This paper describes the process of designing a wheelchair with the main aim of making it
compact and lightweight. A wheelchair is a common device used to assist in terms of mobility for those
with difficulty to walk. Most conventional manual wheelchairs are heavy and bulky, even after they are
folded. The designed wheelchair in this research is able to reduce the weight approximately by 30%.
The wheelchair volume after folding is also reduced significantly. Besides, the designed wheelchair was
evaluated by using 3D CAD software to analyse the strength and possible material failure. Moreover,
a virtual mannequin was used to evaluate the geometry and the comfort of the design. On top of that, a
scale down prototype was produced by using a 3D printer to evaluate the fold-ability function of the
wheelchair.
Despite of the advancement of technology in the present internet age, many college students
lack the information and communication technology (ICT) literacy skills like evaluating those necessary
to navigate, as well as using the information available today. Evaluating the quality of information
sources encompasses students’ ability to determine relevance, accuracy, and overall credibility of
sources and information. Moreover, the quality of information found online is extremely variable
because anyone can post data on the internet, and not all online sources are equally reliable, valuable,
or accurate. From a study conducted on diploma students’ assignments using rubric at an international
university in Kuala Lumpur, it was found that there was a problem in digital information evaluation
skills and lack of ability in using evaluation criteria, including authority, accuracy, currency,
objectivity, and coverage on digital information, as well as sources among diploma students. The future
work of this study will be the use of mobile devices in collaborative and interactive learning to improve
digital information evaluation skills among diploma students. This approach does not only improve the
students’ learning attitude, but also enhances the effectiveness of learning.
This paper presents the work of investigating and comparing the uses of CRS and QTC Pills
as a tactile sensor material for Robotic Hand application. The materials were tested for their resistivity
characteristics to determine the data reproducibility of the materials. The experiments were conducted
based on three parameters; the supply voltage, the separation gap, and the sensor construction against
the force/ load that had been exerted onto the materials. The results showed that CRS could cover the
lower loading range when compared to QTC Pills. However, the data reproducibility of QTC Pills was
better compared to those of CRS, thus making it more suitable to be used as a material for tactile
sensing application. Therefore, this paper highlights the potential of these two materials as a tactile
sensing transducer, and later, can be used as a useful guideline when designing a tactile sensor with
these materials.
This study was performed to review the conceptualization and relationships among user
behaviour, system quality and intention to use eBidding, an eGovernment auction system with user
satisfaction as the moderator. From the theoretical framework, user behaviour and system quality
factors have significant relationships with the adoption of information system (IS). Empirical evidence
also shows that satisfaction has a significant moderating effect on the relationship between system
quality factors with the adoption of IS. Given the significant impact of behavioural factors of officials
in eBidding adoption and role satisfaction on the intention and use of eGovernment system, system
managers could introduce key changes in the workplace to increase satisfaction to address the problems
of low eBidding adoption among users.
This paper studied the heat transfer in an asphalt solar collector with small scale geometry.
Solar energy reaches the earth and consequently increases the temperature of the ground, which then
leads to the increase of the temperature of the air. Water circulates through a series of pipes embedded
in the asphalt pavement for the extraction of solar energy. The radiation in this study was produced
from the top asphalt pavement. In this study, the temperature of the asphalt pavement decreased when
solar energy was collected from the circulating water. This reduces the heat island effect in the city and
decreases the power consumption for air conditioning. The temperature is distributed between the
asphalt pavement and the inner pipes. Increase of the flow rate has a great influence on the energy
collection by reducing the temperature of the asphalt pavement. The result of this test was obtained
using a small-scale asphalt pavement, which showed a high amount of heat collected.
Calciphylaxis on the background of immune thrombocytopenic purpura (ITP) has never been described. The pathogenesis of calciphylaxis is complex and not fully understood as yet. ITP has a complex pathogenesis that leads to bleeding or thrombotic events. Although ITP is treatable and reversible, calciphylaxis on the other hand, responds poorly to treatment and carries high mortality and morbidity. We present a case of a 56-year-old lady with end-stage renal disease with ITP, who complained of 1-month history of painful necrotic patches over the thighs. Due to delayed diagnosis, the patient deteriorated and passed away despite aggressive multidisciplinary approach. This case highlights the importance of early recognition of the increased thrombotic risk in an end-stage renal failure patient with poor phosphate control and ITP.
Sir, I write in regard to Nayar S et al article 'The Effect of a Radiation Positioning Stent (RPS) in the Reduction of Radiation Dosage to the Opposing Jaw and Maintenance of Mouth opening after Radiation Therapy'. I wholeheartedly agree to that patients undergoing radio-therapy who had an Radiation Positioning Stent (RPS) would show a significant reduction in radiation dosage to the opposing jaw and maintained their mouth opening in the short-term. As we know that oral cancer has emerged to be one of most deadliest cancer nowadays.
This paper reveals the hotspots of new mite discovery through of a survey of type localities of new Trombidiformes species described in two journals (Systematic & Applied Acarology and Zootaxa) during the last three years (2013-2015). Taxonomically, the 491 new species of the Trombidiformes are highly unevenly distributed among 55 families with top 10 families accounting for over 66% of the total. The Eriophyidae is the top-ranked family. Geographically, these 491 new species are from 55 countries around the world and their distribution among the countries is highly uneven. The majority of these new species (69%) are from the top 10 countries and six of the top ten countries are also megadiversity countries. The top three countries are all from Asia (Iran, China and Malaysia) and they together accounted for over one third of all new species of the Trombidiformes described in the two journals during 2013-2015.
A 44-year-old woman was admitted to our hospital with dengue fever. She developed a haematoma in the right arm at the site of a previous arterial line insertion. Due to coexisting thrombocytopenia, the bleeding was severe enough to cause compartment syndrome. An emergency fasciotomy was performed and her limb salvaged. The case illustrates one important potential complication of this common infectious disease.
Isoprenoids biosynthesis in plants involves two separate pathways, mevalonate (MVA) pathway and 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. A large group of isoprenoids are found to play crucial roles in common plant biochemical functions and have been produced on a large scale for commercial applications. 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the key enzyme that catalyses the first committing step in the MVA pathway. In mammals and yeast, HMGR is a well-studied enzyme as many studies have been done on this enzyme due to its important function in the biosynthesis of cholesterol. In plants, many researches on HMGR have been done on different plant species, for example, Arabidopsis thaliana, tobacco, gingko, Zea mays, potato, rose, rubber tree, muskmelon, ginseng and others, in the past decades since it was discovered. Previous researches that worked on plant HMGR focused on the cloning and characterisation of its physiological functions. Little is known about the aspect of regulation and structural characteristics of plants’ HMGR. This review is aimed at providing an overview of the characteristics and structure of HMGR, the transcriptional and post-translational events related to HMGR that have been reported in plants, and proposes areas on the regulation event of HMGR in plants that can be explored to further enhance understanding towards HMGR regulatory interactions.
Nigella sativa (Black seeds) has been recognized as one of the most popular herbs in many
parts of the world for centuries. It was used in the world as folk medicine to cure different kinds of diseases. This plant has been considered as one of the main sources of nutrition and healthcare for humans as well as animals. It has been perceived as Kalonji; it is a southwest Asian plan t that flowers annually. The seeds and oil of this plant have been used in food; in addition, it has a long history in the making of medicines. In addition to its being a model plant for better realization of gene and chromosome relationship, the plant species is also significant cytogenetically. Plant based system has not been absorbed fully for human health care despite the remarkable advancements in the field of pharmacology. Cumin, as one of the medicinal plants gifted to humans by nature, has a number of potential uses. It has been proved to be a
useful herbal medicines that can be used for human health and therefore has been extensively studied and investigated to further discover the advantages of this plant.
In recent years, three-dimensional (3D) in vitro cell culture models have earned great attention, especially in the field of human cancer disease modelling research as they provide a promising alternative towards the conventional two-dimensional (2D) monolayer culture of cells with improved tissue organization. In 2D cell culture systems, the complexity of cells on a planar surface does not accurately reflects the in vivo cellular microenvironment. Cells propagated in 3D cell culture model, on the other hand, exhibit physiologically relevant cell-to-cell interactions and cell-to-extracellular matrix (ECM) interactions, important in maintaining a normal homeostasis and specificity of tissues. This review gives an overview on 2D models and their limitations, followed by 3D cell culture models, their advantages, drawbacks and challenges in present perspectives. The review also highlights the dissimilarities of 2D and 3D models and the applicability of 3D models in current cancer research
Chikungunya virus is a reemerging arbovirus transmitted mainly by Aedes mosquitoes. As there are no specific treatments available, Chikungunya virus infection is a significant public health problem. This study investigated 120 extracts from selected medicinal plants for anti-Chikungunya virus activity. The plant materials were subjected to sequential solvent extraction to obtain six different extracts for each plant. The cytotoxicity and antiviral activity of each extract were examined using African monkey kidney epithelial (Vero) cells. The ethanol, methanol and chloroform extracts of Tradescantia spathacea (Commelinaceae) leaves showed the strongest cytopathic effect inhibition on Vero cells, resulting in cell viabilities of 92.6% ± 1.0% (512 μg/ml), 91.5% ± 1.7% (512 μg/ml) and 88.8% ± 2.4% (80 μg/ml) respectively. However, quantitative RT-PCR analysis revealed that the chloroform extract of Rhapis excelsa (Arecaceae) leaves resulted in the highest percentage of reduction of viral load (98.1%), followed by the ethyl acetate extract of Vernonia amygdalina (Compositae) leaves (95.5%). The corresponding 50% effective concentrations (EC50) and selectivity indices for these two extracts were 29.9 ± 0.9 and 32.4 ± 1.3 μg/ml, and 5.4 and 5.1 respectively. Rhapis excelsa and Vernonia amygdalina could be sources of anti-Chikungunya virus agents. [Int Microbiol 19(3):175-182 (2016)].
This study aims to compare muscle functions and functional performances between older persons with and without low back pain (LBP) and to determine the association between muscle functions and functional performances. This is a cross-sectional study, involving 95 older persons (age = 70.27 ± 7.26 years). Anthropometric characteristics, muscle functions, and functional performances were measured. Data were analyzed using ANOVA, Pearson's correlation, and multiple linear regression. The functional performances showed no significant differences (females LBP versus non-LBP, males LBP versus non-LBP) (p < 0.05). For muscle functions, significant differences were found (females LBP versus non-LBP) for abdominal muscle strength (p = 0.006) and back muscle strength (p = 0.07). In the LBP group, significant correlations were found between back and abdominal muscle strength and hand grip strength (r = 0.377 and r = 0.396, resp.), multifidus control and lower limb function (r = 0.363) in females, and back muscle strength and lower limb function (r = 0.393) in males (all p < 0.05). Regression analysis showed that abdominal and back muscle strengths were significant predictors of hand grip strength (p = 0.041 and p = 0.049, resp.), and multifidus control was a significant predictor of lower limb function in females (p = 0.047). This study demonstrates that older women with LBP exhibit poorer muscle functions compared to older women without LBP.