Browse publications by year: 2024

  1. Mphande-Nyasulu FA, Yap NJ, Teo CH, Chang LY, Tay ST
    IJID Reg, 2024 Sep;12:100430.
    PMID: 39290689 DOI: 10.1016/j.ijregi.2024.100430
    OBJECTIVES: The 21st century has witnessed significant disease outbreaks with severe impact in Association of Southeast Asian Nations (ASEAN) countries, including SARS, H1N1, H5N1, and COVID-19. This review aimed to compile and analyze outbreak preparedness and response strategies, highlighting the success of coordinated multi-sectoral approaches and policy responses within the ASEAN region.

    METHODS: The protocol for this review was registered on the Open Science Framework and PROSPERO. A systematic analysis of publications from the 2002-2022 period was conducted following PRISMA guidelines on 4522 records retrieved from PubMed, CINAHL, Web of Science, and Scopus. The titles and abstracts were screened, and 229 articles were selected for full-text screening. Finally, 34 articles were included in this review.

    RESULTS: Four preparedness pillars were identified: governance and stewardship, disease detection, disease prevention, and health care management. The pillars were crucial in preparing for and responding to the COVID-19 pandemic. Coordinated responses among the ASEAN countries and local and international stakeholders were reported.

    CONCLUSIONS: The findings emphasize that understanding the transmission dynamics of infectious diseases is paramount for effective disease prevention, surveillance, and timely response efforts to prevent the next pandemic. A well-coordinated multi-country and multi-agency policy response and understanding the different disease management models are crucial in addressing future outbreaks in the region. Future post-pandemic publications will shed more light on lessons learned and preparedness and response plans for future pandemics.

  2. Guo HT, Lee ZX, Magalingam KB, Radhakrishnan AK, Bhuvanendran S
    Neurochem Int, 2024 Nov;180:105857.
    PMID: 39293662 DOI: 10.1016/j.neuint.2024.105857
    Parkinson's disease (PD) is the second most common neurodegenerative disease, and it has affected the living quality of elderly people significantly. PD is characterised by the accumulation of α-Synuclein and progressive loss of dopaminergic neurons at the substantia nigra pars compacta. In the pathogenesis of Parkinson's disease, α-Synuclein, oxidative stress, and electron transport chain (ETC) are the three main factors that contribute to the production of reactive oxygen species (ROS). Currently, there is no commercial disease-modifying agent available for PD; the first-line treatment, Levodopa (l-DOPA), could only relieve the symptoms of PD, with many side effects. Carotenoids, which encompass red, orange, and yellow pigments found in nature and contribute to the colouration of plants, have been associated with various health benefits, including anti-cancer and neuroprotective effects due to their antioxidant properties. This scoping review delves into the impact and underlying mechanisms of carotenoids on cell-based models of neurodegenerative diseases.
    MeSH terms: Animals; Humans; Reactive Oxygen Species/metabolism; Neuroprotective Agents/pharmacology; Neuroprotective Agents/therapeutic use
  3. Zheng Z, B A M HS, Omar Zaki H, Tan QL
    Heliyon, 2024 Sep 30;10(18):e37501.
    PMID: 39309928 DOI: 10.1016/j.heliyon.2024.e37501
    Recently, the phenomenon of population ageing and its impact on the insurance industry has garnered increasing global attention. However, a notable gap in scholarly research persists in understanding the nuanced effects of ageing on consumer behaviour and insurance purchase intentions. This study maps the current academic evidence on how ageing influences individual consumers' insurance decisions. Using a scoping review methodology aligned with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for scoping reviews and Joanna Briggs Institute guidelines, 44 articles out of 1082 from four databases-Web of Science, Scopus, ScienceDirect, and Emerald Insight-are reviewed. The results reveal a rising interest in this research area, with China emerging as a significant contributor. The focus is predominantly on Theory of Planned Behavior, quantitative methods, questionnaire survey, regression analysis, older population, and general health insurance. Variables capturing the impact of ageing, beyond demographic information, include family-related, risk-related, and expectation-related factors. This study highlights the current state of research on ageing's effect on insurance purchase intentions and offers valuable insights and directions for future research.
  4. Lo MK, Jain S, Davies KA, Sorvillo TE, Welch SR, Coleman-McCray JD, et al.
    Antiviral Res, 2024 Nov;231:106013.
    PMID: 39326503 DOI: 10.1016/j.antiviral.2024.106013
    Nipah virus (NiV) causes near-annual outbreaks of fatal encephalitis and respiratory disease in South Asia with a high mortality rate (∼70%). Since there are no approved therapeutics for NiV disease in humans, the WHO has designated NiV and henipaviral diseases priority pathogens for research and development. We generated a new recombinant green fluorescent reporter NiV of the circulating Bangladesh genotype (rNiV-B-ZsG) and optimized it alongside our previously generated Malaysian genotype reporter counterpart (rNiV-M-ZsG) for antiviral screening in primary-like human respiratory cell types. Validating our platform for rNiV-B-ZsG with a synthetic compound library directed against viral RNA-dependent RNA polymerases, we identified a hit compound and confirmed its sub-micromolar activity against wild-type NiV, green fluorescent reporter, and the newly constructed bioluminescent red fluorescent double reporter (rNiV-B-BREP) NiV. We furthermore demonstrated that rNiV-B-ZsG and rNiV-B-BREP viruses showed pathogenicity comparable to wild-type NiV-B in the Syrian golden hamster model of disease, supporting additional use of these tools for both pathogenesis and advanced pre-clinical studies in vivo.
    MeSH terms: Animals; Bangladesh; Cell Line; Disease Models, Animal*; Drug Evaluation, Preclinical/methods; Genotype*; Cricetinae; Humans; Luminescent Proteins/genetics; Malaysia; Mesocricetus*; Virus Replication/drug effects; Genes, Reporter*; Green Fluorescent Proteins/genetics
  5. Sharief SA, Minhajat R, Riu DS, Bukhari A, Amir H
    Med J Malaysia, 2024 Sep;79(5):646-657.
    PMID: 39352168
    INTRODUCTION: The iron supplementation program for pregnant women is the main program for tackling anemia in various countries, especially in developing countries in which daily diets may lack sufficient iron intake. In Indonesia, it is recommended that expectant mothers ingest 90 iron tablets during their pregnancy; however, the World Health Organization reports that 37% of pregnant women in the country continue to experience anemia. Iron deficiency anemia consistently emerges as the primary etiology for diagnosing anemia; however, it is important to recognize that anemia can stem from various factors beyond just lack of iron. In addition to iron deficiency, chronic illnesses and infections significantly contribute to the prevalence of anemia worldwide. Consequently, this literature review endeavors to uncover the underlying factors responsible for normocytic anemia among pregnant women, focusing on developing countries.

    MATERIALS AND METHODS: Eight search engines, specifically Proquest, EbscoHost, Scopus, Cochrane Library, Science Direct, Wiley Online Library, PubMed, Google Scholar, and Garuda, were utilized to identify primary articles. Three independent reviewers assessed abstracts and full articles based on specific inclusion and exclusion criteria. The data collected encompassed information regarding the population under study, research methods employed, and primary findings pertinent to the review's objectives. Fifteen studies, published between 2014 and 2023, that met the eligibility criteria outlined in the PRISMA-ScR.

    RESULTS: Among the 15 studies on normocytic anemia in pregnant women, malaria and HIV were the highest causes of normocytic anemia, followed by worm/intestinal parasite infections, chronic diseases, and bleeding.. In pregnant women, anemia of chronic disease and infection often coexists with iron deficiency anemia, both show decrease serum iron levels. Hence, other investigations need to be carried out to diagnose with certainty the cause of anemia in pregnant women.

    CONCLUSION: Anemia is not a standalone disease but rather a symptom of various underlying diseases. Therefore, diagnosing anemia requires identifying the basic disease that causes anemia, rather than simply labeling it as anemia.

    MeSH terms: Anemia/diagnosis; Anemia/etiology; Anemia/epidemiology; Female; Humans; Iron/blood; Pregnancy; Anemia, Iron-Deficiency/diagnosis; Anemia, Iron-Deficiency/etiology; Anemia, Iron-Deficiency/epidemiology
  6. World Federation of Chiropractic
    J Chiropr Educ, 2024 Oct 23;38(2):190-196.
    PMID: 39385537 DOI: 10.7899/JCE-24-17
    This conference was convened by the World Federation of Chiropractic from October 30 to November 2, 2024, in Kuala Lumpur, Malaysia. The 2024 program focused on the delivery of technology in chiropractic education.
  7. Muzammil AN, Barathan M, Yazid MD, Sulaiman N, Makpol S, Mohamed Ibrahim N, et al.
    Front Endocrinol (Lausanne), 2024;15:1406531.
    PMID: 39398330 DOI: 10.3389/fendo.2024.1406531
    Phoenixin (PNX) is an emerging neuropeptide that plays a significant role in regulating metabolism and reproduction. This comprehensive review examines findings from human, in vivo, and in vitro studies to elucidate the functions of PNX in metabolic processes. PNX has been identified as a key player in essential metabolic pathways, including energy homeostasis, glucose, lipid and electrolyte metabolism, and mitochondrial dynamics. It modulates food and fluid intake, influences glucose and lipid profiles, and affects mitochondrial biogenesis and function. PNX is abundantly expressed in the hypothalamus, where it plays a crucial role in regulating reproductive hormone secretion and maintaining energy balance. Furthermore, PNX is also expressed in peripheral tissues such as the heart, spleen, and pancreas, indicating its involvement in the regulation of metabolism across central and peripheral systems. PNX is a therapeutic peptide that operates through the G protein-coupled receptor 173 (GPR173) at the molecular level. It activates signaling pathways such as cAMP-protein kinase A (PKA) and Epac-ERK, which are crucial for metabolic regulation. Research suggests that PNX may be effective in managing metabolic disorders like obesity and type 2 diabetes, as well as reproductive health issues like infertility. Since metabolic processes are closely linked to reproduction, further understanding of PNX's role in these areas is necessary to develop effective management/treatments. This review aims to highlight PNX's involvement in metabolism and identify gaps in current knowledge regarding its impact on human health. Understanding the mechanisms of PNX's action is crucial for the development of novel therapeutic strategies for the treatment of metabolic disorders and reproductive health issues, which are significant public health concerns globally.
    MeSH terms: Animals; Humans; Metabolic Diseases/metabolism; Reproduction/physiology; Peptide Hormones/metabolism
  8. Fadli NA, Abdul Rahman M, Karsani SA, Ramli R
    Diagnostics (Basel), 2024 Sep 30;14(19).
    PMID: 39410587 DOI: 10.3390/diagnostics14192184
    Gingival crevicular fluid (GCF) and oral fluid have emerged as promising diagnostic tools for detecting biomarkers. This review aimed to evaluate the existing literature on using oral fluids as a source of biomarkers for bone turnover diseases affecting the jawbone. A comprehensive search strategy was executed between August 2014 and August 2024 across five major databases (Web of Science, EBSCOhost Dentistry & Oral Sciences Source, Cochrane Library, Scopus, and PubMed) and grey literature sources. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) was applied. The screening was facilitated using Rayyan at rayyan.ai and Endnote X20 software tools, culminating in the evaluation of 14,965 citations from databases and 34 from grey literature. Following rigorous scrutiny, 37 articles were selected for inclusion in this review, encompassing diseases such as periodontitis, medication-related osteonecrosis of the jaw (MRONJ), and osteoporosis. The quality of the included observational studies was assessed using the Revised Risk of Bias Assessment Tool for Non-Randomized Studies (RoBANS 2). Interleukin-1 beta (IL-1β), sclerostin, osteoprotegerin (OPG), and interleukin-34 (IL-34) emerged as significant biomarkers in GCF, and they were mainly from periodontitis and osteoporosis. Osteocalcin (OC), IL-1β, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), OPG, and matrix metalloproteinase-9 (MMP-9) were significant in oral fluid or saliva, and they were from periodontitis, MRONJ, and osteoporosis. These findings underscore the potential use of oral fluids, which are regarded as non-invasive tools for biomarker identification in bone turnover. Many biomarkers overlap, and it is important to identify other specific biomarkers to enable accurate diagnosis of these conditions.
  9. Bakhtiar AB, Hanafi MH, Alghwiri A, Manaf H
    Malays J Med Sci, 2024 Oct;31(5):115-134.
    PMID: 39416741 DOI: 10.21315/mjms2024.31.5.8
    Physical activity (PA) is crucial for improving stroke survivors' health outcomes and quality of life (QoL). Impaired PA levels are common among stroke survivors, a significant portion of whom spend their days in sedentary occupations. Understanding the factors that influence physical inactivity and addressing the barriers to exercise participation can contribute significantly to improving stroke survivors' health outcomes and prognoses. Therefore, in the current review, we systematically searched five databases (PubMed/Medline, Scopus, SpringerLink, ScienceDirect and Google Scholar) for published studies reporting PA levels among stroke survivors, which yielded 301 potential articles. Based on the identification and screening processes recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR), 13 articles were finally included in the analysis. The results of these studies, covering 1,318 stroke survivors, revealed physical inactivity among most of the participants and significant heterogeneity among the outcome measures used. The factors affecting PA levels among stroke survivors were mainly categorised as physical, psychological, and sociodemographic, and all were significantly associated with PA levels after strokes.
  10. Ahmad Najmee NA, Mohammed Z, Rahman MHA, Fadzil NM, Ludin AFM
    PLoS One, 2024;19(10):e0308149.
    PMID: 39418250 DOI: 10.1371/journal.pone.0308149
    Creating a universal and supportive learning environment is essential for the holistic education development of visually impaired school children. However, inadequate infrastructure, limited access to specialized tools, and a shortage of skilled teachers may contribute to lower self-confidence and academic performance. This underscores the necessity for specific guidelines and recommendations to address an optimal classroom setting that is tailored to their visual needs. In this paper, a scoping review protocol is introduced, utilizing the framework proposed by Arksey and O'Malley (2005), to address the following research questions: 1) Is there any established standard classroom setting for visually impaired school children? 2) What recommendations or specific guidelines exist regarding the physical measurement, layout, lighting, contrast, and appropriate position for visually impaired school children? The scoping review explored four electronic databases: PubMed, Scopus Emerald Insight, and Web of Sciences. The outcomes from the scoping review will offer conceptual elucidation, synthesize existing theoretical and empirical understandings, and propose the optimal classroom settings tailored to the visual needs of visually impaired schoolchildren. This paper introduces the a-priori study protocol, which outlines the planned methodology for conducting the scoping review in detail. This protocol has been officially registered with the Open Science Framework (OSF) at the following link: http://osf.io/z2sdt.
    MeSH terms: Child; Humans; Schools*; Students
  11. Amsah N, Isa ZM, Ahmad N
    Iran J Public Health, 2024 Sep;53(9):1924-1934.
    PMID: 39429666 DOI: 10.18502/ijph.v53i9.16448
    BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with a wide range of health outcomes, including an increased risk of depression and anxiety and a decline in quality of life. Even though the significance of biopsychological factors in the mental health status of T2DM patients has been discussed in other studies, the role of environmental factors has been lacking. Therefore, this review aimed to identify the relationship between environmental factors and mental health status among T2DM patients.

    METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews was utilized in this study. Using predetermined keywords, a systematic search was conducted on three electronic databases from 2005 to 2023, namely, Web of Science, Scopus, and PubMed. Articles written in English, and studies focusing on the research question are among the inclusion criteria. Ten articles were extracted that were relevant to the research question.

    RESULTS: Poor socioeconomic status, urban areas, the influence of neighborhood, greenness, and air pollution had associations with mental health status among T2DM patients.

    CONCLUSION: The possible implications of these factors for mental health demand further research and policy consideration.

  12. Sandhu V, Ajit Singh V, Puri A
    J Orthop Surg (Hong Kong), 2024;32(3):10225536241297105.
    PMID: 39445490 DOI: 10.1177/10225536241297105
    Background: Denosumab effectively treats RANKL-mediated bone disorders by inhibiting osteoclast activity. While approved for giant cell tumours, its role in aneurysmal bone cysts (ABC) remains unclear. This review explores denosumab's application in ABCs, focusing on its role, outcomes, and adverse effects. Methods: A scoping review adhering to PRISMA Extension for Scoping Reviews guidelines was conducted. The search involved five databases from inception until 31 December 2023. Results: From an initial 390 studies, 29 were selected post-screening involving 67 patients. The most common ABC sites were the spine (n = 42) and pelvis (n = 7). Denosumab served as primary treatment in 25 patients (37.3%), neoadjuvant in 11 (16.4%), second-line therapies after inadequate initial therapies in 24 (35.8%), and adjunct therapy in seven cases. All patients demonstrated favourable clinical and radiological responses post-denosumab. 10 patients (15%) experienced tumour recurrences: six after denosumab discontinuation (3-17 months post-cessation), three post-surgery following neoadjuvant denosumab, and one during ongoing treatment. Adverse effects reported were hypocalcaemia (n = 10), hypercalcemia (n = 14), and sclerotic metaphyseal bands (n = 2), all in the paediatric age group. While hypocalcaemia surfaced early in denosumab therapy, hypercalcaemia manifested 2.5-6 months post-discontinuation, mainly managed with bisphosphonates. Fewer than half of the studies had follow-ups that exceeded 2 years. Conclusion: Denosumab may be an effective therapy for ABC, especially for high-risk cases like spinal and pelvic tumours. It can also be utilized as a second-line for recurrence/failed initial intervention or as neoadjuvant therapy. Concerns exist about tumour recurrence and rebound hypercalcemia, necessitating careful monitoring, longer follow-up, and prophylactic measures. Prospective clinical trials are warranted for deeper insights.
    MeSH terms: Humans
  13. Poo CL, Lau MS, Nasir NLM, Nik Zainuddin NAS, Rahman MRAA, Mustapha Kamal SK, et al.
    Curr Issues Mol Biol, 2024 Oct 16;46(10):11460-11502.
    PMID: 39451562 DOI: 10.3390/cimb46100682
    Liver diseases cause millions of deaths globally. Current treatments are often limited in effectiveness and availability, driving the search for alternatives. Herbal preparations offer potential hepatoprotective properties. Disrupted gut microbiota is linked to liver disorders. This scoping review aims to explore the effects of herbal preparations on hepatoprotective mechanisms, particularly in the context of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatic steatosis, with a focus on gut microbiota modulation. A systematic search was performed using predetermined keywords in four electronic databases (PubMed, Scopus, EMBASE, and Web of Science). A total of 55 studies were included for descriptive analysis, covering study characteristics such as disease model, dietary model, animal model, intervention details, comparators, and study outcomes. The findings of this review suggest that the hepatoprotective effects of herbal preparations are closely related to their interactions with the gut microbiota. The hepatoprotective mechanisms of herbal preparations are shown through their effects on the gut microbiota composition, intestinal barrier, and microbial metabolites, which resulted in decreased serum levels of liver enzymes and lipids, improved liver pathology, inhibition of hepatic fatty acid accumulation, suppression of inflammation and oxidative stress, reduced insulin resistance, and altered bile acid metabolism.
  14. Jing M, Chui P, Chong MC, Maoting T
    Front Med (Lausanne), 2024;11:1479466.
    PMID: 39726680 DOI: 10.3389/fmed.2024.1479466
    INTRODUCTION: Community-based learning approaches are gaining recognition in nursing education as a means to address the needs of aging societies by fostering empathy, emotional intelligence, and caring behaviors among nursing students. These attributes are essential for enhancing the quality of care and building strong interpersonal connections with older adults. While community-based education programs offer promising benefits, there is still limited understanding of their impact on nursing students' empathy, emotional intelligence, and caring behaviors. This scoping review aims to examine how community-based educational interventions can assist nursing students in developing these essential competencies, ultimately contributing to better outcomes in geriatric care.

    METHOD: A scoping review was conducted following the framework of Arksey and O'Malley. The following electronic databases were searched: Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, Web of Science, Psychology and Behavioral Sciences Collection, PubMed, and Google Scholar. Gray literature was also searched through Google Scholar and ProQuest. Studies included reports on nursing students' emotional changes due to educational engagements with older adults.

    RESULTS: A total of 3,001 abstracts were screened, with 78 full texts reviewed, resulting in 9 studies being included in the analysis. The results demonstrate that interactions with older adults enhance nursing students' empathy and emotional intelligence while fostering positive changes in their caring behaviors. Participants reported greater sensitivity to the feelings and physical discomforts of older adults, contributing to improved care and stronger relational dynamics.

    DISCUSSION: Community-based education programs involving older adults represent an effective strategy for enhancing nursing students' empathy, emotional intelligence, and caring behaviors, suggesting valuable implications for nursing education methodologies.

  15. Hui CY, Condon K, Kolekar S, Roberts N, Sreter KB, Simons SO, et al.
    PLoS One, 2024;19(12):e0314914.
    PMID: 39729438 DOI: 10.1371/journal.pone.0314914
    The value of 'data-enabled', digital healthcare is evolving rapidly, as demonstrated in the COVID-19 pandemic, and its successful implementation remains complex and challenging. Harmonisation (within/between healthcare systems) of infrastructure and implementation strategies has the potential to promote safe, equitable and accessible digital healthcare, but guidance for implementation is lacking. Using respiratory technologies as an example, our scoping review process will capture and review the published research between 12th December 2013 to 12th December 2023. Following standard methodology (Arksey and O'Malley), we will search for studies published in ten databases: MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane Library, Web of Science, Scopus, IEEE Xplore, CABI Global Health, and WHO Medicus. Our search strategy will use the terms: digital health, respiratory conditions, and implementation. Using Covidence, screening of abstracts and full texts will be undertaken by two independent reviewers, with conflicts resolved by a third reviewer. Data will be extracted into a pilot-tested data extraction table for charting, summarising and reporting the results. We will conduct stakeholder meetings throughout to discuss the themes emerging from implementation studies and support interpretation of findings in the light of their experience within their own networks and organisations. The findings will inform the future work within the ERS CONNECT clinical research collaboration and contribute to policy statements to promote a harmonised framework for digital transformation of respiratory healthcare.
    MeSH terms: Humans; Telemedicine
  16. Jinah N, Adnan IK, Bakit P, Sharin IA, Lee KY
    BMC Health Serv Res, 2024 Dec 30;24(1):1662.
    PMID: 39734187 DOI: 10.1186/s12913-024-12154-x
    BACKGROUND: High turnover among the medical professions is detrimental to the healthcare system and population well-being, particularly in low- and middle-income countries (LMICs) with limited financial and human resources. To prevent brain drain, effective strategies are vital to improve the retention of healthcare workers, especially doctors. However, little evidence has been synthesised regarding the effectiveness of these strategies, especially in LMICs. This scoping review aimed to evaluate the retention strategies implemented in LMICs and their effectiveness in mitigating doctor turnover.

    METHODS: Four databases; MEDLINE (PubMed), Scopus, ScienceDirect, and EBSCOHost were searched using pre-determined keywords to identify articles published between January 1st, 2013 and February 28th, 2023 that evaluated retention strategies for doctors in LMICs. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Extension for Scoping Reviews (PRISMA-ScR) guidelines to ensure transparency. Relevant studies were identified, screened, and narratively synthesised.

    RESULTS: Thirteen articles were included, representing a diverse range of LMICs. Retention strategies were categorised into educational, financial incentives, regulatory, as well as professional and personal support. Approximately 77% (n = 10) of studies reported positive outcomes, another two did not achieve favourable results, while one showed mixed outcomes. An equal number of studies applying single-strategy (n = 5) and combined-strategy (n = 5) approaches reported successful outcomes, especially when focusing on education and/ or regulatory strategies. More notably, international collaboration in education strategies enhanced success rates while compulsory service enforcement by authorities helped retain doctors in underserved areas to address healthcare worker maldistribution. Efficiency in administrative management, regardless of urban or rural locations, also emerged as a key factor of successful retention.

    CONCLUSIONS: This review highlighted the effectiveness of different retention strategies for doctors in LMICs and its associated factors. It is imperative to emphasise the lack of a one-size-fits-all solution for this global issue. Thus, a multifaceted, comprehensive approach is essential in producing sustainable health workforce development that ensures optimal health outcomes, especially for populations in underserved areas. Future studies should prioritise pre- and post-intervention comparisons using appropriate indicators to enhance understanding and guide effective interventions for doctor retention.

    MeSH terms: Developing Countries*; Humans; Personnel Turnover*; Physicians*
  17. Feldman SE, Lennox L, Dsouza N, Armani K
    PLoS One, 2024;19(12):e0312515.
    PMID: 39739745 DOI: 10.1371/journal.pone.0312515
    OBJECTIVE: Health Inequalities refer to disparities in healthcare access and outcomes based on social determinants of health. These inequalities disproportionately affect Black, Asian, Minority Ethnic (BAME) groups, particularly pregnant women, who face increased risks and limited access to care due to low health literacy. Maternal mortality rates for BAME women can be up to four times higher than for white women. This scoping review aimed to assess the impact of health literacy on BAME pregnant women's health outcomes and experiences. Objectives included evaluating health literacy improvement tools, engaging stakeholders through co-production, and identifying persisting health inequalities.

    DATA SOURCES: A scoping review using the Arksey and O'Malley's framework was conducted. A specific search strategy was developed with a research librarian across three databases: EMBASE, Medline, and the Maternity and Infant Care (MIC) database. Patient, Public Involvement, and Engagement (PPIE) members were consulted from the outset to co-design the research question and to provide feedback on the findings.

    STUDY APPRAISAL AND SYNTHESIS METHODS: Out of 1958 articles, 19 were included in the study, with 47% from the US and 21% from Denmark. Articles were published from EMBASE. 47% of the articles measured health literacy, while 53% implemented health literacy interventions, such as digital or community-based approaches.

    RESULTS: All 19 articles highlighted lower health literacy in BAME women compared to other groups. Ten proposed recommendations, while others emphasized the impact of social determinants of health, collectively underscoring the need for more research on BAME health.

    CONCLUSIONS: The review underscores the inadequate health literacy and patient experience of BAME pregnant women. It also highlights the potential of digital health interventions to improve health literacy and health outcomes. The findings call for increased research into health literacy tools for BAME pregnant women. Healthcare systems, including the NHS, should allocate resources to enhance digital health interventions and address health inequalities in BAME groups during pregnancy.

    MeSH terms: Female; Humans; Pregnancy; Healthcare Disparities*; Health Literacy*
  18. Idrus E, Harsono TS, Lestari W, Suniarti DF
    J Indian Soc Periodontol, 2024;28(3):290-296.
    PMID: 39742069 DOI: 10.4103/jisp.jisp_269_23
    Fusobacterium nucleatum is implicated in periodontitis, a chronic inflammatory disease that destroys the periodontal tissue and alveolar bone due to host-microbe dysbiosis. This study focuses on understanding how F. nucleatum contributes to bone destruction in periodontitis. The literature search was conducted using PubMed and Scopus databases based on Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines by entering preselected keyword combinations of inclusion and exclusion criteria. Qualifying literature was evaluated based on four inclusion criteria: research articles, published in English, within the last ten years, and available in full text. The literature search yielded five articles exploring the mechanism of bone resorption by F. nucleatum. It was found that the bacteria increases the production of inflammatory mediators, such as interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-alpha, C-C motif chemokine ligand (CCL) 2, CCL20, and C-X-C motif chemokine ligand 1, which leads to the destruction of alveolar bone. During infection, biomechanical stress also raises levels of prostaglandin E2 and cyclooxygenase-2. The elevated levels of inflammatory mediators and enzymes generate an imbalance in the receptor activator of nuclear factor kappa-B ligand to osteoprotegerin ratio, hindering osteogenic differentiation and heightening bone destruction. In conclusion, F. nucleatum infection promotes alveolar bone destruction by inducing inflammatory responses and inhibiting osteogenic differentiation stimulated by biomechanical loading. More research is essential to explore the connection between F. nucleatum virulence and its alveolar bone degradation mechanisms.
  19. Lu Y, Shi L, Musib AF
    Front Psychol, 2024;15:1522962.
    PMID: 39881691 DOI: 10.3389/fpsyg.2024.1522962
    BACKGROUND: Executive functions is a crucial ability in the early development of preschool children. While numerous studies have found that music training has a favorable effect on children's executive functions, there is a lack of a consistent perspective on this topic, particularly with regard to the dose-response relationship.

    METHODS: Systematic searches were conducted of Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure. A random-effects meta-analysis was used to compute standardized mean differences (SMD) and 95% confidence intervals (CI).

    RESULTS: In all, 10 studies were included in the meta-analysis, in which children's music training groups showed significantly improved inhibitory control (SMD = 0.38, 95% CI: 0.16-0.6), working memory (SMD = 0.35, 95% CI: 0.16-0.54), and cognitive flexibility (SMD = 0.23, 95% CI: 0.04-0.42) in comparison with control groups. Subgroup analyses indicated significant improvements relative to the control groups for inhibitory control following music training having a duration of ≥12 weeks (SMD = 0.51, 95% CI: 0.22-0.8), occurring ≥3 times per week (SMD = 0.48, 95% CI: 0.2-0.75), and lasting 20-30 min per session (SMD = 0.42, 95% CI: 0.2-0.63). Significant improvements were seen for working memory following music training having a duration of ≥12 weeks (SMD = 0.42, 95% CI: 0.18-0.65), occurring <3 times per week (SMD = 0.49, 95% CI: 0.06-0.93), occurring ≥3 times per week (SMD = 0.28, 95% CI:0.1-0.47), and lasting 20-30 min per session (SMD = 0.39, 95% CI: 0.16-0.54). Music training significantly improved cognitive flexibility following training having a duration of ≥12 weeks (SMD = 0.22, 95% CI: 0.04-0.41), occurring ≥3 times per week (SMD = 0.19, 95% CI: 0.0-0.39), and lasting >40 min per session (SMD = 0.74, 95% CI: 0.22-1.26).

    CONCLUSION: Music training has a positive effect on inhibitory control, working memory, and cognitive flexibility in preschool children aged 3-6 years. This effect is influenced by certain training factors, including the duration of the intervention period, frequency per week, and length of each session.

    SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/#aboutregpage, CRD42024513482.

  20. Khan A, Shafiai MHM, Abbas G, Zaidi SB, Hassan MU
    Front Psychol, 2024;15:1526352.
    PMID: 39881692 DOI: 10.3389/fpsyg.2024.1526352
    INTRODUCTION: Malaysia as an ethnically diverse country has a history of interethnic inequality and poverty which led to the development of different views about the existence of poverty. Among these ethnic groups, some sympathize with the poor and help them through different charity organizations. However, these charity organizations are mostly unaware of the target donors that can aid their charity funds. Therefore, this study explores the attitudinal differences regarding poverty among Malays, Chinese, and Indians and the demographic groups that can be targeted for donation and social policy development purposes.

    METHODOLOGY: A survey is conducted in Selangor, where the data through a questionnaire is extracted from the three ethnic groups. Through the quota sampling technique, a sample of 700 is derived. The results are analyzed through ANOVA, regression, and mediation analysis.

    RESULTS: The results show that attitudinal differences between Malays and Chinese regarding structuralist beliefs could be observed. Moreover, among Malays, it is found that the relationship between gender, income, education, wealth, and structuralist beliefs is significantly mediated by beliefs about charity. On the other hand, mediation analysis for Chinese identifies gender, education, and income while among Indians gender, education, and wealth are identified as key demographic groups.

    DISCUSSION: This study highlights the role of attribution theory to identify the charity donors among the different ethnic groups which was overshadowed by the previous research in Malaysia. The results also hold significance for charity institutions to target the specified groups through their marketing campaigns. Also, based on these results government can reduce the misconception about the existence of poverty and to develop policies that encourage high income groups to support the poor.

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