MATERIALS AND METHODS: The PubMed database was searched, and 242 research articles were screened from which 94 articles qualified for selection from those published by December 31, 2023 and the data was synthesized using the Review Manager software.
KEY FINDINGS: Cisplatin encapsulated as a nanomedicine confirmed the versatility of nanocarriers in significantly diminishing cancer cell viability, half maximal inhibitory concentration, tumour volume, biodistribution of platinum in tumours and kidney; at p
METHOD: This study used guidelines for the systematic review and meta-analysis of PRISMA, Web of Science, EBSCOhost (SPORTDiscus), PubMed, Scopus, and Google Scholar to collect original references in electronic databases. The PICOS method was selected for the inclusion criteria. The physiotherapy evidence database (PEDro) scale was used to assess the scoring for articles' risk range of bias. The scoring of 20 studies ranges from 4-8, and study quality is moderate to high.
RESULTS: Out of 285 identified studies, only 20 articles fulfilled all the eligibility criteria after screening. IRT could significantly improve reciprocal, static, and dynamic balance ability among judo athletes, basketball players, weightlifters, archery athletes, soccer players, rhythmic gymnasts, badminton players, track and field athletes, handball players, volleyball players, and gymnasts using unstable surfaces or environments (i.e., BOSU, Swiss, Wobble boards, Suspension trainer, Sissel pillows, Inflated disc and foam surface, Airex balance pad, Togu power ball, Thera-Band, Elastic band strap, Sand surface and so on).
CONCLUSION: The finding suggests that different types of IRT benefit athletes as this training method can effectively enhance reciprocal, static, and dynamic balance ability in athletes. Therefore, this review suggests that IRT should be considered in athletes' daily training routines for the physical fitness of reciprocal, static, and dynamic balance ability.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42024559872.
METHODS: Following PRISMA guidelines, a systematic search was conducted in the Scopus, Web of Science, SportsDiscuss, and PubMed databases without date constraints, up to July 2024. Studies included in this meta-analysis met PICOS criteria: a) randomized controlled trials with healthy tennis players, b) isolated or combined S&C training programs, c) evaluation of tennis serve speed, and d) adequate data to compute effect sizes (ESs). The PEDro scale was used to assess methodological quality.
RESULTS: Out of 271 identified papers, 16 studies of moderate to high quality were included in the meta-analysis. Resistance training demonstrated a small but significant effect on serve speed (ES = 0.53; p < 0.001), while multimodal training exhibited a moderate and significant effect (ES = 0.79; p = 0.001). However, core training did not have a significant effect on serve speed (ES = 0.32, p = 0.231).
CONCLUSION: The findings suggested that S&C interventions, including resistance and multimodal training, were beneficial for increasing serve speed in tennis players. Further high-quality research is recommended to confirm this conclusion.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_ record.php?RecordID=519790, identifier CRD42024519790.
METHODS: This study employed a completely random survey of three art universities in China to investigate the status of emotional intelligence, self-acceptance, perceived stress and learning burnout among art students and their relationships. The data was analyzed using an independent sample t-test and structural equation modelling.
RESULTS: A total of 678 valid samples were obtained from a study of Chinese art students. No significant differences were observed in the scores of emotional intelligences, self-acceptance, perceived stress, and learning burnout among participants of different genders. The results of the structural equation modelling indicated that emotional intelligence was negatively associated with learning burnout (β = -0.282, p
METHODS: The IC50 of EEROP in SW480 cells was determined by treating the cells with varying doses of EEROP, ranging from 0 to 1000 µg/mL. Apoptosis assay and signaling pathway analysis were performed through immunofluorescence staining and Western Blotting on SW480 cells treated with 250 µg/mL of EEROP for 72 hours.
RESULTS: EEROP treatment induced apoptosis in SW480 cells, marked by elevated levels of active caspase-3 (P<0.001) and cleaved poly-(ADP-ribose) polymerase (PARP)-1. Moreover, it notably decreased β-catenin protein levels, resulting in an augmented occurrence of cells displaying abnormal spindle segregation during mitosis (P=0.04).
CONCLUSION: EEROP treatment reduces β-catenin protein levels, promotes abnormal spindle apparatus segregation, and finally leads to apoptotic cell death in CRC cells.
PURPOSE: This systematic review and meta-analysis evaluated the effectiveness of chatbots for providing breast cancer education. By examining patient satisfaction with and the usability and efficacy of chatbot interventions, this study seeks to support the integration of chatbot technology into cancer education.
METHODS: This review, which was conducted in accordance with PRISMA guidelines, included studies from MEDLINE, Embase, and the Cochrane Library up to May 2024. The main inclusion criterion was chatbot interventions for breast cancer education. Meta-analysis was performed using Review Manager and Open Meta-Analyst software.
RESULTS: Of the 208 articles initially identified, 6 studies met the inclusion criteria, involving a total of 1342 women with early-stage or at-risk hereditary breast cancer. The meta-analysis revealed that most participants (85 to 99%) reported high satisfaction with chatbot interventions for breast cancer education, with no significant differences in satisfaction compared to genetic counselors or physicians. The chatbot interventions also showed positive effects on knowledge acquisition (mean proportion = 90.8%) and alleviated patients' symptoms significantly more than routine care.
CONCLUSION: This study demonstrated that chatbots can effectively provide personalized and interactive educational support, enhancing patients' understanding and retention of disease-related information. The integration of chatbot technology into educational programs can empower patients, ultimately promoting breast cancer awareness and prevention.
MATERIALS AND METHODS: The method used a completely randomized design 5 × 4, with five treatments and four replications. The substrate diet consisted of 60% forage and 40% concentrate. The culture mixture was 1.3 × 1011 CFU/mL with a 50%:50% ratio of S. harbinensis LH 991 and P. kudriavzevii B-5P. The inoculum concentrations used in this study were 0% (control), 1%, 2%, 3%, and 4%. Treatments are arranged based on differences in inoculum concentration as follows: T0: control (0%); T1: 1%; T2: 2%; T3: 3%; and T4: 4%.
RESULTS: The T4 group showed a significant increase (p < 0.01) in short-chain fatty acids (SCFA), including acetate, propionate, butyrate, valerate, isobutyrate, and isovalerate acids, compared with the other treatments. Meanwhile, T4 shows that there is no significant (p > 0.01) effect on in vitro digestibility (in vitro dry matter digestibility, in vitro organic matter digestibility, and in vitro crude fiber digestibility). However, a highly significant (p < 0.01) effect was on volatile fatty acid total, NH3, and microbial crude protein synthesis.
CONCLUSION: It is concluded that the treatment with a 4% inoculum concentration (T4) containing a mixture of S. harbinensis LH 991 and P. kudriavzevii B-5P as LAB and yeast isolated from Budu (fermented fish) in 50%:50% ratio increased SCFA and rumen fermentation significantly, whereas it did not affect in vitro digestibility.
MATERIALS AND METHODS: A bovine single nucleotide polymorphism (SNP) 50K BeadChip was used for the investigation. A total of 46. Sumatran native cattle of three colors as follows: Brown (36 animals), white (9 animals), and black (1 animal), were used as experimental animals.
RESULTS: Results showed that the SNP markers ARS-BFGL-NGS-75486 (p = 2.46 × 10-7) and BTB-01992588 (p = 1.06 × 10-5) were selected as two genetic markers for coat color variation in animals under study, which were located at the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene at BTA7 and small G protein signaling modulator 1(SGSM1) genes at BTA17, respectively. The polymorphic informative content values of both SNP markers were 0.33 (ARS-BFGL-NGS-75486) and 0.13 (BTB-01992588). In this study, a genetic marker for coat color patterns in Sumatran native cattle was obtained based on the haplotypes of both SNP markers.
CONCLUSION: It can be concluded that CYFIP2 and SGSM1 are two coloration genes that affect the phenotype characteristics of Sumatran native cattle.
METHODS: A total of 818 preschool children, aged between 3 and 6 years, and their fathers and mothers were included in the study. Data were collected using the Chinese version of the Emotional Regulation Checklist and the Chinese version of the Mobile Phone Problem Use Scale. SPSS v. 20.0 was used to conduct descriptive statistical analysis, independent sample t-test, one-way ANOVA, and correlation analysis. Mplus v. 7.11 was used to conduct structural equation model analysis.
RESULTS: Girls' emotional regulation was significantly stronger than boys' (P = .037). The emotional regulation of preschool children in the older class was significantly stronger than that of preschool children in the intermediate class and primary class (P = .045). There was no significant difference in emotional regulation between intermediate class children and primary class children (P = .213). Fathers' smartphone addiction (FSA) and mothers' smartphone addiction (MSA) were significant negative predictors of preschool children's emotional regulation (β MSA = -0.541, β FSA = -0.250). Mothers' smartphone addiction had a significantly stronger predictive effect on preschool children's emotional regulation than fathers' smartphone addiction.
CONCLUSION: This study adds to previous research on parental smartphone addiction and preschool children's emotional regulation. The findings suggest that it is necessary to consider parental smartphone addiction, especially mothers' smartphone addiction, when developing intervention programs to enhance preschool children's emotional regulation.
METHODS: This was a cross-sectional study conducted among older persons aged ≥ 60 years, and the exclusion criteria were older persons with known cases of dementia or the inability to stand and have hand problems that limit the ability to hold the dynamometer. Sociodemographic data and anthropometry assessment were conducted. Malnutrition risk screening tool-hospital, modified Barthel Index and the Elderly Cognitive Assessment Questionnaire were used in this study. The data were analysed using descriptive statistics and multiple logistic regression.
RESULTS: A total of 200 older persons participated in the study, and the proportion of the high risk of malnutrition was 27 (13.5%). Poor handgrip strength odd ratio (OR) = 3.56, 95% confidence interval (CI) = 1.41, 8.98; p = 0.007) and living arrangements (OR = 4.6, 95% CI = 1.31, 16.1; p = 0.017) were significantly associated with a high risk of malnutrition in older persons.
CONCLUSIONS: The proportion of older persons at high risk of malnutrition was low (13.5%). Poor handgrip strength and living arrangements are significant factors associated with a high risk of malnutrition among older persons. Nutrition screening can help identify the cause and other factors of malnutrition. The role of healthcare personnel should be emphasised in nutrition screening, as they are commonly the first point of contact for patients seeking medical advice.
METHODS: This prospective cohort study was conducted in the Critical Care Unit of HPUSM from September 2019 to March 2021. Eligible participants included patients with a positive blood culture recorded after 48 hours of admission to hospital.
RESULTS: There was a total of 250 patients, whose positive blood cultures were isolated. The main isolated organisms were Klebsiella pneumonia (23.6%), Pseudomonas spp. (19.2%), Escherichia coli (12.8%) and Acinetobacter sp. (9.2%). The mortality of hospital-acquired BSI was 27.6%. Multiple logistic regression analysis revealed that age [adjusted odds ratio (OR) = 1.06; 95% confidence interval (CI): 1.03, 1.09; p < 0.001], cases with extended-spectrum beta-lactamases (ESBL) (adjusted OR = 5.57; 95% CI: 2.04, 15.21; p = 0.001), with multidrug-resistant (MDR) organisms (adjusted OR = 14.70; 95% CI: 3.97, 54.48; p < 0.001) and those with a sequential organ failure assessment (SOFA) score > 11 (adjusted OR = 4.16; 95% CI: 1.31, 13.19; p = 0.015) had statistically significant associations with treatment failure. Factors significantly associated with 28-day mortality included age (adjusted OR: 1.06: 95% CI; 1.03, 1.09; p < 0.001), MDR organisms (adjusted OR = 14.70; 95% CI: 3.97, 54.48; p < 0.001) and SOFA score > 11 (adjusted OR = 4.16; 95% CI: 1.31, 13.19; p = 0.015).
CONCLUSION: The elderly, ESBL, MDR organisms and high SOFA scores were associated with treatment failure and 28-day mortality in hospital-acquired BSI.