MyMedR

Standard uroflowmetry is performed in a standing position and it is an important investigation for those who are suspected of having lower urinary tract symptoms such as benign prostatic hyperplasia (BPH). Effects of changing positions during uroflowmetry have also been investigated previously but mixed conclusions were made. For Muslims, voiding in squatting position is encouraged as part as daily practice. This is mainly due to cleanliness reason and many Hadiths have emphasised about it. Objective: The aim of this study is to compare uroflowmetry findings between squatting and standing positions amongst BPH patients attending urology clinic Hospital Tengku Ampuan Afzan (HTAA). Methods: This is a cross section observational study carried outfrom March 2015 to December 2015. The maximum flow rate, average flow rate, voiding volume, total voiding time and post-voiding residual volume were measured and recorded. Results:The results were then compared and analysed. 64.2% of patients were non-Muslims. 78.0% of the patients voiding habit were standing and 12.2% squatting position at home. The average International Prostate Symptom Score (IPSS) was 12.07 and 63.4% of them were in moderate group disease. Post void residual (PVR) volume showed a reduction in squatting position (p

Fulltext RE: Emphysematous pyelonephritis: Is nephrectomy warranted?

Kamarulzaman MN, Mohamed SK

Urol Ann, 2016 Apr-Jun;8(2):258-9.

PMID: 27141208 DOI: 10.4103/0974-7796.179236

Fulltext RE: The value of testicular ultrasound in the prediction of the type and size of testicular tumors

Kamarulzaman MN, Mohamed SK

Int Braz J Urol, 2016 Mar-Apr;42(2):397-8.

PMID: 27256199 DOI: 10.1590/S1677-5538.IBJU.2015.0728

Fulltext A rare cause of acute urinary retention in a young man: A median raphe penile cyst

Kamarulzaman MN, Chik A, Ghazali H

Malays Fam Physician, 2021 Mar 25;16(1):114-116.

PMID: 33948149 DOI: 10.51866/cr1016

Background: A penile median raphe cyst is an uncommon congenital lesion that is formed due to failure of the median raphe to close completely during embryo development. The majority of the cysts are asymptomatic and often go unnoticed. Here, we report acute urinary retention as a very rare complication of a penile median raphe cyst.

Case presentation: A 21-year-old single man presented with a sudden onset of acute urinary retention of one days' duration. Urethral catheterization was done at the Emergency Department and this drained 800 ml of urine. On further questioning, he claimed that he had had a painless nodule at the glans penis since childhood. The swelling increased in size in the past week causing discomfort. He denied any history of genitalia trauma or recent sexual intercourse. On examination, there was a bluish lesion over the ventral aspect of the glans penis measuring about 3 x 2 cm. The lesion was later excised and histopathology revealed a median raphe cyst of the penis.

Conclusion: A penile median raphe cyst is a rare lesion. Acute urinary retention caused by this lesion is very rare.

Fulltext Colonic Perforation in Percutaneous Nephrolithotomy: A Case Report

Mohd Fahmi AAziz, NE Mahno, Mohd Nazli MZ, Siti Kamariah CM

IIUM Medical Journal Malaysia, 2019;18(101):10-0.

MyJurnal

We aim to report a rare case of colonic perforation post percutaneous nephrolithotomy (PCNL) and its conservative management.We report a 63-year-old Malay, thalassemia carrier male who underwent an uncomplicated left PCNL fora left renal stone. On second postoperative day, clinically evidence of subcutaneous emphysema. Serial CXR imaging confirmed presence of air under diaphragm. Small colonic perforation was diagnosed which subsequently developed localized collection retroperitoenally. He was successfully treated with non-operative management including intravenous antibiotic, surgical drainage and good nutrional has successfully support healed the collection. Serial CT renal protocol showed a healed retroperitoneal collection and patient made a good clinical recovery.PCNL has promising stone clearance rate. However, it carries complications. A rare yet important complication; colonic perforation is a serious complication that if detected earlier, good clinical recovery can be achieved conservatively.

Fulltext Ruptured Testicular Abscess: A Rare Complication of Epididymo-Orchitis

Lee CY, Abu Syazwan, Syed Omar, Syahril Anuar, Hamid Ghazali, Mohd Nazli, et al.

IIUM Medical Journal Malaysia, 2019;18(101):8-0.

MyJurnal

Epididymo-orchitis is a medical condition characterised by inflammation of epididymis and testis which is a common urological diagnosis encountered by healthcare professionals. Misdiagnosis and under treatment can lead to poor outcome such as infarction and abscess formation.We presented a33-year-old man, with no known medical illness, presented with one-week history of left testicular pain, swelling and fever. He was commenced on Amoxicillin by his general practitioner. Physical examination showed left swollen and tender testis and normal right testis. Investigations showed an elevated white cell count (WCC) 41.3x103 /L and colour doppler ultrasound (USG) testes showed left epididymo-orhitis.He was admitted and treated with IV Unasyn®(Ampicillin+Sulbactam) for 5 days. His symptoms improved, and he discharged home well with one week oral Unasyn®. He represented 2 weeks later with worsening left scrotal swelling and pain. Clinical examination found a swollen, tender and erythematous scrotum with 1x1cm defect in the left scrotum with purulent discharge.He underwent operation incision and drainage of left scrotum and left orchidectomy. Post-operatively he recovered well. Histopathology reported as epididimo-orchitis with abscess, necrosis and perforation.As a conclusion, testicular rupture and abscess formation secondary to epididymo-orchitis is an uncommon reported complication. Immediate recognition and treatment is crucial as a delayed diagnosis can lead to sepsis and infertility.

Fulltext Management of Traumatic Perineal DeglovingInjury: A Case Series

Lee CY, Abu Syazwan, Syed Omar, Syahril Anuar, Hamid Ghazali, Islah Munjih, et al.

IIUM Medical Journal Malaysia, 2019;18(101):9-0.

MyJurnal

Degloving injury is severe and commonly results from a huge rotational force which avulses the skin and subcutaneous tissue from its underlying fascia. This injury is associated with high morbidity and mortality if mismanaged. Perineal degloving injury commonly associated with urethral injury which can be further classified into anterior and posterior urethral injury. This study retrospectively evaluated management of traumatic perineal degloving injury compared to standard approach.A total of 3 cases of open perineal degloving injuries been identified and was managed at our centre at the year 2017. 2 cases of degloving wound of scrotum and one case of crush perineal injury with transected posterior urethral were included. We reviewed methods of management and clinical outcomes of these patients. All patients promptly underwent wound debridement and surgical repair after immediate diagnosis and resuscitation. Suprapubic insertion of catheter is crucial in managing the urethral injury. The case of crush perineal injury with transected urethral treated with operation primary urethral anastomosis, de-functioning of stoma and external fixation of pelvis. Unfortunately, this case was complicated with rupture at anastomotic urethral site after a traumatic CBD insertion during his hospitalization and he was treated conservatively with CBD. All patients did well clinically with their wounds healed well.We showed a multidisciplinary team approach consisting of colorectal surgeon, urologist, orthopaedics surgeon and plastic surgeon, together with prompt diagnosis provides the best outcome were for the treatment of open perineal degloving injury.

Fulltext Evaluation of solvent extraction of Amaranth betacyanins using multivariate analysis

Chong, P.H., Yusof, Y.A., Aziz, M.G., Mohd. Nazli, N., Chin, N.L., Syed Muhammad, S.K.

International Food Research Journal, 2014;21(4):1569-1573.

MyJurnal

The present study was aimed at assessing the effect of solvents on the yield and the color properties of amaranth extract. Two species of amaranth namely Amaranthus gangeticus and Amaranthus blitum were extracted with water, methanol and ethanol. Seven parameters like betacyanin content, total soluble solids, lightness (L*), redness (a*), yellowness (b*), hue angle (h*) and chroma (c*) were analyzed to assess extraction efficiency. Correlation analysis was carried out to assess the linear association among the analytical variables. Principal component analysis was used to establish the relationships between the different analytical variables and to detect the most important factors of variability. Among the two varieties, Amaranthus gangeticus extract contained about two and half time more betacyanin with half of total soluble solids compared to Amaranthus blitum. Water is the best as solvent for extracting betacyanin from Amaranthus gangeticus and ethanol in case of Amaranthus blitum. Among the analytical parameters, a* and c* were perfectly correlated. Three principal components were found among the seven analytical variables accounting 88% of total variability. The first principal components mostly reflected the redness (a*), whereas the second principal components reflected the betacyanin content, total soluble solids and lightness (L* value).

A review: potential usage of cellulose nanofibers (CNF) for enzyme immobilization via covalent interactions

Sulaiman S, Mokhtar MN, Naim MN, Baharuddin AS, Sulaiman A

Appl Biochem Biotechnol, 2015 Feb;175(4):1817-42.

PMID: 25427594 DOI: 10.1007/s12010-014-1417-x

Nanobiocatalysis is a new frontier of emerging nanosized material support in enzyme immobilization application. This paper is about a comprehensive review on cellulose nanofibers (CNF), including their structure, surface modification, chemical coupling for enzyme immobilization, and potential applications. The CNF surface consists of mainly -OH functional group that can be directly interacted weakly with enzyme, and its binding can be improved by surface modification and interaction of chemical coupling that forms a strong and stable covalent immobilization of enzyme. The knowledge of covalent interaction for enzyme immobilization is important to provide more efficient interaction between CNF support and enzyme molecule. Enzyme immobilization onto CNF is having potential for improving enzymatic performance and production yield, as well as contributing toward green technology and sustainable sources.

Fulltext Computed Tomography (CT) of Blunt Abdominal Trauma: The Frequency of Incidental Findings, how it was Documented in Radiology Report and the Implication of These Findings to Acute Trauma Care

Radhiana H, Siti Kamariah CM, Mohd Nazli K, Azian AA

Med J Malaysia, 2014 Feb;69(1):46-8.

PMID: 24814633 MyJurnal

The wide use of computed tomography (CT) scanning for patients with blunt abdominal trauma can reveal incidental findings that vary in their importance. We evaluated these findings, how it was reported by radiologists and its implication on the trauma care. In 30 out of 154 patients, 32 incidental findings were discovered (19.5%). Out of these 32 findings, only 3 cases (9.4%) were considered significant and required immediate attention from the managing team. In all these 3 cases, the findings were described in the body of the report and highlighted in the conclusion section at the end of the radiology report. However, similar reporting style was used in only 58.4% of cases with moderate clinical concern and 23.5% of cases with little clinical concern. In 41.2% of cases with little concern, the incidental findings were not mentioned in the radiology report. In conclusion, incidental findings in CT scan performed for blunt abdominal trauma were common but many were clinically insignificant. There is little consistency in radiology reporting of these findings especially those with moderate and little clinical concern.

Effect of thymol on properties of bionanocomposites from poly (lactic acid)/poly (butylene succinate)/nanofibrillated cellulose for food packaging application

Zabidi N', Zainal NN, Tawakkal ISMA, Mohd Basri MS, Ariffin SH, Naim MN

Int J Biol Macromol, 2023 Aug 09;251:126212.

PMID: 37567533 DOI: 10.1016/j.ijbiomac.2023.126212

The present study developed the formulation of active bionanocomposites films endowed with the abilities of high biodegradability and antimicrobials for active packaging applications. The aim of this work was to prepare poly (lactic acid)/poly (butylene succinate) (PLA/PBS) blended films reinforced with different concentrations of nanofibrillated cellulose (NFC) and 9 % of thymol essential oil (EO) using the casting method. The active films were further evaluated through Fourier transform infrared spectroscopy (FTIR); as well as mechanical, physical, water vapour permeability (WVP), thermal analysis (TGA), biodegradation, morphological, and antimicrobial (% reduction of bacteria) testing. The tensile strength (TS) of PLA/PBS blend films increased by 12 % with the incorporation of 2 wt% of NFC. The PLA/PBS/NFC with 9 % thymol EO has a good water barrier performance with its tensile strength, elongation at break, and tensile modulus was 13.2 MPa, 13.1 %, and 513 MPa respectively. The presence of NFC promoted the disintegration of PLA/PBS films by 70.5 %. These films promoted the antibacterial activity against S. aureus and E. coli. The study demonstrates that the developed films improved the qualities of chicken fillets and have great potential to be used as active bionanocomposites in food packaging applications.

Fulltext Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia

Zainulabid UA, Mat Yassim AS, Hussain M, Aslam A, Soffian SN, Mohd Ibrahim MS, et al.

PLoS One, 2022;17(2):e0263678.

PMID: 35213571 DOI: 10.1371/journal.pone.0263678

SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is no exception. WGS has been a crucial approach in studying the evolution and genetic diversity of SARS-CoV-2 in the ongoing pandemic. Despite considerable number of SARS-CoV-2 genome sequences have been submitted to GISAID and NCBI databases, there is still scarcity of data from Malaysia. This study aims to report new Malaysian lineages of the virus, responsible for the sustained spikes in COVID-19 cases during the third wave of the pandemic. Patients with nasopharyngeal and/or oropharyngeal swabs confirmed COVID-19 positive by real-time RT-PCR with CT value < 25 were chosen for WGS. The selected SARS-CoV-2 isolates were then sequenced, characterized and analyzed along with 986 sequences of the dominant lineages of D614G variants currently circulating throughout Malaysia. The prevalence of clade GH and G formed strong ground for the presence of two Malaysian lineages of AU.2 and B.1.524 that has caused sustained spikes of cases in the country. Statistical analysis on the association of gender and age group with Malaysian lineages revealed a significant association (p <0.05). Phylogenetic analysis revealed dispersion of 41 lineages, of these, 22 lineages are still active. Mutational analysis showed presence of unique G1223C missense mutation in transmembrane domain of the spike protein. For better understanding of the SARS-CoV-2 evolution in Malaysia especially with reference to the reported lineages, large scale studies based on WGS are warranted.

Displaying all 19 publications