Displaying publications 1 - 20 of 109 in total

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  1. Hayati IN, Ismail Y, Zurkurnain Y
    Med J Malaysia, 1993 Dec;48(4):416-20.
    PMID: 8183165
    Between January 1990 and December 1991, 100 cases of extrapulmonary tuberculosis were identified at the General Hospital Kota Bharu representing 11% of all the newly diagnosed tuberculosis. It was commonest in the third decade of life and the sites involved were the lymph nodes (34%), osteoarticular (14%), miliary (12%) and pleura (10%). Tuberculous lymphadenitis appears to be more common in females and younger patients. Fourteen patients had concurrent active pulmonary tuberculosis and in 36 others the chest X-rays showed satisfactory response to standard chemotherapy. Six patients died and six were lost to follow-up.
  2. Ross IN, Abraham T
    Trans R Soc Trop Med Hyg, 1987;81(3):374-7.
    PMID: 3686631
    We used Bayes' theorem to calculate the probability of enteric fever in 260 patients presenting with undiagnosed fever, without recourse to blood or stool culture results. These individuals were divided into 110 patients with enteric fever (63 culture positive, 47 culture negative) and 150 patients with other causes of fever. Comparison of the frequencies of occurrence of 19 clinical and laboratory events, said to be helpful in the diagnosis of enteric fever, in the two groups revealed that only 8 events were significantly more frequent in enteric fever. These were: a positive Widal test at a screening dilution of 1:40; a peak temperature greater than = 39 degrees C; previous treatment for the fever; a white blood cell count less than 9 X 10(6)/litre; a polymorphonuclear leucocyte count less than 3.5 X 10(6)/litre; splenomegaly; fever duration greater than 7 d; and hepatomegaly. When the probability of enteric fever was determined prospectively in 110 patients, using only 6 of these discriminating events, the probability of patients with a positive prediction having enteric fever (diagnostic specificity) was 0.80 (95% confidence interval: 0.68 to 0.91) and the probability of those with a negative prediction not having enteric fever (diagnostic sensitivity) was 0.92 (0.85 to 0.99). Using all 19 events did not alter the diagnostic specificity or diagnostic sensitivity. This study shows that a small number of clinical and laboratory features can objectively discriminate enteric fever from other causes of fever in the majority of patients. Calculating the probability of enteric fever can aid in diagnosis, when culturing for salmonella is either unavailable or is negative.
  3. Ismail IN, Alaga A
    Med J Malaysia, 2023 Nov;78(6):751-755.
    PMID: 38031216
    INTRODUCTION: Ultrasound guided lung biopsy (USLB) is a minimally invasive diagnostic tool with short examination time and real-time monitoring conducted bedside for accurate diagnosis in order to provide the best treatment. However, it is not widely performed by pulmonologists. We aim to explicate the efficacy and safety of USLB led by pulmonologists. The objective of this study is to assess safety and efficacy of USLB performed by pulmonologists in an outpatient setting.

    MATERIALS AND METHODS: We retrospectively enrolled patients who underwent the procedure from January 2018 to April 2022. Under real time ultrasound (Hitachi Medical ProSound F37), thoracic lesions adjacent to the chest wall were sampled with a full-core biopsy needle (CT Core Single Action Biopsy Device, 18G × 15 cm, Vigeo, Italy). Chest x-ray was performed 30 minutes post procedure ruling out pneumothorax. Patients were discharged home 1-2 hours post biopsy. Data was analysed using Microsoft Excel 2010 and Statistical Package for Social Science (SPSS) Version 26.

    RESULTS: A total of 18 patients (14 males, 4 females) underwent USLB for lung tumours. Biopsies were histologically deemed adequate with an overall diagnostic yield of 77.8% (14/18). A total of 57% were positive for thoracic malignancy (21% squamous cell carcinoma, 21% adenocarcinoma, 15% small cell carcinoma) and another 43% were positive for extra thoracic malignancy (1 hepatocellular carcinoma, 2 DLBCL, 1 Hodgkin's lymphoma, 1 seminoma, 1 thymoma). Four patients had inconclusive results but managed to get positive results from surgical or lymph node biopsy (thymoma and adenocarcinoma). Statistical analysis showed more than two passes are needed to achieve a positive HPE yield (p value<0.05). There were nil complications to all the cases done.

    CONCLUSIONS: USLB can safely and effectively be performed by trained pulmonologists with excellent accuracy and low complication rate in outpatients.

  4. Suderman, N., Isa, M. I. N., Sarbon, N. M.
    MyJurnal
    The purpose of this study was to investigate the functional properties (thickness; water vapor
    permeability (WVP); film microstructure, tensile strength (TS) and biodegradability) of
    carboxymethyl cellulose (CMC)/gelatin (gel)/chitosan (chi) biocomposite film as influenced
    by different drying temperature (25 and 60 °C). Seven formulations (CMC/gel/chi) prepared
    were control (100/0/0), formulations A (80/20/0), B (80/0/20), C (80/10/10), D (60/20/20),
    E (60/30/10), and F (60/10/30). Different drying temperature resulted in different time taken
    for the film to dry. Results revealed that formulation F was optimal due to its high tensile
    strength and low WVP rate which support its biodegradability for both drying conditions. FTIR
    assay revealed a strong carboxyl group for CMC, which contributed to high biodegradability
    results (85.3 vs. 85.50%) for room vs. oven dried specimens, respectively. Such desirable
    characteristics demonstrated that film F holds remarkable potential as edible films material
    with enhanced positive impacts on the environment and community.
  5. Sundus, S., Memoona, S., Muhammad, I. N., Rashid, H. N.
    MyJurnal
    Asthma is one of the chronic and long-term diseases of the airways. It is characterized by reversible airflow obstruction, chest tightness, and dyspnea with decreased work of breathing. The inside airway’s walls are swollen or inflamed. The aim of this study was to determine the effectiveness of active cycle of breathing technique as an airway clearance technique in patients with asthma. The health-related quality of life and functional capacity of patients was measured using a standardized airway questionnaire (AQ20) and six-minute walk test. The study was cohort design included 38 patients (mean age 41.131±14.711) of both genders with mild to moderate asthma. Each patient received multiple sessions (3 times/week for one month) of active cycle of breathing technique. Pre and post-treatment measures were recorded for functional capacity and health-related quality of life in the form of six-minute walk test and standardized airway questionnaire. All 38 patients were stable during the study period. The health-related quality of life and functional capacity of patient significantly improved post-treatment sessions with means [205.375±93.594 for week 1, 1248.719±112.187 for week 2, 306.429±140.5554 for week 3, 337.245±134.389 for week 4], for six-minute wall test and mean difference 4.13± 2.3 SD for standardized airway questionnaire with p-value (0.00) significant upon paired t-test. It is concluded that the active cycle of breathing technique is very beneficial intervention for improving quality of life and functional capacity of patients with mild to moderate asthma. Further, investigations are required to explore efficiency of ABCT as a tool for cardio-pulmonary rehabilitation.
  6. Ahmad NH, Isa MIN
    Carbohydr Polym, 2016 Feb 10;137:426-432.
    PMID: 26686147 DOI: 10.1016/j.carbpol.2015.10.092
    Two solid biopolymer electrolytes (SBEs) systems of carboxymethyl cellulose doped ammonium chloride (CMC-AC) and propylene carbonate plasticized (CMC-AC-PC) were prepared via solution casting technique. The ionic conductivity of SBEs were analyzed using electrical impedance spectroscopy (EIS) in the frequency range of 50 Hz-1 MHz at ambient temperature (303K). The highest ionic conductivity of CMC-AC SBE is 1.43 × 10(-3)S/cm for 16 wt.% of AC while the highest conductivity of plasticized SBE system is 1.01 × 10(-2)S/cm when added with 8 wt.% of PC. TGA/DSC showed that the addition of PC had increased the decomposition temperature compared of CMC-AC SBE. Fourier transform infrared (FTIR) spectra showed the occurrence of complexation between the SBE components and it is proved successfully executed by Gaussian software. X-ray diffraction (XRD) indicated that amorphous nature of SBEs. It is believed that the PC is one of the most promising plasticizer to enhance the ionic conductivity and performance for SBE system.
  7. Ross IN, Dass PK
    Med J Malaysia, 1985 Sep;40(3):225-32.
    PMID: 3842717
    We analysed clinical and histological diagnoses in patients admitted with liver-related illnesses in order to determine the spectrum ofliver disease in our community. In a total of 380 such patients, liver disease was sixfold more frequent in males than in females. Admissions for cirrhosis were more common amongst the Indian ethnic group. Indians constituted 39% of the admissions (expected 11. 7%), Chinese 37% (expected 51%) and Malays 21% (expected 36%) (~2 = 293, p = H 0.001). Liver histology from 179 of the patients was reviewed blind by one pathologist. Based on the histological findings, the pre-biopsy diagnosis was 'wrongin 75%of cases. The age standardized incidence rate of hepatocellular carcinoma was 22/100,000/year in males 225 and 5/100,000/year in females. However, the peak age of onset was in the seventh decade and the age specific incidence in males aged 60 years or older was 93/100,000/year. The ethnic group representation of patients with hepatocellular carcinoma did notshow a racial preponderance. This study highlights a public health problem related to acute viral hepatitis and alcohol abuse. It also confirms a high incidence of hepatocellular carcinoma
  8. Ramlli MA, Isa MI
    J Phys Chem B, 2016 11 10;120(44):11567-11573.
    PMID: 27723333
    Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and transference number measurement (TNM) techniques were applied to investigate the complexation, structural, and ionic transport properties of and the dominant charge-carrier species in a solid biopolymer electrolyte (SBE) system based on carboxymethyl cellulose (CMC) doped with ammonium fluoride (NH4F), which was prepared via a solution casting technique. The SBEs were partially opaque in appearance, with no phase separation. The presence of interactions between the host polymer (CMC) and the ionic dopant (NH4F) was proven by FT-IR analysis at the C-O band. XRD spectra analyzed using Origin 8 software disclose that the degree of crystallinity (χc%) of the SBEs decreased with the addition of NH4F, indicating an increase in the amorphous nature of the SBEs. Analysis of the ionic transport properties reveals that the ionic conductivity of the SBEs is dependent on the ionic mobility (μ) and diffusion of ions (D). TNM analysis confirms that the SBEs are proton conductors.
  9. Hafiza MN, Isa MI
    Carbohydr Polym, 2017 Jun 01;165:123-131.
    PMID: 28363531 DOI: 10.1016/j.carbpol.2017.02.033
    Addition of doping materials can possibly enhance the ionic conduction of solid polymer electrolyte (SPE). In this work, a new SPE using 2-hydroxyethyl cellulose (2-HEC) incorporated with different ammonium nitrate (NH4NO3) composition was prepared via solution casting method. Studies of structural properties were conducted to correlate the ionic conductivity of 2-HECNH4NO3SPE using X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. Encouraging result was obtained as the ionic conductivity increased about two orders of magnitude upon addition of 12wt% of NH4NO3. XRD analysis shows the most amorphous SPE was obtained at 12-NH4NO3. From FTIR spectra, the interactions between 2-HEC and NH4NO3were observed by the shifts of COH peak from 1355cm-1to 1330cm-1and the presence of new NH peak in the OH region. The spectrum has been validated theoretically using Gaussian software. The results obtained from this study corroborate that the complexes of 2-HEC and NH4NO3responsible to promote the ionic conductivity to the higher value.
  10. Ross IN, Jayakumar CR
    Singapore Med J, 1987 Aug;28(4):314-7.
    PMID: 3423798
    We determined the prevalence of cholelithiasis, by ultrasound in 728 Asian subjects and calculated the annual incidence of disease amongst the gallstone carriers. The prevalence of asymptomatic cholelithiasis in the age group> 29 years, was 11.8% (95% confidence interval: 7.2-16.4%) in males and 13.7% (8.4-19.0%) in females. The median diameter of the stones 10mm (range 4-17) did not differ from that of symptomatic stones - 12.5mm (3·21). The odds of having cholelithiasis increased by 5% each year of life (p 29 years) developing symptoms leading to a hospltal-based investigation was estimated as only 1/1000, whilst the annual cholecystectomy rate was 6/100,000. The chance of a carrier having a cholecystectomy in Malaysia was approximately 5 times less than the chance in the United Kingdom. We conclude that asymptomatic gallstones are common In Malaysians, but the risk of disease is low. The low cholecystectomy rate may be the result of a conservative approach to cholelithiasis due to limited surgical resources.
  11. Chai MN, Isa MI
    Sci Rep, 2016 Jun 06;6:27328.
    PMID: 27265642 DOI: 10.1038/srep27328
    The plasticized solid bio-polymer electrolytes (SBEs) system has been formed by introducing glycerol (Gly) as the plasticizer into the carboxymethyl cellulose (CMC) doped with oleic acid (OA) via solution casting techniques. The ionic conductivity of the plasticized SBEs has been studied using Electrical Impedance Spectroscopy. The highest conductivity achieved is 1.64 × 10(-4) S cm(-1) for system containing 40 wt. % of glycerol. FTIR deconvolution technique had shown that the conductivity of CMC-OA-Gly SBEs is primarily influenced by the number density of mobile ions. Transference number measurement has shown that the cation diffusion coefficient and ionic mobility is higher than anion which proved the plasticized polymer system is a proton conductor.
  12. Chan RS, Vijayananthan A, Kumar G, Hilmi IN
    Med J Malaysia, 2012 Aug;67(4):424-5.
    PMID: 23082456
    Endoscopic injection of N-Butyl-2-cyanoacrylate is a widely accepted treatment for esophagogastric varices. This procedure is commonly associated with minor complications which include transient pyrexia and abdominal discomfort. Serious vascular complications secondary to systemic embolization of cyanoacrylate have rarely been reported. We describe the CT findings of extensive splenic infarction in a patient following cyanoacrylate injection for gastric varices.
  13. Soelaiman IN, Merican Z, Mohamed J, Kadir KB
    Asia Pac J Clin Nutr, 1996 Dec;5(4):244-8.
    PMID: 24394618
    We determined the relative atherogenicity of two saturated fats by studying their effects on lipid peroxidation (LP), by way of malonaldehyde (MDA) and conjugated dienes (CD) and glutathione peroxidase (GSHPx) activity in serum, liver and heart; and on serum lipid profile after 4 months and 9 months of feeding. Male Rattus norwegicus rats were fed a basal diet (control) or basal diet fortified with 20% weight/weight butterfat (ghee) (BF) or coconut oil (CO). Serum high-density-lipoprotein-cholesterol (HDL-chol) and HDL-chol:LDL-chol ratio was lower in the BF group compared to CO after both feeding periods. Conjugated dienes (CDs) were higher in the serum and liver after 4 months, and heart after 9 months, of the rats fed BF compared to CO. Serum low-density-lipoprotein-cholesterol (LDL-chol) was higher, but CD were lower at 9 months than at 4 months feeding for all three groups. Liver and heart MDA and CD were higher in both groups after 9 months compared to 4 months. Liver GSHPx activity was higher after 9 months compared to 4 months in the BF group. Heart GSHPx activity was lower after 9 months compared to 4 months for both BF and CO groups. In conclusion, BF is potentially more atherogenic than CO in terms of serum lipids and LP. The unfavourable responses in serum lipids, with the exception of triglycerides, and LP were exaggerated with the longer duration of feeding with both oils.
  14. Ibrahim NNIN, Rasool AHG
    Skin Res Technol, 2017 Aug;23(3):321-325.
    PMID: 27868242 DOI: 10.1111/srt.12338
    BACKGROUND: Pulse wave analysis (PWA) and laser Doppler fluximetry (LDF) are non-invasive methods of assessing macrovascular endothelial function and microvascular reactivity respectively. The aim of this study was to assess the correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF.

    METHOD: 297 healthy and non-smoking subjects (159 females, mean age (±SD) 23.56 ± 4.54 years) underwent microvascular reactivity assessment using LDF followed by macrovascular endothelial function assessments using PWA.

    RESULTS: Pearson's correlation showed no correlation between macrovascular endothelial function and microvascular reactivity (r = -0.10, P = 0.12).

    CONCLUSION: There was no significant correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF in healthy subjects.

  15. Guspianto G, Ibnu IN, Veruswati M, Asyary A
    Ann Ig, 2023;35(2):149-158.
    PMID: 35603972 DOI: 10.7416/ai.2022.2529
    BACKGROUND: Postpartum care (postnatal care, or PNC) is crucial for the health of mothers and newborns. After child delivery, mothers and babies should have optimal access to the health care system to utilize the facilities and skilled health workers. The involvement of men has a positive impact on the use of PNC and plays an important role in reducing delays, especially in preventing maternal and newborn deaths.

    OBJECTIVES: This study assessed the level of the involvement of men in PNC and analyzed the factors that determined this involvement.

    METHODS: A cross-sectional study was conducted through a survey of 381 males who were selected by multistage random sampling in Muaro Jambi, Indonesia, from April to August 2020. The dependent variable was the involvement of men in PNC, which was constructed from four dichotomous indicators. Multiple logistic regression analysis was performed using SPSS 24.0 at a significance level of 0.05.

    RESULTS: Over 50% of respondents were highly involved in PNC, with the predicting factors being the number of children (OR = 2.195, 95% CI = 1.096-4.397), the quality of health service (OR = 6.072, 95% CI = 3.324-11.09), communication (OR = 6.908, 95% CI = 3.255-14.66), and culture (OR = 4.031, 95% CI = 2.196-7.399). The communication factor was the main predictor of male involvement in PNC in Muaro Jambi Regency.

    CONCLUSION: The involvement of men in PNC in Muaro Jambi Regency was related to the number of children, quality of health service, communication, and culture. Counseling "as a couple" is needed to improve the communication between husband and wife so that they can understand each other's needs in PNC.

  16. Ross IN, Nair S, Jayakumar CR
    Singapore Med J, 1985 Jun;26(3):271-8.
    PMID: 4048988
    The results of 2449 investigations of the upper gastrointestinal tract were analysed to determine the incidence of disease. Abnormalities were detected in 53% of patients who had endoscopy, but were found in only 24% of patients who had barium studies (p <= 0.001). Altogether 916 patients had abnormal findings. Duodenal ulcer accounted for 42% of cases, gastric ulcer 16% and gastric cancer 9%. The prevalence of perforated ulcer was 13%. The annual incidence/1000 in males and females (>14 years) were respectively, for duodenal ulcer 1.66 and 0.42, for gastric ulcer 0.57 and 0.25, for perforated ulcer 0.36 and 0.05, and for gastric cancer 0.29 and 0.14. Most types of gastro-duodenal disease were less common in Malays than expected (p = <0.001). However oesophageal cancer and varices were more common in Indians compared to Malays and Chinese (p = <0.001). This study showed that the pallern of perforating ulcers was not the same as that of non-peforating ulcers, suggesting a differing pathogenesis. Identification of the factors causing a different prevalence of disease between the three ethnic groups would help in the understanding of the causes of upper gastrointestinal disease.
  17. Ahmad M, Dhanasekar B, Aparna IN, Naim H
    J Indian Prosthodont Soc, 2014 Sep;14(3):297-300.
    PMID: 25183915 DOI: 10.1007/s13191-012-0188-8
    As more and more dental practitioners are focusing on implant-supported fixed restorations, some clinicians favor the use of cement retained restorations while others consider screw-retained prosthesis to be the best choice. As both types of prostheses have certain advantages and disadvantages, clinicians should be aware of the limitations of each type. Screw-retained implant restorations have an advantage of predictable retention, retrievability and lack of potentially retained sub-gingival cement. However, a few disadvantages exist such as precise placement of the implant for optimal and esthetic location of the screw access hole and obtaining passive fit. On the other hand, cement retained restorations eliminates unaesthetic screw access holes; have passive fit of castings; reduce stress to splinted implants because of minor misfit of the framework; reduced complexity of lab procedures; enhanced esthetics; reduced cost factors and non disrupted morphology of the occlusal table. This case report presents the replacement of missing left central incisor using screw-retained implant prosthesis due to palatal trajectory of the implant placement and inadequate abutment height for retention of cement retained prosthesis.
  18. Ibrahim, M. I., Mohd Norsuddin, N., Che Isa, I. N., Azman, N. F., Mohamad Shahimin, M.
    MyJurnal
    The radiographer's role in the imaging field is producing the best image to diagnose. Hence, this study is conducted to justify the ability of radiographers in terms of diagnostic performance and visual search patterns during radiographic image interpretation based on their experience. The musculoskeletal radiographic images were chosen as radiographers are expected to perform image interpretation in the red dot system as one of the expanded and extended roles of the radiographer. Sensitivity and specificity in the detection of abnormality are measured. The gaze plot, fixation count and duration are compared between groups of radiographers by using an eye tracker. 19 radiographic images consist of upper and lower extremities are used as stimuli in this study. The result from this study shows no significant difference in terms of sensitivity and specificity with a p-value of 0.818 and 0.146 respectively. For visual search pattern, two images have significant different in term of fixation count (Image 1, p = 0.017; Image 2, p = 0.042) and two images in fixation duration (Image 1, p = 0.001; Image 15, p = 0.021). The gaze plot is not different from an unstructured pattern and less coverage. In conclusion, the experience did not give an influence on the radiographic image interpretation. This may suggest that specific training in areas appropriate to the development of the radiographer could improve the image interpretation.
  19. Nazmi, N. N. M., Isa, M. I. N., Sarbon, N. M.
    MyJurnal
    Protein-based films are thin and flexible films derived from protein sources. They are
    completely biodegradable and used in food engineering, packaging, drug recovery, and other
    applications. In food packaging, gelatin is widely used due to properties such as low cost,
    availability, functional attributes, mechanical (flexibility and tension) and optical (brightness
    and opacity) strength, barrier against gas flow, and structural resistance to water and
    microorganisms. Therefore, this paper reviews the characterisation of biodegradable
    protein-based films from gelatin alternatives, mainly from fish and chicken skin, as food
    packaging materials. The properties of film packaging derived from gelatin alternatives were
    compared with films derived from mammalian gelatin. The findings showed that the blended
    gelatin alternatives with polysaccharide improved physical properties such as water vapour
    permeability, gas permeability, light transmission and transparency, thermal properties,
    microstructure, colour, and heat sealability. Moreover, improvements in mechanical
    properties such as tensile strength and elongation at break were also investigated. This review
    also comes out with suggestions for future research on the compatibility between gelatin films
    and food ingredients. This paper provides a comprehensive overview that promotes the
    development of biodegradable blended films from gelatin alternatives for packaging
    applications in the food industry and related fields.
  20. Jahit, I. S., Nazmi, N. N. M., Isa, M. I. N., Sarbon, N. M.
    MyJurnal
    This study examined the effects of drying temperatures (25 and 45 °C) on the physical properties
    of different formulations of gelatin/CMC/chitosan composite films. The physical properties
    of each formulated film were assessed via Fourier Transform Infra-Red (FTIR) spectroscopy,
    X-Ray Diffractometry (XRD), Water Vapour Permeability (WVP) and biodegradability. The
    incorporation of CMC and chitosan significantly influenced film properties. Increased chitosan
    concentrations reduced the film’s amorphous character by increasing its crystalline structure.
    The blended films also exhibited amino peaks that shifted from 1542 to ~1548 cm-1 while NH
    and/or OH peaks shifted from 3384 to 3288 cm-1. Formulation E had the second lowest WVP
    for both drying condition and the highest weight loss for biodegradability after burial in soil for
    5 days. In conclusion, different temperature did not affect the properties of film produced and
    formulation E qualified as ‘high quality packaging material’ with promising potential for the
    food packaging industry.
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