Browse publications by year: 2014

  1. Gundamaraju R, Maheedhar K, Hwi KK
    Pharmacognosy Res, 2014 Jul;6(3):227-33.
    PMID: 25002803 DOI: 10.4103/0974-8490.132600
    Ulcerations have been effecting humans and causing major damage in the gastro intestinal tract. A need for development of a flawless anti-ulcer medication was always in the agenda. Thus, the need to conduct a study was provoked.
    MeSH terms: Anti-Ulcer Agents; Humans; Ulcer; Gastrointestinal Tract
  2. Rai V, Shariffuddin II, Chan YK, Muniandy RK, Wong KK, Singh S
    BMC Anesthesiol, 2014;14:49.
    PMID: 25002831 DOI: 10.1186/1471-2253-14-49
    BACKGROUND: Complete heart block in pregnancy has serious implications particularly during the period of delivery. This is more so if the delivery is an operative one as the presence of heart block may produce haemodynamic instability in the intra operative period. We report a unique case of a pregnant mother with complete heart block undergoing hysterostomy, complicated by placenta accreta and intrauterine death.

    CASE PRESENTATION: A 37 year old Malaysian Chinese parturient was admitted at 25 weeks gestation following a scan which suggested intrauterine death and placenta accreta. She was diagnosed to have congenital complete heart block after her first delivery eight years previously but a pacemaker was never inserted. These medical conditions make her extremely likely to experience massive bleeding and haemodynamic instability. Among the measures taken to optimise her pre-operatively were the insertion of a temporary intravenous pacemaker and embolization of the uterine arteries to minimize peri-operative blood loss. She successfully underwent surgery under general anesthesia, which was relatively uneventful and was discharged well on the fourth post-operative day.

    CONCLUSION: Congenital heart block in pregnancies in the presence of potential massive bleeding is best managed by a team, with meticulous pre-operative optimization. Suggested strategies would include insertion of a temporary pacemaker and embolization of the uterine arteries to reduce the risk of the patient getting into life threatening situations.

    MeSH terms: Adult; Anesthesia, General/methods; Embolization, Therapeutic/methods; Female; Fetal Death/etiology*; Heart Block/complications*; Heart Block/congenital; Heart Block/surgery; Humans; Hysterectomy/methods*; Pacemaker, Artificial; Placenta Accreta/physiopathology*; Pregnancy; Pregnancy Complications, Cardiovascular/physiopathology; Pregnancy Complications, Cardiovascular/surgery; Blood Loss, Surgical/prevention & control
  3. Kiong TS, Salem SB, Paw JK, Sankar KP, Darzi S
    ScientificWorldJournal, 2014;2014:164053.
    PMID: 25003136 DOI: 10.1155/2014/164053
    In smart antenna applications, the adaptive beamforming technique is used to cancel interfering signals (placing nulls) and produce or steer a strong beam toward the target signal according to the calculated weight vectors. Minimum variance distortionless response (MVDR) beamforming is capable of determining the weight vectors for beam steering; however, its nulling level on the interference sources remains unsatisfactory. Beamforming can be considered as an optimization problem, such that optimal weight vector should be obtained through computation. Hence, in this paper, a new dynamic mutated artificial immune system (DM-AIS) is proposed to enhance MVDR beamforming for controlling the null steering of interference and increase the signal to interference noise ratio (SINR) for wanted signals.
    MeSH terms: Artificial Intelligence*; Immune System/physiology; Models, Theoretical*; Signal Transduction
  4. Alam MA, Juraimi AS, Rafii MY, Hamid AA, Aslani F
    ScientificWorldJournal, 2014;2014:627916.
    PMID: 25003141 DOI: 10.1155/2014/627916
    Purslane (Portulaca oleracea L.) is an herbaceous leafy vegetable crop, comparatively more salt-tolerant than any other vegetables with high antioxidants, minerals, and vitamins. Salt-tolerant crop variety development is of importance due to inadequate cultivable land and escalating salinity together with population pressure. In this view a total of 25 purslane accessions were initially selected from 45 collected purslane accessions based on better growth performance and subjected to 5 different salinity levels, that is, 0.0, 10.0, 20.0, 30.0, and 40.0 dS m(-1) NaCl. Plant height, number of leaves, number of flowers, and dry matter contents in salt treated purslane accessions were significantly reduced (P ≤ 0.05) and the enormity of reduction increased with increasing salinity stress. Based on dry matter yield reduction, among all 25 purslane accessions 2 accessions were graded as tolerant (Ac7 and Ac9), 6 accessions were moderately tolerant (Ac3, Ac5, Ac6, Ac10, Ac11, and Ac12), 5 accessions were moderately susceptible (Ac1, Ac2, Ac4, Ac8, and Ac13), and the remaining 12 accessions were susceptible to salinity stress and discarded from further study. The selected 13 purslane accessions could assist in the identification of superior genes for salt tolerance in purslane for improving its productivity and sustainable agricultural production.
    MeSH terms: Selection, Genetic; Sodium Chloride/pharmacology; Portulaca/drug effects; Portulaca/genetics*; Portulaca/growth & development; Salt-Tolerance*
  5. Arifin N, Abu Osman NA, Ali S, Gholizadeh H, Abas WA
    ScientificWorldJournal, 2014;2014:856279.
    PMID: 25003155 DOI: 10.1155/2014/856279
    This study aimed to evaluate the effects of prosthetic foot types on the postural stability among transtibial amputees when standing on different support surfaces.
    MeSH terms: Adult; Amputees/rehabilitation*; Artificial Limbs*; Postural Balance*; Humans; Male; Middle Aged; Case-Control Studies
  6. Shah SA, Tan HL, Sultan S, Faridz MA, Shah MA, Nurfazilah S, et al.
    Int J Mol Sci, 2014;15(7):12027-60.
    PMID: 25003642 DOI: 10.3390/ijms150712027
    Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.
    MeSH terms: Bacteria/metabolism; Biotransformation*; Fungi/metabolism; Triterpenes/metabolism*; Crops, Agricultural/chemistry; Limonins/metabolism
  7. Teh X, Khosravi Y, Lee WC, Leow AH, Loke MF, Vadivelu J, et al.
    PLoS One, 2014;9(7):e101481.
    PMID: 25003707 DOI: 10.1371/journal.pone.0101481
    Helicobacter pylori is the etiological agent for diseases ranging from chronic gastritis and peptic ulcer disease to gastric adenocarcinoma and primary gastric B-cell lymphoma. Emergence of resistance to antibiotics possesses a challenge to the effort to eradicate H. pylori using conventional antibiotic-based therapies. The molecular mechanisms that contribute to the resistance of these strains have yet to be identified and are important for understanding the evolutional pattern and selective pressure imposed by the environment.
    MeSH terms: Anti-Bacterial Agents/pharmacology*; Genes, Bacterial; Humans; Malaysia/epidemiology; Metronidazole/pharmacology; Microbial Sensitivity Tests; Mutation; RNA, Ribosomal, 23S/genetics; Genetic Variation; Prevalence; Helicobacter pylori/drug effects*; Helicobacter pylori/genetics*; Helicobacter Infections/microbiology*; Helicobacter Infections/epidemiology*; Clarithromycin/pharmacology; Drug Resistance, Multiple; Fluoroquinolones/pharmacology; Drug Resistance, Bacterial*
  8. Liam CK, Pang YK, Chua KT
    Asian Pac J Allergy Immunol, 2014 Jun;32(2):145-52.
    PMID: 25003728 DOI: 10.12932/AP0359.32.2.2013
    OBJECTIVE: To evaluate Malaysian patients' satisfaction levels and asthma control with Symbicort SMART® in the primary care setting.
    METHOD: This is a cross-sectional, multicentre study involving adult patients with persistent asthma who were prescribed only Symbicort SMART in the preceding one month prior to recruitment. Patients' satisfaction with Symbicort SMART and asthma control were evaluated using the self-administered Satisfaction with Asthma Treatment Questionnaire (SATQ) and the Asthma Control Test (ACT).
    RESULTS: Asthma was controlled (ACT score >20) in 189 (83%) of 228 patients. The mean overall SATQ score for patients with controlled asthma was 5.65 indicating a high satisfaction level, which was positively correlated with high ACT scores. There were differences in asthma control based on ethnicity, number of unscheduled visits and treatment compliance.
    CONCLUSIONS: Symbicort SMART resulted in a high satisfaction level and asthma control among Malaysian patients treated in the primary care setting and it is an effective and appealing treatment for asthmatic patients.
    Study site: General practice clinics, Malaysia
    MeSH terms: Budesonide, Formoterol Fumarate Drug Combination; Adolescent; Adrenal Cortex Hormones/administration & dosage*; Adrenal Cortex Hormones/adverse effects; Adult; Ambulatory Care Facilities; Asthma/drug therapy*; China/ethnology; Cross-Sectional Studies; Drug Combinations; Ethanolamines/administration & dosage*; Ethanolamines/adverse effects; Female; Humans; India/ethnology; Malaysia; Malaysia/ethnology; Male; Middle Aged; Primary Health Care/methods*; Patient Satisfaction*; Anti-Asthmatic Agents/administration & dosage*; Anti-Asthmatic Agents/adverse effects; Budesonide/administration & dosage*; Budesonide/adverse effects; Private Facilities
  9. Ghafourian S, Good L, Sekawi Z, Hamat RA, Soheili S, Sadeghifard N, et al.
    Mem Inst Oswaldo Cruz, 2014 Jul;109(4):502-5.
    PMID: 25004148
    Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates. The aim of the current study was to screen for functional TA systems among clinical isolates of A. baumannii and to identify the systems' locations. For this purpose, we screened 85 A. baumannii isolates collected from different clinical sources for the presence of the mazEF, relBE and higBA TA genes. The results revealed that the genes coding for the mazEF TA system were commonly present in all clinical isolates of A. baumannii. Reverse transcriptase-polymerase chain reaction analysis showed that transcripts were produced in the clinical isolates. Our findings showed that TA genes are prevalent, harboured by chromosomes and transcribed within A. baumannii. Hence, activation of the toxin proteins in the mazEF TA system should be investigated further as an effective antibacterial strategy against this bacterium.
    MeSH terms: Antitoxins/genetics; Antitoxins/metabolism*; Bacterial Toxins/genetics; Bacterial Toxins/metabolism*; Humans; Transcription, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Acinetobacter baumannii/genetics; Acinetobacter baumannii/metabolism*
  10. Chou LY, Clarke CM, Dykes GA
    Arch Microbiol, 2014 Oct;196(10):709-17.
    PMID: 25005571 DOI: 10.1007/s00203-014-1011-1
    Nepenthes pitcher plants produce modified jug-shaped leaves to attract, trap and digest insect prey. We used 16S rDNA cloning and sequencing to compare bacterial communities in pitcher fluids of each of three species, namely Nepenthes ampullaria, Nepenthes gracilis and Nepenthes mirabilis, growing in the wild. In contrast to previous greenhouse-based studies, we found that both opened and unopened pitchers harbored bacterial DNA. Pitchers of N. mirabilis had higher bacterial diversity as compared to other Nepenthes species. The composition of the bacterial communities could be different between pitcher types for N. mirabilis (ANOSIM: R = 0.340, p < 0.05). Other Nepenthes species had similar bacterial composition between pitcher types. SIMPER showed that more than 50 % of the bacterial taxa identified from the open pitchers of N. mirabilis were not found in other groups. Our study suggests that bacteria in N. mirabilis are divided into native and nonnative groups.
    MeSH terms: Bacteria/classification; Bacteria/genetics; Bacteria/isolation & purification*; Plant Leaves/microbiology*; Angiosperms/microbiology*
  11. Chun TS, Malek MA, Ismail AR
    Environ Sci Process Impacts, 2014 Sep 20;16(9):2208-14.
    PMID: 25005632 DOI: 10.1039/c4em00282b
    Effluent discharge from septic tanks is affecting the environment in developing countries. The most challenging issue facing these countries is the cost of inadequate sanitation, which includes significant economic, social, and environmental burdens. Although most sanitation facilities are evaluated based on their immediate costs and benefits, their long-term performance should also be investigated. In this study, effluent quality-namely, the biological oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solid (TSS)-was assessed using a biomimetics engineering approach. A novel immune network algorithm (INA) approach was applied to a septic sludge treatment plant (SSTP) for effluent-removal predictive modelling. The Matang SSTP in the city of Kuching, Sarawak, on the island of Borneo, was selected as a case study. Monthly effluent discharges from 2007 to 2011 were used for training, validating, and testing purposes using MATLAB 7.10. The results showed that the BOD effluent-discharge prediction was less than 50% of the specified standard after the 97(th) month of operation. The COD and TSS effluent removals were simulated at the 85(th) and the 121(st) months, respectively. The study proved that the proposed INA-based SSTP model could be used to achieve an effective SSTP assessment and management technique.
    MeSH terms: Algorithms; Borneo; Models, Theoretical*; Sewage; Waste Disposal, Fluid/methods*; Water Pollutants/analysis; Biomimetics*; Biological Oxygen Demand Analysis
  12. Ahmad N, Cheong SM, Ibrahim N, Rosman A
    Asia Pac J Public Health, 2014 Sep;26(5 Suppl):63S-9S.
    PMID: 25005932 DOI: 10.1177/1010539514540746
    Adolescence is the time of greatest risk for the first onset of suicidal behaviors. This study aimed to identify the risk and protective factors associated with suicidal ideation among Malaysian adolescents. Data from the 2012 Malaysia Global School-based Student Health Survey, a nationwide study using a 2-stage cluster sampling design, were analyzed. The survey used a self-administered validated bilingual questionnaire and the Depression Anxiety and Stress Scale. The prevalence of suicidal ideation was 7.9%. Analysis revealed that suicidal ideation was positively associated with depression, anxiety, stress, substance use, being bullied, and being abused at home, either physically or verbally. In addition, suicidal ideation was significantly higher among females and among the Indians and Chinese. Having close friends and married parents were strongly protective against suicidal ideation. Understanding the risk and protective factors is important in providing comprehensive management for suicidal ideation.
    Study name: Global School-Based Student Health Survey (GSHS)
    MeSH terms: Adolescent; Female; Health Surveys; Humans; Malaysia; Malaysia/epidemiology; Male; Risk Factors; Students/psychology*; Students/statistics & numerical data; Multivariate Analysis; Logistic Models; Bullying; Suicidal Ideation*
  13. Lean SS, Suhaili Z, Ismail S, Rahman NI, Othman N, Abdullah FH, et al.
    ISRN Microbiol, 2014;2014:953417.
    PMID: 25006521 DOI: 10.1155/2014/953417
    Nosocomial infection caused by Acinetobacter baumannii is of great concern due to its increasing resistance to most antimicrobials. In this study, 54 nonrepeat isolates of A. baumannii from the main tertiary hospital in Terengganu, Malaysia, were analyzed for their antibiograms and genotypes. Out of the 54 isolates, 39 (72.2%) were multidrug resistant (MDR) and resistant to carbapenems whereas 14 (25.9%) were categorized as extensive drug resistant (XDR) with additional resistance to polymyxin B, the drug of "last resort." Pulsed-field gel electrophoresis analyses showed that the polymyxin-resistant isolates were genetically diverse while the carbapenem-resistant isolates were clonally related. The 14 XDR isolates were further investigated for mutations in genes known to mediate polymyxin resistance, namely, pmrCAB, and the lipopolysaccharide biosynthesis genes, lpxA, lpxC, lpxD, and lpsB. All 14 isolates had a P102H mutation in pmrA with no mutation detected in pmrC and pmrB. No mutation was detected in lpxA but each polymyxin-resistant isolate had 2-4 amino acid substitutions in lpxD and 1-2 substitutions in lpxC. Eight resistant isolates also displayed a unique H181Y mutation in lpsB. The extent of polymyxin resistance is of concern and the novel mutations discovered here warrant further investigations.
  14. Madan JR, Khude PA, Dua K
    Int J Pharm Investig, 2014 Apr;4(2):60-4.
    PMID: 25006550 DOI: 10.4103/2230-973X.133047
    Solid lipid nanoparticles (SLNs) are the new generation of submicron sized lipid emulsions where liquid lipid (oil) has been substituted by solid lipid. Lipids used in the formulation are safe, stable and biodegradable in nature. SLNs offer various advantages for topical drug delivery like ability of deposition into skin with the reduced systemic exposure and reduced local side-effects along with providing sustained release of drug. Mometasone furoate (MF) is a topical glucocorticoid having anti-inflammatory, anti-pruritic, anti-hyper proliferative activity. Owing to these properties it is recommended in chronic inflammation and psoriasis. In market, MF cream and lotion (0.1%) are available, which show slight skin irritation, burning and common side-effects due to steroids.
  15. Mirhassani SM, Zourmand A, Ting HN
    ScientificWorldJournal, 2014;2014:534064.
    PMID: 25006595 DOI: 10.1155/2014/534064
    Automatic estimation of a speaker's age is a challenging research topic in the area of speech analysis. In this paper, a novel approach to estimate a speaker's age is presented. The method features a "divide and conquer" strategy wherein the speech data are divided into six groups based on the vowel classes. There are two reasons behind this strategy. First, reduction in the complicated distribution of the processing data improves the classifier's learning performance. Second, different vowel classes contain complementary information for age estimation. Mel-frequency cepstral coefficients are computed for each group and single layer feed-forward neural networks based on self-adaptive extreme learning machine are applied to the features to make a primary decision. Subsequently, fuzzy data fusion is employed to provide an overall decision by aggregating the classifier's outputs. The results are then compared with a number of state-of-the-art age estimation methods. Experiments conducted based on six age groups including children aged between 7 and 12 years revealed that fuzzy fusion of the classifier's outputs resulted in considerable improvement of up to 53.33% in age estimation accuracy. Moreover, the fuzzy fusion of decisions aggregated the complementary information of a speaker's age from various speech sources.
    MeSH terms: Age Factors; Child; Decision Support Techniques*; Female; Humans; Male; Voice/physiology; Fuzzy Logic*
  16. Chean KY
    Aust Fam Physician, 2014 Jul;43(7):443-4.
    PMID: 25006604
    MeSH terms: Child; Diagnosis, Differential; Erythema Multiforme/complications; Erythema Multiforme/diagnosis*; Female; Humans; Lip/pathology*; Lip Diseases/diagnosis*; Lip Diseases/etiology; Ulcer/diagnosis*; Ulcer/etiology
  17. Ang M, Chong W, Huang H, Wong TY, He MG, Aung T, et al.
    PLoS One, 2014;9(7):e101483.
    PMID: 25006679 DOI: 10.1371/journal.pone.0101483
    To describe the corneal and anterior segment determinants of posterior corneal arc length (PCAL) and posterior corneal curvature (PCC).
    MeSH terms: Adult; Aged; Aged, 80 and over; Biometry; China/ethnology; Cornea/pathology*; Corneal Diseases/diagnosis*; Corneal Diseases/surgery; Cross-Sectional Studies; Female; Humans; Image Interpretation, Computer-Assisted; India/ethnology; Malaysia/ethnology; Male; Middle Aged; Singapore; Multivariate Analysis; Linear Models; Tomography, Optical Coherence
  18. Tan WS, Yunos NY, Tan PW, Mohamad NI, Adrian TG, Yin WF, et al.
    Sensors (Basel), 2014;14(7):12104-13.
    PMID: 25006994 DOI: 10.3390/s140712104
    N-acylhomoserine lactones (AHL) plays roles as signal molecules in quorum sensing (QS) in most Gram-negative bacteria. QS regulates various physiological activities in relation with population density and concentration of signal molecules. With the aim of isolating marine water-borne bacteria that possess QS properties, we report here the preliminary screening of marine bacteria for AHL production using Chromobacterium violaceum CV026 as the AHL biosensor. Strain T33 was isolated based on preliminary AHL screening and further identified by using 16S rDNA sequence analysis as a member of the genus Vibrio closely related to Vibrio brasiliensis. The isolated Vibrio sp. strain T33 was confirmed to produce N-hexanoyl-L-homoserine lactone (C6-HSL) and N-(3-oxodecanoyl)-L-homoserine lactone (3-oxo-C10 HSL) through high resolution tandem mass spectrometry analysis. We demonstrated that this isolate formed biofilms which could be inhibited by catechin. To the best of our knowledge, this is the first report that documents the production of these AHLs by Vibrio brasiliensis strain T33.
    MeSH terms: Oceans and Seas; Seawater/microbiology*; Species Specificity; Vibrio/classification; Vibrio/genetics*; Vibrio/metabolism*; Quorum Sensing/physiology*; Acyl-Butyrolactones/metabolism*
  19. Levitan CA, Ren J, Woods AT, Boesveldt S, Chan JS, McKenzie KJ, et al.
    PLoS One, 2014;9(7):e101651.
    PMID: 25007343 DOI: 10.1371/journal.pone.0101651
    Colors and odors are associated; for instance, people typically match the smell of strawberries to the color pink or red. These associations are forms of crossmodal correspondences. Recently, there has been discussion about the extent to which these correspondences arise for structural reasons (i.e., an inherent mapping between color and odor), statistical reasons (i.e., covariance in experience), and/or semantically-mediated reasons (i.e., stemming from language). The present study probed this question by testing color-odor correspondences in 6 different cultural groups (Dutch, Netherlands-residing-Chinese, German, Malay, Malaysian-Chinese, and US residents), using the same set of 14 odors and asking participants to make congruent and incongruent color choices for each odor. We found consistent patterns in color choices for each odor within each culture, showing that participants were making non-random color-odor matches. We used representational dissimilarity analysis to probe for variations in the patterns of color-odor associations across cultures; we found that US and German participants had the most similar patterns of associations, followed by German and Malay participants. The largest group differences were between Malay and Netherlands-resident Chinese participants and between Dutch and Malaysian-Chinese participants. We conclude that culture plays a role in color-odor crossmodal associations, which likely arise, at least in part, through experience.
    MeSH terms: Adult; Association*; China/ethnology; Color; Color Perception*; Cross-Cultural Comparison; Female; Germany; Humans; Malaysia; Male; Netherlands; Odors; United States; Olfactory Perception*; Young Adult
  20. Husain IA, Alkhatib MF, Jammi MS, Mirghani ME, Bin Zainudin Z, Hoda A
    J Oleo Sci, 2014;63(8):747-52.
    PMID: 25007744
    Presence of fat, oil, and grease (FOG) in wastewater is an ever-growing concern to municipalities and solid-waste facility operators. FOG enters the sewer system from restaurants, residences, and industrial food facilities. Its release into the sewer system results in a continuous build-up that causes eventual blockage of sewer pipes. Several researchers have investigated FOG deposition based on the local conditions of sewers and lifestyle. This paper attempts to review the physical and chemical characteristics of FOG, sources of FOG, and potential chemical and biological reactions of FOG. The effect of the aforementioned factors on the FOG-deposition mechanism is also discussed. Moreover, insight into the current control and treatment methods and potential reuse of FOG is highlighted. It is expected that this review would provide scientists and the concerned authorities a holistic view of the recent researches on FOG control, treatment, and reuse.
    MeSH terms: Cooking; Fatty Acids, Nonesterified/analysis; Food Handling; Hydrolysis; Industrial Waste; Oxidation-Reduction; Refuse Disposal*; Saponins/chemistry; Sewage*; Waste Disposal, Fluid*; Waste Management/methods*; Water Purification/methods*; Physicochemical Phenomena; Waste Water*
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