MyMedR

Hemorrhagic bullous Henoch- Schonlein purpura: a case report

Nirmala Ponnuthurai, Sabeera Begum, Lee, Bang Rom

Malaysian Journal of Paediatrics and Child Health, 2016;22(101):0-0.

MyJurnal

Henoch – Schonlein purpura (HSP) is a vasculitis of small sized blood vessels. It is the most common acute systemic vasculitis in childhood. It mainly affects skin, gastrointestinal tract, joints and kidney. It results from Immunoglobulin A mediated inflammation. The characteristic skin findings are palpable purpuric lesions over the lower limbs and buttocks. The occurance of haemorrhagic bullae in children with HSP is rarely encountered. This case report describes a 12 year old boy with bullous haemorrhagic HSP treated at Institute Paediatric, Hospital Kuala Lumpur.

Matched MeSH terms: Purpura, Schoenlein-Henoch*

Fulltext Non-specific skin purpura

Shalihin SE, Harun Z, Osman IF

Malays Fam Physician, 2018;13(2):39-41.

PMID: 30302184 MyJurnal

Essential thrombocythemia is one of the myeloproliferative neoplasms. Palpable purpura is a rare manifestation that may delay diagnosis and treatment. We report a case of essential thrombocythemia in a 50-year-old man, who presented with recurrent thigh pain for the past one year with nonspecific localized purpura. His full blood count revealed isolated thrombocytosis of 880,000/µL with an impression of myeloproliferative disorder from peripheral blood film. He was referred urgently to the hematology team, which proceeded with a venesection. His condition improved with hydroxyurea. This was a rare case of chronic presentation of myeloproliferative neoplasm detected at a primary care clinic.

Matched MeSH terms: Purpura*

Glanzmann disease (thrombasthenia)--A case report

Zulkifli A

Med J Malaysia, 1979 Dec;34(2):174-5.

PMID: 575788

Matched MeSH terms: Purpura, Thrombocytopenic/diagnosis; Purpura, Thrombocytopenic/genetics*

Thrombotic Thrombocytopenic Purpura in Dengue Fever

Tee TY, Cader RA

Acta Med Indones, 2021 Apr;53(2):208-212.

PMID: 34251350

Thrombotic thrombocytopenic purpura is a rare but life threatening medical condition. Early recognition and treatment of thrombotic thrombocytopenic purpura is important especially in patients who do not present with the classic pentad to reduce the high mortality. Herein, we describe a case of a patient who does not fulfil the classic pentad features thrombotic thrombocytopenic purpura that was induced by dengue fever. The patients' initial full blood picture did not have all the typical features of microangiopathic haemolytic anaemia but there were fragmented red blood cells. However, even a small number of fragmented red blood cells in the peripheral blood should alert physicians of the possible diagnosis of thrombotic thrombocytopenic purpura together with other symptoms. Furthermore, signs and symptoms of thrombotic thrombocytopenic purpura and dengue fever can overlap such as fever, thrombocytopenia, neurological deficit mimicking dengue encephalopathy and dengue induced acute kidney injury.

Matched MeSH terms: Purpura, Thrombotic Thrombocytopenic/blood; Purpura, Thrombotic Thrombocytopenic/etiology*

Schonlein-Henoch purpura responding to prednisolone; report of four cases

WELLS R, STEPHENS D

Med J Malaya, 1958 Mar;12(3):550-4.

PMID: 13565027

Matched MeSH terms: Purpura*; Purpura, Schoenlein-Henoch/therapy*

Fulltext Helicobacter pylori infection in chronic immune thrombocytopenic purpura patients in Malaysia

Gan GG, Norfaizal AL, Bee PC, Chin EF, Habibah AH, Goh KL

Med J Malaysia, 2013 Jun;68(3):231-3.

PMID: 23749012 MyJurnal

Helicobacter Pylori has been implicated with a possible link to immune thrombocytopenia purpura (ITP) and studies have shown contradicting results in platelet recovery after eradication of H pylori infection.

Matched MeSH terms: Purpura, Thrombocytopenic, Idiopathic*

Pneumococcal sepsis presenting as purpura fulminans in a healthy infant

Intan IH, Rozita AR, Norlijah O

Ann Trop Paediatr, 2009 Sep;29(3):235-8.

PMID: 19689868 DOI: 10.1179/027249309X12467994694139

The majority of cases of purpura fulminans are associated with Neisseria meningitidis sepsis. However, other bacteria, including Streptococcus pneumoniae, can also be the cause. Underlying predisposing conditions are immunodeficiencies and splenic dysfunction, the latter being the most frequent in the paediatric age group. Purpura fulminans secondary to pneumococcal sepsis in a healthy infant is described.

Matched MeSH terms: Purpura Fulminans/etiology*

Splenectomy in idiopathic thrombocytopaenic purpura

Singh N

Med J Malaysia, 1974 Jun;28(4):257-9.

PMID: 4278838

Matched MeSH terms: Purpura, Thrombocytopenic/therapy*

Thirty-three cases of acute arthritis in Sabah

Burns-Cox CJ

Med J Malaya, 1964 Sep;19:25-9.

PMID: 14240057

Matched MeSH terms: Purpura*

Fulltext Detection of antiplatelet antibodies in patients with idiopathic thrombocytopenic purpura (ITP) by immunofluorescence

Pereira RA, Bosco J, Pang T

Singapore Med J, 1981 Aug;22(4):203-C.

PMID: 7034209

An immunofluorescence test (IFT) using platelet suspensions was used to detect the presence of serum anti-platelet antibodies (APA) in the sera of Malaysian patients with idiopathic thrombocytopenic purpura. Of the 28 patients tested, 19 (or 68%) had detectable APA with percentage platelet fluorescence ranging from 34% - 80% (mean 51% +/- 10). Normal sera gave fluorescence values of 6 - 15% (mean 9% +/- 5). Sera from patients with SLE, thyrotoxicosis and dengue haemorrhagic fever gave mean values of 29%, 8% and 9% respectively. Additionally, no apparent correlation was observed between percentage platelet fluorescence and the severity of thrombocytopenia. The importance and significance of these findings are discussed.

Matched MeSH terms: Purpura, Thrombocytopenic/immunology*

Primary versus secondary immune thrombocytopenia in adults; a comparative analysis of clinical and laboratory attributes in newly diagnosed patients in Southern Pakistan

Sultan S, Ahmed SI, Murad S, Irfan SM

Med J Malaysia, 2016 10;71(5):269-274.

PMID: 28064294

BACKGROUND: Immune thrombocytopenic purpura (ITP) is a hemorrhagic diathesis, characterized by platelets destruction alongside impaired production. Patients from Asian regions often exhibit distinctive characteristics in comparison to the western patients. We accomplished this study to evaluate the prevalence of primary versus secondary ITP along with the comparative analysis between them. The secondary objective was to determine the etiological spectrum of secondary ITP.

METHODS: We illustrate the results of a large cohort of newly diagnosed adults ITP from southern Pakistan. The study extended from January 2009-December 2013. Complete blood counts, HbsAg, Anti-HCV, ANA, stool for Helicobacterpylori were done on all. HIV, TSH, anti-dsDNA, RA factor, APLA and direct coombs test were evaluated in cases where indicated.

RESULTS: A total of 417 patients were included with a mean age of 40.95±14.82 years. Primarily disease was observed in the 3rd decade of life. Male to female ratio was 1:1.5. Mean platelets count was 46.21±27.45x109/l. At diagnosis 43.16% (n=180) patients had hemorrhagic manifestations whilst 56.8% (n=237) were asymptomatic. None of the patient presented with visceral, retropharyngeal or intracranial bleed. The prevalence of secondary ITP was substantially higher (64.8%) as compared to primary ITP (35.2%). Secondary ITP was predominantly seen in HCV reactive patients (24.4%) followed by helicobacter-pylori infection (11%). Nevertheless 16.4% patients had underlying autoimmune disorders. Providentially no study subject was found to be HIV reactive.

CONCLUSIONS: Our study revealed predominance of secondary ITP. However bleeding manifestations and degree of thrombocytopenia were high in primary-ITP. Infectious etiology followed by autoimmune disorders is mainly implicated for secondary ITP in our setting.

Matched MeSH terms: Purpura, Thrombocytopenic, Idiopathic/complications; Purpura, Thrombocytopenic, Idiopathic/diagnosis*; Purpura, Thrombocytopenic, Idiopathic/etiology

Fulltext Ibuprofen-induced Henoch-Schönlein purpura nephritis: First reported case

Seong CL, Shanmuganathan M

Indian J Pharmacol, 2016 Nov-Dec;48(6):739-740.

PMID: 28066119 DOI: 10.4103/0253-7613.194848

Ibuprofen is a nonsteroidal anti-inflammatory drug that is used widely in treating pain, fever, and inflammation. Its side effects are mainly due to acute renal impairment and gastric discomfort. We hereby report a rare case of Henoch-Schönlein purpura nephritis secondary to ibuprofen consumption which has not been reported in literature before.

Matched MeSH terms: Purpura, Schoenlein-Henoch/chemically induced*; Purpura, Schoenlein-Henoch/complications; Purpura, Schoenlein-Henoch/diagnosis*

Purtscher retinopathy as an initial presentation of thrombotic thrombocytopenic purpura

Tajunisah I, Patel DK, Subrayan V

J Thromb Thrombolysis, 2010 Jul;30(1):112-3.

PMID: 19834784 DOI: 10.1007/s11239-009-0399-y

Matched MeSH terms: Purpura, Thrombotic Thrombocytopenic/complications*

A four-point clinical criteria distinguishes immune thrombocytopenia from acute lymphoblastic leukaemia

Lum SH, How SJ, Ariffin H, Krishnan S

Med J Malaysia, 2016 02;71(1):28-9.

PMID: 27130741

Immune thrombocytopenia is the most common diagnosis of isolated thrombocytopenia. The dilemma encountered by paediatricians is missing diagnosis of acute leukaemia in children with isolated thrombocytopenia. We demonstrated childhood ITP could be diagnosed using a four point clinical criteria without missing a diagnosis of acute leukaemia. Hence, bone marrow examination is not necessary in children with typical features compatible with ITP prior to steroid therapy. This can encourage paediatricians to choose steroid therapy, which is cheaper and non-blood product, as first line platelet elevating therapy in children with significant haemorrhage.

Matched MeSH terms: Purpura, Thrombocytopenic, Idiopathic/diagnosis*

Thrombotic thrombocytopenic purpura with terminal pancytopenia

Ng SC, Adam BA

Postgrad Med J, 1990 Nov;66(781):955-7.

PMID: 2267212

A 27 year old housewife developed thrombotic thrombocytopenic purpura during the twelfth week of pregnancy. She had partial response to initial plasma infusion and subsequent plasmapheresis. However, her clinical course was complicated by the development of severe pancytopenia the consequence of a hypocellular marrow. She succumbed to septicaemic shock one month after diagnosis. The development of hypocellular marrow in thrombotic thrombocytopenic purpura has not been reported before.

Matched MeSH terms: Purpura, Thrombotic Thrombocytopenic/complications*

Kaposi's sarcoma following long term steroid therapy

Akmal SN, Wahab YA

Malays J Pathol, 1989 Aug;11:65-8.

PMID: 2633002

An 18-year-old Malay lady was treated with high dose steroids for three and a half years for idiopathic thrombocytopaenic purpura. At 21 years, after a series of relapses, a splenectomy was carried out. In addition, two nodules at the hilum of the spleen were also removed. Histological examination of these nodules revealed features of Kaposi's sarcoma. Kaposi's sarcoma resulting from immunosuppression by corticosteroids is rare. Our patient is the first such case reported in Malaysia.

Matched MeSH terms: Purpura, Thrombocytopenic/drug therapy

Fulltext Acquired platelet dysfunction with eosinophilia (APDE): an underrecognised condition

Ramanathan M, Duraisamy G

Med J Malaysia, 1987 Mar;42(1):53-5.

PMID: 3431503

We present three cases of Acquired Platelet Dysfunction with Eosinophilia (APDE). The importance of recognising this benign condition, which usually does not require any specific therapy, is stressed to avoid the pitfalls of diagnosing more serious bleeding disorders in children presenting with ecchymosis.

Matched MeSH terms: Purpura, Thrombocytopenic/blood

Fulltext Haemangioma-thrombocytopenia syndrome--a case report

Liam CK, Nuruddin R

Med J Malaysia, 1989 Sep;44(3):263-6.

PMID: 2626143

A 29 year old Chinese female who presented with spontaneous purpura, was found to have gross hepatomegaly and thrombocytopenia. The thrombocytopenia responded to steroid therapy but relapsed when the dose of steroid was tapered down. Subsequent investigations revealed that the hepatomegaly was due to a large haemangioma of her liver. For symptomatic hepatic haemangioma, surgical excision is the treatment of choice; this was refused by the patient.

Matched MeSH terms: Purpura, Thrombocytopenic/complications*

Fulltext A rare case of autoimmune hepatitis overlapping with autoimmune haemolytic anaemia and immune thrombocytopenic purpura in a male patient

Palaniappan S, Ramanaidu S

Med J Malaysia, 2012 Jun;67(3):326-8.

PMID: 23082427 MyJurnal

Matched MeSH terms: Purpura, Thrombocytopenic, Idiopathic/complications*; Purpura, Thrombocytopenic, Idiopathic/diagnosis; Purpura, Thrombocytopenic, Idiopathic/drug therapy

Thrombotic thrombocytopenic purpura-like syndrome associated with arcanobacterium pyogenes endocarditis in a post-transplant patient: A case report

Andy Tang SO, Leong TS, Ruixin T, Chua HH, Chew LP

Med J Malaysia, 2018 10;73(5):344-346.

PMID: 30350823 MyJurnal

Systemic Arcanobacterium pyogenes is a rare bacterial infection in humans.1The diagnosis of thrombotic thrombocytopenic purpura (TTP)-like syndrome and infective endocarditis (IE) is often elusive. We report a case of TTP-like syndrome associated with A. pyogenes endocarditis in a post-allogenic transplant patient.

Matched MeSH terms: Purpura, Thrombotic Thrombocytopenic

Displaying publications 1 - 20 of 55 in total