Browse publications by year: 2023

  1. Zhao Y, Sazlina SG, Rokhani FZ, Su J, Chew BH
    Asian Nurs Res (Korean Soc Nurs Sci), 2023 Oct;17(4):208-218.
    PMID: 37661084 DOI: 10.1016/j.anr.2023.08.002
    PURPOSE: This study aims to explore the expectations and acceptability of a smart nursing home model among Chinese older adults and their family members based on a scoping review that defines the concept of smart nursing homes.

    METHODS: A qualitative case study was employed for this research. Semi-structured, in-depth interviews and focus group discussions were conducted on WeChat. Participants were purposively sampled through snowball sampling in Hainan and Dalian, China. A total of 28 older adults aged 60-75 and six adult children were interviewed until data saturation was achieved, followed by a thematic analysis.

    RESULTS: The expectations of smart nursing homes include: 1) quality of care supported by governments and societies; 2) smart technology applications; 3) the presence of a skilled healthcare professional team; 4) access to and scope of basic medical services; and 5) integration of medical services. The acceptability of smart nursing homes included factors such as stakeholders' perceived efficaciousness, usability, and collateral damages of using smart technologies, and the coping process of adoption was influenced by factors such as age, economic status, health status, education, and openness to smart technologies among older adults.

    CONCLUSIONS: Chinese older adults and their family members have a positive perception of the smart nursing home model. The qualitative evidence regarding their expectations and acceptability of smart nursing homes contributes valuable insights for a wide range of stakeholders involved in the planning and implementation of smart nursing homes.

  2. Mat Amin NA, Nor Mohamed I, Lai YS
    Transfus Apher Sci, 2023 Oct;62(5):103798.
    PMID: 37661487 DOI: 10.1016/j.transci.2023.103798
  3. Anuar MA, Lee JX, Musa H, Abd Hadi D, Majawit E, Anandakrishnan P, et al.
    Brain Dev, 2023 Nov;45(10):547-553.
    PMID: 37661525 DOI: 10.1016/j.braindev.2023.06.004
    INTRODUCTION: Since the emergence of COVID-19, we have experienced potent variants and sub-variants of the virus with non-specific neurological manifestations. We observed a surge of the Omicron variant of COVID-19 patients with neurological manifestations where less cases of multisystem inflammatory syndrome in children (MIS-C) were reported. This article describes our experience of children with severe and rare neurological manifestations following COVID-19 infection.

    METHODS: This is a retrospective observational case series of patients under 18 years old who fulfilled the WHO COVID-19 case definition and were referred to our paediatric neurology unit at Hospital Tunku Azizah Kuala Lumpur. Their demographic data, neurological symptoms, laboratory and supporting investigations, neuroimaging, treatment and outcomes were collected and analysed.

    RESULTS: There were eleven patients with neurological manifestations who fulfilled the WHO COVID-19 case definition. Nine patients presented with seizures and/or encephalopathy, one patient with eye opsoclonus and another patient with persistent limbs myokymia. Based on the history, clinical, electrophysiological and radiological findings, two of them had febrile infection-related epilepsy syndrome, two had acute disseminated encephalomyelitis, two had acute necrotising encephalopathy of childhood, one each had hemiconvulsion-hemiplegia-epilepsy syndrome, acute encephalopathy with bilateral striatal necrosis, hemi-acute encephalopathy with biphasic seizures and reduced diffusion, infection-associated opsoclonus and myokymia.

    CONCLUSIONS: This case series highlighted a wide spectrum of neurological manifestations of COVID-19 infection. Early recognition and prompt investigations are important to provide appropriate interventions. It is essential that these investigations should take place in a timely fashion and COVID-19 quarantine period should not hinder the confirmation of various presenting clinical syndromes.

    MeSH terms: Brain Diseases*; Child; Humans; Seizures/etiology; Seizures/therapy; Ocular Motility Disorders*; Myokymia*
  4. McEllistrem B, Owens M, Whitford DL
    Int J Med Educ, 2023 Aug 31;14:117-122.
    PMID: 37661729 DOI: 10.5116/ijme.64e3.740e
    OBJECTIVES: This study explores a method of transferring a post graduate medical education curriculum internationally and contextualising it to the local environment. This paper also explores the experiences of those local medical educationalists involved in the process.

    METHODS: Several methods were implemented. Firstly, a modified Delphi process for the contextualisation of learning outcomes was implemented with a purposefully sampled expert group of Malaysian Family Medicine Specialists. Secondly a small group review for supporting materials was undertaken. Finally, qualitative data in relation to the family medicine specialists' experiences of the processes was collected via online questionnaire and analysed via template analysis. Descriptive statistics were used.

    RESULTS: Learning outcomes were reviewed over three rounds; 95.9% (1691/1763) of the learning outcomes were accepted without modification, with the remainder requiring additions, modifications, or deletions. Supporting materials were extensively altered by the expert group. Template analysis showed that Family Medicine Specialists related positively to their involvement in the process, commenting on the amount of similarity in the medical curriculum whilst recognising differences in disease profiles and cultural approaches.

    CONCLUSIONS: Learning outcomes and associated material were transferable between "home" and "host" institution. Where differences were discovered this novel approach places "host" practitioners' experiences and knowledge central to the adaptation process, thereby rendering a fit for purpose curriculum. Host satisfaction with the outcome of the processes, as well as ancillary benefits were clearly identified.

    MeSH terms: Curriculum*; Education, Medical, Graduate; Family Practice*; Health Facilities; Humans; Learning
  5. Sundaram T, Rajendran S, Gnanasekaran L, Rachmadona N, Jiang JJ, Khoo KS, et al.
    Bioengineered, 2023 Dec;14(1):2252228.
    PMID: 37661811 DOI: 10.1080/21655979.2023.2252228
    Algae-based biofuel developed over the past decade has become a viable substitute for petroleum-based energy sources. Due to their high lipid accumulation rates and low carbon dioxide emissions, microalgal species are considered highly valuable feedstock for biofuel generation. This review article presented the importance of biofuel and the flaws that need to be overcome to ensure algae-based biofuels are effective for future-ready bioenergy sources. Besides, several issues related to the optimization and engineering strategies to be implemented for microalgae-based biofuel derivatives and their production were evaluated. In addition, the fundamental studies on the microalgae technology, experimental cultivation, and engineering processes involved in the development are all measures that are commendably used in the pre-treatment processes. The review article also provides a comprehensive overview of the latest findings about various algae species cultivation and biomass production. It concludes with the most recent data on environmental consequences, their relevance to global efforts to create microalgae-based biomass as effective biofuels, and the most significant threats and future possibilities.
    MeSH terms: Biomedical Engineering; Biomass; Biofuels*; Bioengineering; Microalgae*
  6. Bustam A, Poh K, Shuin Soo S, Naseem FS, Md Yusuf MH, Hishamudin NU, et al.
    Digit Health, 2023;9:20552076231197961.
    PMID: 37662675 DOI: 10.1177/20552076231197961
    OBJECTIVE: Direct urine color assessment has been shown to correlate with hydration status. However, this method is subject to inter- and intra-observer variability. Digital image colorimetry provides a more objective method. This study evaluated the diagnostic accuracy of urine photo colorimetry using different smartphones under different lighting conditions, and determined the optimal cut-off value to predict clinical dehydration.

    METHODS: The urine samples were photographed in a customized photo box, under five simulated lighting conditions, using five smartphones. The images were analyzed using Adobe Photoshop to obtain Red, Green, and Blue (RGB) values. The correlation between RGB values and urine laboratory parameters were determined. The optimal cut-off value to predict dehydration was determined using area under the receiver operating characteristic curve.

    RESULTS: A total of 56 patients were included in the data analysis. Images captured using five different smartphones under five lighting conditions produced a dataset of 1400 images. The study found a statistically significant correlation between Blue and Green values with urine osmolality, sodium, urine specific gravity, protein, and ketones. The diagnostic accuracy of the Blue value for predicting dehydration were "good" to "excellent" across all phones under all lighting conditions with sensitivity >90% at cut-off Blue value of 170.

    CONCLUSIONS: Smartphone-based urine colorimetry is a highly sensitive tool in predicting dehydration.

  7. Arai T, Taha H, Alidon N, Jumat J, Azmey S, Zan ND, et al.
    Heliyon, 2023 Sep;9(9):e19348.
    PMID: 37662727 DOI: 10.1016/j.heliyon.2023.e19348
    The yellowfin snapper, Lutjanus xanthopinnis, was recorded as a newly described species in the Indo-Pacific region in 2015. However, the knowledge of its biology, biogeography and ecology is scarcely understood, and, hence, its current conservation status is categorized as Data Deficient. The mitochondrial cytochrome c oxidase subunit I (COI) gene was examined to confirm species identification. We also examined the COI gene haplotypes of L. xanthopinnis in Brunei Darussalam and Malaysia together with other waters, i.e., Bangladesh, Indonesia, Japan, Singapore, Sri Lanka and Taiwan. Our molecular analyses found that Brunei Darussalam and eastern Peninsular Malaysia samples were genetically similar. However, the former showed higher genetic diversity than the latter. The samples from these two sites also showed signatures of population expansion. Furthermore, identical haplotypes could be found in different locations, suggesting the absence of spatial genetic structure. On the other hand, Lutjanus lutjanus showed a population structure associated with geographical locations, i.e., western Pacific Ocean, Indian Ocean and Maluku in Indonesia.
  8. Hazrin NA, Chong KL, Huang YF, Ahmed AN, Ng JL, Koo CH, et al.
    Heliyon, 2023 Sep;9(9):e19426.
    PMID: 37662729 DOI: 10.1016/j.heliyon.2023.e19426
    In consideration of the distinct behavior of machine learning (ML) algorithms, six well-defined ML used were carried out in this study for predicting sea level on a day-to-day basis. Data compiled from 1985 to 2018 was utilized for training and testing the developed models. An assessment of the multiple statistics-driven regression algorithms resulted such that each tested location was associated with a particular preferred model. The following were the developed best models for their respective study areas: In Peninsular Malaysia, the interactions linear regression model was the best at Pulau Langkawi (RMSE = 19.066), the Matern 5/2 gaussian process regression model at Geting (RMSE = 49.891), and the trilayered artificial neural network at Pulau Pinang (RMSE = 20.026), while the linear regression model was the best at Sandakan in Sabah, East Malaysia (RMSE = 14.054). Other metrics, such as MAE and R-square, were also at their best values, each providing its best values, further substantiating the RMSE respectively, at each of the study areas. These empirical statistics (or metrics) also revealed that despite employing sea level as the sole parameter, results obtained were exceptional better when utilizing a 7-day lag, regardless of the model used. Notably, lag variables with less than a 7-day lag could degrade the model's accuracy in representing ground reality. The study emphasizes the importance of thorough training and testing of ML to aid decision-makers in developing mitigation actions for the climate change phenomena of sea level rise through reliable ML.
  9. Ren D, Jiang H, Cheng J, Peng C, Zou Y
    Heliyon, 2023 Sep;9(9):e19200.
    PMID: 37662732 DOI: 10.1016/j.heliyon.2023.e19200
    Building on the upper echelons theory and demographic faultline theory, this paper investigates the role of the top management team (TMT) faultline as a mediator and explores the moderating effect of CEO power as an important contextual factor. We utilize a sample of A-share listed companies on the Shanghai and Shenzhen Stock Exchanges from 2009 to 2020. Our findings show that outside CEO successors are significantly and positively related to corporate strategic change. TMT faultline mediates the effect of CEO successor origins on corporate strategic change, while CEO power reinforces the relationship between the two. Heterogeneity tests reveal that the effect of outside CEO successors on strategic change is insignificant in state-owned enterprises (SOEs) but has a significant impact on firms at their growth and maturity stages. Furthermore, our findings suggest that outside CEO successors inhibit the positive role of strategic change in promoting firm value.
  10. Zhang H, Gopinath SCB, Hu Y
    Heliyon, 2023 Sep;9(9):e19304.
    PMID: 37662784 DOI: 10.1016/j.heliyon.2023.e19304
    A spinal cord injury is damage to the nerves and cells that receive and provide a signal from the brain to the rest of the body. Spinal injury causes changes in movement, sensation, and strength, affect the body functions near the injury site, and may lead to paralysis. S100β was found as a suitable biomarker for identifying spinal cord injury and its causing problem. Herein, S100β immunoassay was developed on interdigitated electrode sensor to diagnose spinal cord injury. For effective anti-S100β antibody immobilization, the antibody was premixed with 3-Aminopropyl)triethoxsilane and then attached to the hydroxylated interdigitated electrode surface. This method of antibody immobilization enhanced the antibody attachment two-times than the method without premix. Antibody-attached surfaces increased current responses as S100 concentrations increased, and the limit of detection was seen to be 1 pg/mL on the linearity until 3000 pg/mL at an R2 value of 0.9907 [y = 7x - 6.4667]. Further, biofouling experiments with glial fibrillary acidic protein and γ-aminobutyric acid failed to enhance the current response, indicating the specific detection of S100β. This immunoassay identifies S100β at its lower level and helps to diagnose spinal cord injury and its related problem.
  11. Jabbar AAJ, Alamri ZZ, Abdulla MA, Salehen NA, Salim Amur Al Sinawi Z, Alfaifi SM
    Heliyon, 2023 Sep;9(9):e19418.
    PMID: 37662795 DOI: 10.1016/j.heliyon.2023.e19418
    Gynura procumbens is an edible flowering plant that has been utilized as traditional therapy for numerous diseases. The current experiment investigates the hepatoprotective potentials of the ethanol extract of Gynura procumbens leaf (EEGPL) against thioacetamide (TAA)-induced liver cirrhosis in rats. Thirty Sprague Dawley rats were randomly divided into 5 clusters: A, rats received orally 10% Tween 80 and intraperitoneal (i.p) inoculation of sterile distal water; B, rats received orally10% Tween 80; C, rats received orally daily 50 mg/kg of silymarin, while groups; D and E, rats received orally daily doses of 200 and 400 mg/kg of EEGPL, respectively. Furthermore, B-E clusters received 200 mg/kg thioacetamide (i.p) three times a week for 60 days. The liver gross morphology of rats that received only TAA (B) revealed irregular rough surface layers compared to smoother livers of rats that received EEGPL. Histopathology of group B revealed clear hepatic necrosis and fibrous connective tissue, which were significantly reduced in C-E groups. EEGPL treatment caused a significant down-regulation of PCNA and α-SMA protein expressions. Antioxidant (SOD and CAT) enzymes in hepatic homogeneity were meaningfully lower, and MDA levels were significantly higher in TAA controls compared to those of C-E groups. Moreover, EEGPL treatment caused a reduction of TNF-α and IL-6 and increased expression of IL-10 cytokines. Therefore, the hepatoprotective potentials of EEGPL might be contributed to its modulation of detoxification enzymes, anti-inflammatory, and antioxidant activities.
  12. Yao P, Osman S, Sabri MF, Zainudin N, Li Y
    Heliyon, 2023 Sep;9(9):e19131.
    PMID: 37662809 DOI: 10.1016/j.heliyon.2023.e19131
    Online-to-offline food delivery (O2OFD) services have become popular worldwide, and consumers' O2OFD usage and sedentary behavior have increased during the COVID-19 pandemic. However, whether consumers will continue to use O2OFD in the post-pandemic era is uncertain, and the relationship between sedentary lifestyle and O2OFD usage is poorly understood to date. Therefore, this study aims to investigate consumers' continued intention to use O2OFD in the post-pandemic era and their subsequent use behavior, as well as to explore the roles of sedentary lifestyle. A research model based on the unified theory of acceptance and use of technology 2 (UTAUT2), integrating network externalities and including sedentary lifestyle, was proposed. A two-stage online survey was conducted in China, with 409 eligible responses used in the data analysis. The results indicate that habit, perceived network size, and perceived complementarity were the main predictors of continued intention, whereas habit and continued intention were the primary determinants of use behavior. Sedentary lifestyle was positively related to O2OFD use behavior and moderated the effects of habit and continued intention on use behavior. In addition to its theoretical contributions, this study has implications for public policies, marketing strategies, and consumer well-being.
  13. Gandla K, Islam F, Zehravi M, Karunakaran A, Sharma I, Haque MA, et al.
    Heliyon, 2023 Sep;9(9):e19454.
    PMID: 37662819 DOI: 10.1016/j.heliyon.2023.e19454
    P-glycoprotein (P-gp) is known as the "multidrug resistance protein" because it contributes to tumor resistance to several different classes of anticancer drugs. The effectiveness of such polymers in treating cancer and delivering drugs has been shown in a wide range of in vitro and in vivo experiments. The primary objective of the present study was to investigate the inhibitory effects of several naturally occurring polymers on P-gp efflux, as it is known that P-gp inhibition can impede the elimination of medications. The objective of our study is to identify polymers that possess the potential to inhibit P-gp, a protein involved in drug resistance, with the aim of enhancing the effectiveness of anticancer drug formulations. The ADMET profile of all the selected polymers (Agarose, Alginate, Carrageenan, Cyclodextrin, Dextran, Hyaluronic acid, and Polysialic acid) has been studied, and binding affinities were investigated through a computational approach using the recently released crystal structure of P-gp with PDB ID: 7O9W. The advanced computational study was also done with the help of molecular dynamics simulation. The aim of the present study is to overcome MDR resulting from the activity of P-gp by using such polymers that can inhibit P-gp when used in formulations. The docking scores of native ligand, Agarose, Alginate, Carrageenan, Chitosan, Cyclodextrin, Dextran, Hyaluronic acid, and Polysialic acid were found to be -10.7, -8.5, -6.6, -8.7, -8.6, -24.5, -6.7, -8.3, and -7.9, respectively. It was observed that, Cyclodextrin possess multiple properties in drug delivery science and here also demonstrated excellent binding affinity. We propose that drug efflux-related MDR may be prevented by the use of Agarose, Carregeenan, Chitosan, Cyclodextrin, Hyaluronic acid, and/or Polysialic acid in the administration of anticancer drugs.
  14. Ahmed OS, Aabid A, Mohamed Ali JS, Hrairi M, Yatim NM
    ACS Omega, 2023 Aug 29;8(34):30824-30837.
    PMID: 37663505 DOI: 10.1021/acsomega.3c03695
    Most engineering technologies, gadgets, and systems have been developed around the use of sophisticated materials. Composite laminates have found widespread application in various significant and innovative industries, such as aviation, maritime transportation, automobiles, and civil engineering. Recent studies have revealed that composite materials are extensively utilized in automotive, undersea, and structural applications. Extensive efforts have been dedicated to exploring the structural components constructed from composite materials due to their importance in engineering. While composite materials offer certain advantages over their metallic counterparts, they also present analysts and designers with intricate and challenging issues. Hence, this Review aims to highlight noteworthy studies on composite materials and their engineering applications, specifically focusing on structural components. Furthermore, this Review includes a comprehensive summary of the application of composite laminates, accompanied by a critical analysis of the existing literature in this field. By presenting this information, the Review intends to provide a valuable resource and guideline for researchers interested in leveraging composite materials for engineering structures.
  15. Rajabathar JR, Al-Lohedan HA, Aldhayan DM, Appaturi JN, Musthafa YM
    ACS Omega, 2023 Aug 29;8(34):31060-31070.
    PMID: 37663519 DOI: 10.1021/acsomega.3c02992
    The present study compares the surface, textural, and catalytic properties of porous silica doped with bimetallic metal ions that was made from rice husk (RH) biomass. Due to the use of a surfactant during the synthesis process, porous RH-silica (RHS) was derived. In situ doping of silver/copper and ruthenium/copper has been achieved via the xerogel and hydrogel formation methods. The prepared catalysts have been analyzed by various methods, such as surface area and narrow pore size distribution, to confirm their porosity. Powder X-ray diffraction, Fourier transform infrared, and electron microscopy examination were further performed for physicochemical characterization of the synthesized materials. Transmission electron microscopy images showed that ruthenium and copper ions were incorporated perfectly, forming a hexagonal mesoporous (MCM-41) texture due to hydrogel formation and the method of preparation. Copper oxide nanoparticles with silver incorporation in RHS form cube-shaped particles for CuO formation on the surface of the silica matrix instead due to the method of preparation. In this case, ruthenium/copper-doped porous silica forms hexagon-shaped particles of RuO formation in the mesoporous matrix. Finally, the acetylation of glycerol using acetic acid on as-prepared catalysts has been studied. The catalytic activity increases with an increase in temperature and optimization of the molar ratio of glycerol and acetic acid. Increases in temperature result in higher selectivity toward triacetin formation instead of the conventional formation of monoacetin. Hence, we compared the surface physicochemical properties, catalytic conversion, and selectivity nature of bimetallic metal (Ru/Cu and Ag/Cu) ions incorporated in RHS prepared by different synthetic routes.
  16. Sumri N, Mokhtar DM
    Data Brief, 2023 Oct;50:109497.
    PMID: 37663775 DOI: 10.1016/j.dib.2023.109497
    The data belongs to a sample of 201 frontline workers in Malaysia. This demographic data was collected using a cross-sectional questionnaire via an online survey and analyzed using SPSS version 25. This data was used to investigate the relationship between workplace incivility, emotional exhaustion and adaptive performance (handling emergencies, handling work stress, creative problem solving, learning new tasks, technology and procedure and demonstrating interpersonal adaptability) among frontline workers. The analyzed data will be useful in contributing to further research into the effects of workplace incivility on employees' well-being and job performance. It will also give insights to stakeholders and those at managerial level who formulate appropriate intervention plans to overcome or reduce the issue of workplace bullying among frontline workers.
  17. Syafrawati S, Machmud R, Aljunid SM, Semiarty R
    Front Public Health, 2023;11:1147709.
    PMID: 37663851 DOI: 10.3389/fpubh.2023.1147709
    OBJECTIVE: To identify the incidence of moral hazards among health care providers and its determinant factors in the implementation of national health insurance in Indonesia.

    METHODS: Data were derived from 360 inpatient medical records from six types C public and private hospitals in an Indonesian rural province. These data were accumulated from inpatient medical records from four major disciplines: medicine, surgery, obstetrics and gynecology, and pediatrics. The dependent variable was provider moral hazards, which included indicators of up-coding, readmission, and unnecessary admission. The independent variables are Physicians' characteristics (age, gender, and specialization), coders' characteristics (age, gender, education level, number of training, and length of service), and patients' characteristics (age, birth weight, length of stay, the discharge status, and the severity of patient's illness). We use logistic regression to investigate the determinants of moral hazard.

    RESULTS: We found that the incidences of possible unnecessary admissions, up-coding, and readmissions were 17.8%, 11.9%, and 2.8%, respectively. Senior physicians, medical specialists, coders with shorter lengths of service, and patients with longer lengths of stay had a significant relationship with the incidence of moral hazard.

    CONCLUSION: Unnecessary admission is the most common form of a provider's moral hazard. The characteristics of physicians and coders significantly contribute to the incidence of moral hazard. Hospitals should implement reward and punishment systems for doctors and coders in order to control moral hazards among the providers.

    MeSH terms: Child; Female; Health Personnel*; Hospitals; Humans; Indonesia/epidemiology; Insurance, Health; Morals; Pregnancy; Incidence; Universal Coverage*
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