Browse publications by year: 2024

  1. Kwan LL, Abdul Rashid AM, Md Noh MSF, Hoo FK, Inche Mat LN
    Cureus, 2024 Nov;16(11):e73242.
    PMID: 39650868 DOI: 10.7759/cureus.73242
    Moyamoya syndrome (MMS) is characterized by progressive narrowing of intracranial arteries and the development of collateral vessel networks, often presenting with recurrent ischemic or hemorrhagic strokes. MMS poses significant challenges in diagnosis due to its overlapping symptoms with other cerebrovascular conditions. Treatment aims to improve cerebral blood flow, reduce symptom frequency, and prevent future strokes. Management requires a multidisciplinary approach, including medical optimization and potential surgical intervention. This case report discusses a 37-year-old woman with poorly controlled type 2 diabetes and hyperlipidemia who experienced multiple strokes before being diagnosed with MMS. Initial symptoms included intermittent headaches, hemiparesis, and slurred speech. The presence of underlying metabolic conditions led to an initial assumption of atherosclerosis as the primary cause of her strokes. This case underscores the diagnostic challenge of distinguishing MMS from more common vascular conditions, highlighting the need for careful evaluation when typical risk factors like atherosclerosis do not fully explain recurrent cerebrovascular events.
  2. Tamilchelvan SK, Rozhan A, Kuppusamy S, Hamid Z
    Cureus, 2024 Nov;16(11):e73234.
    PMID: 39650892 DOI: 10.7759/cureus.73234
    Laryngocele is a rare condition marked by an abnormal enlargement of the air-filled saccule of the laryngeal ventricle. This case report showcases a distinctive presentation of external laryngocele to assist clinicians in its diagnosis and management. A 43-year-old male, with a 20-year history of painless swelling on the right side of his neck, likened to the size of an orange, presented with a recent increment in size. He noticed a gurgling sound when pressing on the swelling but did not experience any hoarseness or difficulty swallowing. During the physical examination, it was observed that there was a swelling on the right side of the neck at level II that measured approximately 3 x 5 cm. This swelling seemed to increase when the Valsalva maneuver was performed. A computed tomography scan revealed a 5 x 3 cm air-filled lesion, indicative of an external laryngocele. Although surgical excision was advised, the patient decided not to proceed with treatment and did not attend follow-up appointments. Laryngocele mainly impacts men, especially those in their fifth and sixth decades of life and is linked to activities that raise laryngeal pressure. Diagnosis is mainly based on clinical evaluation, complemented by imaging techniques such as CT and MRI. Surgical excision remains the preferred treatment, with approaches differing, depending on the laryngocele subtype. This particular case highlights the infrequency of laryngocele, and how it may manifest as a swelling in the neck. It underscores the importance of clinicians being aware of this harmless condition, highlighting the significance of taking a detailed patient history and using suitable imaging for accurate diagnosis and effective management, especially to rule out any malignancies. This report adds to the current body of knowledge on laryngocele, offering valuable information on its clinical symptoms and treatment implications.
  3. Hayat J, Lari M, AlHerz M, Lari A
    Cureus, 2024 Nov;16(11):e73127.
    PMID: 39650926 DOI: 10.7759/cureus.73127
    At the intersection of artificial intelligence (AI) and healthcare, it is essential that clinicians grasp the ability of chatbots. AI-powered chatbots such as ChatGPT are being explored for their potential benefits by both individuals and institutions. The utility of ChatGPT (OpenAI) in various scenarios was explored through a series of recorded prompts and responses. In the clinical aspects, the chatbot facilitated tasks such as triage, patient consultation, diagnosis, and administrative responsibilities. Their capacity to translate and simplify intricate medical topics was also evaluated. For research purposes, the chatbots' abilities to suggest ideas, prepare protocols, assist in manuscript writing, guide statistical analyses, and recommend suitable journals were assessed. In the educational domain, chatbots were tested for simplifying complex subjects, reviewing procedural steps, generating clinical scenarios, and formulating multiple-choice questions. A comprehensive literature review was also conducted across Medline, Embase, and Web of Science. Chatbots, when optimally employed, can serve as invaluable resources in healthcare, spanning clinical, research, and educational domains. Their potential lies in enhancing efficiency, guiding decision-making, and facilitating patient care and education. However, their application requires a nuanced understanding and caution regarding their limitations.
  4. Khaw MJ, Chin WV
    Cureus, 2024 Nov;16(11):e73217.
    PMID: 39650973 DOI: 10.7759/cureus.73217
    Pericardial effusion is a relatively common classical pericardial syndrome that poses a diagnostic challenge for clinicians. There are varying clinical presentations of pericardial effusion, ranging from asymptomatic incidental findings on chest X-ray (CXR) or point-of-care ultrasound (POCUS) to hemodynamic instability in cardiac tamponade. Pericardial effusion is a notable cardiac manifestation of severe and long-standing hypothyroidism. We report the case of a 57-year-old female with a previous history of Graves' disease treated with radioactive iodine (RAI) more than 30 years prior but who had never been followed up on post-RAI. Admission CXR depicted a water bottle-shaped cardiomegaly. POCUS portrayed a massive pericardial effusion with no echocardiographic evidence of cardiac tamponade. Laboratory investigations showed raised thyroid-stimulating hormone and low free thyroxine. The pericardial effusion gradually subsided during the surveillance echocardiogram after initiation of thyroid hormone replacement therapy. Early POCUS assessments in this case expedite the diagnosis and management of hypothyroidism-induced pericardial effusion. With timely and adequate thyroid hormone replacement therapy, pericardial effusion can be reversed, thereby averting the fatal complications of cardiac tamponade.
  5. Iida M, Ho A, Huang XJ, Liu K, Lv M, Huang H, et al.
    Blood Cell Ther, 2024 Nov 25;7(4):129-137.
    PMID: 39651061 DOI: 10.31547/bct-2024-020
    COVID-19 became a global pandemic in 2020 and significantly affected the activity of hematopoietic cell transplants (HCT) worldwide. Despite these challenges, a total of 28,793 transplants, including 18,518 allogeneic and 10,275 autologous transplants, were performed in 719 facilities in 2020 in the Asia-Pacific (AP) region. This represented a 5.1% increase in allogeneic transplants and a 3.1% increase in autologous transplants, an overall increase of 4.4% compared to the numbers in 2019. With respect to the donor source, haploidentical transplants increased significantly by 18.6%, related transplants by 8.8%, and cord blood transplants (CBT) by 9.2%. However, the number of unrelated transplants, excluding CBT, decreased for the first time by 8.2%. As a result, COVID-19 facilitated the growth of haploidentical transplants due to cross-border restrictions. Regarding the changes in the total number of transplants by country/region in 2020, it increased by 2,048 transplants in China, followed by Japan (210 transplants) and Korea (230 transplants); however, 14 of the 22 countries and regions decreased their number of transplants in 2020 compared to the previous year. There was no correlation between the increase or decrease in the number of transplants in 2020 and the Gross National Income (GNI) per capita of each country/region in 2020, as well as Domestic General Government Health Expenditure as a percentage of General Government Expenditure (GGHE-D/GGE). In 2021, the total number of transplants in this region was 34,754. With the exception of a few countries/regions that decreased the number of transplants in 2020, most countries/regions have started to see a recovery in 2021. The COVID-19 pandemic significantly affected the supply chain and logistics involved in HCT rather than its numbers; however, we have found ways to overcome logistical challenges to carry out transplant medicine without delay, even under these circumstances.
  6. Bhattacharya T, Joshi R, Tufa LT, Goddati M, Lee J, Tewari A, et al.
    ACS Omega, 2024 Dec 03;9(48):47647-47660.
    PMID: 39651080 DOI: 10.1021/acsomega.4c07090
    In this work, environmentally friendly fluorescent carbon dots (C-dots) were developed for the purpose of thiram identification in the leaves of perilla plants. Powdered plant petals from Hibiscus rosa-sinensis were hydrothermally combined to create C-dots. Analytical techniques, such as scanning electron microscopy, energy dispersive X-ray spectroscopy, high resolution transmission electron microscopy, Raman spectroscopy, ultraviolet spectroscopy, Fourier transmission infrared spectroscopy, and photoluminescence were employed to examine the properties of C-dots. To enhance their functionality, an l-cysteine dopant was added to the C-dots. Since this process produces highly soluble C-dots in water, it is simple, inexpensive, and safe. The excitation process and the size of the blue luminescent C-dots both affect their photoluminescent activity. Furthermore, thiram in aqueous solutions was effectively identified by using the generated C-dots. Additionally, the ImageJ program was used to measure the colors red, green, and blue. High-resolution TEM (HR-TEM) revealed that the l-cysteine-doped carbon dots had an average particle size of 2.208 nm. Additionally, the lattice fringes observed in the HRTEM image showed a d-spacing of around 0.285 nm, which nearly corresponds to the (100) lattice plane of graphitic carbon. A Raman spectrum study was also performed to investigate the relationship between carbon dots and pesticides in the actual samples. In the end, thiram levels in perilla leaves with nondoped and doped C-dots could be distinguished with 100% accuracy using the constructed partial least-squares discriminant analysis machine learning model. The information gathered therefore demonstrated that the synthetic C-dots successfully and efficiently provide rapid and sensitive detection of hazardous pesticides in edible plant products.
  7. Almashwali AA, Lal B, Khor SF
    ACS Omega, 2024 Dec 03;9(48):47442-47452.
    PMID: 39651083 DOI: 10.1021/acsomega.4c05430
    This experimental study reports the thermodynamic influence of three different amino acids on methane hydrate in oil-dominated systems, namely, glycine, proline, and alanine. To thoroughly examine the effect of selected amino acids on methane (CH4) hydrate formation compared to the commercial inhibitor monoethylene glycol (MEG) in the presence of oil, the hydrate liquid-vapor equilibrium (H-Lw-Lo-V) curve is used to measure amino acid aqueous solutions. All experiments are performed at a concentration of 10 wt % by using the isochoric T-cycle technique in a high-pressure reactor cell at the selected range of pressures with temperatures of 4.0-9.0 MPa and 276.5-286.0 K, respectively. Results show that all studied amino acids inhibit hydrate formation of methane; the inhibition trend shows as glycine > alanine > proline in both systems; in the brine water system, the inhibition performance was higher than in the pure water system due to the presence of NaCl. Glycine showed the highest inhibition strength in both systems with an average reduced temperature in pure and brine water of 0.92 and 1.75 K, respectively, at 10 wt %, making the inhibition performance of glycine comparable to the commercial inhibitor MEG. The inhibition effect is attributed to the amino acid's hydrogen bonding energies and side group alkyl chain. Calculating the dissociation enthalpies of methane hydrates in the presence of amino acids using the Clausius-Clapeyron equation implies that the amino acids do not occupy the cage structures during methane hydrate formation.
  8. CMS Collaboration
    Eur Phys J C Part Fields, 2024;84(12):1264.
    PMID: 39651650 DOI: 10.1140/epjc/s10052-024-13244-0
    A search is reported for charge-parity CP violation in D 0 → K S 0 K S 0 decays, using data collected in proton-proton collisions at s = 13 Te V recorded by the CMS experiment in 2018. The analysis uses a dedicated data set that corresponds to an integrated luminosity of 41.6 fb - 1 , which consists of about 10 billion events containing a pair of b hadrons, nearly all of which decay to charm hadrons. The flavor of the neutral D meson is determined by the pion charge in the reconstructed decays D ∗ + → D 0 π + and D ∗ - → D ¯ 0 π - . The CP asymmetry in D 0 → K S 0 K S 0 is measured to be A CP ( K S 0 K S 0 ) = ( 6.2 ± 3.0 ± 0.2 ± 0.8 ) % , where the three uncertainties represent the statistical uncertainty, the systematic uncertainty, and the uncertainty in the measurement of the CP asymmetry in the D 0 → K S 0 π + π - decay. This is the first CP asymmetry measurement by CMS in the charm sector as well as the first to utilize a fully hadronic final state.
  9. Nawanir G, Fauzi MA
    J Health Organ Manag, 2024 Dec 10.
    PMID: 39652095 DOI: 10.1108/JHOM-04-2024-0167
    PURPOSE: This study intends to reveal the existing research stream and predict future research avenues for lean healthcare (LH). This paper analyzes the progress of LH research and identifies key trends, research gaps and future directions. By mapping the knowledge structure, the study offers insights into the effects of LH on healthcare efficiency, patient care and organizational performance.

    DESIGN/METHODOLOGY/APPROACH: The review used the bibliometric approach, involving 319 journal articles retrieved from the Web of Science database. Two science mapping approaches (i.e. bibliographic coupling and co-word analysis) were performed to investigate the current knowledge structure and future research direction in LH.

    FINDINGS: The current research trend in LH focuses on developing frameworks and strategic implementation by considering critical determinants and decision-making strategies. In the future, the research on LH will emphasize the holistic frameworks and efficient strategies for healthcare excellence, along with strategies to overcome barriers to its implementation.

    RESEARCH LIMITATIONS/IMPLICATIONS: This study will benefit researchers and practitioners by advancing their understanding and applying LH principles.

    ORIGINALITY/VALUE: This study provides valuable practical implications for healthcare managers to navigate the complexities of lean implementation, optimize processes and drive sustainable improvements in the healthcare context.

  10. Ramli SR, Azhar ZI, Raman S, Yusof SN, Mohamad M
    Cancer Causes Control, 2024 Dec 09.
    PMID: 39652251 DOI: 10.1007/s10552-024-01945-6
    BACKGROUND: Large geographical variations in colorectal cancer (CRC) survival rates have been reported across regions. Poorer survival rates were mainly found in socioeconomically deprived areas, highly dense areas, and areas lacking healthcare accessibility. The objective of this study was to identify, compare, and contrast the spatial patterns of 5-year CRC-specific survival rates and identify high-priority areas by districts in Malaysia.

    METHODS: This retrospective cohort study utilized secondary data from the National Cancer Registry. CRC patients (ICD10 C18-21) diagnosed between 2013 and 2018 were selected. Patient addresses were geocoded into districts and states via geospatial data from the National Geospatial Centre, whereas district population density data were gathered from the Population Census of Malaysia. Kaplan‒Meier survival analysis and log-rank test were conducted to determine and compare the 5-year CRC-specific survival rates, and the spatial distribution of CRC survival by district was determined via ArcGIS software.

    RESULTS: A total of 18,513 CRC patients were registered from 143 districts, with 10,819 deaths occurring during follow-up. The national 5-year CRC-specific survival rate was 42%, with median survival time of 36 months (95% CI: 34.46, 37.54). The eastern region (Kelantan, Terengganu, and Pahang) had the lowest survival (38.0%). Among the 143 districts, eighty-one (56.6%) reported survival rates below the national average while thirty-six (25.2%) were identified as high-priority districts.

    CONCLUSION: The differences in CRC survival rates were evident according to geographical location. Area-based targeted interventions to improve CRC detection, management, and access to healthcare are imperative to address cancer survival disparities and help effectively allocate resources.

  11. Lim SM, Ng YL, Majeed ABA, Tan MP, Khor HM, Kamaruzzaman SB, et al.
    Geroscience, 2024 Dec 09.
    PMID: 39653973 DOI: 10.1007/s11357-024-01462-z
    The present study explored for the first time the blood-based proteomic signature that could potentially distinguish older adults with and without cognitive frailty (CF). The participants were recruited under the Malaysian Elders Longitudinal Research (MELoR) study. Cognition and physical frailty were determined using the Montreal Cognitive Assessment (MoCA) and Fried's criteria, respectively. The differential protein expression in the blood samples (38 CF vs 40 robust) were then determined using the Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH) analysis. A total of 294 proteins were found to be differentially expressed in the CF group as opposed to the robust group. Considering proteins with fold change (FC) ≥  ± 2 and p-values  78%, specificity > 75%, accuracy > 80% and area under the curve (AUC) > 0.8. The major biological pathways that could be potentially dysregulated by the nine proteins were associated with lipid metabolism and the retinoid system. The present findings warrant further validation in future studies that involve a larger cohort.
  12. Oladimeji TE, Oyedemi M, Emetere ME, Agboola O, Adeoye JB, Odunlami OA
    Heliyon, 2024 Dec 15;10(23):e40370.
    PMID: 39654720 DOI: 10.1016/j.heliyon.2024.e40370
    The incidence of water pollution in developing countries is high due to the lack of regulatory policies and laws that protect water bodies from anthropogenic activities and industrial wastewater. Industrial wastewater contains significant amounts of heavy metals that are detrimental to human health, aquatic organisms, and the ecosystem. The focus of this review was to evaluate the sources and treatment methods of wastewater, with an emphasis on technologies, advantages, disadvantages, and innovation. It was observed that conventional methods of wastewater treatment (such as flotation, coagulation/flocculation, and adsorption) had shown promising results but posed certain limitations, such as the generation of high volumes of sludge, relatively low removal rates, inefficiency in treating low metal concentrations, and sensitivity to varying pH. Recent technologies like nanotechnology, photocatalysis, and electrochemical coagulation have significant advantages over conventional methods for removing heavy metals, including higher removal rates, improved energy efficiency, and greater selectivity for specific contaminants. However, the high costs associated with these advanced methods remain a major drawback. Therefore, we recommend that future developments in wastewater treatment technology focus on reducing both costs and waste generation.
  13. Alotaibi MA, Din IU, Alharthi AI, Saeed T, Shaharun MS, Naeem A
    Heliyon, 2024 Dec 15;10(23):e40545.
    PMID: 39654778 DOI: 10.1016/j.heliyon.2024.e40545
    Green methanol fuel synthesis by CO2 hydrogenation is regarded as one of the potential viable techniques for meeting future energy demands. Enhancing catalytic performance and process knowledge are crucial for the practicality of catalyzed CO2 conversion pathways. Here, co-precipitation was utilized to prepare Cu-Zn bimetallic catalysts based on silica gel. To examine the stimulating function of Cd metal, the produced catalysts were doped with varying concentrations of the Cd metal. The nitrogen adsorption-desorption isotherm revealed mesoporous nature of catalysts. The X-ray diffraction (XRD) investigations as well as Field Emission Scanning Electron Microscopy (FESEM) studies concluded higher degree of metal oxides dispersion on surface of silica gel support. The study of Fourier-transform infrared (FTIR) spectroscopy revealed successful incorporation of metal oxides on surface of silica gel support by originating absorption band in metal oxides regions. The X-ray photoelectron spectroscopy (XPS) exposed surface chemical nature of the Cu-Zn/SiO2 catalysts promoted by Cd metal. On the top of that, XPS investigations confirmed the results derived from XRD and FESEM investigations in terms of catalysts dispersion over silica gel support by Cd promotion. The methanol synthesis rate was accelerated from 167 to 197 g.meth/kg.cat.h by incorporating Cd to the parent Cu-Zn/SiO2 catalyst. Furthermore, similar trend in terms of accelerating methanol synthesis rate was sustained with further addition of Cd content to Cd-promoted silica gel supported Cu-Zn catalysts. The activity data demonstrated active and selective profile of Cd for CO2 reduction to methanol by taking into account methanol synthesis rate and selectivity. Structure-activity studied documented in promoting character of Cd metal as structural promoter in CO2 hydrogenation to methanol.
  14. Subramanian A, J A, T T, Kumarasamy V, Begum MY, Sekar M, et al.
    J Inflamm Res, 2024;17:10453-10470.
    PMID: 39654856 DOI: 10.2147/JIR.S483958
    Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, represents a complex and growing global health issue with a multifaceted origin. This review delves into the intricate relationship between gut microbiota, autophagy, and the development of IBD. The gut microbiota, a diverse community of microorganisms, plays a vital role in maintaining gut health, while imbalances in this microbial community, known as dysbiosis, are linked to IBD. Autophagy, a process by which cells recycle their components, is essential for gut homeostasis and the regulation of immune responses. When autophagy is impaired and dysbiosis occurs, they individually contribute to IBD, with their combined impact intensifying inflammation. The interconnectedness of gut microbiota, autophagy, and the host's immune system is central to the onset of IBD. The review also examines how diet influences gut microbiota and its subsequent effects on IBD. It highlights the therapeutic potential of targeting the microbiota and modulating autophagic pathways as treatment strategies for IBD. Understanding these interactions could lead to personalized therapies within the rapidly advancing fields of microbiome research and immunology.
  15. Albazah NIJ, Loh HM, Lee JY, Chen WK, Khaw EYJ, Ngu PK, et al.
    PMID: 39654866 DOI: 10.51866/rv.669
    INTRODUCTION: Acute otitis media is a common disease in children under the age of 5 years due to their primitive ear anatomy. One of its consequences is otitis media with effusion (OME), which is a condition wherein serous secretion accumulates in the middle ear due to Eustachian tube dysfunction. OME results in conductive hearing loss, impacting children's learning and development. This review aimed to identify discrepancies in clinical practice guidelines (CPGs) for managing OME in children across Asian and Western countries, focusing on updates to these guidelines.

    METHODS: A comparative review involving critical appraisal using the Appraisal of Guidelines for Research and Evaluation II tool was conducted. CPGs for managing ear effusion in children in Western and Asian countries published in the PubMed, Cochrane Library, Scopus and Science Direct databases were reviewed. Four CPGs from Western countries (Scotland, England, the United States of America and France) and three CPGs from Asian countries (Japan, Korea and Malaysia) were selected.

    RESULTS: There was a mild discrepancy regarding conducting surgery after 3 months, particularly myringotomy and adenoidectomy with or without grommets, between the Scottish CPG and other CPGs.

    CONCLUSION: Asian CPGs for the management of OME share many similarities with Western CPGs. However, Asian CPGs tend to be stronger in most domains and levels of evidence. Japanese and American CPGs are up to date as of 2022 and 2016, respectively, while other CPGs are outdated for about 10 years.

  16. Wan Fadzleen Ezyani MF, Yaacob LH, Abdul Rahman R, Lau CC
    PMID: 39654867 DOI: 10.51866/cr.698
    Achondroplasia, a genetic disorder causing limb shortening, is the most common form of disproportionate dwarfism. It can be diagnosed prenatally through sonographic findings and postnatally through clinical and radiological findings. Currently, an increasing number of affected foetuses are diagnosed antenatally since prenatal ultrasonography is routinely conducted in primary care settings. Herein, we present the case of a healthy 26-year-old primigravida who received a diagnosis of achondroplasia for her foetus during the late third trimester based on her prenatal ultrasonographic findings. Following birth, the diagnosis was confirmed by the baby's clinical and radiological findings, which showed shortening of the long bones. This case highlights the importance of recognising the soft markers of achondroplasia during routine third-trimester ultrasonography in primary care settings. Early diagnosis of achondroplasia is important to ensure timely referral to tertiary centres and adequate preparation of parents for the delivery of their baby.
  17. Sahdi H, Prabaharan R, Cheah WL, Rasit AH, Sultan Abdul Kader MABA, Bujang MA, et al.
    PMID: 39654868 DOI: 10.51866/oa.697
    INTRODUCTION: Non-orthopaedic-trained healthcare professionals face challenges in identifying postnatal clubfoot deformities due to the lack of suitable assessment tools, resulting in misdiagnosis. Therefore, this study aimed to develop and validate the Neonatal Clubfoot Screening Checklist (NCSC) to assist non-orthopaedic-trained healthcare professionals in postnatal clubfoot assessment.

    METHODS: The NCSC development involved five phases: conceptual understanding of deformity components, creation of pictorial representations, tool structure design, content and face validation, pilot study and field study. A cross-sectional prospective study was conducted in Sarawak General Hospital from January to June 2021. Non-orthopaedic-trained healthcare professionals were randomly assigned to two groups: one utilising the NCSC for newborn screening and another without it. Results were compared with assessments by the paediatric orthopaedic team. Kappa agreement tests and sensitivity and specificity analyses were performed to evaluate the tool's reliability and validity, respectively.

    RESULTS: The content and face validity were satisfactory. Six hundred twelve feet were screened using the NCSC, and 596 feet were checked without the tool. The kappa agreement tests showed strong concordance (kappa coefficient=0.725-1.000, P<0.001) between the non-orthopaedic-trained personnel and paediatric orthopaedic team for all NCSC items. The NCSC exhibited 100% sensitivity, specificity and positive and negative predictive values.

    CONCLUSION: The NCSC is a reliable tool for postnatal clubfoot screening, offering high sensitivity and specificity. It facilitates accurate differentiation of true-positive congenital talipes equinovarus from other foot conditions, reducing misdiagnoses and unnecessary referrals. The NCSC is valuable in resource-constrained settings and for healthcare professionals lacking specialised orthopaedic training.

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