Affiliations 

  • 1 School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
  • 2 School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. Electronic address: melati@usm.my
  • 3 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
Fitoterapia, 2014 Sep;97:261-7.
PMID: 24924287 DOI: 10.1016/j.fitote.2014.06.003

Abstract

A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.