MyMedR

Odontogenic keratocyst and ameloblastoma: radiographic evaluation

Kitisubkanchana J, Reduwan NH, Poomsawat S, Pornprasertsuk-Damrongsri S, Wongchuensoontorn C

Oral Radiol, 2021 Jan;37(1):55-65.

PMID: 32030659 DOI: 10.1007/s11282-020-00425-2

OBJECTIVES: To describe the radiographic features of odontogenic keratocysts (OKCs) and ameloblastomas and to compare the radiographic findings between these 2 lesions.

METHODS: Radiographs of OKCs and ameloblastomas were retrospectively reviewed. Location, border, shape, association with impacted tooth, tooth displacement, root resorption, and bone expansion were evaluated. Chi-squared or Fisher's exact tests were used for statistical analysis. A p value

Matched MeSH terms: Odontogenic Tumors*

Fulltext Re: Controversies in Odontogenic Tumours: Review

Gopinath D, Menon RK

Sultan Qaboos Univ Med J, 2018 05;18(2):e249-e250.

PMID: 30210864 DOI: 10.18295/squmj.2018.18.02.026

Matched MeSH terms: Odontogenic Tumors*

Fulltext The complexity of stromal changes in desmoplastic ameloblastoma

Ramesh V, Singh S, Bailwad S, Kiran K, Agarwal R, Singh A

Ann Med Health Sci Res, 2014 Mar;4(Suppl 1):S14-7.

PMID: 25031898 DOI: 10.4103/2141-9248.131694

Ameloblastoma is usually considered a homogenous neoplasm and is thought of as the most primitive of all odontogenic neoplasms. However, detailed investigations have proven clinicopathological diversity in a significant number of cases, thus mounting the evidence in favor of considering ameloblastoma as a mysterious lesion. The purpose of this article is to report a unique case of desmoplastic ameloblastoma and to throw light on the atypical changes noticed in the stromal component. The findings of this case have served to add interesting parameters to the study of stromal changes associated with this perplexing odontogenic tumor.

Matched MeSH terms: Odontogenic Tumors

Intra-epithelially entrapped blood vessels in ameloblastoma

Siar CH, Ishak I, Ng KH

J Oral Pathol Med, 2015 May;44(5):378-85.

PMID: 25155411 DOI: 10.1111/jop.12247

The ameloblastoma is a benign but locally aggressive odontogenic neoplasm with a high recurrence rate. While significant progress has been made in our understanding regarding the role of tumoral vasculature relative to the diverse behavioral characteristics of this tumor, no attention has been paid to a distinct subset of blood vessels entrapped within its epithelial compartment. As vascular niches are known to influence tumoral growth, clarification of these vessels is important. The objectives of this study were to investigate the morphologic characteristics of intra-epithelially entrapped blood vessels (IEBVs) in ameloblastoma and to speculate on their relevance.

Matched MeSH terms: Odontogenic Tumors

Fulltext Calcifying Epithelial Odontogenic Tumour - Case Report And Review Of The Literature

Khoo, Suan Phaik, Jalil, N., Yaacob, H.B.

Ann Dent, 1997;4(1):-.

MyJurnal

The calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic neoplasm which was first described by Pindborg in 1955. It accounts for less than 1% of all odontogenic lesions. A case of CEOT which presented together with cardiac abnomlalities is presented here and the literature of CEOT is reviewed.

Matched MeSH terms: Odontogenic Tumors

Granular ameloblastoma: report of two cases with atypical cytological aspects

Arora S, Urs AB, Kumar P, Augustine J, Saran RK

Rom J Morphol Embryol, 2017;58(3):997-1001.

PMID: 29250680

Ameloblastoma is an aggressive odontogenic tumor, which arises from odontogenic epithelium. Ameloblastomas can present in several clinical and histomorphological patterns. The granular cell variant accounts for only 3.5% to 5% of ameloblastomas. We have presented two cases of granular cell ameloblastoma (GCA) occurring in a 44-year-old and 50-year-old man, respectively. Case No. 1 on incisional biopsy was diagnosed as unicystic ameloblastoma (UA), which later after excisional biopsy was finally diagnosed as GCA owing to the features observed in excisional biopsied tissue. Case No. 2 on incisional biopsy showed darker and lighter stained cells arranged in small follicular pattern, and anastomosing cords. Meticulous immunohistochemistry, histochemical examination and careful literature search helped us to diagnose it as GCA. We have made an attempt to elucidate the diagnosis of GCA especially in cases of GCA with unusual granular component.

Matched MeSH terms: Odontogenic Tumors/diagnosis*; Odontogenic Tumors/pathology; Odontogenic Tumors/therapy

Adenomatoid odontogenic tumour: a case study with radiographic differential diagnostic considerations

Siar CH, Ong ST, Ng KH

Singapore Dent J, 1996 Jul;21(1):19-22.

PMID: 10597178

Adenomatoid odontogenic tumours (AOT) are benign, hamartomatous odontogenic lesions that not uncommonly mimic a dentigerous cyst radiographically. Such a case as found involving an unerupted left maxillary canine in a 19-year-old Chinese female is described. The differential diagnosis of some common odontogenic cysts and neoplasms occurring in Malaysians, that may present in a dentigerous relationship to an unerupted tooth is discussed. A brief review of the radiographic literature on AOT is also included.

Matched MeSH terms: Odontogenic Tumors/complications; Odontogenic Tumors/pathology*; Odontogenic Tumors/radiography; Odontogenic Tumors/surgery

Combined granular cell ameloblastoma and plexiform granular cell odontogenic tumour

Siar CH, Ng KH, Chia TY

Singapore Dent J, 1990 Dec;15(1):35-7.

PMID: 2097728

Granular cell ameloblastomas are uncommon lesions accounting for about 3-5% of all histologic subtypes of ameloblastoma. The plexiform granular cell odontogenic tumour, on the other hand, is a newly described lesion characterised by a monophasic plexiform pattern of granular cells. This article reports a tumour found occurring in the left mandible of a 67-year-old Indian male which histologically showed features of both the aforementioned lesions.

Matched MeSH terms: Odontogenic Tumors/complications; Odontogenic Tumors/pathology*

Fulltext Acanthomatous ameloblastoma in anterior mandibular region of a young patient: A rare case report

Ugrappa S, Jain A, Fuloria NK, Fuloria S

Ann Afr Med, 2017 Apr-Jun;16(2):85-89.

PMID: 28469123 DOI: 10.4103/aam.aam_51_16

Ameloblastoma is the most known of the epithelial odontogenic benign tumor. It is slow growing and locally aggressive in nature and most commonly seen in the posterior mandible. Various histopathological variants exist, among which acanthomatous type of ameloblastoma is one of the rarest types. Acanthomatous ameloblastoma is usually seen in older aged human population and most commonly reported in canine region of dogs in literature. Here, we report a rare case of acanthomatous ameloblastoma in a young male patient involving mandibular anterior region crossing the midline with recurrence over a period of 2 years of follow-up after surgical resection.

Matched MeSH terms: Odontogenic Tumors/pathology*; Odontogenic Tumors/surgery

A clinicopathologic study of 173 odontogenic tumours in Northern Peninsular Malaysia (2007-2014)

Ismail S, Saw CL

Malays J Pathol, 2018 Aug;40(2):129-135.

PMID: 30173229 MyJurnal

INTRODUCTION: The objectives of this study were to analyse, compare and contrast the demographic, clinical and pathological data of odontogenic tumours seen at a regional oral pathology centre in the Northern part of Peninsular Malaysia with other international data as an aid to clinicians in diagnosing odontogenic tumours.

MATERIALS AND METHODS: This was a descriptive, retrospective study of odontogenic tumours diagnosed from January 2007 to December 2014 at this centre. The odontogenic tumours were classified using the 2005 World Health Organization classification system.

RESULTS: Among 2,733 biopsy specimens, 173 cases were diagnosed as odontogenic tumours (6.3%), of which 171 (98.8%) are benign and 2 (1.2%) are malignant. The most frequently encountered tumour was ameloblastoma (n=96, 55.5%), followed by keratocystic odontogenic tumour (KCOT) (n=38, 22.0%) and odontomas (n=16, 9.2%). Malignant tumours accounted for 1.2% of the tumours. Most ameloblastomas and KCOTs affected the mandible preferentially. The mean age was 33.5 (± 17.8) years and 64.7% of patients were in the age group of 10 to 39. Odontogenic tumours were slightly more common in males, with a male to female ratio of 1.4:1.

CONCLUSION: The findings of this study are similar to the other studies in Asia in which the most common tumour encountered is the ameloblastoma, followed by KCOT. The most common signs and symptoms are pain and swelling, while paraesthesia and root resorption are less frequently reported. Such clinical and radiographic features should alert the clinician of a possible odontogenic tumour and though rare, malignant tumours should also be included in the differential diagnoses.

Matched MeSH terms: Odontogenic Tumors/epidemiology*; Odontogenic Tumors/pathology*

Fulltext Clinical statistics of the adenomatoid odontogenic tumour in Malaysia (1968-1986)

Siar CH, Ng KH, Murugasu P

Med J Malaysia, 1987 Dec;42(4):284-9.

PMID: 3331408

The records of the Division of Stomatology were reviewed for the incidence of adenomatoid odontogenic tumour diagnosed between 1968 and 1986. Forty-five cases were found. The prevalence of this tumour according to their age, sex, site and its distribution in the various states in Malaysia are reported. Many features were similar to previous reports of this entity. However the incidence of AOT appears to be higher among the Indians and lower in the Chinese population. It is suggested that this feature may be peculiar to Malaysians.

Matched MeSH terms: Odontogenic Tumors/epidemiology*

Benign osteoblastoma of the maxilla

Yip WK, Lee HT

Oral Surg. Oral Med. Oral Pathol., 1974 Aug;38(2):259-63.

PMID: 4528442

Matched MeSH terms: Odontogenic Tumors/diagnosis

Peripheral odontogenic fibroma with clear cell odontogenic epithelium

Siar CH, NG KH

J N Z Soc Periodontol, 1995.

PMID: 9227094

The clinical and histological features of the peripheral odontogenic fibroma are briefly outlined. A case arising from the attached lingual gingiva between the mandibular right permanent first molar and the second molar in a 67 year old Indian female is reported here. The unusual occurrence of marked clear cell differentiation within the odontogenic epithelial component, and histogenetic link to the clear cell rests of the dental lamina and surface epithelium are discussed.

Matched MeSH terms: Odontogenic Tumors/pathology*

The combined epithelial odontogenic tumour in Malaysians

Siar CH, Ng KH

Br J Oral Maxillofac Surg, 1991 Apr;29(2):106-9.

PMID: 2049349

The combined epithelial odontogenic tumour represents a hybrid lesion comprising primarily areas of adenomatoid odontogenic tumour intermixed with foci of calcifying epithelial odontogenic tumour. Five such cases retrieved from the files of the Division of Stomatology, Institute for Medical Research, Kuala Lumpur, and four others from the existing literature were analysed. A mean age of 18.8 years, a female preponderance (66.7%) with a male to female ratio of 1:2 and predilection for the mandible (55.6%) were observed. All cases were treated by conservative surgery and the lack of recurrence confirmed the innocuous nature of this lesion.

Matched MeSH terms: Odontogenic Tumors/pathology*

Plexiform granular cell odontogenic tumor: unicystic variant

Siar CH, Ng KH, Jalil NA

Oral Surg. Oral Med. Oral Pathol., 1991 Jul;72(1):82-5.

PMID: 1891247

Plexiform granular cell odontogenic tumor of the mandible has recently been described. The cardinal histopathologic feature, as its name suggests, is a monophasic plexiform pattern of granular cells; the principal tumor in the differential diagnosis is granular cell ameloblastoma. Unlike the two previously reported cases of plexiform granular cell odontogenic tumor, which occurred as solid tumors in elderly men, the lesion reported here is a unicystic variant occurring in a middle-aged woman.

Matched MeSH terms: Odontogenic Tumors/pathology*

Fulltext Adenomatoid odontogenic tumour: gross and histogical examination of 45 cases

Siar CH, Ng KH, Murugasu P

Singapore Med J, 1987 Apr;28(2):180-9.

PMID: 3629275

This paper represents a reappraisal of the gross and histological features of 45 cases of adenomatoid odontogenic tumours as observed under conventional light and fluorescence microscopy. The findings conformed largely to those of previous studies. Usage of the term adenomatoid odontogenic tumour in preference to its old name 'adenoameloblastoma' is emphasized. The differential diagnosis of this entity from the ameloblastoma and salivary gland tumours is discussed.

Matched MeSH terms: Odontogenic Tumors*

Cemento-ossifying fibroma with mandibular fracture. Case report in a young patient

Ong AH, Siar CH

Aust Dent J, 1998 Aug;43(4):229-33.

PMID: 9775467

The cemento-ossifying fibroma is classified as an osteogenic neoplasm of the jaws. It commonly presents as a progressively growing lesion that can attain an enormous size with resultant deformity if left untreated. A case of a large cemento-ossifying fibroma involving the left mandible is described in a 15 year old male patient. The clinical, radiographic and histological features as well as surgical findings are presented. The treatment of choice of this lesion is also emphasized. Two years after surgery, there was no evidence of recurrence and the transosseous wire used to immobilize the fracture was found to be completely buried in the jaw bone.

Matched MeSH terms: Odontogenic Tumors/complications; Odontogenic Tumors/pathology; Odontogenic Tumors/surgery*

Fulltext Unusual Presentation of Primary Squamous Cell Carcinoma of Mandible

Shanmugasundaram K, Subramanian S, Vedam V, Kumar V

Case Rep Pathol, 2016;2016:9154309.

PMID: 28078158 DOI: 10.1155/2016/9154309

Carcinoma arising primarily from the jaw is a locally aggressive lesion with poor prognosis. Primary intraosseous carcinoma (PIOC) lesion develops either de novo remnants of odontogenic epithelium, odontogenic cyst/tumor, epithelium remnants, or/and salivary gland residues. We describe very interesting case of primary intraosseous carcinoma of mandible. This extensive lesion was sent for oncological opinion and further management. Due to the uncertainty of diagnostic criteria of PIOC, only few cases of this lesion with a typical presentation have been reported. This article presents a case of primary intraosseous carcinoma with a unique appearance and detailed review stating its clinicopathological correlation.

Matched MeSH terms: Odontogenic Tumors

Clinicopathological study of peripheral odontogenic fibromas (WHO-type) in Malaysians (1967-95)

Siar CH, Ng KH

Br J Oral Maxillofac Surg, 2000 Feb;38(1):19-22.

PMID: 10783442

Analysis of case records of 46 patients with peripheral odontogenic fibroma (1967-95) diagnosed in the Division of Stomatology, Institute for Medical Research, Kuala Lumpur, disclosed a relatively young age of onset (mean, 32.2 years; range 5 months-64 years; peak incidence second decade of life), a slight female preponderance (M:F ratio 1:1.3), no racial predilection, a slight bias towards location in the mandible (52%) and a wide histomorphological range. All cases were treated by simple excision. Follow-up records were generally not available, so we do not know what the recurrence rate is.

Matched MeSH terms: Odontogenic Tumors/epidemiology; Odontogenic Tumors/pathology*

Erupted compound odontoma

Nik-Hussein NN, Majid ZA

Ann Dent, 1993;52(2):9-11.

PMID: 8267378

A case is described in which a compound odontoma erupted into the oral cavity in an 8 1/2-year-old girl. The odontoma was initially discovered as a chance radiographic finding 2 years 8 months previously.

Matched MeSH terms: Odontogenic Tumors/radiography; Odontogenic Tumors/surgery

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