METHODS: Over 14 days, 60 adults followed protocol requirements, completed food diaries and study questionnaires, avoided consuming supplements with prebiotics, probiotics or postbiotics, and ingested food containing 5 g of total daily fibre [placebo (10.75 g), GBP (10.75 g) or PFP (7.41 g)]. Participants' medical and baseline wellness histories, as well as stool samples, were collected at baseline, day 7 and 14. Stool DNA was processed for sequencing.
RESULTS: Dietary fibre and resistant starches (RS) in GBP and PFP promoted temporal increases in beneficial bacteria. GBP significantly elevated 7 species (F. prausnitzii, B. longum, B. bifidum, B. adolescentis, B. pseudocatenulatum, B. obeum, and R. inulinivorans), while PFP enriched 6 species (B. ovatus, B. cellulosilyticus, B. bifidum, B. intestinalis, R. inulinivorans, and E. siraeum). These bacteria, found to be deficient in younger adults, were promoted by both powders. PFP benefitted both genders aged 16-23, while GBP benefitted overweight/obese individuals, including females. GBP and PFP fiber and RS improved bowel regularity and health as well as metabolism by promoting histidine, branched-chain amino acids, short-chain fatty acids, and biotin production. The additional fiber caused "low" bloatedness and reduced "fairly bad" sleep disruptions, without affecting sleep durations.
CONCLUSION: GBP and PFP supplementation increased beneficial bacteria and metabolites, improved host gut health, and present a valuable nutritional strategy for enhancing human health.
CLINICAL TRIAL REGISTRATION: AMILI Institutional Review Board, Identifier 2023/0301.
METHOD: This study investigated the potential use of a combination of chemical and mechanical methods in the extraction of jute CNFs. Through this method, the jute fibers were first chemically treated using sodium hydroxide (NaOH), sodium chlorite (NaClO 2) and sulphuric acid (H 2SO 4) to remove the non-cellulosic elements followed by mechanical milling by using a planetary ball mill.
RESULTS: The shape and size of the obtained CNFs were observed under a field emission scanning electron microscope (FESEM). This study revealed that jute CNFs were successfully extracted through the combination of chemical and mechanical treatment methods where the obtained CNFs reveal themselves in smooth fibrous morphology with a diameter of 23 nm and 150-200nm in length.
CONCLUSIONS: Jute cellulose nanofibers were successfully drawn out from raw jute fibers by means of a combination of chemical and mechanical treatment. The results obtained confirmed that the chemomechanical method is an effective technique for isolating the CNFs and its potential use as reinforcement material was explained.
METHODS: Dengue patients were recruited from a public health clinic in Malaysia and randomised to either use the DengueAid application plus standard care for dengue or receive only the standard care. The outcomes evaluated were the (1) feasibility of recruitment, data collection and follow-up procedures; (2) preliminary clinical outcome measures; and (3) acceptability of DengueAid. Qualitative interviews were conducted for participants in the intervention arm to assess the acceptability of DengueAid.
RESULTS: Thirty-seven patients were recruited with 97% (n = 36) retention rates. The recruitment rate was low (63% refusal rate, n = 62/99) with difficulty in data collection and follow-up due to the variable interval of care for dengue in an outpatient setting. DengueAid application was acceptable to the participants, but preliminary clinical outcomes and qualitative data suggested limited utility of the application. Unwell conditions of patients and limited access to healthcare are important factors impacting the application's utility.
CONCLUSION: The feasibility trial uncovered issues with recruitment, data collection and follow-up processes. Further research and modification to the application are needed to improve its utility and usability.
METHODS: This prospective study involved paediatric patients admitted to the paediatric intensive care unit (PICU) of the largest central children's hospital in the Mekong Delta region, Vietnam, from 2019 to 2021. The discriminative ability and calibration of both individual and combined tests were assessed using the receiver operating characteristic (ROC) curves and the Hosmer-Lemeshow goodness-of-fit test.
RESULTS: Among the patients studied, 63.1% did not survive. Lactate and D-dimer concentrations were significantly higher in the non-survivor group (P < 0.001). The area under the curve (AUC) values for lactate, D-dimer and the combined lactate-D-dimer test were 0.742, 0.775 and 0.804, respectively, with the combination showing the highest AUC value, though without statistical significance. Specific thresholds for lactate, D-dimer and the combination yielded sensitivities of 75.5%, 71.7%, and 66.0%, respectively. All three tests showed no statistically significant differences between observed and predicted mortality in the Hosmer-Lemeshow test (all P-values > 0.05).
CONCLUSION: Lactate and D-dimer levels showed a significant association with mortality, along with good discrimination and calibration abilities. These results highlight the utility of lactate and D-dimer as effective predictors in paediatric MODS, particularly in resource-limited settings, and their role in improving patient outcomes.
METHODS: A total of 30 male adolescents living in the Kelantan state in Malaysia who were between 14 years old and 20 years old were enrolled and divided into three groups: i) sedentary (control), ii) taekwondo and iii) wushu. Each participant underwent a lung function test, 20 m shuttle run, Wingate anaerobic test and a Sit and Reach test, as well as tests of standing long jump power, handgrip, back and leg strength.
RESULTS: Relative to the sedentary control group, the wushu group had significantly higher values than the sedentary control group for fat free mass (P = 0.047), explosive leg power (P < 0.001), aerobic capacity (P < 0.001), forced expiratory volume in 1 s (FEV1) (P = 0.021) and Wingate anaerobic capacity (P < 0.05). The taekwondo group also showed significantly greater values than the sedentary control group for explosive leg power (P = 0.018), forced vital capacity (FVC) (P = 0.014) and FEV1 (P < 0.001). The wushu group exhibited significantly higher explosive leg power (P = 0.010) and Wingate anaerobic capacity parameters including mean power (P = 0.001), anaerobic capacity (P < 0.001) and anaerobic power (P = 0.002) than the taekwondo group.
CONCLUSION: Engagement of male adolescents in wushu and taekwondo was associated with improved physiological profiles compared to those who were in the sedentary control group. Practice of wushu could result in greater explosive leg power and anaerobic capacities than taekwondo.
METHODS: A cross-sectional study was conducted from January 2020 to May 2023 at Rumah Sakit Akademik, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher's exact test evaluated the association between DRPs and LoS.
RESULTS: A total of 60.7% (n = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old (n = 11, 29.7%). A significant portion experienced LoS > 7 days (n = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction (n = 15, 40.5%), dosage too high (n = 6, 16.2%), wrong drug (n = 6, 16.2%), non-adherence (n = 4, 10.8%), need for additional therapy (n = 4, 10.8%) and dosage too low (n = 2, 5.4%). A significant association was observed between non-adherence and LoS (P = 0.016). The possibility of experiencing LoS of 1-7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). In this context, non-adherence refers to DRPs associated with the non-compliance of patients with the prescribed treatment plan.
CONCLUSION: This study concludes that non-adherence was significantly associated with hospital LoS.
METHOD: We conducted a cross-sectional study in which we used purposive sampling and a self-administered questionnaire. Based on the literature review, experts' input and in-depth interviews, new items were generated for SS-Bloat scale. Content validity was assessed by experts and pre-tested with 30 individuals with AB. Construct validity was determined based on exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Reliability was determined based on Cronbach's alpha and composite reliability (CR).
RESULTS: During the development stage, eight items were generated for SS-Bloat scale and remained the same after content validity and pre-testing. A total of 152 participants with a mean age of 31.27 years old (68.3% female, 32.7% male) completed the questionnaire. Based on the EFA, three problematic items were removed. The total variance explained was 35.6% with acceptable reliability (α = 0.66). The model was then tested using CFA. The initial model did not fit the data well. After several model re-specifications, the final measurement model of SS-Bloat scale fit the data well with acceptable fit indices (comparative fit index [CFI] = 0.994 and Tucker-Lewis index [TLI] = 0.984). The CR was satisfactory with value of 0.84.
CONCLUSION: SS-Bloat scale was deemed valid and reliable for assessing the level of social support among AB patients. The questionnaire can be useful for both research studies and clinical purposes, as it is easy to use.
METHODS: The research datasets were acquired from the Scopus database. The search terms used were 'reward' AND 'human' AND 'diffusion imaging' OR 'diffusion tensor imaging' OR 'diffusion MRI' OR 'diffusion-weighted imaging' OR 'tractography' in the abstract, article title and keywords. A total of 336 publications were analysed using Harzing's Publish or Perish and VOSviewer software.
RESULTS: The results revealed an upward trend in the number of publications with the highest number of articles in 2020 and 2022. Most publications were limited to countries, authors, and institutions in the USA, China and Europe. Bracht, Coenen, Wiest, Federspiel and Feng were among the top authors from Switzerland, Germany and the UK. Neuroimage, Neuroimage Clinical, Frontiers in Human Neuroscience, Human Brain Mapping, and the Journal of Neuroscience were the top journals. Among the top articles, six were reviews and four were original articles, while the top keywords in human reward research were 'diffusion MRI', 'adolescence', 'depression' and 'reward-related brain areas'.
CONCLUSION: These findings may serve as researchers' references to find collaborative authors, relevant journals, cooperative countries/institutions, and hot topics related to dMRI and reward research.
METHODS: A cross-sectional study using cluster sampling was conducted in a state in Malaysia. Each respondent completed BFI-10 and BFI-13 using an online survey with a 1-month interval between each response. Reliability testing was evaluated using internal consistency and a 2-week interval test-retest. The model fit of these two BFI questionnaires was evaluated via confirmatory factor analysis (CFA).
RESULTS: A total of 124 firefighters participated in the study, with a zero-dropout rate. The Malay version of BFI-13 exhibited higher reliability by displaying good internal consistency with Cronbach's alpha of 0.919, 0.838, 0.871 and 0.896 for the domains conscientiousness, neuroticism, agreeableness and extraversion, respectively, and acceptable test-retest reliability with moderate to good intraclass correlation (0.588-0.806). The CFA model also indicated that BFI-13 has a better model fit (comparative fit index [CFI] = 0.993; Tucker-Lewis index [TLI] = 0.991; standardised root mean squared residual [SRMR] = 0.029; root mean square error of approximation [RMSEA] = 0.035).
CONCLUSION: The Malay version of BFI-13 is reliable and applicable enough to be supplementarily used in surveys among Malaysian firefighters. By using a brief personality assessment, it will reduce the cognitive and emotional burden on respondents.