Browse publications by year: 2014

  1. Harbarth S, Tuan Soh S, Horner C, Wilcox MH
    J Hosp Infect, 2014 Aug;87(4):194-202.
    PMID: 24996517 DOI: 10.1016/j.jhin.2014.04.012
    Given the breadth and depth of antiseptic use, it is surprising how few large-scale studies have been undertaken into the consequences of their use, particularly in clinical practice. Depending on your point of view, this may either reflect an assurance that reduced susceptibility to antiseptics, and notably whether this confers cross-resistance to systemically administered antimicrobial agents, is not an issue of concern, or relative ignorance about the potential threat.
    MeSH terms: Anti-Infective Agents, Local/pharmacology*; Cross Infection/epidemiology*; Cross Infection/prevention & control; Disinfectants/pharmacology*; Health Facilities*; Humans; United States; Risk Assessment; Drug Resistance, Bacterial*
  2. Chia YC, Ching SM
    BMC Fam Pract, 2014;15:131.
    PMID: 24997591 DOI: 10.1186/1471-2296-15-131
    Patients with resistant hypertension are subjected to a higher risk of getting stroke, myocardial infarction, congestive heart failure and renal failure. However, the exact prevalence of resistant hypertension in treated hypertensive patients in Malaysia is not known. This paper examines the prevalence and determinants of resistant hypertension in a sample of hypertensive patients.

    Study site: Primary care clinic, Universiti Malaya Medical Centre
    MeSH terms: Adrenergic beta-Antagonists/therapeutic use; Age Factors; Aged; Ambulatory Care Facilities; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Antihypertensive Agents/therapeutic use; Calcium Channel Blockers/therapeutic use; China/ethnology; Cross-Sectional Studies; Diabetes Mellitus/epidemiology; Diuretics/therapeutic use; Drug Resistance*; Drug Therapy, Combination; Female; Hospitals, University; Humans; Hypertension/drug therapy; Hypertension/epidemiology*; India/ethnology; Malaysia; Malaysia/ethnology; Malaysia/epidemiology; Male; Middle Aged; Outpatient Clinics, Hospital; Primary Health Care*; Comorbidity; Prevalence; Multivariate Analysis; Logistic Models; Treatment Failure; Renal Insufficiency, Chronic/epidemiology*; Angiotensin Receptor Antagonists/therapeutic use
  3. Zulkifli A, Abidin NZ, Abidin EZ, Hashim Z, Rahman AA, Rasdi I, et al.
    Asian Pac J Cancer Prev, 2014;15(12):4815-21.
    PMID: 24998546
    BACKGROUND: This study aimed to examine the relationship between respiratory health of Malaysian adolescents with secondhand smoke (SHS) exposure and smoke-free legislation (SFL) implementation.

    MATERIALS AND METHODS: A total of 898 students from 21 schools across comprehensive- and partial-SFL states were recruited. SHS exposures and respiratory symptoms were assessed via questionnaire. Prenatal and postnatal SHS exposure information was obtained from parental-completed questionnaire.

    RESULTS: The prevalence of respiratory symptoms was: 11.9% ever wheeze, 5.6% current wheeze, 22.3% exercise-induced wheeze, 12.4% nocturnal cough, and 13.1% self-reported asthma. SHS exposure was most frequently reported in restaurants. Hierarchical logistic regression indicates living in a comprehensive-SFL state was not associated with a lower risk of reporting asthma symptoms. SHS exposure in public transport was linked to increased risk for wheeze (Adjusted Odds Ratio (AOR) 16.6; 95%confidence interval (CI), 2.69-101.7) and current wheezing (AOR 24.6; 95%CI, 3.53-171.8).

    CONCLUSIONS: Adolescents continue to be exposed to SHS in a range of public venues in both comprehensive- and partial-SFL states. Respiratory symptoms are common among those reporting SHS exposure on public transportation. Non-compliance with SFL appears to be frequent in many venues across Malaysia and enforcement should be given priority in order to reduce exposure.

    MeSH terms: Adolescent; Cross-Sectional Studies; Female; Follow-Up Studies; Health Plan Implementation*; Humans; Malaysia; Male; Parents; Prognosis; Surveys and Questionnaires; Respiratory Tract Diseases/etiology*; Respiratory Tract Diseases/prevention & control; Smoking/adverse effects; Smoking/legislation & jurisprudence*; Tobacco Smoke Pollution/adverse effects; Tobacco Smoke Pollution/legislation & jurisprudence*; Tobacco Smoke Pollution/prevention & control
  4. Yaakup H, Eng TC, Shah SA
    Asian Pac J Cancer Prev, 2014;15(12):4885-91.
    PMID: 24998558
    BACKGROUND: Successful implementation of pain management procedures and guidelines in an institution depends very much on the acceptance of many levels of healthcare providers.

    AIM: The main purpose of this study was to determine the level of knowledge and attitudes regarding pain among nurses working in tertiary care in a local setting and the factors that may be associated with this.

    MATERIALS AND METHODS: This cross-sectional research study used a modified version of the Nurses' Knowledge and Attitudes Survey (NKAS) regarding pain. Basic demographic data were obtained for further correlation with the level of pain knowledge.

    RESULTS: A total of 566 nurses, 34 male and 532 female, volunteered to participate in this study. The response rate (RR) was 76%, with an overall mean percentage score of 42.7±10.9 (range: 5-92.5). The majority of participants were younger nurses below 40 years of age and more than 70% had worked for less than 10 years (6.6±4.45). Up to 92% had never had any formal education in pain management in general. The total mean score of correct answers was 58.6±9.58, with oncology nursing staff scoring a higher percentage when compared with nurses from other general and critical care wards (63.52±9.27, p<0.045). Only 2.5% out of all participants obtained a score of 80% or greater. The majority of the oncology nurses achieved the expected competency level (p<0.03).

    CONCLUSIONS: The present findings give further support for the universal concern about poor knowledge and attitudes among nurses related to the optimal management of pain. The results indicated that neither number of years working nor age influenced the level of knowledge or attitudes of the practising nurses. Oncology nursing staff consistently scored better than the rest of the cohort. This reflects that clinical experience helps to improve attitudes and knowledge concerning better pain management.

    MeSH terms: Adult; Attitude of Health Personnel*; Clinical Competence*; Cross-Sectional Studies; Data Collection; Female; Follow-Up Studies; Humans; Health Knowledge, Attitudes, Practice*; Malaysia; Male; Middle Aged; Neoplasms/complications*; Neoplasms/nursing; Nursing Staff, Hospital/psychology*; Oncology Nursing*; Pain/diagnosis; Pain/etiology; Pain/prevention & control*; Surveys and Questionnaires; Young Adult; Pain Management; Tertiary Healthcare
  5. Ahmadian M, Samah AA, Saidu MB
    Asian Pac J Cancer Prev, 2014;15(12):5097-105.
    PMID: 24998591
    Knowledge of health and community psychology in health professionals influences psychosocial and community determinants of health and promoting participation in disease prevention at the community level. This paper appraises the potential of knowledge on psychology in health care professionals and its contribution to community empowerment through individual behavior change and health practice. The authors proposed a schematic model for the use of psychological knowledge in health professionals to promote participation in health interventions/disease prevention programs in developing countries. By implication, the paper provides a vision on policies towards supporting breast cancer secondary prevention efforts for community health development in Asian countries.
    MeSH terms: Attitude of Health Personnel*; Breast Neoplasms/prevention & control*; Community Health Services/legislation & jurisprudence; Delivery of Health Care; Female; Health Personnel/psychology*; Health Services Needs and Demand*; Humans; Health Knowledge, Attitudes, Practice*; Practice Patterns, Physicians'*; Prognosis; Psychology/education*
  6. Hambali SN, Khodapanahandeh S
    Glob J Health Sci, 2014 Jul;6(4):76-83.
    PMID: 24999124 DOI: 10.5539/gjhs.v6n4p76
    Medical malpractice cases are a matter of much concern in many countries including Malaysia where several cases caught the attention of the public and authorities. Although comprehensive annual statistics on medical negligence claims are not available in Malaysia since such data are not collected systematically in this country there are indications of an upward trend. Medical malpractice cases have been publicized by the media, academic researchers and in government annual reports prompting government policy makers, oversight agencies and the medical profession itself to take appropriate action. The increasing dissatisfaction with the current tort litigation system requires exploring alternatives and new approaches for handling medical malpractice cases. This study aims to examine the difficulties inherent in the tort system in Malaysia for solving medical malpractice claims and evaluates the structure of this system from the perspective of effectiveness, fairness, compensation, accessibility, and accountability.
    MeSH terms: Humans; Malaysia; Malpractice/legislation & jurisprudence*; Time Factors; Liability, Legal*; Patient Access to Records/legislation & jurisprudence
  7. Rahman MS, Mohamad OB, Zarim Zb
    Glob J Health Sci, 2014 Apr 16;6(4):196-204.
    PMID: 24999143 DOI: 10.5539/gjhs.v6n4p196
    In recent time climate change and its impact on human health and awareness constitute a set of complex and serious consequences to be tackled by an individual country. Climate change is not merely an environmental issue, but also it is a threat that goes beyond national borders. The purpose of this study is to identify the awareness and the impact of climate change, perceived by the young citizens in Malaysia by focusing on gender differences. Based on a survey of 200 respondents from different public and private University's students in Malaysia, this research used descriptive statistics and T-test to look into the research objective. The results revealed media can play an important role in the awareness of climate change. Meanwhile the male respondents have shown considerable attention on the physical impact of climate change like heat related stress. On the other hand female respondents have shown considerable attention to the psychological impact by the climate change. From a pragmatic perspective, the findings from this research will assists the policy makers to understand more about the perceived awareness on the climate change issues of the young citizens which ultimately assist them to inaugurate new initiatives to confront the challenges of climate changes. This research is among the pioneer study on the issue of the perceived awareness in regards to climate change in Malaysia by focusing on gender differences.
    MeSH terms: Adult; Awareness*; Female; Humans; Malaysia; Male; Mental Health*; Perception*; Sex Factors; Students/psychology*; Universities; Climate Change*
  8. Othman N, Nagoor NH
    Biomed Res Int, 2014;2014:318030.
    PMID: 24999473 DOI: 10.1155/2014/318030
    Lung cancer remains to be one of the most common and serious types of cancer worldwide. While treatment is available, the survival rate of this cancer is still critically low due to late stage diagnosis and high frequency of drug resistance, thus highlighting the pressing need for a greater understanding of the molecular mechanisms involved in lung carcinogenesis. Studies in the past years have evidenced that microRNAs (miRNAs) are critical players in the regulation of various biological functions, including apoptosis, which is a process frequently evaded in cancer progression. Recently, miRNAs were demonstrated to possess proapoptotic or antiapoptotic abilities through the targeting of oncogenes or tumor suppressor genes. This review examines the involvement of miRNAs in the apoptotic process of lung cancer and will also touch on the promising evidence supporting the role of miRNAs in regulating sensitivity to anticancer treatment.
    MeSH terms: Antineoplastic Agents/therapeutic use; Humans; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics*; Lung Neoplasms/pathology; Biomarkers, Tumor/genetics*; Gene Expression Regulation, Neoplastic; Apoptosis/drug effects; Apoptosis/genetics*; MicroRNAs/genetics*
  9. Jalooli A, Shaghaghi E, Jabbarpour MR, Noor RM, Yeo H, Jung JJ
    ScientificWorldJournal, 2014;2014:629412.
    PMID: 24999493 DOI: 10.1155/2014/629412
    Variable speed limits (VSLs) as a mean for enhancing road traffic safety are studied for decades to modify the speed limit based on the prevailing road circumstances. In this study the pros and cons of VSL systems and their effects on traffic controlling efficiency are summarized. Despite the potential effectiveness of utilizing VSLs, we have witnessed that the effectiveness of this system is impacted by factors such as VSL control strategy used and the level of driver compliance. Hence, the proposed approach called Intelligent Advisory Speed Limit Dedication (IASLD) as the novel VSL control strategy which considers the driver compliance aims to improve the traffic flow and occupancy of vehicles in addition to amelioration of vehicle's travel times. The IASLD provides the advisory speed limit for each vehicle exclusively based on the vehicle's characteristics including the vehicle type, size, and safety capabilities as well as traffic and weather conditions. The proposed approach takes advantage of vehicular ad hoc network (VANET) to accelerate its performance, in the way that simulation results demonstrate the reduction of incident detection time up to 31.2% in comparison with traditional VSL strategy. The simulation results similarly indicate the improvement of traffic flow efficiency, occupancy, and travel time in different conditions.
    MeSH terms: Anniversaries and Special Events; Automobile Driving*
  10. Ayiesah R, Leonard JH, Chong CY
    Clin Ter, 2014;165(3):123-8.
    PMID: 24999563 DOI: 10.7417/CT.2014.1708
    OBJECTIVE: Non-adherence is a serious issue among the participants in pulmonary rehabilitation program (PRP). Till date, no clinical tool is available to screen participants who will show poor adherence towards PRP. This study aimed to develop and validate a tool called "Adherence to Pulmonary Rehabilitation Questionnaire (APRQ)", a self-administered questionnaire to screen the risk of non-adherence to PRP among the patients with chronic obstructive pulmonary disease. APRQ comprises of 6 main constructs such as disease management behaviour, perceived treatment benefits, emotional factors, perceived severity of disease, barriers towards treatment and coping attitude.
    MATERIALS AND METHODS: This was a preliminary validity study carried out in the physiotherapy department and respiratory clinic in an university teaching hospital. A total of 109 patients with average age of 58.8 ± 1 year participated in the study. The inclusion criteria for subjects were: patients diagnosed with chronic obstructive pulmonary diseases (COPD) (Stage II and III). Exclusion criteria include those COPD patients with mental problems and disabled patients. The tool was developed based on thematic analysis and in-depth interview with focus group and literature search on the factors that lead to non-adherence among the PRP's participants. Principal component analysis was carried out to examine the construct validity and content validity of APRQ.
    RESULTS: A total of 20 items were created under 6 constructs. However, 2 items (smoking and hospital admission) were eliminated due to poor correlations. Thus, the final version of APRQ was developed and validated with 18 items. Reliability was measured using internal consistency and achieved Cronbach's Alpha of 0.762.
    CONCLUSIONS: The findings from this preliminary study supports that APRQ may be a valid and reliable tool to screen adherence towards PRP among chronic lung disease patients.
    Study site: Respiratory clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
    MeSH terms: Adult; Hospitals, University; Humans; Malaysia; Outpatient Clinics, Hospital; Rehabilitation; Pulmonary Disease, Chronic Obstructive*
  11. Hamidah NH, Shahrom S, Siti Aishah MA, Das S, Gendeh BS, Fadilah SA
    Clin Ter, 2014;165(3):139-42.
    PMID: 24999566 DOI: 10.7417/CT.2014.1711
    Primary nasal lymphomas are rare. One of the most common cellular subtypes in the Asian population is natural killer (NK)/T-cell lymphoma (NKTL) with a high association of EBV. We report a case of a 42-year-old female, who presented with a worsening sore throat, odynophagia, dysphagia to solid food due to oropharyngeal ulcers and bilateral nasal blockage and recurrent fever for the past two weeks prior to admission. Physical examination revealed ulcers over the soft palate with nasopharyngeal slough. Computerized Tomography (CT) scan of the neck showed nasopharyngeal abscess with bilateral maxillary ethnoidal sinusitis. The diagnostic and management challenge is discussed.
  12. Suria AA, Nurasyikin Y, Adibah AG, Cheah FC, Leong CF
    Clin Ter, 2014;165(3):151-4.
    PMID: 24999569 DOI: 10.7417/CT.2014.1714
    ABO incompatibility and glucose-6-phosphate dehydrogenase deficiency G6PD are common haematological problems affecting the newborn. The resulting haemolytic disease of foetus and newborn (HDFN) caused by either of these pathologies generally follows a benign course. It is typically characterized by mild jaundice without significant anaemia. ABO incompatibility alone as a cause of foetal hydrops is extremely rare. We report a case of a newborn baby girl with an anti-B isoimmunisation and G6PD deficiency manifesting with hydrops foetalis, anaemia and hyperbilirubinaemia, born to a mother with blood group O.
    MeSH terms: ABO Blood-Group System; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant, Newborn; Malaysia; Hydrops Fetalis
  13. Dashti S, Esfehani AJ, Leonard Joseph HJ
    Clin Ter, 2014;165(3):155-61.
    PMID: 24999570 DOI: 10.7417/CT.2014.1715
    Prevalence of obesity has increased recently especially in women. Obesity is related to mortality due to non-communicable diseases and has become a public health issue. Among the two important factors to reduce weight calorie limitation alone is modestly effective in initial weight but can result in weight gain after primary weight reduction is common. Therefore adding physical activity to weight maintenance program can reduce weight gain rebound. The aim of this review article was to identify the preventive effect of physical activity on weight maintenance in overweight women. Articles were selected from PubMed database and screened for the relativity to the study objectives, using scoring systems. Eleven studies were found appropriate. No statistical test was done on the data except simple mean and some descriptive analyses. Physical activity is proved to have a significant effect in weight loss/maintenance both in induction and maintenance period. This effect was more significant in higher intensities. Sever intensity physical activity can be effective in weight maintenance in long term but the effect of moderate and light physical activity could not be evaluated due to lack of data.
  14. Norhayati MN, George A, Hazlina NH, Azidah AK, Idiana HI, Law KS, et al.
    J Med Food, 2014 Aug;17(8):929-38.
    PMID: 25000151 DOI: 10.1089/jmf.2013.2953
    This study evaluated the effectiveness and safety of Labisia pumila var alata (L. pumila) water extract for improving quality of life, cardiovascular and hormonal balance. A randomized, double-blind, placebo-controlled, parallel group, 16-week study in healthy pre- and postmenopausal women aged 40-60 years was conducted in Kelantan, Malaysia. The subjects were randomized to 400 mg propriety extract of L. pumila or placebo. A Women's Health Questionnaire was used to assess quality of life. Repeated-measures analysis of variance was used to evaluate the data. A total of 197 subjects (L. pumila: n=102 and placebo: n=95) were analyzed. Subjects in the herbal group showed improved memory/concentration, vasomotor symptoms, menstrual symptoms, and sleep problems by 8.3%, 15.9%, 11.8%, and 31.0%, respectively. The greatest improvement was observed for the question: "I get frightened or panic feelings for apparently no reason at all" with a 53% decrease as compared with placebo. Improvements were also seen in the cardiovascular parameters, and the safety profiles were normal. Postmenopausal women supplemented with L. pumila showed no changes in gynecological relevant hormones luteinizing hormone (LH), follicle-stimulating hormone (FSH), and 17β-Estradiol. Water extract of L. pumila was shown to be safe and effective for improving several parameters of quality of life and cardiovascular risks factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C]).
    MeSH terms: Adult; Female; Follicle Stimulating Hormone/metabolism; Humans; Memory/drug effects; Middle Aged; Plant Extracts/administration & dosage*; Plant Extracts/adverse effects; Plant Extracts/pharmacology*; Quality of Life; Premenopause/drug effects*; Premenopause/metabolism; Premenopause/psychology; Postmenopause/drug effects*; Postmenopause/metabolism; Postmenopause/psychology; Primulaceae/chemistry*
  15. Zaman Huri H, Lian Choo T, Sulaiman CZ, Mark R, Abdul Razack AH
    BMJ Open, 2014 Jul 07;4(7):e005381.
    PMID: 25001396 DOI: 10.1136/bmjopen-2014-005381
    OBJECTIVE: To investigate factors associated with demographic/clinical characteristics and drug selection in patients with erectile dysfunction (ED). The prevalence of ED is increasing worldwide. Studies have shown that ED is associated with age, lifestyle and comorbidities. However, the factors associated with patient characteristics as well as drug selection are incompletely understood.

    SETTING: A tertiary medical centre in Kuala Lumpur, Malaysia.

    PARTICIPANTS: A total of 219 patients (range 23-80 years) who had received phosphodiesterase type-5 (PDE-5) inhibitors as ED treatment were evaluated.

    INCLUSION CRITERIA: Adult patients aged ≥18 years, diagnosed with ED, and prescribed with sildenafil, tadalafil or vardenafil.

    EXCLUSION CRITERIA: Patients diagnosed with ED but who did not receive any PDE-5 inhibitor, or those with missing data.

    PRIMARY AND SECONDARY OUTCOME MEASURES: Factors associated with demographic and clinical characteristics as well as drug selection were assessed.

    RESULTS: Ischaemic heart disease (p=0.025), benign prostatic hyperplasia (p<0.001), obesity (p=0.005), lower urinary tract symptoms (LUTS) (p=0.006) and α-blockers (p<0.001) were significantly associated with elderly patients with ED. Additionally, LUTS (p=0.038) and α-blockers (p=0.008) were significantly associated with the selection of PDE-5 inhibitor.

    CONCLUSIONS: These data showed that elderly patients with ED were significantly associated with comorbidities and α-blockers, whereas LUTS and α blockers were associated with drug selection.

    MeSH terms: Administration, Oral; Adrenergic alpha-Antagonists/administration & dosage; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Humans; Erectile Dysfunction/complications*; Erectile Dysfunction/drug therapy; Male; Middle Aged; Retrospective Studies; Prescription Drugs/administration & dosage*; Young Adult; Phosphodiesterase 5 Inhibitors/administration & dosage; Lower Urinary Tract Symptoms/complications; Lower Urinary Tract Symptoms/drug therapy
  16. Almulaifi AM, Lee WJ, Hong PE
    Surg Obes Relat Dis, 2014 Nov-Dec;10(6):e73-5.
    PMID: 25002323 DOI: 10.1016/j.soard.2014.04.013
    MeSH terms: Adenocarcinoma/etiology; Adenocarcinoma/surgery*; Diabetes Mellitus, Type 2/prevention & control; Diagnostic Imaging; Esophageal Neoplasms/etiology; Esophageal Neoplasms/surgery*; Humans; Lymph Node Excision; Male; Middle Aged; Neoplasm Staging; Obesity, Morbid/complications; Obesity, Morbid/surgery*; Gastric Bypass/methods*; Body Mass Index
  17. Qureshi N, Chawla S, Likitvivatanavong S, Lee HL, Gill SS
    Appl Environ Microbiol, 2014 Sep;80(18):5689-97.
    PMID: 25002432 DOI: 10.1128/AEM.01139-14
    The management and control of mosquito vectors of human disease currently rely primarily on chemical insecticides. However, larvicidal treatments can be effective, and if based on biological insecticides, they can also ameliorate the risk posed to human health by chemical insecticides. The aerobic bacteria Bacillus thuringiensis and Lysinibacillus sphaericus have been used for vector control for a number of decades. But a more cost-effective use would be an anaerobic bacterium because of the ease with which these can be cultured. More recently, the anaerobic bacterium Clostridium bifermentans subsp. malaysia has been reported to have high mosquitocidal activity, and a number of proteins were identified as potentially mosquitocidal. However, the cloned proteins showed no mosquitocidal activity. We show here that four toxins encoded by the Cry operon, Cry16A, Cry17A, Cbm17.1, and Cbm17.2, are all required for toxicity, and these toxins collectively show remarkable selectivity for Aedes rather than Anopheles mosquitoes, even though C. bifermentans subsp. malaysia is more toxic to Anopheles. Hence, toxins that target Anopheles are different from those expressed by the Cry operon.
    MeSH terms: Aedes/drug effects*; Aedes/physiology*; Animals; Anopheles/drug effects; Anopheles/physiology; Bacterial Toxins/genetics*; Bacterial Toxins/toxicity*; Operon*; Survival Analysis; Clostridium bifermentans/genetics*; Clostridium bifermentans/metabolism*
  18. Perrineau MM, Le Roux C, Galiana A, Faye A, Duponnois R, Goh D, et al.
    Appl Environ Microbiol, 2014 Sep;80(18):5709-16.
    PMID: 25002434 DOI: 10.1128/AEM.02007-14
    Introducing nitrogen-fixing bacteria as an inoculum in association with legume crops is a common practice in agriculture. However, the question of the evolution of these introduced microorganisms remains crucial, both in terms of microbial ecology and agronomy. We explored this question by analyzing the genetic and symbiotic evolution of two Bradyrhizobium strains inoculated on Acacia mangium in Malaysia and Senegal 15 and 5 years, respectively, after their introduction. Based on typing of several loci, we showed that these two strains, although closely related and originally sampled in Australia, evolved differently. One strain was recovered in soil with the same five loci as the original isolate, whereas the symbiotic cluster of the other strain was detected with no trace of the three housekeeping genes of the original inoculum. Moreover, the nitrogen fixation efficiency was variable among these isolates (either recombinant or not), with significantly high, low, or similar efficiencies compared to the two original strains and no significant difference between recombinant and nonrecombinant isolates. These data suggested that 15 years after their introduction, nitrogen-fixing bacteria remain in the soil but that closely related inoculant strains may not evolve in the same way, either genetically or symbiotically. In a context of increasing agronomical use of microbial inoculants (for biological control, nitrogen fixation, or plant growth promotion), this result feeds the debate on the consequences associated with such practices.
    MeSH terms: Acacia/microbiology*; Agriculture/methods; DNA, Bacterial/genetics; DNA, Bacterial/chemistry; Malaysia; Molecular Sequence Data; Senegal; Symbiosis*; Time Factors; Genetic Variation*; Evolution, Molecular*; Bradyrhizobium/classification*; Bradyrhizobium/genetics*; Bradyrhizobium/isolation & purification; Bradyrhizobium/physiology; Multilocus Sequence Typing
  19. Martin AG, Singh MS, Idris B, Abdullah JM
    J Neurosci Rural Pract, 2014 Jul;5(3):258-60.
    PMID: 25002765 DOI: 10.4103/0976-3147.133580
    Tuberous sclerosis is a known phakomatosis and the associated finding of a subependymal giant cell astrocytoma is common with this disorder. A case of tuberous sclerosis with a finding not previously reported, i.e. that of a pleomorphic xanthoastrocytoma, is presented here.
    MeSH terms: Astrocytoma; Brain Neoplasms; Tuberous Sclerosis; Neurocutaneous Syndromes
  20. Hashim YZ, Phirdaous A, Azura A
    Pharmacognosy Res, 2014 Jul;6(3):191-4.
    PMID: 25002797 DOI: 10.4103/0974-8490.132593
    Agarwood is a priceless non-timber forest product from Aquilaria species belonging to the Thymelaeaceae family. As a result of a defence mechanism to fend off pathogens, Aquilaria species develop agarwood or resin which can be used for incense, perfumery, and traditional medicines. Evidences from ethnopharmacological practices showed that Aquilaria spp. have been traditionally used in the Ayurvedic practice and Chinese medicine to treat various diseases particularly the inflammatory-associated diseases. There have been no reports on traditional use of agarwood towards cancer treatment. However, this is most probably due to the fact that cancer nomenclature is used in modern medicine to describe the diseases associated with unregulated cell growth in which inflammation and body pain are involved.
    MeSH terms: Inflammation; Medicine, Traditional; Neoplasms; Pain; Resins, Plant; Ethnopharmacology; Thymelaeaceae; Forests
External Links