Displaying publications 1 - 20 of 98 in total

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  1. S. JW
    Matched MeSH terms: Parasitic Diseases
  2. Lavoipierre MM, Lavoipierre M
    Med J Malaya, 1965 Sep;20(1):72-3.
    PMID: 4221429
    Matched MeSH terms: Parasitic Diseases*
  3. Thomas V
    Med J Malaysia, 1977 Dec;32(2):120-6.
    PMID: 614477
    Matched MeSH terms: Parasitic Diseases/diagnosis*
  4. Tappe D, Büttner DW
    PLoS Negl Trop Dis, 2009;3(2):e320.
    PMID: 19238218 DOI: 10.1371/journal.pntd.0000320
    Visceral pentastomiasis in humans is caused by the larval stages (nymphs) of the arthropod-related tongue worms Linguatula serrata, Armillifer armillatus, A. moniliformis, A. grandis, and Porocephalus crotali. The majority of cases has been reported from Africa, Malaysia, and the Middle East, where visceral pentastomiasis may be an incidental finding in autopsies, and less often from China and Latin America. In Europe and North America, the disease is only rarely encountered in immigrants and long-term travelers, and the parasitic lesions may be confused with malignancies, leading to a delay in the correct diagnosis. Since clinical symptoms are variable and serological tests are not readily available, the diagnosis often relies on histopathological examinations. This laboratory symposium focuses on the diagnosis of this unusual parasitic disease and presents its risk factors and epidemiology.
    Matched MeSH terms: Parasitic Diseases/diagnosis*; Parasitic Diseases/epidemiology*; Parasitic Diseases/parasitology; Parasitic Diseases/pathology
  5. Mak JW
    Med J Malaysia, 1995 May;50 Suppl A:S60-4.
    PMID: 10968018
    Matched MeSH terms: Parasitic Diseases/epidemiology; Parasitic Diseases/prevention & control
  6. Nissapatorn V, Sawangjaroen N, Lee R, Chandra Parija S
    Biomed Res Int, 2014;2014:780715.
    PMID: 25587540 DOI: 10.1155/2014/780715
    Matched MeSH terms: Parasitic Diseases/genetics*; Parasitic Diseases/parasitology; Parasitic Diseases/transmission*
  7. Shivaji R
    Family Practitioner, 1985;8:51-58.
    Matched MeSH terms: Parasitic Diseases
  8. Heyneman D
    Med J Malaya, 1966 Sep;21(1):84-9.
    PMID: 4224884
    Matched MeSH terms: Parasitic Diseases*
  9. Sandosham AA
    Singapore Med J, 1963 Mar;4(1):42-51.
    PMID: 13976263
    Matched MeSH terms: Parasitic Diseases*
  10. John DV, Sreenivas N, Deora H, Purushottam M, Debnath M, Mahadevan A, et al.
    Trop Biomed, 2023 Dec 01;40(4):406-415.
    PMID: 38308827 DOI: 10.47665/tb.40.4.005
    The pathogenesis of chronic parasitic central nervous system (CNS) infections, including granulomatous amoebic meningoencephalitis (GAE), cerebral toxoplasmosis (CT), and neurocysticercosis (NCC), is primarily due to an inflammatory host reaction to the parasite. Inflammatory cytokines produced by invading T cells, monocytes, and CNS resident cells lead to neuroinflammation which underlie the immunopathology of these infections. Immune molecules, especially cytokines, can therefore emerge as potential biomarker(s) of CNS parasitic infections. In this study, cerebral spinal fluid (CSF) samples from suspected patients with parasitic infections were screened for pathogenic free-living amoebae by culture (n=2506) and PCR (n=275). Six proinflammatory cytokines in smear and culture-negative CSF samples from patients with GAE (n = 2), NCC (n = 7), and CT (n = 23) as well as control (n = 7) patients were measured using the Multiplex Suspension assay. None of the CSF samples tested was positive for neurotropic free-living amoebae by culture and only two samples showed Acanthamoeba 18S rRNA by PCR. Of the six cytokines measured, only IL-6 and IL-8 were significantly increased in all three infection groups compared to the control group. In addition, TNFa levels were higher in the GAE and NCC groups and IL-17 in the GAE group compared to controls. The levels of IL-1b and IFNg were very low in all the infection groups and the control group. There was a correlation between CSF cellularity and increased levels of IL-6, IL-8, and TNFa in 11 patients. Thus, quantifying inflammatory cytokine levels in CSF might help with understanding the level of neuroinflammation in patients with neurotropic parasitic diseases. Further studies with clinico-microbiological correlation in the form of reduction of cytokine levels with treatment and the correlation with neurological deficits are needed.
    Matched MeSH terms: Parasitic Diseases*
  11. Colley FC, Rahman MA, Omar IB
    PMID: 5165246
    Matched MeSH terms: Parasitic Diseases, Animal*
  12. Mohd Zain SN, Sahimin N, Pal P, Lewis JW
    Vet Parasitol, 2013 Sep 23;196(3-4):469-77.
    PMID: 23664711 DOI: 10.1016/j.vetpar.2013.03.030
    The occurrence of macroparasites was studied from 543 stray cats in four urban cities from the west (Kuala Lumpur), east (Kuantan), north (Georgetown) and south (Malacca) of Peninsular Malaysia from May 2007 to August 2010. Five ectoparasites species were recovered namely, Ctenocephalides felis, Felicola subrostratus, Haemaphysalis bispinosa, Heterodoxus spiniger and Lynxacarus radovskyi. Two cats from Georgetown were infested with the dog louse, H. spiniger and this represented the first host record for this species in Malaysia. Up to nine species of helminths were recovered with overall high prevalences of infection of 83% in Kuantan, followed by 75.1% in Kuala Lumpur, 71.6% in Georgetown and 68% in Malacca. The helminth species comprised five nematodes, Toxocara malaysiensis, Toxocara cati, Ancylostoma braziliensis, Ancylostoma ceylanicum, Physaloptera praeputialis, two cestodes Taenia taeniaeformis, Dipylidium caninum and one trematode, Playtnosomum fastosum. The majority of helminths were present in the four study sites except for the absence of P. praeputialis in Kuala Lumpur. The prevalence and abundance of infections were analysed taking intrinsic (host age and sex) and extrinsic (season) factors into consideration. Levels of infection and infestation were mainly influenced by host age and to a lesser extent sex and season, whereas four nematode species exhibited significant interactions within the intestine of the cat host. The potential for transmission of some macroparasite species from stray cats to the human population in urban areas is discussed.
    Matched MeSH terms: Parasitic Diseases, Animal/epidemiology; Parasitic Diseases, Animal/parasitology*
  13. Mohd-Qawiem F, Nur-Mahiza MI, Ahmad NI, Yasmin AR, Nur-Fazila SH
    J Vet Sci, 2024 Nov;25(6):e81.
    PMID: 39608775 DOI: 10.4142/jvs.24098
    IMPORTANCE: Rodents, particularly those inhabiting urban areas, are sources of infections that cause major human diseases. The number of recorded zoonotic infections has increased in recent decades, exacerbating public concerns. Zoonotic diseases in humans, such as capillariasis, hymenolepiasis, and toxoplasmosis, are life-threatening in severe cases, particularly in immunocompromised individuals. A thorough understanding of pathogens, particularly the parasites infecting rodents, is critical for predicting future zoonotic disease outbreaks and developing effective mitigation strategies. This review summarizes the information on parasites in rodents inhabiting Malaysia to identify the knowledge gaps that could serve as a foundation for future research.

    OBSERVATIONS: Thirty-eight previous parasite studies in rodents conducted in Malaysia were reviewed, and 44 ectoparasites species and 58 endoparasites species across 19 rodent species were revealed. Six ectoparasite and eight endoparasite species were identified as zoonotic among these parasites. Morphological identification of parasite species typically succeeded only at the genus level because of their identical morphological characteristics. However, these studies used a molecular approach to identify parasites at the species level using species-specific primers. The pathological findings of various organs of infected rodents were also summarized, including gross and histological lesions exhibited by parasites.

    CONCLUSIONS AND RELEVANCE: This review highlights the list of parasites infecting rodents in Malaysia, provides information on the molecular and pathological findings from previous studies, and identifies some of the limitations and knowledge gaps that suggest future research to address the issues, including the paucity of information on blood parasites, molecular, and histopathological studies of parasites in rodents.

    Matched MeSH terms: Parasitic Diseases, Animal/epidemiology; Parasitic Diseases, Animal/parasitology
  14. GRIFFITHS RB
    Med J Malaysia, 1964 Sep;19:40-1.
    PMID: 14240062
    Matched MeSH terms: Parasitic Diseases*
  15. Kok A, Robinson MJ
    Lancet, 1976 Sep 18;2(7986):633.
    PMID: 61371
    Matched MeSH terms: Parasitic Diseases/epidemiology*
  16. Burns-Cox CJ, Prathap K, Clark E, Gillman R
    Trans R Soc Trop Med Hyg, 1969;63(3):409-11.
    PMID: 5815876
    Matched MeSH terms: Parasitic Diseases*
  17. Griffiths RB
    Med J Malaya, 1966 Jun;20(4):316-20.
    PMID: 4224340
    Matched MeSH terms: Parasitic Diseases, Animal*
  18. AUDY JR
    Med J Malaya, 1956 Sep;11(1):21-32.
    PMID: 13399540
    Matched MeSH terms: Parasitic Diseases/transmission*
  19. Desowitz RS
    Med J Malaya, 1966 Sep;21(1):35-40.
    PMID: 4224875
    Matched MeSH terms: Parasitic Diseases/diagnosis*
  20. Jamil Al-Obaidi MM, Desa MNM
    J Neurosci Res, 2024 Jan;102(1).
    PMID: 38284852 DOI: 10.1002/jnr.25288
    Parasites have a significant impact on the neurological, cognitive, and mental well-being of humans, with a global population of over 1 billion individuals affected. The pathogenesis of central nervous system (CNS) injury in parasitic diseases remains limited, and prevention and control of parasitic CNS infections remain significant areas of research. Parasites, encompassing both unicellular and multicellular organisms, have intricate life cycles and possess the ability to infect a diverse range of hosts, including the human population. Parasitic illnesses that impact the central and peripheral nervous systems are a significant contributor to morbidity and mortality in low- to middle-income nations. The precise pathways through which neurotropic parasites infiltrate the CNS by crossing the blood-brain barrier (BBB) and cause neurological harm remain incompletely understood. Investigating brain infections caused by parasites is closely linked to studying neuroinflammation and cerebral impairment. The exact molecular and cellular mechanisms involved in this process remain incomplete, but understanding the exact mechanisms could provide insight into their pathogenesis and potentially reveal novel therapeutic targets. This review paper explores the underlying mechanisms involved in the development of neurological disorders caused by parasites, including parasite-derived elements, host immune responses, and modifications in tight junctions (TJs) proteins.
    Matched MeSH terms: Parasitic Diseases*
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