Displaying publications 1 - 20 of 289 in total

  1. Karikalan B, Pasupati T, George SM
    West Afr J Med, 2021 Jun 26;38(6):604-606.
    PMID: 34180217
    Adenocarcinoma constitutes around 0.5 to 2% of all neoplastic lesions of the urinary bladder, out of which, the mucinous variant is seen on rare occasions. Intestinal metaplasia resulting from nephrolithiasis, chronic inflammation and hydronephrosis could be the precursor lesion. Bladder exstrophy and remnants of the urachus are considered as other possible risk factors. The tumour prefers patients who are over 50 years. Hematuria, difficult voiding and suprapubic pain are the most common presenting symptoms. The tumour has a very bad prognosis and is poorly responsive to chemo and radiotherapy and hence surgery is the treatment of choice. Hence early diagnosis is of paramount importance. While managing adenocarcinoma of the bladder, it is important to rule out any possibility of a metastatic lesion that could have come from other organs where mucinous adenocarcinoma is more common.
    Matched MeSH terms: Adenocarcinoma*; Adenocarcinoma, Mucinous*
  2. Tharmaseelan NK, Sundralingam S
    Med J Malaysia, 1989 Dec;44(4):354-6.
    PMID: 2520049
    Adenocarcinoma of the fallopian tube is a rare clinical entity. The incidence of primary tubal carcinoma has been reported as varying from 0.1 to 1.0 percent of all gynaecological malignancies. In Malaysia the incidence is unknown. A case of primary adenocarcinoma of the fallopian tube is reported.
    Matched MeSH terms: Adenocarcinoma/diagnosis; Adenocarcinoma/pathology*; Adenocarcinoma/therapy
  3. Ho, C.C.K., Razman, J., Shaharin, S.
    Percutaneous needle procedures are known to carry the rare complication of seeding along the tract. Here we would like to present a case of seeding along a percutaneous transhepatic biliary drainage (PTBD) tract, to the skin, from a pancreatic adenocarcinoma.
    Matched MeSH terms: Adenocarcinoma
  4. Dutt AK, Kutty MK
    Med J Malaya, 1969 Jun;23(4):298-9.
    PMID: 4242177
    Matched MeSH terms: Adenocarcinoma*
  5. Ang KP, Chan PF, Hamid RA
    J Biol Inorg Chem, 2021 10;26(7):833-853.
    PMID: 34476610 DOI: 10.1007/s00775-021-01892-6
    Tricyclohexylphosphanegold(I) n-mercaptobenzoate (n = 2, 3, 4) labelled as 1-3 were previously reported to significantly suppress thioredoxin reductase (TrxR) activities towards ovarian cancer cells, A2780, in vitro. Herein, we explored the role of 1-3 for their apoptosis inducing ability against A2780 cells. 1-3 exhibited IC50 values at 1.19 ± 0.03 µM, 2.28 ± 0.04 μM and 0.78 ± 0.01 μM, respectively, compared to cisplatin at 26.8 ± 0.15 µM. The compounds induced A2780 apoptosis via a caspase-dependent mitochondrion pathway as evidenced by ROS production, cytochrome c release, caspases-3/7, -8, -9 and -10 activation, APAF1 and BAX upregulation as well as BCL2A1 and BCL2 genes' downregulation. In addition, the death mode of 1-3 was also mediated via death receptor extrinsic pathway manifested by FAS, FASL, FADD, and TNFR1 genes' upregulation via Human Rt PCR analysis. In addition, 1-3 significantly caused A2780 arrest at S phase, which was associated with the upregulation of TP53, E2F1, RB1 and CDKN1A upregulation and downregulation of CDK1, CDK4, CDC25A and CDC25C genes. Based on these promising results, these phosphanegold(I) thiolate derivatives could act as feasible candidates for further advanced in vivo ovarian cancer studies to develop novel chemotherapeutic agents derived from metal-based agents.
    Matched MeSH terms: Adenocarcinoma*
  6. Liam CK, Looi LM, Pailoor J, Alhady SF
    Ann Acad Med Singap, 1989 Nov;18(6):713-6.
    PMID: 2624423
    Three cases of progressive dyspnoea in young female adults due to pulmonary lymphangitic carcinomatosis are reported. The underlying primary neoplasm was gastric carcinoma in all 3 cases. The diagnosis was not suspected in 2 patients because of their young age.
    Matched MeSH terms: Adenocarcinoma/complications; Adenocarcinoma/secondary*
  7. Tan PH, Lui WO, Ong P, Lau LC, Tao M, Chong Y
    Cancer Genet. Cytogenet., 2000 Aug;121(1):61-6.
    PMID: 10958943
    Tumor cytogenetic analysis from 27 patients with breast cancer diagnosed at the Singapore General Hospital revealed complex karyotypic aberrations in 12 cases. The study group comprised 25 women and 2 men, ranging in age from 33 to 78 years (median 52 years). Ethnic distribution consisted of 22 Chinese, 3 Malaysian, and 2 Indian patients. Pathologic assessment disclosed 24 invasive ductal, 2 invasive mucinous, and 1 mixed invasive mucinous and ductal carcinomas. Histologic grading showed 3 grade 1, 10 grade 2, and 12 grade 3 tumors; 2 cancers were not graded, because they had been subjected to prior chemotherapy. Tumor sizes ranged from 1.5 to 10 cm (median 3 cm). Eleven cases were axillary node negative, whereas the remaining 16 node-positive cancers affected as many as 3 nodes in 8 cases and 4 or more nodes in another 8. Twenty cases demonstrated estrogen-receptor positivity, and 8 cases progesterone-receptor positivity. The spectrum of cytogenetic abnormalities involved chromosomes 1, 3, 6, 7, 8, 11, 16, and 17 and ranged from gains and deletions of both long and short arms, trisomy, monosomy, and other rearrangements. There was a trend toward the presence of karyotypic abnormalities in tumors of higher grade.
    Matched MeSH terms: Adenocarcinoma/genetics; Adenocarcinoma/pathology; Adenocarcinoma, Mucinous/genetics; Adenocarcinoma, Mucinous/pathology
  8. Sukumar N, Qureshi A
    Med J Malaysia, 2001 Jun;56(2):255-6.
    PMID: 11771091
    An elderly gentleman with adenocarcinoma of the rectum who had abdominoperineal resection presented with scrotal skin and penile metastasis. Adenocarcinoma of the rectum metastasizing to the groin and penis is very rare and few cases have been reported.
    Matched MeSH terms: Adenocarcinoma/secondary*
  9. Ong HC, Chan WF, Sinnathuray TA
    Med J Malaysia, 1978 Mar;32(3):217-9.
    PMID: 683046
    Matched MeSH terms: Adenocarcinoma/pathology*
  10. Dharmalingam SK, Narasimha K
    Med J Malaya, 1972 Sep;27(1):73-6.
    PMID: 4264829
    Matched MeSH terms: Adenocarcinoma/diagnosis*
  11. KHOO FY
    Med J Malaya, 1955 Jun;9(4):281-3.
    PMID: 13253128
    Matched MeSH terms: Adenocarcinoma*
  12. Rhodes A, Vallikkannu N, Jayalakshmi P
    Br J Biomed Sci, 2017 Apr;74(2):65-70.
    PMID: 28367736 DOI: 10.1080/09674845.2016.1220709
    BACKGROUND: Ovarian cancer is particularly lethal due to late stage at presentation. The subtypes behave differently with respect to their biology and response to treatment. Two recent markers reported to be useful in assisting in the diagnosis are WT1 and PAX8. Malaysia, with its multi-ethnic population provides an opportunity to study the expression of these biomarkers in ovarian cancer in the three most populous ethnicities in Asia and ascertain their usefulness in the diagnosis of ovarian carcinoma.

    MATERIALS AND METHODS: Tissues from ovarian epithelial neoplasms diagnosed between 2004 and 2012 were tested using antibodies to WT1 and PAX8. The slides were assessed to determine levels of marker expression and related to ethnicity, ovarian tumour type, grade and stage.

    RESULTS: Serous tumours were the main histological type (n = 44), the remaining being endometrioid (n = 15), mucinous (n = 15) and clear cell tumours (n = 7). Late stage at diagnosis was significantly associated with serous (p 

    Matched MeSH terms: Adenocarcinoma, Mucinous; Adenocarcinoma, Clear Cell
  13. Lau LL, Lung CK, Ahmad SS
    Indian J Ophthalmol, 2015 Nov;63(11):856-8.
    PMID: 26669339 DOI: 10.4103/0301-4738.171969
    A 34-year-old patient with a swelling over the upper eyelid for nearly 1 year was seen in our clinic. The history, examination and investigations were suggestive of a benign lacrimal gland tumor. The tumor and lacrimal gland were resected. Subsequent histopathological examination revealed the tumor was a primary ductal adenocarcinoma of the lacrimal gland. This is a very rare tumor with less than half a dozen cases reported so far. This case report is being presented to highlight an unusual presentation of this rare malignancy.
    Matched MeSH terms: Adenocarcinoma
  14. Liam CK, Pang YK, Poh ME
    J Thorac Oncol, 2014 Sep;9(9):e70-1.
    PMID: 25122441 DOI: 10.1097/JTO.0000000000000251
    Matched MeSH terms: Adenocarcinoma/genetics*; Adenocarcinoma, Bronchiolo-Alveolar/genetics*
  15. bin Sabir Husin Athar PP, bte Ahmad Norhan N, bin Saim L, bin Md Rose I, bte Ramli R
    Ann Acad Med Singap, 2008 Sep;37(9):788-3.
    PMID: 18989497
    INTRODUCTION: Metastatic adenocarcinoma from the gastrointestinal tract to the sinonasal tract is rare. The histological morphology of this lesion is indistinguishable from the colonic variant of primary sinus adenocarcinoma or intestinal-type adenocarcinoma (ITAC).

    CLINICAL PICTURE: This is a report of a case of metastatic adenocarcinoma of colorectal origin to the paranasal sinuses in a 52-year-old female who was previously treated for adenocarcinoma of the sigmoid colon. A histologic study of the surgical specimen from the sinonasal cavity demonstrated a tumour identical to the patient's prior primary tumour of the colon. The sinonasal neoplastic tissue showed marked positivity for carcinoembryonic antigen and expressed cytokeratin 20, which differentiates metastatic colonic adenocarcinoma from ITAC.

    TREATMENT/OUTCOME: The patient received palliative radiation but died 3 months after the diagnosis.

    CONCLUSION: Distinguishing metastatic adenocarcinoma from gastrointestinal tract from ITAC can be difficult. In view of the resemblance, immunohistochemical staining can help in differentiating them. It is important to recognise these as metastatic lesions as the treatment is mainly palliative.

    Matched MeSH terms: Adenocarcinoma/metabolism; Adenocarcinoma/radiotherapy; Adenocarcinoma/secondary*
  16. Khan FA, Shukla AN
    J Cancer Res Ther, 2007 11 14;2(4):196-9.
    PMID: 17998703
    Gastric cancer is one of the most common cancers and most frequent causes of cancer-related deaths in the world. The overall survival rate is 15-20%. Although the incidence is declining, its prognosis remains poor. The etiological factors and pathogenesis of gastric cancer are not yet fully understood. The integrated research in molecular pathology clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of development and progression of gastric cancer. Although epidemiological evidences indicate that environmental factors play a major role in the carcinogenesis, the role of immunological, genetic and immunogenetic factors are thought to contribute to etiopathogenesis of gastric carcinoma. In addition to better understanding of pathogenesis of gastric cancer, the incidence, diagnostic studies and the therapeutic options have also undergone important changes in the last decade. There is ongoing debate regarding the role of adjuvant treatment. In advanced disease, palliation of symptoms, rather than cure, is the primary goal of patient management. Several combination therapies have been developed and have been examined in phase III trials; however, in most cases, they have failed to demonstrate a survival advantage over the reference arm. This review summarizes the newer concepts of molecular biology on gastric carcinogenesis and the new important recommendations for the management of patient with gastric carcinoma.
    Matched MeSH terms: Adenocarcinoma/etiology*; Adenocarcinoma/pathology; Adenocarcinoma/therapy*
  17. Liew KL, Jee JM, Yap I, Yong PV
    PLoS One, 2016;11(4):e0153356.
    PMID: 27054608 DOI: 10.1371/journal.pone.0153356
    Cryptococcus neoformans is an encapsulated basidiomycetous yeast commonly associated with pigeon droppings and soil. The opportunistic pathogen infects humans through the respiratory system and the metabolic implications of C. neoformans infection have yet to be explored. Studying the metabolic profile associated with the infection could lead to the identification of important metabolites associated with pulmonary infection. Therefore, the aim of the study was to simulate cryptococcal infection at the primary site of infection, the lungs, and to identify the metabolic profile and important metabolites associated with the infection at low and high multiplicity of infections (MOI). The culture supernatant of lung epithelial cells infected with C. neoformans at MOI of 10 and 100 over a period of 18 hours were analysed using gas chromatography mass spectrometry. The metabolic profiles obtained were further analysed using multivariate analysis and the pathway analysis tool, MetaboAnalyst 2.0. Based on the results from the multivariate analyses, ten metabolites were selected as the discriminatory metabolites that were important in both the infection conditions. The pathways affected during early C. neoformans infection of lung epithelial cells were mainly the central carbon metabolism and biosynthesis of amino acids. Infection at a higher MOI led to a perturbance in the β-alanine metabolism and an increase in the secretion of pantothenic acid into the growth media. Pantothenic acid production during yeast infection has not been documented and the β-alanine metabolism as well as the pantothenate and CoA biosynthesis pathways may represent underlying metabolic pathways associated with disease progression. Our study suggested that β-alanine metabolism and the pantothenate and CoA biosynthesis pathways might be the important pathways associated with cryptococcal infection.
    Matched MeSH terms: Adenocarcinoma/metabolism*; Adenocarcinoma/microbiology; Adenocarcinoma/pathology
  18. Nojeg MM, Jalaludin MA, Jayalakshmi P
    Med J Malaysia, 1998 Mar;53(1):104-6.
    PMID: 10968147
    We report a rare tumour of the nasopharynx- papillary adenocarcinoma. This is usually of low grade and certainly in out patient it behaved so. It is even rarer to have this tumour in a patient with Turner's syndrome in whom there is a high incidence of gynaecological malignancy. It has not previously been documented and the occurrence in this patient is probably coincidental.
    Matched MeSH terms: Adenocarcinoma, Papillary/pathology; Adenocarcinoma, Papillary/radiography; Adenocarcinoma, Papillary/radiotherapy*
  19. Sathasivam H, Loh YM, Saw CL, Khalid N
    Gerodontology, 2017 Jun;34(2):276-279.
    PMID: 27384017 DOI: 10.1111/ger.12240
    OBJECTIVE: A case of oral metastatic follicular thyroid carcinoma is presented.

    BACKGROUND: Metastatic tumours are more frequent in older individuals and can be the only sign/symptom of an undiagnosed primary malignancy.

    CASE REPORT: A 69-year-old lady presented with an enlarging mandibular swelling. Incisional biopsy and imaging studies were suggestive of metastatic follicular thyroid carcinoma.

    CONCLUSION: Metastatic tumours should be considered in the differential diagnosis of mandibular swellings especially in older individuals.

    Matched MeSH terms: Adenocarcinoma, Follicular
  20. Valan A, Najid F, Chandran P, Abd Rahim AB, Chuah JA, Roslani AC
    Asian Pac J Cancer Prev, 2021 Mar 01;22(3):749-755.
    PMID: 33773538 DOI: 10.31557/APJCP.2021.22.3.749
    BACKGROUND: Malaysia is an ethnically diverse nation, comprising Malay, Chinese, Indian and indigenous groups. However, epidemiological studies on colorectal cancer have mainly focused on the three main ethnic groups. There is evidence that the clinico-pathological characteristics of some cancers may differ in indigenous populations, namely that they occur earlier and behave more aggressively. We aimed to determine if there were similar differences in colorectal cancer, focusing on the indigenous populations of Sabah.

    METHODS: Histopathological reports of all patients diagnosed with colorectal carcinoma from January 2012 to December 2016 from public hospitals in Sabah were retrieved from the central computerized database of the Pathology Department of Queen Elizabeth Hospital in Kota Kinabalu, Sabah. Supplementary data was obtained from patients' case files from each hospital. Clinico-pathological data were analysed using the IBM SPSS Statistical Software Version 23 for Windows for descriptive statistics (mean, median, ASR, AR, relative risk) and inferential statistics (Chi square test).

    RESULTS: A total of 696 patients met the inclusion criteria. The median age for colorectal cancer in Sabah was 62 years (95% CI 60.3 to 62.3), with an age specific incidence rate of 21.4 per 100 000 population. The age specific incidence rate in the indigenous populations was 26.6 per 100 000, much lower than the Chinese, at 65.0 per 100 000. The risk of colorectal cancer occurring before the age of 50 was three times higher in the indigenous population compared to the Chinese. The tumours were mainly left-sided (56.5%), adenocarcinoma in histology (98.4%) and moderately differentiated (88.7%). Approximately 79.2% of patients received curative treatment.

    CONCLUSION: Indigenous populations in Sabah develop colorectal cancer at an earlier age, and present at more advanced stages. This has implications for screening and therapeutic strategic planning. 

    Matched MeSH terms: Adenocarcinoma/ethnology*; Adenocarcinoma/pathology; Adenocarcinoma/therapy
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