AIM: To investigate the effects of the combining nanoemulsion extract of purple leaves and hydroxyapatite on the expression of RUNX2, OSX, OPN, ALP, and calcium deposition.
METHOD: This research used MTT Assay, ICC, and Alizarin Red staining. The study groups were as follows: Group 1: Ad-MSCs; Group 2: Ad-MSCs + αmem; Group 3: Ad-MSCs + osteogenic medium + 1 % nano-extract of Purple leaves & Hydroxyapatite; Group 4: Ad-MSCs + osteogenic medium + 2 % nano-extract of Purple leaves & Hydroxyapatite. Observations were conducted on days 7, 14, and 21.
RESULTS: The combination of nanosuspension extract of Purple leaves and hydroxyapatite significantly increased the expression of RUNX2, OSX, OPN,ALP and calcium deposition compared to other groups. The combination of nanoemulsion extract of Purple leaves and hydroxyapatite were significant (P
METHODS: The session was structured using Gagné's instructional events, including engaging case vignettes, multimedia presentations, guided practical activities, and immediate feedback. Pre- and post-tests measured knowledge gains, while a 12-item Likert scale questionnaire assessed student satisfaction. A focus group discussion (FGD) was conducted to explore student perceptions and analyzed thematically to identify key areas for improvement.
RESULTS: The session demonstrated significant knowledge improvement, with post-test scores (mean: 82.9%, 95% CI: 76.8-81.1) significantly higher than pre-test scores (mean: 68.4%, 95% CI: 60.7-66.1; p < 0.001). The instructional activities received high ratings (mean: 5/5), highlighting the alignment of objectives and content. The FGD thematic analysis revealed five key themes: "learning effectiveness", "realism and application", "feedback and improvement", "session challenges", and "recommendations for enhancement". Students suggested more diverse scenarios, extended debriefing sessions, and standardized feedback delivery.
CONCLUSION: The integration of Gagné's instructional model into simulation-based learning enhanced knowledge acquisition and student satisfaction. Recommendations for improvement include refining feedback mechanisms, increasing session diversity, and extending reflective discussions. This approach supports its utility in teaching critical obstetric skills and highlights opportunities for further enhancement.
METHODS: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and the researchers performed a systematic search of five international electronic databases using the predefined terms "functional training" and "athletes" on 15th November 2023: Web of Science, CINAHL PLUS, PubMed, Scopus, and SPORTDiscus. A PICOS approach was used to identify the following inclusion criteria: (1) athletes, (2) a functional training program, (3) an active control group, (4) a measure of physical and/or technical performance, and (5) randomized controlled studies. A methodological quality assessment of the original research was conducted using the Physiotherapy Evidence Database (Pedro) scale. The review was performed using the PRIMSA guidelines and registered in PROSPERO (ID: CRD42022347943).
RESULTS: Of the 1059 potentially eligible studies identified, 28 studies met the inclusion criteria. The studies included were conducted on 819 athletes from 12 different countries and were published between 2011 and 2023. The assessment was performed on the Pedro scale, and the mean Pedro score for the included studies was 5.57 (moderate quality, ranging from 4 to 10). The eligibility study reported on 14 different types of sports, with 22 studies focusing on physical performance and 11 studies focusing on technical performance. These studies have shown that functional training can significantly improve the physical and technical performance of athlete populations, but in some studies, no significant difference in the data was observed between groups.
CONCLUSION: Functional training is an effective training method for enhancing the physical and technical performance of athlete populations. However, no significant difference in the data was observed between the functional training groups and the regular training group, which may be due to the duration of the training program, the different training experiences of the athletes, and the different focuses of the training regimens. Therefore, future studies should focus on the physical and technical performance of different sports groups with different types and durations of functional training programs to expand the current evidence base.
METHOD: A systematic search was conducted in numerous databases (Scopus, Web of Science, IEEE Xplore, ScienceDirect, MDPI, and PubMed) that identified 1614 peer-reviewed articles published between 2019 and 2023.
RESULTS: 52 articles were selected for detailed analysis that showed a growing trend in the application of LIME techniques in healthcare, with significant improvements in the interpretability of ML models used for diagnostic and prognostic purposes.
CONCLUSION: The findings suggest that the integration of XAI techniques, particularly LIME, enhances the transparency and trustworthiness of AI systems in healthcare, thereby potentially improving patient outcomes and fostering greater acceptance of AI-driven solutions among medical professionals.
METHODS: This sub-analysis included patients randomized to receive methadone in PCCs as part of an implementation trial in which the control group received methadone in specialty addiction clinics in Ukraine. Methadone integration in PCCs was supported through continuous tele-education for providers. Provider stigma towards people who inject drugs, methadone, and attitudes towards evidence-based practices were assessed at baseline, 12, and 24 months using standardized scales (range 1-10). Patient-level outcomes were measured bi-annually over 24 months using a quality health indicator (QHI) score, a percentage of guideline-concordant primary and specialty health services accessed. Linear mixed-effects models examined the changes in provider stigma and attitudes, and the association of these measures with patient outcomes.
RESULTS: The sample included 583 patients and the 112 providers in 24 clinics. Provider fear and stereotypes toward people who inject drugs improved significantly, by 0.6 (95 % CI 0.2-1.1) and 0.4 points (95 % CI 0.1-0.8), respectively, as did preference for methadone over abstinence-based treatment (0.7 points, 95 % CI 0.2-1.1). A 1-point improvement in provider prejudice correlated with a 7.0-point increase (95 % CI: 1.1-13.0) in patient primary care QHI scores at 12 months, while improved attitudes towards evidence-based practices were associated with an 8.3-point increase (95 % CI: 1.1-13.0). Preference for methadone maintenance over abstinence was associated with a 3.7-point increase (95 % CI: 0.6-6.7) in specialty care QHI scores at 12 months, and reduced stereotypes were associated with a 10.9-point increase (95 % CI: 1.2-20.7) at 24 months.
CONCLUSIONS: Integrating methadone into PCCs with the support of provider tele-education may reduce provider stigma, particularly fear and stereotypes, toward people who inject drugs and methadone maintenance. Reducing provider stigma has the potential to improve patient outcomes through increased access to preventive care and screenings.
OBJECTIVES: The objectives of this study were to investigate the effect of adherence to postoperative recommendations on anthropometric measurements and body composition and assess the percentage of total weight loss (%TWL) and excess weight loss (%EWL) 3 months postoperative.
SETTINGS: Fifty-two participants who underwent a Roux-en-Y gastric bypass or sleeve gastrectomy in the University of Jordan Hospital were included.
METHODS: Participants have filled out a preoperative questionnaire. Anthropometric measurements were obtained preoperative and 3 months postoperative using a Body Impedance Analyzer (Inbody 270). The adherence to postoperative recommendations was assessed by the Bariatric Surgery Self-management Questionnaire 3 months postoperative and classified to 3 adherence levels.
RESULTS: Most anthropometric measurements decreased 3 months postoperative in the 3 adherence groups (P ≤ .05). No significant differences were observed between groups in anthropometric measurements and body composition, except for minerals and visceral fat levels. The mineral loss has decreased in both the high and intermediate adherence groups (-.09 ± .22 kg, and -.09 ± .18 kg, respectively). Also, the high adherence group showed less loss in protein amount postoperatively (P = .06). Visceral fat level decreased in the high adherence group (P ≤ .05).
CONCLUSIONS: Adherence to postoperative behavioral and nutritional recommendations was associated with less protein and mineral loss and enhanced visceral fat reduction postoperatively.
OBJECTIVE: This research aims to provide a literature review study and an in-depth analysis to (1) investigate the procedure and roles of remote diagnosis in telemedicine; (2) review the technical tools and technologies used in remote diagnosis; (3) review the diseases diagnosed remotely in telemedicine; (4) compose a crossover taxonomy among diseases, technologies, and telemedicine; (5) present lists of input variables, vital signs, data and output decisions already applied in remote diagnosis; (6) Summarize the performance assessment measures utilized to assess and validate remote diagnosis models; and (7) identify and categorize open research issues while providing recommendations for future advancements in intelligent remote diagnosis within telemedicine systems.
METHODS: A systematic search was conducted using online libraries for articles published from 1 January 2016 to 13 September 2023 in IEEE, PubMed, Science Direct, Springer, and Web of Science. Notably, searches were limited to articles in the English language. The papers examine remote diagnosis in telemedicine, the technologies employed for this function, and the ramifications of diagnosing patients outside hospital settings. Each selected study was synthesized to furnish proof about the implementation of remote diagnostics in telemedicine.
RESULTS: A new crossover taxonomy between the most important diagnosed diseases and technologies used for this purpose and their relationship with telemedicine tiers is proposed. The functions executed at each tier are elucidated. Additionally, a compilation of diagnostic technologies is provided. Additionally, open research difficulties, advantages of remote diagnosis in telemedicine, and suggestions for future research prospects that require attention are systematically organized and presented.
CONCLUSIONS: This study reviews the role of remote diagnosis in telemedicine, with a focus on key technologies and current approaches. This study highlights research challenges, provides recommendations for future directions, and addresses research gaps and limitations to provide a clear vision of remote diagnosis in telemedicine. This study emphasizes the advantages of existing research and opens the possibility for new directions and smart healthcare solutions.
METHODS: The searches were completed in April 2024 using the databases PsycINFO, CINAHL Plus, MEDLINE, and Embase. Fifteen studies with a total of 1041 participants were included. These studies used quantitative measures to assess mania and depression in participants aged 50-98 with BD I or II. The studies' risk of bias was evaluated using the appropriate critical appraisal tools.
RESULTS: The Young Mania Rating Scale (YMRS) was the most commonly used measure of mania, while the Center for Epidemiologic Studies Depression Scale (CES-D) and the Hamilton Depression Rating Scale (HAM-D) were the most commonly used measures of depression. The pooled analysis revealed that older adult scores on the YMRS were relatively similar to younger cohorts in both euthymic and manic states. Variability in scores was seen across the depression scales.
LIMITATIONS: The review followed rigorous systematic processes. However, in some studies, the participant's mood state was unknown, possibly impacting their pooled scores on the measures.
CONCLUSIONS: The findings from the review add to our existing knowledge regarding the presentation of mania and depression in later life. There is still a great disparity in research developed for the older BD population. Large-scale studies are warranted to inform the development of tailored measures and interventions to improve the outcomes for this population.