Displaying publications 1 - 20 of 409 in total

  1. Yee A, Ng CG, Seng LH
    Curr Drug Targets, 2018;19(12):1412-1423.
    PMID: 29149828 DOI: 10.2174/1389450118666171117131151
    BACKGROUND: Vortioxetine is a multimodal antidepressant that has been developed for the treatment of major depressive and anxiety disorders. The aim of this review is to quantitatively synthesize all data of the efficacy, safety and tolerability of Vortioxetine in treating anxiety disorder.

    METHOD: Terms of "Vortioxetine" OR "LuAA21004" AND "anxiety" OR "fear" OR "panic" OR "phobia" were searched. A total of two phase II and five phase III clinical trials were found.

    RESULTS: Vortioxetine was overall superior to placebo in terms of the mean change from baseline in HAM-A total score at week 8 with the pool effect size of -2.95, 95% CIs, -4.37 to -1.53, p<0.01. The patients who received 5 mg of Vortioxetine had higher response rate when compared to placebo (pooled odds ratio=1.4, 95% CI = 1.08 to 1.82, p=0.01). However, the pooled odds ratio of the HAMA remission rate was not statistically significant for both Vortioxetine and placebo (pooled odds ratio= 1.06, 95% CI = 0.86 to 1.30, p=0.62). Although the discontinuation due to adverse effects was higher in Vortioxetine than placebo group (pooled OR= 1.55, 95% CI = 1.04 to 2.31, P= 0.037), the lack of efficacy (pooled OR= 0.39, 95% CI = 0.27 to 0.57, P<0.01) was higher in placebo than Vortioxetine group. Most of the adverse effects were mild and moderate. Overall, Vortioxetine displayed a good safety and tolerability profile.

    CONCLUSION: This review supports the use of Vortioxetine for anxiety disorder. However, further longterm placebo-control observational study or a post market survey would help in strengthening the evidence for this treatment modality.

    Matched MeSH terms: Anxiety Disorders/drug therapy*; Anti-Anxiety Agents/therapeutic use*
  2. Ping LT, Subramaniam K, Krishnaswamy S
    Malays J Med Sci, 2008 Apr;15(2):18-23.
    PMID: 22589620
    Test anxiety is defined as the reaction to stimuli that is associated with an individual's experience of testing or evaluating situations. This study aims to examine the fluctuation pattern of anxiety symptoms during a clinical examination and its relationship with underlying anxiety traits. Fourth year medical students of Penang Medical College undertaking the Ophthalmology clinical examination participated in this study. First phase of the survey, on anxiety symptoms was conducted immediately after the Ophthalmology clinical examination while the second phase, on pre-existing anxiety traits was conducted six weeks later with the aid of STAI instrument. Responses for both stages were combined and analyzed. Sixty-three of 122 students responded to both phases of the study, giving a response rate of 52%. All symptoms except trembling peaked 10 minutes before the exam begun showing a downward progression with no resurgence thereafter. Students with pre-existing anxiety traits had high anxiety scores 10 minutes into the examination and while with the examiners. Anticipatory anxiety is a source of concern and can effect performance and appropriate steps should be taken to help the students with this. A few other studies should be done to conclude.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  3. Patrick E
    Med. J. Malaysia, 1963 Sep;18:25-9.
    PMID: 14064293
    Matched MeSH terms: Anxiety*
  4. Saravanan C, Kingston R
    J Res Med Sci, 2014 May;19(5):391-7.
    PMID: 25097619
    BACKGROUND: Test anxiety aggravates psychological distress and reduces the motivation among graduate students. This study aimed to identify psychological intervention for test anxiety, which reduces the level of psychological distress, amotivation and increases the intrinsic and extrinsic motivation among medical students.
    MATERIALS AND METHODS: Westside test anxiety scale, Kessler Perceived Stress Scale and Academic Motivation Scale were used to measure test anxiety, psychological distress and motivation on 436 1(st) year medical students. Out of 436 students, 74 students who exhibited moderate to high test anxiety were randomly divided into either experimental or waiting list group. In this true randomized experimental study, 32 participants from the intervention group received five sessions of psychological intervention consist of psychoeducation, relaxation therapy and systematic desensitization. Thirty-three students from waiting list received one session of advice and suggestions.
    RESULTS: After received psychological intervention participants from the intervention group experienced less anxiety, psychological distress, and amotivation (P < 0.01) and high intrinsic and extrinsic motivation (P < 0.01) in the postassessment compared with their preassessment scores.
    CONCLUSION: Overall psychological intervention is effective to reduce anxiety scores and its related variables.
    KEYWORDS: Anxiety; motivation; psychological distress
    Matched MeSH terms: Anxiety*
  5. Azhar, M.Z.
    Anxiety Disorders have been said to account for the majority of psychiatric cases treated in out patient clinics all over the world. However not much input Is being given to it in the teaching of futufe doctors mainly because although it is common it is not generally seen by students posted to psychiatry wards in Malaysia. The students have the advantage of visiting patients in the wards daily but may only spend about 20% of the entire psychiatry posting in the clinics. As such, emphasis in identifying and treating anxiety disorders becomes diminished. More time is spent on discussing management issues of schizophrenia and bipolar disorders when the likelihood of students treating anxiety disorders in primary care and family physician clinics are more after they graduate. This short editorial looks at the current trend in combining psychotherapy and pharmacotherapy in anxiety pathology for the benefit of both practicing doctors and students.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  6. Fatahyah Yahya, Ng, Jocelyn Xiao Huix, Nor Mazlina Ghazali, Azzahrah Anuar, Aina Razlin Mohammad Roose, Mohamad Azhari Abu Bakar
    This research was aimed to study the relationship between attachment style and relationship quality among young couples. A correlational research design was adopted to answer the objectives of this study. A total of 257 students of Universiti Malaysia Sarawak (UNIMAS), Sarawak participated in this study. Two types of questionnaire were used in this study; the Experience in Close Relationship (ECR) to measure the attachment styles, and Couples Satisfaction Index (CSI) to measure the relationship satisfaction of the couples. The results showed that there was a significant relationship between attachment style and relationship quality among the young couples in UNIMAS. Attachment avoidance and attachment anxiety had a significant effect on the relationship quality of the young couples. It is suggested for future studies to consider selecting the samples by using simple random sampling as the targeted population would be able to represent the whole population and the result would be more accurate.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  7. Tengku Kashfil
    Cast removal procedures can be a daunting experience for children giving
    rise to anxiety. The objective of this study is to measure the level of anxiety in children
    during cast removal at Hospital Tengku Ampuan Afzan. (Copied from article).
    Matched MeSH terms: Anxiety; Anxiety Disorders
  8. Nanthakumar C
    J Integr Med, 2018 01;16(1):14-19.
    PMID: 29397087 DOI: 10.1016/j.joim.2017.12.008
    The number of children suffering from stress and anxiety in Malaysia is on the rise. Evidence shows that mind-body therapies such as mindfulness therapy, meditation and yoga have been practiced in many other countries to reduce and/or manage the psychological effects of stress and anxiety. This review article looks at the intervention of yoga as a meditative movement practice in helping school children manage stress and anxiety. Articles were retrieved using a combination of databases including PubMed/MEDLINE, and PsycINFO. Not only peer-reviewed articles, but also those written in English language were included in this review. All studies reviewed had incorporated some form of meditative movement exercise. The intervention encompassed asanas (postures), pranayama (expansion of life force), dharana (concentration) and dhyana (meditation), which are the different paths in yoga. A total of eight articles met the inclusion criteria and were reviewed. The findings of this review reveal that the practice of yoga has brought about, among other things, improvement in managing and reducing stress and anxiety. Despite the limitations in most, if not all of the studies reviewed, in terms of heterogeneity and sample size, yoga appears to be an effective modality for helping children cope with stress and anxiety. It appears that if schools in Malaysia can incorporate yoga as part of the physical education curriculum, it will definitely benefit the students.
    Matched MeSH terms: Anxiety/psychology; Anxiety/therapy*
  9. Edimansyah, B.A., Rusli, B.N., Naing, L.
    To examine the reliability and construct validity of the Malay Version of the Depression Anxiety Stress Scales (DASS), a validation study was conducted in 184 automotive assembly workers. The internal consistency and construct validity were assessed using Cronlaach's alpha coeffcient
    and exploratory factor analysis. The Cronliachls alpha coefficients for DASS-Depression, DASS·An.xiety and DASS·Stress were 0.91, 0.88 and j 0.89, respectively, indicating satisfactory internal consistenqi Exploratory factor analysis showed three meaningful common factors that could
    l expbin the three theoretical constructs of this instrument. These results suggested that the Malay version DASS is reliable and valid for assessing , the selfperceived depression, anxiety and stress among Malaysian automotive workers.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  10. Ramli Musa, Kartini Abdullah, Roszaman Ramli, Rosnani Sarkarsi
    ASEAN Journal of Psychiatry, 2011;12(1):66-70.
    Objectives: The Bahasa Malaysia (BM) version of Depression Anxiety Stress Scales 21-item (DASS-21) has been widely used ever since the establishment of its validity. To consolidate the evidence of the BM DASS-21 validity by examining its concurrent validity.
    Methods: The BM DASS was administered together with the Hospital Anxiety and Depressive Scale (HADS) to a total of 246 patients at International Islamic University Malaysia (IIUM) Infertility Centre.
    Results: The anxiety domain of BM DASS-21 had good correlation with anxiety domain in HADS (0.61) but for DASS depressive domain, it had modest correlation with its respective domain in HADS (0.49).
    Conclusions: The results of this study further ensconced the evidence that the BM DASS-21 had relatively satisfactory psychometric properties for clinical subjects in Malaysia.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  11. Muhamad Saiful Bahri Yusoff
    Objective: The objective of this study was to evaluate whether students exposed to a brief stress reduction intervention would have lesser stress, anxiety and depression levels compared to their non-exposed classmates during stressful events. Methods: The Ex Post Facto design was applied in this study. Students who were exposed and not exposed to a brief stress reduction intervention were surveyed during a continuous examination and during the final examination. The Depression Anxiety Stress Scales (DASS) was used to
    examine effects on anxiety, stress, and depression levels. Results: The exposed students statistically had lower anxiety and depression scores than the nonexposed students during the stressful period. Reduction of stress, anxiety and depression scores was sustained during the stressful period. Conclusion: The significant reduction of anxiety and depression scores suggested that brief intervention was effective in the enhancement of the psychological wellbeing of exposed medical students during stressful period.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  12. Nor Zuraida, Z., Ng, C.G.
    JUMMEC, 2010;13(1):12-18.
    Distress has become a major issue in cancer population. Patients may suffer from either physical,psychological distress or both. Cancer patients who are undergoing chemotherapy are more likely to experience psychological distress. This could be due to the negative effects of chemotherapy agents, the uncertainty of post-treatment, and the occurrence of psychosocial problems. As a result, the patient may experience a normal reaction such as sadness or may develop common psychiatric disorders such as depression and anxiety.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  13. Kelly Ee Lu Ting, Maria Sau Sim Ng, Wei Fern Siew
    Surgeries are seen as stressors that trigger preoperative anxiety. Preparing the patients for surgery through preoperative teaching becomes crucial to allay anxiety level. In a cross sectional descriptive study conducted on eighty patients (age: 18–65 yr) who had undergone open abdominal surgery, 78.8% (n=63) stated that they experienced anxiety prior to surgery. Among these anxious respondents, 47.5% (n=38) experienced high state anxiety. Three of the top information that patients perceived as important to allay anxiety towards major surgery were: details of surgery, details of nursing care to surgery and information on anaesthesia. Nurses working in the surgical wards need to proactively address patients’ psychological concerns towards surgery and provide preoperative information based on patients’ needs to allay anxiety.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  14. Maneeton N, Suttajit S, Maneeton B, Likhitsathian S, Eurviyanukul K, Udomratn P, et al.
    Nord J Psychiatry, 2017 Oct;71(7):503-508.
    PMID: 28632428 DOI: 10.1080/08039488.2017.1335344
    BACKGROUND: Anxious distress in major depressive disorder (MDD) is common and associated with poor outcomes and management difficulties.

    AIMS: This post hoc analysis aimed to examine the socio-demographic and clinical correlates of anxiety distress in Asian outpatients with MDD.

    METHODS: Instead of two out of five specifiers defined by the Diagnostic and Statistical Manual Version-5, anxious distress defined in this study was operationalized as the presence of at least two out of four proxy items drawn from the 90-item Symptom Checklist, Revised (SCL-90-R). Other measures included the Montgomery-Asberg Depression Rating Scale (MADRS), the Fatigue Severity Scale, the Sheehan Disability Scale and the Multidimensional Scale of Perceived Social Support.

    RESULTS: The data of 496 patients with MDD were included. Anxious distress was found in 371 participants (74.8%). The binary logistic regression analysis found that anxious distress was independently and significantly correlated with working status, higher MADRS scores, severe insomnia and functional impairment.

    CONCLUSIONS: Three-fourths of Asian patients with MDD in tertiary care settings may have DSM-5 anxious distress of at least moderate distress. Its prevalence may vary among working groups. The specifier was associated with greater depressive symptom severity, severe insomnia and functional impairment.

    Study site: n tertiary care
    settings in China, Korea, Malaysia, Singapore, Taiwan and
    Matched MeSH terms: Anxiety*
  15. Modai I, Munitz H, Aizenberg D
    Br J Psychiatry, 1986 Oct;149:503-5.
    PMID: 3814937
    The Koro syndrome, a 'special cultural psychiatric syndrome', is encountered in South China, Malaysia and Indonesia, especially among people of Chinese origin. There are only eight case reports of Koro from the Western hemisphere. We present a typical primary Koro patient from Israel. Jewish cultural mores are a contributory factor.
    Matched MeSH terms: Anxiety, Castration/ethnology*; Anxiety, Castration/therapy
  16. Shamsuddin K, Fadzil F, Ismail WS, Shah SA, Omar K, Muhammad NA, et al.
    Asian J Psychiatr, 2013 Aug;6(4):318-23.
    PMID: 23810140 DOI: 10.1016/j.ajp.2013.01.014
    University students face not only challenges related with independent living, but also academic challenges. This predisposes them to depression, anxiety and stress, which are fairly common.
    Matched MeSH terms: Anxiety/diagnosis*; Anxiety/epidemiology; Anxiety Disorders/diagnosis*; Anxiety Disorders/epidemiology
  17. Farah Naquiah MZ, James RJ, Suratman S, Lee LS, Mohd Hafidz MI, Salleh MZ, et al.
    Behav Brain Funct, 2016 Aug 31;12(1):23.
    PMID: 27582026 DOI: 10.1186/s12993-016-0107-y
    Heroin addiction is a growing concern, affecting the socioeconomic development of many countries. Little is known about transgenerational effects on phenotype changes due to heroin addiction. This study aims to investigate changes in level of anxiety and aggression up to four different generations of adult male rats due to paternal exposure to heroin.
    Matched MeSH terms: Anxiety/metabolism; Anxiety/psychology*; Anxiety Disorders/genetics; Anxiety Disorders/psychology
  18. Nor Wahida Yakub, Sherina Mohd Sidik
    The information on job strain among crane operators in Malaysia is lacking. The aim of this study was to determine the prevalence and contributing factors of job strain among crane operators working in port container terminals. A cross sectional study was carried out at a port container terminal in Malaysia. Data was collected using validated self-administered questionnaires, which consisted of the Job Content Questionnaire (JCQ), and the Depression, Anxiety, and Stress Scale (DASS-21). All crane operators in the selected terminal participated in the study. Data was analyzed using SSPS version 19. Two-hundred- and-forty crane operators participated in the study.. The prevalence of job strain determined from the JCQ was 43.8%. Job strain was significantly associated with psychological job demand, decision latitude, anxiety, physical isometric loads and muscle ache. The prevalence of job strain in this study was high. There is an urgent need to recognize the existence of this problem among crane operators by their respective management. Implementation of comprehensive stress management programs are recommended to reduce job strain among these workers.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  19. Ramli, M., Aidil Faszrul, A.R., Rosnani, S.
    Background: The Malay short version of Depressive Anxiety and Stress Scale (DASS-21) has been widely used as a tool to measure psychological parameters in studies in Malaysia. The version has been found to be reliable for clinical and non-clinical populations. Objectives: To analyse and establish the psychometric properties of the Malay version of the DASS 42-item (BM DASS-42) among medical students. Methods: Concurrent forward and backward translations of original English DASS-42 were completed. Construct validity of the DASS-42 was established by looking at its exploratory factor analysis. Malay DASS-42 and Malay HADS were administered to a total of 411 medical students. Results: Reliability of DASS-
    42 revealed excellent Cronbach’s alpha values of 0.94, 0.90 and 0.87 for depressive, anxiety and stress domains respectively. Construct validity yielded 38 items out of 42 items (90%) had good factor loadings of 0.4 and more. DASS and HADS were strongly correlated for both anxiety (r=0.87) and depression (r=0.68) domains. Conclusions: The BM DASS-42 had admirable psychometric properties among the tested population. Further studies are needed to verify these preliminary outcomes in other Malaysian subjects.
    Matched MeSH terms: Anxiety; Anxiety Disorders
  20. Ramli, M., Abdullah, A.A.W., Saiful, M.I.B., Fafiz, M.N., Fahmi, A.A.Z.
    Introduction: Maternal psychological well-being determines early mother-infant relationship and babys health. Paying attention on this aspect is essential particularly in early postpartum period. This study aimed to determine early psychological reactions toward socioeconomic profi les, delivery methods and delivery outcomes among postpartum mothers in Kuala Lumpur Hospital. Materials and Methods: A total of 150 two week-postpartum mothers participated in this cross sectional study and their psychological perspective was measured by using the Depressive, Anxiety and Stress Scale (DASS). Results: 4%, 16% and 4.7% of respondents had significant depressive, anxiety and stress levels respectively. Conclusion: Socioeconomic variables such household income, level of education and presence of medical illness were statistically signifi cant to determine early postpartum psychological reactions but not the modes or outcomes of delivery.
    Matched MeSH terms: Anxiety; Anxiety Disorders
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