MyMedR

Fulltext Fundamentals of the management of non-Hodgkin lymphoma

Fadilah SA

Med J Malaysia, 2009 Dec;64(4):333-9; quiz 340.

PMID: 20954564 MyJurnal

The incidence of Non-Hodgkin's lymphomas (NHL) is rising worldwide and if not adequately treated carries a high mortality rate. The pattern and frequency of NHL vary in different populations and geographical regions. It has considerable biologic and clinical heterogeneity and a definitive diagnosis can be made only after histopathogical examination. The histology and the extent of the lymphoma are the major determinants of optimal therapeutic regimen and treatment outcome. Additionally, the overall treatment strategies should be tailored according to medical status and preference of the patient. A holistic approach provided by a multi-disciplinary team of health care professionals is the cornerstone of ensuring successful treatment outcome. Importantly, therapy should be expedited and where possible performed in experienced centers. Patients achieving remission would require long-term monitoring for disease recurrence and late effects of cytotoxic chemotherapy and radiotherapy. Hence, clinicians should have a fundamental understanding in the biology and the principles of treatment of NHL. This review provides an evidence-based and systematic approach in designing therapeutic strategies for individual patients with newly diagnosed and relapsed NHL focusing on the common types of NHL with particular reference to the current practice within the local settings. The role of standard and novel therapeutic modalities in treatment will be summarized.

Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/etiology; Lymphoma, Non-Hodgkin/therapy*

Fulltext Bone marrow and peripheral blood changes in non-Hodgkin's lymphoma

Lim EJ, Peh SC

Singapore Med J, 2000 Jun;41(6):279-85.

PMID: 11109344

47 patients with non-Hodgkin's lymphoma (NHL) were studied retrospectively to determine their marrow and blood changes at diagnosis.

Matched MeSH terms: Lymphoma, Non-Hodgkin/blood*; Lymphoma, Non-Hodgkin/complications; Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/epidemiology; Lymphoma, Non-Hodgkin/pathology*

Fulltext Clinical Characteristics and Treatment Outcome of Gastrointestinal Non-Hodgkin's Lymphoma

Praveen S, Ho CC, Fadilah S, Sagap I

Med J Malaysia, 2010 Jun;65(2):98-100.

PMID: 23756789

Primary gastrointestinal (GIT) lymphoma constitutes only 5 - 10% of all gastrointestinal tumours. The optimal therapy for these lymphomas is poorly defined and still controversial. We present our experience in the treatment and outcome of primary GIT lymphomas in UKM Medical Center, Malaysia. A retrospective review of all patients with primary GIT lymphoma from the year 2002 until 2007 was done. Our series has shown that primary GIT lymphoma is a rare disease as it comprises only 6.5% of all lymphomas treated in this institution. We had a female predominance of this disease with a large majority at an advanced stage of the disease. There was equal distribution involving stomach, small and large intestines. The incidence of primary GIT lymphomas was 6.5% with a female predominance. The majority had advanced diseases (stage III and IV) with equal distribution involving the stomach, small and large intestines. The most common histological variant was diffuse large B cell lymphoma (66%). Most (83%) patients with intestinal lymphoma had surgical resection and adjuvant chemotherapy. All patients with gastric lymphomas had chemotherapy alone. The mortality rate was 22% predominantly in younger patients with aggressive histology subtypes and advanced disease.

Matched MeSH terms: Lymphoma, Non-Hodgkin*

Fulltext Primary non-Hodgkin's lymphoma of the cranial vault mimicking a meningioma: a case report

Muin IA, Saffari HM, Hasimah YN

Med J Malaysia, 1997 Mar;52(1):86-8.

PMID: 10968060

Primary non-Hodgkin's lymphoma of the brain is rare. Majority of the lesions are intraaxial, multicentric and involve the leptomeninges. We report a case of malignant primary non-Hodgkin's lymphoma arising from the cranial vault. Computed tomography of the brain showed an extraaxial lesion in the right parietal region mimicking a meningioma.

Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis*

Fulltext Clinicopathological spectrum of Diffuse Large B Cell lymphoma: a study targeting population yet unexplored in Pakistan

Mahmood H, Habib M, Aslam W, Khursheed S, Fatima S, Aziz S, et al.

BMC Res Notes, 2021 Sep 10;14(1):354.

PMID: 34507605 DOI: 10.1186/s13104-021-05768-5

OBJECTIVE: Diffuse Large B Cell Lymphoma (DLBCL) is the most common type of Non-Hodgkin Lymphoma (NHL). The aim of this study was to assess the clinico pathological characteristics of DLBCL specifically, among the affected individuals residing in Northern areas of Pakistan who had not been previously included in major lymphoma studies due to their remote location.

RESULTS: Mean age of the patients was 49.7 years. Male: female ratio was 1.5:1. Primary site was lymph node in 99 (71.74%) patients, out of which, 36 (26.09%) patients had B symptoms and 19 (13.77%) patients had stage IV disease. 39 (28.26%) patients had primary extra nodal involvement, 4 (2.90%) patients had B symptoms and 3 (2.17%) had stage IV disease. Extra nodal sites involved in primary extra nodal DLBCL were gastrointestinal tract (GIT) 19 (48.72%), tonsils 6 (15.38%), spine 4 (10.26%), soft tissue swelling 3 (7.69%), parotid gland 2 (5.13%), thyroid 2 (5.13%) central nervous system (CNS) 1 (2.56), breast 1 (2.56%) and bone marrow 1 (2.56%). Our study revealed increased percentage of patients with nodal DLBCL in stage IV and with B symptoms. Few patients with primary extra nodal DLBCL had B symptoms and stage IV disease at presentation. GIT was the most common site of involvement in primary extra nodal DLBCL.

Matched MeSH terms: Lymphoma, Non-Hodgkin*

An interesting case of lymphosarcoma

MAYCOCK H

Med J Malaya, 1956 Mar;10(3):246-50.

PMID: 13347455

Matched MeSH terms: Lymphoma, Non-Hodgkin*

Fulltext Primary non-Hodgkin's lymphoma of the pelvic bone in a child

Hoe TS, Sivanantham M, Phang KS, Yogeswary S, Foo LS

Med J Malaysia, 1994 Sep;49(3):289-91.

PMID: 7845282

Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis*; Lymphoma, Non-Hodgkin/pathology; Lymphoma, Non-Hodgkin/therapy

Fulltext Non-Hodgkin's Lymphoma Masquerading as Psoas Abscess: A Case Report

Ng, W.M., Ong, T.C., Kwan, M.K., Cheok, C.Y.

Malays Orthop J, 2008;2(1):49-51.

MyJurnal

We report here a rare presentation of an extra-nodal non-Hodgkin's lymphoma. Both clinical presentation radiological findings were suggestive of psoas abscess. Surgical debridement was performed and histopathological examination of the tissue sample revealed the diagnosis of non-Hodgkin's lymphoma. It is therefore important to note that non-Hodgkin's lymphoma can mimic psoas abscess and that psoas lesion with vertebral involvement does not necessarily indicate infection. It is always advisable to obtain needle biopsy to establish diagnosis before embarking on surgical intervention. The practice to send any suspicious tissue obtained intra-operatively for histopathological examination is also warranted.

Matched MeSH terms: Lymphoma, Non-Hodgkin

One patient, two lymphomas, three primaries

Eshra A, Al-Hendal A, Al Enezi M, Al-Mishaan M, Abo Dief W

Gulf J Oncolog, 2010 Jul.

PMID: 20601338

Concomitant adenocarcinoma and non-Hodgkin's lymphoma, both located in the intestinal tract, are unusual. Collision tumors of the colon on the other hand are extremely rare neoplasms. A case of true collision tumor of a marginal zone lymphoma and a moderately differentiated adenocarcinoma of the ascending colon (hepatic flexure) is reported. Simultaneously, a third primary is identified as follicular lymphoma involving the terminal ileum. Correlation with clinical history, radiology investigations, endoscopic findings and histological examination of the resected specimen as well as the use of ancillary techniques such as immunohistochemistry are the most useful in making the correct diagnosis of a synchronous three primaries involving the small bowel and colon. Therefore, we present these three primary synchronous neoplasms involving two different parts of the gastrointestinal tract, with two of these three primaries colliding at one organ.

Matched MeSH terms: Lymphoma, Non-Hodgkin/pathology*

Eosinophilic myocarditis mimicking acute coronary syndrome in a young man with T-lymphoblastic lymphoma and hypereosinophilia

Raffali MAA, Boon Cong B, Muhammad SF, Che Hassan HH

BMJ Case Rep, 2023 Sep 25;16(9).

PMID: 37748814 DOI: 10.1136/bcr-2023-255396

A man in his 20s with underlying chemorefractory primary T-lymphoblastic lymphoma and hypereosinophilia developed acute chest pain in the ward after readmission for disease progression. ECG showed widespread ST depression and serum troponin was markedly elevated. Transthoracic echocardiography showed diffused thrombus deposition with preserved ejection fraction consistent with eosinophilic myocarditis. The patient ultimately succumbed to the disease, after complications with severe hospital-acquired pneumonia.

Matched MeSH terms: Lymphoma, Non-Hodgkin*

Primary non-Hodgkins lymphoma of the lacrimal sac: mortality-related epiphora

Maharajah KR, Hussein A, Mohamad H, Khan SA, At LS

Orbit, 2009;28(5):306-8.

PMID: 19874126 DOI: 10.3109/01676830903044346

We report a case of primary non-Hodgkins lymphoma of the lacrimal sac in a 60-year-old Asian lady, who presented with persistent epiphora and recurrent medial canthal swelling. Primary lymphoma of the lacrimal sac is rare and it can be easily misdiagnosed. Delayed in diagnosis may be related to mortality. To minimize the risk of overlooking specific pathology it is important to assess the appearance of the lacrimal sac and its surrounding structures intraoperatively. Biopsy of the lacrimal sac is required in cases where specific pathology is suspected.

Matched MeSH terms: Lymphoma, Non-Hodgkin/complications; Lymphoma, Non-Hodgkin/diagnosis*; Lymphoma, Non-Hodgkin/therapy

Congenital dyserythropoietic anaemia type II-like dysplastic anaemia preceding the development of non-Hodgkin lymphoma--a case report

Leong CF, Zainina S, Cheong SK

Malays J Pathol, 2005 Jun;27(1):39-43.

PMID: 16676692

Anaemia is a frequent complication in patients with haematological malignancies and is caused by a variety of mechanisms including neoplastic cell infiltration into the bone marrow, haemolysis, nutritional deficiencies and defect in erythropoiesis or dysplastic anaemia as a result of the disease itself. However, acquired dysplastic anaemia which mimic congenital dyserythropoietic anaemia (CDA) type II morphology in the bone marrow is very rare. A 41-year-old Chinese man presented with refractory symptomatic anaemia in September 2001. He was clinically pale with no other significant physical finding. His initial peripheral blood picture showed normochromic normocytic anaemia with haemoglobin level of 26g/L, with no evidence of haemolysis and a poor reticulocyte response of 0.6%. Bone marrow aspiration was done and showed congenital dyserythropoietic anaemia (CDA) type II-like morphology. He was treated symptomatically with regular blood transfusions approximately every 3 weeks, until August 2002 when he developed multiple cervical lymphadenopathy with loss of appetite, loss of weight and low grade fever. Biopsy of the lymph node confirmed the diagnosis of small lymphocytic lymphoma. Staging with computed tomography and bone marrow aspirate revealed the infiltration of lymphoma cells into the marrow cavity consistent with the staging of IVB. This case report illustrates that CDA type II-like dysplastic anaemia can preceed the development of lymphoma.

Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/pathology*; Lymphoma, Non-Hodgkin/radiography

Pattern of Epstein-Barr virus association in childhood non-Hodgkin's lymphoma: experience of university of malaya medical center

Peh SC, Nadarajah VS, Tai YC, Kim LH, Abdullah WA

Pathol. Int., 2004 Mar;54(3):151-7.

PMID: 14989737

The pattern of childhood non-Hodgkin's lymphoma (NHL) usually differs in adults. The most common subtypes are lymphoblastic, Burkitt's and anaplastic large cell lymphoma. Recent data indicate that a higher risk of developing lymphoma is associated in children of certain ethnic origins. The difference is probably related to the underlying etiological factors of these diseases, and Epstein-Barr virus (EBV) is a strong candidate. The present study aims to determine the disease pattern of childhood lymphomas in the University Hospital Kuala Lumpur, for a direct comparison to the reported data of adults from the same medical center. A total of 69 and 34 childhood NHL and Hodgkin's lymphomas, respectively, were retrieved. The most common subtypes were lymphoblastic (23 cases), Burkitt's (25 cases) and anaplastic large cell lymphomas (9 cases). Epstein-Barr virus association was more prevalent in B-cell (23%) than T-cell (12%) lymphomas. The most common EBV-associated tumor was Burkitt's lymphoma, and there was an increased risk of EBV association for Burkitt's lymphoma in Chinese patients. In conclusion, the pattern of childhood lymphoma in Malaysia is relatively similar to children elsewhere in the world. The EBV association of B- and T-NHL differs between children and adults from the same medical center because of differences in the subtype composition in these two age groups.

Matched MeSH terms: Lymphoma, Non-Hodgkin/epidemiology; Lymphoma, Non-Hodgkin/pathology; Lymphoma, Non-Hodgkin/virology*

Fulltext A rare case of primary extranodal laryngeal non hodgkin lymphoma

Mark P., Najihah Hanim A., Eshamsol Kamar O., Suhaila A., Irfan M.

International Medical Journal Malaysia, 2018;17(3):85-88.

MyJurnal

Lymphoma is generally a nodal disease and arises from lymphoid tissues or organs. Extranodal lymphoma accounts for almost a third of malignant lymphomas. Squamous cell carcinoma accounts for 90 % of laryngeal carcinoma, while extranodal Non Hodgkin Lymphoma (NHL) attributes only less than 1% of laryngeal neoplasms. Less than 100 of such cases been reported in literature since 1952. As to our best knowledge, no such case was ever reported in our country. We report a case of a 58-year-old gentleman who presented the typical history of laryngeal malignancy however the pathology turned out to be as NHLof Diffuse Large B-cell subtype.

Matched MeSH terms: Lymphoma, Non-Hodgkin

Fulltext A rare extrapyramidal manifestation in a patient with primary central nervous system lymphoma

Tee TY, Khoo CS, Ibrahim NM, Osman SS

Neurol India, 2019 3 13;67(1):297-299.

PMID: 30860142 DOI: 10.4103/0028-3886.253620

Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/drug therapy*; Lymphoma, Non-Hodgkin/pathology

Genetic polymorphisms in the one-carbon metabolism pathway genes and susceptibility to non-Hodgkin lymphoma

Suthandiram S, Gan GG, Mohd Zain S, Bee PC, Lian LH, Chang KM, et al.

Tumour Biol., 2015 Mar;36(3):1819-34.

PMID: 25384508 DOI: 10.1007/s13277-014-2785-0

Corroborating evidence related to the role of aberrations on one-carbon metabolism (OCM) genes has been inconsistent. We evaluated the association between polymorphisms in 12 single nucleotide polymorphisms (SNPs) in 8 OCM genes (CBS, FPGS, FTHFD, MTRR, SHMT1, SLC19A1, TCN1, and TYMS), and non-Hodgkin lymphoma (NHL) risk in a multi-ethnic population which includes Malay, Chinese and Indian ethnic subgroups. Cases (N = 372) and controls (N = 722) were genotyped using the Sequenom MassARRAY platform. Our results of the pooled subjects showed a significantly enhanced NHL risk for CBS Ex9 + 33C > T (T versus C: OR 1.55, 95% CI 1.22-1.96, P = 0.0003), CBS Ex18-319G > A (A versus G: OR 1.15, 95% CI 1.14-1.83; P = 0.002), SHMT1 Ex12 + 236 T > C (T versus C: OR 1.44, 95% CI 1.15-1.81, P = 0.002), and TYMS Ex8 + 157C > T (T versus C: OR 1.29, 95% CI 1.06-1.57, P = 0.01). Haplotype analysis for CBS SNPs showed a significantly decreased risk of NHL in subjects with haplotype CG (OR 0.69, 95% CI 0.56-0.86, P = <0.001). The GG haplotype for the FTHFD SNPs showed a significant increased risk of NHL (OR 1.40, 95% CI 1.12-1.76, P = 0.002). For the TYMS gene, haplotype CAT at TYMS (OR 0.67, 95% CI 0.49-0.90, P = 0.007) was associated with decreased risk of NHL, while haplotype TAC (OR 1.29, 95% CI 1.05-1.58, P = 0.01) was found to confer increased risk of NHL. Our study suggests that variation in several OCM genes (CBS, FTHFD, SHMT1, TCN1, and TYMS) may influence susceptibility to NHL.

Matched MeSH terms: Lymphoma, Non-Hodgkin/genetics*; Lymphoma, Non-Hodgkin/metabolism*

Fulltext A skin lesion and fever of unknown origin - a case study

Wong S, Ng CJ

Aust Fam Physician, 2012 Jan-Feb;41(1-2):41-4.

PMID: 22276283

Matched MeSH terms: Lymphoma, Non-Hodgkin/complications*; Lymphoma, Non-Hodgkin/diagnosis*

The pattern of Ki-67 and bcl-2 expression in lymphoid malignancies

Wang PL, Peh SC

Malays J Pathol, 1997 Jun;19(1):59-64.

PMID: 10879243

The International Working Formulation divides non-Hodgkin's lymphoma (NHL) into three grades: low, intermediate and high. This grading system implies rate of tumour growth and hence prognosis. Ki-67 antigen is a proliferation-related nuclear antigen and bcl-2 oncogene product is known to inhibit apoptosis. This study aimed to determine the pattern of expression of Ki-67 antigen and bcl-2 oncoprotein in various grades of NHL. Paraffin-embedded tissues from 42 cases of NHL (7 low, 15 intermediate, 20 high grade) were retrieved from the files of the Department of Pathology, University of Malaya. Ki-67 antigen and bcl-2 oncoprotein were detected using immunohistochemistry. The percentage of positively stained neoplastic cells was determined by semi-quantitative estimation and given scores ranging from 0 to 6. Partition chi square test demonstrated the association of Ki-67 antigen expression and histological grade (p = 0.007). There was no significant difference in Ki-67 antigen expression between intermediate and high grade malignant lymphomas (p = 0.28), whereas significant difference was demonstrated between low and intermediate/high grade tumours (p = 0.003). Bcl-2 oncoprotein expression in the neoplastic cells varied widely within the three histological grades. Statistical analysis showed no association between the expression of bcl-2 oncoprotein and histological grade (p = 0.25). Ki-67 immunostaining is therefore a useful adjunct to histological grading of NHL.

Matched MeSH terms: Lymphoma, Non-Hodgkin/metabolism*; Lymphoma, Non-Hodgkin/pathology

Fulltext Malignant non-Hodgkin's lymphomas of the nose and paranasal sinuses

Tan J, Said H, Chong SM

Med J Malaysia, 1988 Mar;43(1):49-54.

PMID: 3244320

Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/pathology*

Oral candidosis in non-Hodgkin's lymphoma: a case report

Siar CH, Ng KH, Rasool S, Ram S, Abdul Jalil A, Ng KP

J Oral Sci, 2003 Sep;45(3):161-4.

PMID: 14650581

Though oral candidosis is an opportunistic fungal infection that commonly affects immunocompromised patients, little is known of its occurrence as a complication of Non-Hodgkin's lymphoma. This paper reports a case of oral candidosis in a 20-year-old Indonesian woman with this lymphoproliferative disease. She presented with acute pseudomembranous candidosis on the dorsum and lateral borders of the tongue, bilateral angular cheilitis and cheilocandidosis. The latter is a rare clinical variant of oral candidosis, and the lesions affecting the vermilion borders presented as an admixture of superficial erosions, ulcers and white plaques. Clinical findings were confirmed with oral smears and swabs that demonstrated the presence of hyphae, pseudohyphae and blastospores, and colonies identified as Candida albicans. A culture from a saline rinse was also positive for multiple candidal colonies. Lip and oral lesions were managed with Nystatin. The lesions regressed with subsequent crusting on the lips, and overall reduction in oral thrush. As Non-Hodgkin's lymphoma is a neoplastic disease that produces a chronic immunosuppressive state, management of its oral complications, including those due to oral candidosis, is considered a long-term indication.

Matched MeSH terms: Lymphoma, Non-Hodgkin/complications*; Lymphoma, Non-Hodgkin/immunology

Displaying publications 1 - 20 of 56 in total