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  1. Vijayasingham L, Bischof E, Wolfe J, Gender and COVID-19 Research Agenda-setting Initiative
    Lancet, 2021 Mar 13;397(10278):966-967.
    PMID: 33684351 DOI: 10.1016/S0140-6736(21)00384-6
    Matched MeSH terms: Sex Factors*
  2. Sun Y, Zhong Y, Sun W, Chu L, Long J, Fan XW
    Front Public Health, 2023;11:1167234.
    PMID: 37521991 DOI: 10.3389/fpubh.2023.1167234
    BACKGROUND: Adolescent depression has become a leading problem around the world, especially as the COVID-19 pandemic has remained prevalent and heavily influenced people's mental health. While gender difference has always been a topic in the field of psychiatry, there are cultural differences across the world that must be taken into account. The current study is examining gender differences in symptoms of Chinese adolescents with depression.

    METHODS: The sample was obtained from a total of 574 adolescent patients (172 males and 402 females) diagnosed with depression following the DSM-IV/ICD-10 diagnostic criteria; patients who also had other severe mental or physical illnesses were excluded. The ages of participants ranged from 10 to 19 years. Additionally, independent t-test and one-way ANOVA were used to examine differences in symptoms between different gender and age groups. The LPA was used to examine whether females and males were having different patterns of symptoms.

    RESULTS: Our analysis showed that compared to males, females exhibited higher rates of depression and more severe depressive symptoms across age groups. Likewise, the analysis also revealed an earlier onset of depression among Chinese adolescents compared to that in Western countries in previous studies. Finally, the LPA showed that mild to moderate depression was predominant in male patients, while severe depression was predominant in female patients.

    CONCLUSION: This study highlights the gender differences in the prevalence and severity of depressive symptoms in Chinese adolescents. The current study highlighted the importance of gender equality and developing gender-friendly interventions in maintaining the overall mental health of adolescents in China.

    Matched MeSH terms: Sex Factors*
  3. Power S, Biondi A, Saatci I, Bennett K, Mahadevan J, Januel AC, et al.
    Interv Neuroradiol, 2022 Jun;28(3):311-322.
    PMID: 34516279 DOI: 10.1177/15910199211030783
    BACKGROUND AND PURPOSE: Women's representation in medicine has increased over time yet the proportion of women practicing neurointervention remains low. We conducted an anonymous online survey through which we could explore the gender gap in neurointervention, identify potential issues, difficulties, or obstacles women might face, and evaluate if men encounter similar issues.

    METHODS: An online questionnaire was designed in SurveyMonkey®. Invitation to participate was emailed through national and international neurointerventional societies as well as directly through private mailing lists to men and women working in neurointervention. Responses were collected from 10 May 2019 to 10 September 2019.

    RESULTS: There were 295 complete responses, 173 (59%) male and 122 (41%) female. Most respondents (83%) fell within age categories 35-60 years, with representation from 40 countries across five continents. In all 95% were working full time, 73% had worked as a neurointerventionalist for >6 years, 77% worked in University-affiliated teaching institutions. Almost half of the respondents indicated no female neurointerventionalist worked in their center. Female respondents were younger and age-adjusted analysis was undertaken. Significantly fewer females than males were married and had children. Significantly fewer females held supervisory roles, held academic titles, and significantly less had a mentor. Females were less satisfied in their careers. More females felt they receive less recognition than colleagues of the opposite sex. Males had a greater proportion of work time dedicated to neurointervention. Similar proportions of both genders experienced bullying in work (40%-47%); however, sexual harassment was more common for females. There were no differences between genders in how they dealt with complications or their effects on mental well-being.

    CONCLUSION: There are many potential reasons why women are underrepresented in neurointervention, however, the literature suggests this is not unique to our specialty. Multiple long-term strategies will be necessary to address these issues, some of which are discussed in the article.

    Matched MeSH terms: Sex Factors*
  4. Hitchman SC, Fong GT
    Citation: Hitchman SC, Fong GT. The Bad With the Good? The Relation Between Gender Empowerment and Female-to-Male Cigarette Smoking Rates Across 74 Countries. ITC Project Working Paper Series. University of Waterloo, Waterloo, Ontario, Canada.; 2010

    Objective: Worldwide it is estimated that men smoke at nearly five times the rate of women. However, there is wide variation across countries in the gender smoking ratio (ratio of female-to-male smoking prevalence rates). Lower smoking rates among women have been attributed to social norms against women smoking, and women’s lower social status and economic resources. We tested the hypothesis that in countries with higher gender empowerment, the gender smoking ratio would be closer to 1.
    Methods: We correlated the gender smoking ratio (calculated from the 2008 WHO Global Tobacco Control Report) and the United Nations Development Programme’s Gender Empowerment Measure (GEM). Because a country’s progression through stages of the tobacco epidemic and its gender smoking ratio has been attributed to its level of development, we also examined this relation partialling on economic development (Gross National Income (GNI) per capita), and income inequality (Gini).
    Findings: The gender smoking ratio was significantly and positively correlated with the GEM. GEM was also the strongest predictor of the gender smoking ratio when controlling for GNI per capita and Gini in a multiple regression analysis.
    Key Conclusions: The findings identify a challenge for countries undergoing economic development and greater gender equality: can such progress take place without a corresponding increase in smoking rates among women? These findings thus highlight the need for strong tobacco control in countries in which gender equality is increasing.
    Matched MeSH terms: Sex Factors
  5. Ibrahim A, Singh DKA, Shahar S
    PLoS One, 2017;12(10):e0185641.
    PMID: 28972994 DOI: 10.1371/journal.pone.0185641
    AIMS: The aim of this study was to establish 'Timed up and Go' test (TUG) normative data among community dwelling older adults stratified based on cognitive status, gender and age groups.

    METHODS: A total of 2084 community dwelling older adults from wave I and II were recruited through a multistage random sampling method. TUG was performed using the standard protocol and scores were then stratified based on with and without mild cognitive impairment (MCI), gender and in a 5-year age groups ranging from ages of 60's to 80's.

    RESULTS: 529(16%) participants were identified to have MCI. Past history of falls and medical history of hypertension, heart disease, joint pain, hearing and vision problem, and urinary incontinence were found to have influenced TUG performance. Cognitive status as a mediator, predicted TUG performance even when both gender and age were controlled for (B 0.24, 95% CI (0.02-0.47), β 0.03, t 2.10, p = 0.36). Further descriptive analysis showed, participants with MCI, women and older in age took a longer time to complete TUG, as compared to men with MCI across all age groups with exceptions for some age groups.

    CONCLUSION: These results suggested that MCI needs to be taken into consideration when testing older adults using TUG, besides age and gender factors. Data using fast speed TUG may be required among older adults with and without MCI for further understanding.

    Matched MeSH terms: Sex Factors*
  6. Hairi NN, Cumming RG, Blyth FM, Naganathan V
    Maturitas, 2013 Jan;74(1):68-73.
    PMID: 23103063 DOI: 10.1016/j.maturitas.2012.10.001
    To establish if there is any gender difference in associations between chronic pain, impact of pain and pain severity with physical disability.
    Matched MeSH terms: Sex Factors*
  7. Chai, Sian Yi, Zaiton Hassan, Abang Ekhsan Abang Othman
    MyJurnal
    Influx of women in the paid labor force had been identified as one of the important factors in raising awareness about work-family balance in organizations in developed countries in the west. The same phenomenon also occurs in Malaysia. Malaysia is considered as having traditional gender role ideology, whereby men and women have separate role in the workplace and in the family. Specifically, this study aims to identify whether there are differences in perception between men and women in public sector towards factors associated with work-life balance. Work-life balance factors examined in this study are work demands, supervisor support, organization’s family-friendly policies, family demands, work-family conflict (WFC) and family-work conflict (FWC). Sixty questionnaires were administered to employees in a government health training institution in Sarawak, Malaysia. Data were analyzed using SPPS version 17 and independent t-Test was employed in testing the hypotheses. The study found that men and women are significantly different in terms of supervisor support, work-family conflict and family demands. However, there was no significant difference between men and women employees with regard to work demands, family-work conflict and utilization of family-friendly policies. In line with previous Western findings, women experienced higher level of work to family conflict (WFC) than men employees. In addition, women also reported higher family demands than men. These findings strengthened the traditional gender role ideology ascribed by majority of Malaysians and lend support to the gender role theory. Therefore, the organization could provide relevant training, such as, time and stress management. Supervisors could be trained to be more aware of work-family balance issues faced by their employees and assist them accordingly.
    Matched MeSH terms: Sex Factors
  8. Ng King Kwi, Yong SL
    Med J Malaysia, 1973 Jun;27(4):258-61.
    PMID: 4270782
    Matched MeSH terms: Sex Factors
  9. Wang X, Yang X, Juzaily Bin Mohd Nasiruddin N, Wei S, Dong D, Bin Samsudin S
    Health Educ Behav, 2024 Aug;51(4):533-543.
    PMID: 38305027 DOI: 10.1177/10901981231216735
    Although physical activity (PA) has a profound impact on health, many college and university students are still physically inactive. There is some evidence to suggest that social support (SS) could impact the PA levels of students, but the internal relationship and specific effects are not very clear. The purpose of this review was to determine the strength of the relationship between SS and PA and examine whether any potential associations differed in terms of age, gender, and region among college and university students. Studies were identified using the following electronic databases: PubMed, SPORTDiscus, Web of Science, and Sociological Abstracts. Moderator analyses investigating the effects of students' age, gender, and region (nation) were performed. This review included 19 articles. The results showed total SS was significantly associated with PA (r = 0.30, 95% confidence interval [CI]: [0.22, 0.37], p < .001). With respect to different types of support, friend support was more strongly associated with PA than family support. Gender factors had a significant moderating effect on the correlation between SS and PA (QM = 17.433, p < .001). Separate analyses examining the moderating effects of gender (percentage of females) found that the association between SS and PA was stronger with the increase in female percentage. In conclusion, SS is an important factor associated with PA levels and should foster SS within intervention programs according to types of SS and gender differences to increase PA levels among college and university students.
    Matched MeSH terms: Sex Factors
  10. Aziz ZA, Lee YY, Sidek NN, Ngah BA, Looi I, Hanip MR, et al.
    Neurol Res, 2016 May;38(5):406-13.
    PMID: 27142804 DOI: 10.1080/01616412.2016.1178948
    Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke.
    Matched MeSH terms: Sex Factors
  11. Chapman N, Ching SM, Konradi AO, Nuyt AM, Khan T, Twumasi-Ankrah B, et al.
    Hypertension, 2023 Jun;80(6):1140-1149.
    PMID: 36919603 DOI: 10.1161/HYPERTENSIONAHA.122.20448
    Hypertension is the leading risk factor for cardiovascular disease and premature death among women globally. However, there is a fundamental lack of knowledge regarding the sex-specific pathophysiology of the condition. In addition, risk factors for hypertension and cardiovascular disease unique to women or female sex are insufficiently acknowledged in clinical guidelines. This review summarizes the existing evidence on women and female-specific risk factors and clinical management of hypertension, to identify critical knowledge gaps relevant to research, clinical practice, and women's heart health awareness. Female-specific risk factors relate not only to reproduction, such as the association of gynecological conditions, adverse pregnancy outcomes or menopause with hypertension, but also to the specific roles of women in society and science, such as gender differences in received medical care and the underrepresentation of women in both the science workforce and as participants in research, which contribute to the limited evidence-based, gender- or sex-specific recommendations. A key point is that the development of hypertension starts in young, premenopausal women, often in association with disorders of reproductive organs, and therefore needs to be managed early in life to prevent future cardiovascular disease. Considering the lower blood pressure levels at which cardiovascular disease occurs, thresholds for diagnosis and treatment of hypertension may need to be lower for women.
    Matched MeSH terms: Sex Factors
  12. Gong J, Harris K, Lipnicki DM, Castro-Costa E, Lima-Costa MF, Diniz BS, et al.
    Alzheimers Dement, 2023 Aug;19(8):3365-3378.
    PMID: 36790027 DOI: 10.1002/alz.12962
    INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups.

    METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models.

    RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs.

    DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.

    Matched MeSH terms: Sex Factors
  13. Du C, Adjepong M, Zan MCH, Cho MJ, Fenton JI, Hsiao PY, et al.
    Nutrients, 2022 Sep 20;14(19).
    PMID: 36235535 DOI: 10.3390/nu14193882
    We thank Kuo et al. for their comments [...].
    Matched MeSH terms: Sex Factors
  14. Tan JY, Yeo YH, Kin HWK, Ang QX, Chisti MM, Ezekwudo D, et al.
    Cancer Med, 2025 Mar;14(6):e70831.
    PMID: 40129265 DOI: 10.1002/cam4.70831
    BACKGROUND: Chimeric Antigen Receptor (CAR) T-cell therapy has arisen as a revolutionary treatment for hematologic malignancies. Our study aimed to evaluate how sex differences affect outcomes and complications following CAR T-cell therapy.

    METHODS: Utilizing the Nationwide Readmissions Database (2018-2020), we identified patients and divided them into male and female groups. Hospital outcomes and complications were compared among these two groups after propensity score matching to match groups based on comorbidities, producing two comparable cohorts.

    RESULTS: We analyzed 2928 patients (1832 males, 62.6%, mean age 60.3 ± 13.7 years; 1096 females, 37.4%, mean age 59.1 ± 13.8 years). After propensity score matching (1:1ratio), 1092 males and females were compared. There were no significant sex differences in early mortality (adjusted odd ratios (aOR): 1.04 [95% CI 0.69-1.57]), 30-day readmissions (aOR: 1.05 [95% CI 0.86-1.30]), or nonhome discharge (aOR: 0.89 [95% CI 0.60-1.31]). Females had higher odds of leukopenia (aOR: 1.26 [95% CI 1.06-1.50]) but lower odds of acute kidney injury (aOR: 0.68 [95% CI 0.52-0.88]).

    CONCLUSIONS: No sex differences were found in hospital outcomes, including early mortality, 30-day readmission, and nonhome discharge after CAR T-cell therapy.

    Matched MeSH terms: Sex Factors
  15. Bezak E, Sharrad KJ, Marcu LG, Stoeva M, Lhotska L, Barabino G, et al.
    Phys Med, 2025 Feb;130:104897.
    PMID: 39787677 DOI: 10.1016/j.ejmp.2025.104897
    BACKGROUND: Working from home during the Covid-19 pandemic was perceived differently by men and women working in STEM fields. The aim of this paper is to highlight the unexpected benefits generated by working from home during the pandemic.

    METHODS: Qualitative methodology was used to analyze data, collected via survey. The survey designed and conducted by WiMPBME targeted both males and females working in medical-related STEM fields (physics and engineering) and was answered by 921 individuals from 76 countries across all continents. This report analysed the responses to one open-ended question of the survey, namely: "What is the one positive that you have learnt/experienced as a result of working from home during this pandemic?".

    RESULTS: 594 responded to the question of interest. Access to home office was reported by 72.2% of survey participants. Males were more likely than females to report no positives of working from home (62.9%). Females were more likely to cite quality time, physical and mental health as positive factors than males, and to mention children in their responses. The most commonly coded thematic unit for males was remote working, with many males reporting the feasibility of working from home. Increased work productivity, better time management and work organisation were other common themes highlighted by responders irrespective of gender.

    CONCLUSION: The findings of the survey show the diversity of perceptions about remote working in STEM fields, while highlighting the importance of considering family dynamics, individual circumstances as well as gender when evaluating varied experiences of STEM professionals.

    Matched MeSH terms: Sex Factors
  16. Packiriswamy V, Kumar P, Bashour M
    Facial Plast Surg, 2018 Aug;34(4):400-406.
    PMID: 29723879 DOI: 10.1055/s-0038-1648224
    In oculoplastic operations, knowledge of the dimensions of periorbital features based on age, gender, and race is essential for achieving better aesthetic result. This article seeks to determine the racial and gender differences of periorbital features among Malaysian Malay (MM), Malaysian Indian (MI), and Malaysian Chinese (MI) subjects. Evaluation of periorbital features was done on photographs of 200 MM, 200 MI, and 200 MC subjects, aged 18 to 26 years. The measured values were evaluated by an independent t-test. A significant difference was found between MM and MI in all measurements except interbrow distance in males, eyebrow thickness in females, and apex to lateral limbus distance in both sexes. Between MI and MC the difference was insignificant for interbrow distance in male groups, apex to lateral limbus distance in females, and palpebral fissure inclination and eyebrow apex angle in both sexes. Between MM and MC, significant differences were found for eyebrow thickness and medial canthus tilt in female group. Male groups showed significant difference for apex to lateral limbus and lateral canthus distance and eyebrow apex angle. Eyebrow height, palpebral fissure width, and intercanthal distance were significantly different in both sexes. Sexual dimorphism was found for all measurements in MI, but MM and MC showed insignificant difference for eyebrow apex angle. Four types of epicanthus were observed in MM and MC and three types in MI. Eyebrow apex between lateral limbus and lateral canthus was the most common position in all racial groups. Significant racial and gender differences exist for certain periorbital measurements. The knowledge of these differences is expected to influence the surgical outcome.
    Matched MeSH terms: Sex Factors
  17. Kamarunzaman, N.Z., Selamat, N.H.
    MyJurnal
    This article aims at exploring the trust establishment among patients with depression during their journey to psychiatric patient-hood. This study was undertaken in government hospital involving 29 psychiatric outpatient users in Kedah and Pulau Pinang respectively using phenomenological study and gender lens. Semi-structured in-depth interview and non-participant observation were the tools used in data collection. The data explicated with the aid of a qualitative data analysis tool, Atlas.ti., version 7.5. Through the findings, the study identified “Trust” appears critical in the accounts of the patients in shaping the doctor-patient relationship. Five interlocking subthemes describing the health professional’s characteristic while giving the service include doctor’s integrity, concern, competencies, empathy, and autonomy enabler. The findings had highlighted that both female and male physicians had different approach to their patients, where the female physician had better chances in getting the mandate of trust. This research is useful to health professionals and governance of mental health care to fulfil the patients’ needs based on their genders.

    Study site: government hospital involving 29 psychiatric outpatient users
    in Kedah and Pulau Pinang
    Matched MeSH terms: Sex Factors
  18. Abd Ghani A, Muslim NH, Zakaria MN
    Int J Pediatr Otorhinolaryngol, 2020 May;132:109907.
    PMID: 32018165 DOI: 10.1016/j.ijporl.2020.109907
    OBJECTIVE: Language disorders can affect reading skills contributing to poor academic achievements. As such, it is vital for speech language pathologists to identify the potential language-based reading problems among children. To achieve this, specific reading assessments should be developed and studied. Thus, the present study aimed to determine the effects of gender and academic achievement on oral reading fluency (ORF) and silent reading fluency (SRF) among Year 2 Malaysian children.

    METHODS: In this study that employed a comparative design, fifty-nine typically developing Malaysian children (24 boys, aged from 8 years, 0 months to 8 years, 11 months) were enrolled. They were chosen from three different classrooms (consisting of high achieving, medium achieving and low achieving students, respectively) in a primary school. Their ORF and SRF skills were assessed according to the established methods.

    RESULTS: As revealed by two-way ANOVA results, both ORF and SRF scores were found to be comparable between boys and girls (p > 0.05). In contrast, ORF and SRF results between the three classrooms were significantly different from each other (p 

    Matched MeSH terms: Sex Factors
  19. Mahil SK, Dand N, Mason KJ, Yiu ZZN, Tsakok T, Meynell F, et al.
    J Allergy Clin Immunol, 2021 Jan;147(1):60-71.
    PMID: 33075408 DOI: 10.1016/j.jaci.2020.10.007
    BACKGROUND: The multimorbid burden and use of systemic immunosuppressants in people with psoriasis may confer greater risk of adverse outcomes of coronavirus disease 2019 (COVID-19), but the data are limited.

    OBJECTIVE: Our aim was to characterize the course of COVID-19 in patients with psoriasis and identify factors associated with hospitalization.

    METHODS: Clinicians reported patients with psoriasis with confirmed/suspected COVID-19 via an international registry, Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection. Multiple logistic regression was used to assess the association between clinical and/or demographic characteristics and hospitalization. A separate patient-facing registry characterized risk-mitigating behaviors.

    RESULTS: Of 374 clinician-reported patients from 25 countries, 71% were receiving a biologic, 18% were receiving a nonbiologic, and 10% were not receiving any systemic treatment for psoriasis. In all, 348 patients (93%) were fully recovered from COVID-19, 77 (21%) were hospitalized, and 9 (2%) died. Increased hospitalization risk was associated with older age (multivariable-adjusted odds ratio [OR] = 1.59 per 10 years; 95% CI = 1.19-2.13), male sex (OR = 2.51; 95% CI = 1.23-5.12), nonwhite ethnicity (OR = 3.15; 95% CI = 1.24-8.03), and comorbid chronic lung disease (OR = 3.87; 95% CI = 1.52-9.83). Hospitalization was more frequent in patients using nonbiologic systemic therapy than in those using biologics (OR = 2.84; 95% CI = 1.31-6.18). No significant differences were found between classes of biologics. Independent patient-reported data (n = 1626 across 48 countries) suggested lower levels of social isolation in individuals receiving nonbiologic systemic therapy than in those receiving biologics (OR = 0.68; 95% CI = 0.50-0.94).

    CONCLUSION: In this international case series of patients with moderate-to-severe psoriasis, biologic use was associated with lower risk of COVID-19-related hospitalization than with use of nonbiologic systemic therapies; however, further investigation is warranted on account of potential selection bias and unmeasured confounding. Established risk factors (being older, being male, being of nonwhite ethnicity, and having comorbidities) were associated with higher hospitalization rates.

    Matched MeSH terms: Sex Factors
  20. Foong HF, Hamid TA, Ibrahim R, Haron SA
    Psychogeriatrics, 2020 Nov;20(6):891-899.
    PMID: 32985044 DOI: 10.1111/psyg.12614
    BACKGROUND: Little is known about gender differences in the relationship between religious orientation and life satisfaction in older adults living with chronic disease(s). Therefore, the purpose of this article was to examine the moderating effect of gender on the association between religious orientation and life satisfaction in older adults living with morbidity and multimorbidity.

    METHODS: The study involved 1790 community-dwelling older adults aged 60 and above living with at least one chronic medical condition. The Satisfaction with Life Scale and Revised Intrinsic/Extrinsic Religious Orientation Scale were used to measure life satisfaction and religious orientation. Moderated hierarchical multiple regression was used to test the moderation effect.

    RESULTS: Results showed that while intrinsic religiosity was positively associated with life satisfaction, extrinsic religiosity was found to have a negative relationship with life satisfaction. Gender moderated the association between intrinsic religiosity and life satisfaction.

    CONCLUSIONS: The findings suggested that the positive impact of intrinsic religiosity on life satisfaction was stronger in older women living with morbidity and multimorbidity. Healthcare practitioners can help disadvantaged older women in identifying their religious values and practices to improve their subjective wellbeing.

    Matched MeSH terms: Sex Factors
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