI: 10.1002/ijop.12895

The extent to which culture moderates the effects of need for approval from others on a person's handling of interpersonal conflict was investigated. Students from 24 nations rated how they handled a recent interpersonal conflict, using measures derived from face-negotiation theory. Samples varied in the extent to which they were perceived as characterised by the cultural logics of dignity, honour, or face. It was hypothesised that the emphasis on harmony within face cultures would reduce the relevance of need for approval from others to face-negotiation concerns. Respondents rated their need for approval from others and how much they sought to preserve their own face and the face of the other party during the conflict. Need for approval was associated with concerns for both self-face and other-face. However, as predicted, the association between need for approval from others and concern for self-face was weaker where face logic was prevalent. Favourable conflict outcome was positively related to other-face and negatively related to self-face and to need for approval from others, but there were no significant interactions related to prevailing cultural logics. The results illustrate how particular face-threatening factors can moderate the distinctive face-concerns earlier found to characterise individualistic and collectivistic cultural groups.
Policy as normative influence? On the relationship between parental leave policy and social norms in gender division of childcare across 48 countries

Schindler S, Schuster C, Olsson MIT, Froehlich L, Hübner AK, Block K, et al.

Br J Soc Psychol, 2025 Apr;64(2):e12806.
PMID: 39439425 DOI: 10.1111/bjso.12806

In the present work, we addressed the relationship between parental leave policies and social norms. Using a pre-registered, cross-national approach, we examined the relationship between parental leave policies and the perception of social norms for the gender division of childcare. In this study, 19,259 students (11,924 women) from 48 countries indicated the degree to which they believe childcare is (descriptive norm) and should be (prescriptive norm) equally divided among mothers and fathers. Policies were primarily operationalized as the existence of parental leave options in the respective country. The descriptive and prescriptive norms of equal division of childcare were stronger when parental leave was available in a country - also when controlling for potential confounding variables. Moreover, analyses of time since policy change suggested that policy change may initially affect prescriptive norms and then descriptive norms at a later point. However, due to the cross-sectional nature of the data, drawing causal inferences is difficult.

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